S L Dewey

Summary

Affiliation: Brookhaven National Laboratory
Country: USA

Publications

  1. ncbi request reprint A novel strategy for the treatment of cocaine addiction
    S L Dewey
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Synapse 30:119-29. 1998
  2. ncbi request reprint GABAergic blockade of cocaine-associated cue-induced increases in nucleus accumbens dopamine
    M R Gerasimov
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Eur J Pharmacol 414:205-9. 2001
  3. ncbi request reprint Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Nature 386:830-3. 1997
  4. ncbi request reprint Comparison between intraperitoneal and oral methylphenidate administration: A microdialysis and locomotor activity study
    M R Gerasimov
    Chemistry, Brookhaven National Laboratory, Upton, New York, USA
    J Pharmacol Exp Ther 295:51-7. 2000
  5. ncbi request reprint Dopamine-transporter occupancy after intravenous doses of cocaine and methylphenidate in mice and humans
    S J Gatley
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Psychopharmacology (Berl) 146:93-100. 1999
  6. ncbi request reprint Comparable changes in synaptic dopamine induced by methylphenidate and by cocaine in the baboon brain
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 31:59-66. 1999
  7. ncbi request reprint Chiral drugs: comparison of the pharmacokinetics of [11C]d-threo and L-threo-methylphenidate in the human and baboon brain
    Y S Ding
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Psychopharmacology (Berl) 131:71-8. 1997
  8. ncbi request reprint [18F]haloperidol binding in baboon brain in vivo
    K A Yousef
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 23:47-52. 1996
  9. ncbi request reprint Synergistic interactions between nicotine and cocaine or methylphenidate depend on the dose of dopamine transporter inhibitor
    M R Gerasimov
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 38:432-7. 2000
  10. ncbi request reprint gamma-aminobutyric acid mimetic drugs differentially inhibit the dopaminergic response to cocaine
    M R Gerasimov
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Eur J Pharmacol 395:129-35. 2000

Collaborators

Detail Information

Publications49

  1. ncbi request reprint A novel strategy for the treatment of cocaine addiction
    S L Dewey
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Synapse 30:119-29. 1998
    ..Human trials with GVG are currently being developed to directly examine the utility of this novel strategy for the treatment of cocaine addiction...
  2. ncbi request reprint GABAergic blockade of cocaine-associated cue-induced increases in nucleus accumbens dopamine
    M R Gerasimov
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Eur J Pharmacol 414:205-9. 2001
    ..Combined with our earlier findings, these studies support the potential therapeutic benefit of this enzyme-based GABAergic strategy to modulate brain dopamine and the subsequent treatment of drug addiction...
  3. ncbi request reprint Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Nature 386:830-3. 1997
    ..Moreover, they suggest a participation of thalamic dopamine pathways in cocaine addiction, a possibility that merits further investigation...
  4. ncbi request reprint Comparison between intraperitoneal and oral methylphenidate administration: A microdialysis and locomotor activity study
    M R Gerasimov
    Chemistry, Brookhaven National Laboratory, Upton, New York, USA
    J Pharmacol Exp Ther 295:51-7. 2000
    ..p. routes are due to central drug bioavailability...
  5. ncbi request reprint Dopamine-transporter occupancy after intravenous doses of cocaine and methylphenidate in mice and humans
    S J Gatley
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Psychopharmacology (Berl) 146:93-100. 1999
    ..The present experiments were conducted to examine dose-occupancy and dose-effect relationships in mice for cocaine and also for methylphenidate, a dopamine uptake blocker used in pediatric psychiatry...
  6. ncbi request reprint Comparable changes in synaptic dopamine induced by methylphenidate and by cocaine in the baboon brain
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 31:59-66. 1999
    ....
  7. ncbi request reprint Chiral drugs: comparison of the pharmacokinetics of [11C]d-threo and L-threo-methylphenidate in the human and baboon brain
    Y S Ding
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Psychopharmacology (Berl) 131:71-8. 1997
    ..These results indicate that pharmacological specificity of MP resides entirely in the d-threo isomer and directly show that binding of the l-isomer in human brain is mostly nonspecific...
  8. ncbi request reprint [18F]haloperidol binding in baboon brain in vivo
    K A Yousef
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 23:47-52. 1996
    ..Haloperidol increased the clearance rate from all brain regions. These results indicate that the binding profile of [18F]haloperidol does not permit the selective examination of either dopamine D2 or sigma sites using PET...
  9. ncbi request reprint Synergistic interactions between nicotine and cocaine or methylphenidate depend on the dose of dopamine transporter inhibitor
    M R Gerasimov
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 38:432-7. 2000
    ..These findings suggest that the degree of DA transporter (DAT) occupancy contributes to the synergistic interaction between nicotine and cocaine or MP...
  10. ncbi request reprint gamma-aminobutyric acid mimetic drugs differentially inhibit the dopaminergic response to cocaine
    M R Gerasimov
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Eur J Pharmacol 395:129-35. 2000
    ..Our data suggest that in addition to irreversible inhibition of GABA transaminase, inhibition of GABA uptake represent another potentially effective, indirect strategy for the treatment of cocaine abuse...
  11. ncbi request reprint A pharmacologic strategy for the treatment of nicotine addiction
    S L Dewey
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 31:76-86. 1999
    ....
  12. doi request reprint Imaging dopamine release with Positron Emission Tomography (PET) and (11)C-raclopride in freely moving animals
    Vinal D Patel
    Medical Department, Brookhaven National Laboratory, Upton NY 11973, USA
    Neuroimage 41:1051-66. 2008
    ..This imaging strategy extends the applicability of small animal PET to include functional neurotransmitter imaging and the neurochemical correlates of behavioral tasks...
  13. ncbi request reprint Place preference and microdialysis studies with two derivatives of methylphenidate
    S J Gatley
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Life Sci 58:PL345-52. 1996
    ..It is concluded that the methylphenidate derivatives share the general pharmacological properties of other psychostimulant drugs...
  14. ncbi request reprint Gamma vinyl-GABA differentially modulates NMDA antagonist-induced increases in mesocortical versus mesolimbic DA transmission
    W K Schiffer
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuropsychopharmacology 25:704-12. 2001
    ....
  15. ncbi request reprint A consideration of the dopamine D2 receptor monomer-dimer equilibrium and the anomalous binding properties of the dopamine D2 receptor ligand, N-methyl spiperone
    J Logan
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    J Neural Transm 108:279-86. 2001
    ..If increasing DA favors cluster with fewer receptors, an increase in NMSP binding sites may also occur under some circumstances with an increase in DA...
  16. ncbi request reprint Therapeutic doses of amphetamine or methylphenidate differentially increase synaptic and extracellular dopamine
    W K Schiffer
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 59:243-51. 2006
    ..The similar potencies of MP and AMP to alter synaptic DA, despite their different potencies in raising ECF DA, could reflect their different molecular mechanisms...
  17. ncbi request reprint In vitro and ex vivo autoradiographic studies of nicotinic acetylcholine receptors using [18F]fluoronochloroepibatidine in rodent and human brain
    S J Gatley
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 25:449-54. 1998
    ..However, similar Kd values close to 50 pM were calculated for all regions. These studies support the suitability of [18F]NFEP as a radioligand for PET studies of nAcChR in the living human brain...
  18. ncbi request reprint Gamma-vinyl GABA (vigabatrin) blocks the expression of toluene-induced conditioned place preference (CPP)
    Dianne E Lee
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 54:183-5. 2004
  19. ncbi request reprint The selective sigma(1) receptor agonist, 1-(3,4-dimethoxyphenethyl)-4-(phenylpropyl)piperazine (SA4503), blocks the acquisition of the conditioned place preference response to (-)-nicotine in rats
    B Horan
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Eur J Pharmacol 426:R1-2. 2001
    ..Pretreatment of animals with either 1 or 3 mg/kg of SA4503 significantly attenuated the conditioned place preference response to (-)-nicotine...
  20. ncbi request reprint The effects of inhaled acetone on place conditioning in adolescent rats
    Dianne E Lee
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Pharmacol Biochem Behav 89:101-5. 2008
    ..Therefore, we systematically investigated the conditioned response to inhaled acetone in a place conditioning apparatus...
  21. doi request reprint Cue-induced dopamine release predicts cocaine preference: positron emission tomography studies in freely moving rodents
    Wynne K Schiffer
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurosci 29:6176-85. 2009
    ....
  22. ncbi request reprint Reproducibility of intraperitoneal 2-deoxy-2-[18F]-fluoro-D-glucose cerebral uptake in rodents through time
    Douglas A Marsteller
    Graduate Program in Molecular and Cellular Pharmacology, SUNY Stony Brook, NY 11794 8651, USA
    Nucl Med Biol 33:71-9. 2006
    ..However, the variability of within-rodent brain glucose uptake after an intraperitoneal injection across an extended time has not been measured...
  23. ncbi request reprint Serial microPET measures of the metabolic reaction to a microdialysis probe implant
    Wynne K Schiffer
    Graduate Program in Neuroscience, Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY 11794 5230, USA
    J Neurosci Methods 155:272-84. 2006
    ..Despite the extent and persistence of these reductions, 11C-raclopride binding and ECF DA concentrations remained stable...
  24. ncbi request reprint Metabolic correlates of toluene abuse: decline and recovery of function in adolescent animals
    Wynne K Schiffer
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Psychopharmacology (Berl) 186:159-67. 2006
    ..Children and adolescents will readily abuse household products that contain solvents such as toluene. It is likely that reinforcing exposures to toluene alter brain glucose metabolism...
  25. doi request reprint PET imaging of thin objects: measuring the effects of positron range and partial-volume averaging in the leaf of Nicotiana tabacum
    David L Alexoff
    Medical Department, Brookhaven National Laboratory, Upton, New York, USA
    Nucl Med Biol 38:191-200. 2011
    ..Although these limitations are acknowledged by researchers, little data have been published on them...
  26. ncbi request reprint Optimizing experimental protocols for quantitative behavioral imaging with 18F-FDG in rodents
    Wynne K Schiffer
    Medical Department, Brookhaven National Laboratory, Upton, New York, New York 11973, USA
    J Nucl Med 48:277-87. 2007
    ....
  27. pmc PET studies of d-methamphetamine pharmacokinetics in primates: comparison with l-methamphetamine and ( --)-cocaine
    Joanna S Fowler
    Brookhaven National Laboratory, Upton, New York, USA
    J Nucl Med 48:1724-32. 2007
    ....
  28. ncbi request reprint Targeting the treatment of drug abuse with molecular imaging
    Wynne K Schiffer
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 34:833-47. 2007
    ..Imaging can also give some insights into potential pharmacotherapeutic targets to manage the reinforcing effects of addictive compounds, as well as into protective strategies to minimize their toxic consequences...
  29. pmc Development of a simultaneous PET/microdialysis method to identify the optimal dose of 11C-raclopride for small animal imaging
    Wynne K Schiffer
    Department of Neurobiology and Behavior, State University of New York at Stony Brook, NY 11794 5230, USA
    J Neurosci Methods 144:25-34. 2005
    ..0 and 3.5 pmol/ml, around which the measured BP can be compromised by system sensitivity, endogenous DA, or excessive competition with unlabeled compound...
  30. ncbi request reprint Imaging addiction with PET: is insight in sight?
    Wynne K Schiffer
    Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY 11794, USA
    Drug Discov Today 10:547-62. 2005
    ..Thus, with this tool and the knowledge it provides, the potential for developing novel drugs and treatment strategies for drug addiction is now close at hand...
  31. ncbi request reprint Effect of vehicle on brain uptake of [11C]toluene
    Madina R Gerasimov
    Brookhaven National Laboratory, Department of Chemistry, Upton, NY 11973, USA
    Nucl Med Biol 29:607-12. 2002
    ..Present results clearly demonstrate that the choice of a vehicle has a significant effect on tracer uptake and should be considered as a potential factor contributing to the pharmacokinetic measurements...
  32. ncbi request reprint Selegiline potentiates cocaine-induced increases in rodent nucleus accumbens dopamine
    Wynne K Schiffer
    Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, New York 11794, USA
    Synapse 48:35-8. 2003
    ..On the other hand, chronic selegiline treatment may improve DA deficits, which are thought to contribute to relapse through a decreased response to natural rewards...
  33. ncbi request reprint Sub-chronic low dose gamma-vinyl GABA (vigabatrin) inhibits cocaine-induced increases in nucleus accumbens dopamine
    Wynne K Schiffer
    Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY 11794, USA
    Psychopharmacology (Berl) 168:339-43. 2003
    ..gamma-Vinyl GABA (GVG) irreversibly inhibits GABA-transaminase. This non-receptor mediated inhibition requires de novo synthesis for restoration of functional GABA catabolism...
  34. ncbi request reprint Positron emission tomography studies of potential mechanisms underlying phencyclidine-induced alterations in striatal dopamine
    Wynne K Schiffer
    SUNY Stony Brook, Department of Neurobiology and Behavior, Stony Brook, NY 11973, USA
    Neuropsychopharmacology 28:2192-8. 2003
    ..5%, consistent with a competitive interaction at the DAT. These results suggest that PCP may be exerting some direct effects through the DAT and that GABA partially modulates NMDA-antagonist-induced increases in striatal DA...
  35. ncbi request reprint Toluene inhalation produces regionally specific changes in extracellular dopamine
    Madina R Gerasimov
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Drug Alcohol Depend 65:243-51. 2002
    ..As further evidence of specific effects, our results indicate regionally specific changes in dopaminergic transmission following toluene exposure...
  36. ncbi request reprint Acute handling stress modulates methylphenidate-induced catecholamine overflow in the medial prefrontal cortex
    Douglas A Marsteller
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuropsychopharmacology 27:163-70. 2002
    ..These findings suggest that persistent alterations in mesocorticolimbic DA-ergic activity are induced by a short exposure to restraint stress as evidenced by the altered response to MP challenge...
  37. ncbi request reprint Study of brain uptake and biodistribution of [11C]toluene in non-human primates and mice
    M R Gerasimov
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Life Sci 70:2811-28. 2002
    ..Taken together, our data provides insight into pharmacokinetic features possibly associated with the abuse liability of toluene...
  38. doi request reprint Subchronic racemic gamma vinyl-GABA produces weight loss in Sprague Dawley and Zucker fatty rats
    Amy DeMarco
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 62:870-2. 2008
    ....
  39. doi request reprint Racemic gamma vinyl-GABA (R,S-GVG) blocks methamphetamine-triggered reinstatement of conditioned place preference
    Amy DeMarco
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 63:87-94. 2009
    ..Given that drug re-exposure may potentiate relapse to drug-seeking behavior, the ability of R,S-GVG to block METH-triggered reinstatement offers further support for its use in the successful management of METH dependence...
  40. ncbi request reprint Systemic administration of 1R,4S-4-amino-cyclopent-2-ene-carboxylic acid, a reversible inhibitor of GABA transaminase, blocks expression of conditioned place preference to cocaine and nicotine in rats
    Charles R Ashby
    Department of Pharmaceutical Sciences, St John s University, Jamaica, Queens, New York 11439, USA
    Synapse 44:61-3. 2002
    ..These results are the first to suggest that reversible inhibition of GABA transaminase may be useful in blocking cue-induced relapse to nicotine and cocaine...
  41. pmc A novel approach for imaging brain-behavior relationships in mice reveals unexpected metabolic patterns during seizures in the absence of tissue plasminogen activator
    Martine M Mirrione
    Graduate Program in Molecular and Cellular Pharmacology, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    Neuroimage 38:34-42. 2007
    ..Furthermore, we report unexpected activations that may underlie the tPA modulation of seizure susceptibility. The methods described here should be applicable to other mouse models of human neurological disease...
  42. ncbi request reprint Gamma-vinyl GABA, an irreversible inhibitor of GABA transaminase, alters the acquisition and expression of cocaine-induced sensitization in male rats
    Eliot L Gardner
    Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, Maryland 21224, USA
    Synapse 46:240-50. 2002
    ....
  43. ncbi request reprint Safety and efficacy of gamma-vinyl GABA (GVG) for the treatment of methamphetamine and/or cocaine addiction
    Jonathan D Brodie
    Department of Psychiatry, NYU School of Medicine, New York, New York 10016, USA
    Synapse 55:122-5. 2005
    ..Thus, under conditions that appear to be appropriate for the successful treatment of methamphetamine and/or cocaine addiction, GVG is safe...
  44. ncbi request reprint PET imaging of glucose metabolism in a mouse model of temporal lobe epilepsy
    Martine M Mirrione
    Graduate Program in Molecular and Cellular Pharmacology, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
    Synapse 59:119-21. 2006
    ..These studies provide a foundation upon which we can begin to identify genetic contributions to the metabolic signature of TLE in mice, since many transgenics are in the C57Bl/6 background strain...
  45. ncbi request reprint MicroPET imaging in an animal model of anorexia nervosa
    Nicole C Barbarich-Marsteller
    Graduate Program in Neuroscience, Department of Neurobiology and Behavior, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
    Synapse 57:85-90. 2005
    ..This is the first study to establish support for the use of microPET imaging in an animal model of anorexia nervosa as a means for studying the neurobiological changes that occur due to chronic food restriction...
  46. ncbi request reprint Brain metabolic changes following 4-week citalopram infusion: increased 18FDG uptake and gamma-amino butyric acid levels
    Douglas A Marsteller
    Graduate Program in Molecular and Cellular Pharmacology, SUNY Stony Brook, Stony Brook, New York 11794, USA
    Synapse 61:877-81. 2007
    ..We found increased striatal 18FDG uptake, reduced tissue levels of noradrenaline and serotonin in the striatum and prefrontal cortex, and increased striatal gamma-amino-butyric acid following 4-week citalopram infusion...
  47. doi request reprint Treatment of methamphetamine dependence
    John Mendelson
    Mayo Clin Proc 83:369-70; author reply 370-1. 2008
  48. ncbi request reprint Treating cocaine addiction: from preclinical to clinical trial experience with gamma-vinyl GABA
    Jonathan D Brodie
    Department of Psychiatry, New York University School of Medicine, New York, New York 10016, USA
    Synapse 50:261-5. 2003
  49. ncbi request reprint Short-term treatment of cocaine and/or methamphetamine abuse with vigabatrin: ocular safety pilot results
    Robert D Fechtner
    Institute of Ophthalmology and Visual Science, University of Medicine and Dentistry of New Jersey New Jersey Medical School, 90 Bergen Street, Newark, NJ 07103, USA
    Arch Ophthalmol 124:1257-62. 2006
    ..To evaluate the ocular safety of short-term use of vigabatrin to treat cocaine and/or methamphetamine addiction...

Research Grants3

  1. Feto-Maternal Pharmacokinetics of Abused Inhalants
    STEPHEN DEWEY; Fiscal Year: 2004
    ..Ultimately, the hope is to relate the mother's exposure to inhalants to the dose received by the fetus and to post-natal behavioral deficits. ..
  2. Treating Adolsecent and Adult Methamphetamine or Inhalant Abuse with S-(+)-GVG
    STEPHEN DEWEY; Fiscal Year: 2007
    ....