L Chang

Summary

Affiliation: Brookhaven National Laboratory
Country: USA

Publications

  1. ncbi request reprint Neural correlates of attention and working memory deficits in HIV patients
    L Chang
    Department of Neurology, UCLA School of Medicine, Harbor UCLA Medical Center, Torrance, CA, USA
    Neurology 57:1001-7. 2001
  2. ncbi request reprint Perfusion MRI and computerized cognitive test abnormalities in abstinent methamphetamine users
    Linda Chang
    Medical Department, Brookhaven National Laboratory, Building 490, Upton, NY, 11973 5000, USA
    Psychiatry Res 114:65-79. 2002
  3. ncbi request reprint Relationships among brain metabolites, cognitive function, and viral loads in antiretroviral-naïve HIV patients
    Linda Chang
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
    Neuroimage 17:1638-48. 2002
  4. ncbi request reprint Magnetic resonance spectroscopy studies of GABA in neuropsychiatric disorders
    Linda Chang
    Brookhaven National Laboratory, Upton, NY 11973, USA
    J Clin Psychiatry 64:7-14. 2003
  5. ncbi request reprint Persistent brain abnormalities in antiretroviral-naive HIV patients 3 months after HAART
    Linda Chang
    Medical Department, Brookhaven National Laboratory, Upton, NY, USA
    Antivir Ther 8:17-26. 2003
  6. ncbi request reprint Increased glial metabolites predict increased working memory network activation in HIV brain injury
    T Ernst
    Medical Department, Brookhaven National Laboratory, Building 490, P O Box 5000, Upton, NY 11973 5000, USA
    Neuroimage 19:1686-93. 2003
  7. ncbi request reprint Low level of brain dopamine D2 receptors in methamphetamine abusers: association with metabolism in the orbitofrontal cortex
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Am J Psychiatry 158:2015-21. 2001
  8. doi request reprint Measuring symptoms in the irritable bowel syndrome: development of a framework for clinical trials
    B M R Spiegel
    Department of Gastroenterology, VA Greater Los Angeles Healthcare System, CA, USA
    Aliment Pharmacol Ther 32:1275-91. 2010
  9. ncbi request reprint Cerebral metabolites in HIV-infected children followed for 10 months with 1H-MRS
    M A Keller
    Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Neurology 66:874-9. 2006
  10. pmc Characterizing abdominal pain in IBS: guidance for study inclusion criteria, outcome measurement and clinical practice
    B M R Spiegel
    Department of Gastroenterology, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
    Aliment Pharmacol Ther 32:1192-202. 2010

Detail Information

Publications80

  1. ncbi request reprint Neural correlates of attention and working memory deficits in HIV patients
    L Chang
    Department of Neurology, UCLA School of Medicine, Harbor UCLA Medical Center, Torrance, CA, USA
    Neurology 57:1001-7. 2001
    ..To evaluate the neural correlates of attention and working memory deficits in patients with HIV-1...
  2. ncbi request reprint Perfusion MRI and computerized cognitive test abnormalities in abstinent methamphetamine users
    Linda Chang
    Medical Department, Brookhaven National Laboratory, Building 490, Upton, NY, 11973 5000, USA
    Psychiatry Res 114:65-79. 2002
    ..These findings suggest that METH abuse is associated with persistent physiologic changes in the brain, and these changes are accompanied by slower reaction times on computerized measures of cognitive function...
  3. ncbi request reprint Relationships among brain metabolites, cognitive function, and viral loads in antiretroviral-naïve HIV patients
    Linda Chang
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
    Neuroimage 17:1638-48. 2002
    ..Metabolite concentrations, rather than metabolite ratios, should be measured since [CR], a commonly used reference for metabolite ratios, varies with disease severity in both frontal lobe and basal ganglia...
  4. ncbi request reprint Magnetic resonance spectroscopy studies of GABA in neuropsychiatric disorders
    Linda Chang
    Brookhaven National Laboratory, Upton, NY 11973, USA
    J Clin Psychiatry 64:7-14. 2003
    ..Examples of such a rational therapeutic approach include anticonvulsants that elevate brain GABA levels and are effective for the treatment of epilepsy and anxiety disorder...
  5. ncbi request reprint Persistent brain abnormalities in antiretroviral-naive HIV patients 3 months after HAART
    Linda Chang
    Medical Department, Brookhaven National Laboratory, Upton, NY, USA
    Antivir Ther 8:17-26. 2003
    ..We aimed to evaluate whether brain abnormalities will improve 3 months after HAART...
  6. ncbi request reprint Increased glial metabolites predict increased working memory network activation in HIV brain injury
    T Ernst
    Medical Department, Brookhaven National Laboratory, Building 490, P O Box 5000, Upton, NY 11973 5000, USA
    Neuroimage 19:1686-93. 2003
    ..The same mechanism may also contribute to cognitive dysfunction in other brain diseases that involve inflammation...
  7. ncbi request reprint Low level of brain dopamine D2 receptors in methamphetamine abusers: association with metabolism in the orbitofrontal cortex
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Am J Psychiatry 158:2015-21. 2001
    ..Because the orbitofrontal cortex is associated with compulsive behaviors, its disruption may contribute to compulsive drug intake in addicted subjects. This study explored whether a similar association occurs in methamphetamine abusers...
  8. doi request reprint Measuring symptoms in the irritable bowel syndrome: development of a framework for clinical trials
    B M R Spiegel
    Department of Gastroenterology, VA Greater Los Angeles Healthcare System, CA, USA
    Aliment Pharmacol Ther 32:1275-91. 2010
    ..The Food and Drug Administration (FDA) emphasizes that PROs must be couched in a conceptual framework, yet existing IBS PROs were not based on such a framework...
  9. ncbi request reprint Cerebral metabolites in HIV-infected children followed for 10 months with 1H-MRS
    M A Keller
    Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Neurology 66:874-9. 2006
    ..0 years +/- 3.7 years) and repeated the MR spectroscopy at 24.1 +/- 3.7 weeks and 42.2 +/- 3.5 weeks following the entry time with repeated neuropsychological testing...
  10. pmc Characterizing abdominal pain in IBS: guidance for study inclusion criteria, outcome measurement and clinical practice
    B M R Spiegel
    Department of Gastroenterology, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
    Aliment Pharmacol Ther 32:1192-202. 2010
    ..Despite consensus that IBS trials should measure pain to define study entry and determine efficacy, the optimal method of measuring pain remains uncertain...
  11. ncbi request reprint Proton spectroscopy in myotonic dystrophy: correlations with CTG repeats
    L Chang
    Department of Neurology, Harbor UCLA Medical Center, Torrance, Calif 90509, USA
    Arch Neurol 55:305-11. 1998
    ....
  12. pmc Sex differences in sensory gating of the thalamus during auditory interference of visual attention tasks
    D Tomasi
    Medical Department, Building 490, Brookhaven National Laboratory, 30 Bell Avenue, Upton, NY 11973, USA
    Neuroscience 151:1006-15. 2008
    ..Together, these sex-specific differences in brain activation during the VA task, at different cognitive and acoustic levels suggest differences in auditory gating of the thalamus for men and women...
  13. ncbi request reprint Changes in cerebral metabolism are detected prior to perfusion changes in early HIV-CMC: A coregistered (1)H MRS and SPECT study
    T Ernst
    Department of Radiology, Harbor UCLA Medical Center, Torrance, California 90502, USA
    J Magn Reson Imaging 12:859-65. 2000
    ..This finding suggests that metabolite concentrations on (1)H MRS are better surrogate markers than rCBF measurements with SPECT for the evaluation of brain injury in early HIV-CMC. J. Magn. Reson. Imaging 2000;12:859-865...
  14. ncbi request reprint Brain N-acetyl aspartate concentrations measured by H MRS are reduced in adult male rats subjected to perinatal stress: preliminary observations and hypothetical implications for neurodevelopmental disorders
    R E Poland
    Department of Psychiatry, Harbor UCLA Medical Center, Torrance, CA 90509, USA
    J Psychiatr Res 33:41-51. 1999
    ..particularly in relation to NAA. For hypothesis-generating purposes, the possible relevance of stress and NAA to the neurodevelopmental hypothesis of schizophrenia is discussed in greater detail...
  15. pmc Neuropsychological function and cerebral metabolites in HIV-infected youth
    R Nagarajan
    David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, CA, USA
    J Neuroimmune Pharmacol 7:981-90. 2012
    ..Scy and Glu ratios are also potential markers of brain health in chronic, lifelong HIV infection in perinatally infected youths receiving antiretroviral therapy...
  16. ncbi request reprint Cerebral (1)H MRS alterations in recreational 3, 4-methylenedioxymethamphetamine (MDMA, "ecstasy") users
    L Chang
    Department of Neurology, UCLA School of Medicine, Harbor UCLA Medical Center, Torrance, California 90502, USA
    J Magn Reson Imaging 10:521-6. 1999
    ..However, the usage-related increase in MI suggests that exposure to MDMA, even at recreational doses, may cause increased glial content. J. Magn. Reson. Imaging 1999;10:521-526...
  17. ncbi request reprint Highly active antiretroviral therapy reverses brain metabolite abnormalities in mild HIV dementia
    L Chang
    Department of Neurology, University of California at Los Angeles School of Medicine, USA
    Neurology 53:782-9. 1999
    ..To determine whether cerebral metabolite abnormalities normalize with highly active antiretroviral therapy (HAART)...
  18. pmc Different activation patterns for working memory load and visual attention load
    D Tomasi
    Medical Department, Bldg 490, Brookhaven National Laboratory, 30 Bell Ave, Upton, NY 11973, USA
    Brain Res 1132:158-65. 2007
    ..Conversely, VA tasks activated more strongly an occipito-parietal network comprising the postcentral (PostCG) and the superior occipital (SOG) gyri, suggesting complex visual processing in this network...
  19. ncbi request reprint Altered neurometabolite development in HIV-infected children: correlation with neuropsychological tests
    M A Keller
    Harbor UCLA Research and Education Institute, Torrance, CA, USA
    Neurology 62:1810-7. 2004
    ..HIV-infected children have abnormal cerebral metabolites, measured by proton MR spectroscopy ((1)H-MRS), but how these abnormalities relate to brain function is unclear...
  20. ncbi request reprint Gender effects on persistent cerebral metabolite changes in the frontal lobes of abstinent cocaine users
    L Chang
    Department of Neurology, UCLA School of Medicine, Harbor UCLA Medical Center, Torrance 90509, USA
    Am J Psychiatry 156:716-22. 1999
    ..The aim of this study was to investigate persistent neurochemical changes in the frontal lobes of subjects with a history of crack cocaine dependence and to determine whether these changes are different in male and female users...
  21. ncbi request reprint Brain areas specific for attentional load in a motion-tracking task
    J Jovicich
    California Institute of Technology and Harbor UCLA Medical Center, CA, USA
    J Cogn Neurosci 13:1048-58. 2001
    ..Our results suggest a general role for posterior parietal areas in the deployment of visual of attentional resources...
  22. pmc fMRI-acoustic noise alters brain activation during working memory tasks
    D Tomasi
    Medical Department, Bldg 490, Brookhaven National Laboratory, 30 Bell Avenue, Upton, NY 11973, USA
    Neuroimage 27:377-86. 2005
    ....
  23. ncbi request reprint Biexponential modeling of multigradient-echo MRI data of the brain
    O Speck
    Department of Neurology, Harbor UCLA Medical Center, UCLA School of Medicine, Torrance, California, USA
    Magn Reson Med 45:1116-21. 2001
    ..The activation-induced parameter changes are detected with a sensitivity equal to that of a monoexponential method. The resulting T2* and DeltaT2* values describe the experimental data more accurately...
  24. ncbi request reprint Methamphetamine and AIDS: 1HMRS studies in a feline model of human disease
    C C Cloak
    Medical Department, Brookhaven National Laboratory, Buliding 490, Upton, NY, USA
    J Neuroimmunol 147:16-20. 2004
    ..The decreased glutamate in FIV cats normalized with MA exposure. FIV and MA both affect brain metabolites individually and combined. 1HMRS is useful for evaluating the effects of FIV and drug abuse in the brain...
  25. ncbi request reprint Effect of ecstasy [3,4-methylenedioxymethamphetamine (MDMA)] on cerebral blood flow: a co-registered SPECT and MRI study
    L Chang
    Department of Neurology, UCLA School of Medicine, Harbor UCLA Medical Center, 1000 W Carson Street, B 4, Torrance, CA 90509, USA
    Psychiatry Res 98:15-28. 2000
    ....
  26. ncbi request reprint Differences in somatic perception in female patients with irritable bowel syndrome with and without fibromyalgia
    L Chang
    UCLA CURE Neuroenteric Disease Program, Departments of Medicine and Physiology, UCLA School of Medicine, Los Angeles, CA 90024, USA
    Pain 84:297-307. 2000
    ..Because there is a significant overlap of IBS and FM, shared pathophysiological mechanisms have been suggested. Although visceral perception has been well studied in IBS, somatic perception has not...
  27. ncbi request reprint Brain proton magnetic resonance spectroscopy and imaging in children exposed to cocaine in utero
    L M Smith
    Department of Pediatrics, Harbor University of California, Los Angeles Medical Center, Torrance, CA 90502, USA
    Pediatrics 107:227-31. 2001
    ..The purpose of this study was to examine the possible neurotoxic effects of prenatal cocaine exposure on the developing brain using (1)H-MRS...
  28. ncbi request reprint Automatic scan prescription for brain MRI
    L Itti
    Harbor UCLA Research and Education Institute, University of California Los Angeles, Torrance, California, USA
    Magn Reson Med 45:486-94. 2001
    ..Magn Reson Med 45:486-494, 2001...
  29. ncbi request reprint Correlation of regional cerebral blood flow from perfusion MRI and spect in normal subjects
    T Ernst
    Department of Radiology, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Magn Reson Imaging 17:349-54. 1999
    ..pMRI is a reliable noninvasive method for rCBF measurements...
  30. ncbi request reprint Evidence for long-term neurotoxicity associated with methamphetamine abuse: A 1H MRS study
    T Ernst
    Department of Neurology, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Neurology 54:1344-9. 2000
    ..To determine whether proton MRS (1H MRS) can detect long-term metabolite abnormalities in abstinent methamphetamine users...
  31. ncbi request reprint Practice-induced changes of brain function during visual attention: a parametric fMRI study at 4 Tesla
    D Tomasi
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuroimage 23:1414-21. 2004
    ..Since short-term practice-effects in the prefrontal cortex may be similar to attentional load-effects, studies of attentional load need to take practice effects into account...
  32. ncbi request reprint Neuroimaging findings in patients with AIDS
    I Walot
    Department of Radiology, Harbor UCLA Medical Center, Torrance 90509, USA
    Clin Infect Dis 22:906-19. 1996
    ..As therapeutic modes improve, imaging may assume a growing role in monitoring the responses to therapy among these patients...
  33. pmc Characterization of symptoms in irritable bowel syndrome with mixed bowel habit pattern
    A M Su
    Feinberg School of Medicine, Northwestern University, Chicago, IL, USA Department of Medicine, Stanford University, Stanford, CA, USA
    Neurogastroenterol Motil 26:36-45. 2014
    ..We aimed to characterize gastrointestinal (GI) and non-GI symptoms in IBS-M patients from a US patient population, and to compare them with IBS with constipation (IBS-C) and diarrhea (IBS-D)...
  34. ncbi request reprint V. Stress and irritable bowel syndrome
    E A Mayer
    UCLA CURE Neuroenteric Disease Program, Departments of Medicine, Physiology, and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, California 90024, USA
    Am J Physiol Gastrointest Liver Physiol 280:G519-24. 2001
    ..Functional brain imaging techniques are beginning to identify brain circuits involved in the perceptual alterations. Animal models have recently been proposed that mimic key features of the human syndrome...
  35. ncbi request reprint Brain proton magnetic resonance spectroscopy in children exposed to methamphetamine in utero
    L M Smith
    Department of Pediatrics, Harbor UCLA Medical Center, University of California, Los Angeles School of Medicine, Torrance 90502, USA
    Neurology 57:255-60. 2001
    ..To examine the possible neurotoxic effects of prenatal methamphetamine exposure on the developing brain using 1H-MRS...
  36. ncbi request reprint HIV-2 infection with cerebral toxoplasmosis and lymphomatoid granulomatosis
    M Issakhanian
    Department of Neurology, University of California, Los Angeles (UCLA) School of Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA
    J Neuroimaging 11:212-6. 2001
    ..The lesion showed a biochemical and perfusion pattern that was intermediate for infectious and neoplastic processes. Further neuropathology confirmed a secondary diagnosis of lymphomatoid granulomatosis...
  37. ncbi request reprint Higher cortical and lower subcortical metabolism in detoxified methamphetamine abusers
    N D Volkow
    Department of Psychiatry, State University of New York at Stony Brook, USA
    Am J Psychiatry 158:383-9. 2001
    ..The authors measured regional brain glucose metabolism, which serves as a marker of brain function, to assess if there is evidence of functional changes in methamphetamine abusers in regions other than those innervated by dopamine cells...
  38. ncbi request reprint Association of dopamine transporter reduction with psychomotor impairment in methamphetamine abusers
    N D Volkow
    Department of Psychiatry, State University of New York at Stony Brook, USA
    Am J Psychiatry 158:377-82. 2001
    ..The authors evaluated if similar changes occur in humans and assessed if they were functionally significant...
  39. pmc Autonomic response to a visceral stressor is dysregulated in irritable bowel syndrome and correlates with duration of disease
    P Cheng
    Gail and Gerald Oppenheimer Family Center for the Neurobiology of Stress, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Neurogastroenterol Motil 25:e650-9. 2013
    ..This study examined heart rate variability (HRV) and plasma catecholamines as an index of ANS responsiveness in IBS during flexible sigmoidoscopy (FS) and explored associations of HRV with clinical measures...
  40. pmc Perceptual responses in patients with inflammatory and functional bowel disease
    L Chang
    UCLA CURE Neuroenteric Disease Program, Department of Medicine and Physiology, UCLA School of Medicine, Los Angeles, California 90073, USA
    Gut 47:497-505. 2000
    ....
  41. ncbi request reprint Approaches to the modulation of abdominal pain
    E A Mayer
    UCLA CURE Neuroenteric Disease Program, Department of Medicine, Physiology and Brain Research Institute, UCLA School of Medicine, Los Angeles, California 90073, USA
    Can J Gastroenterol 13:65A-70A. 1999
    ....
  42. ncbi request reprint Abnormal brain activation on functional MRI in cognitively asymptomatic HIV patients
    T Ernst
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neurology 59:1343-9. 2002
    ..The current study aims to determine whether patients who are HIV-1 positive and have normal cognitive function also show increased brain activation on fMRI...
  43. ncbi request reprint Loss of dopamine transporters in methamphetamine abusers recovers with protracted abstinence
    N D Volkow
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurosci 21:9414-8. 2001
    ..These findings have treatment implications because they suggest that protracted abstinence may reverse some of methamphetamine-induced alterations in brain DA terminals...
  44. pmc Measuring irritable bowel syndrome patient-reported outcomes with an abdominal pain numeric rating scale
    B Spiegel
    VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
    Aliment Pharmacol Ther 30:1159-70. 2009
    ..Pain numeric rating scales (NRS) are widely used in the non-IBS pain literature. The Food and Drug Administration has proposed using the NRS in IBS...
  45. ncbi request reprint Cerebral perfusion abnormalities in abstinent cocaine abusers: a perfusion MRI and SPECT study
    T Ernst
    Department of Neurology, UCLA School of Medicine, Harbor UCLA Medical Center, 100 West Carson Street, B 4, 90509, Torrance, CA, USA
    Psychiatry Res 99:63-74. 2000
    ..The hypoperfusion in the cortex and deep gray matter of the cocaine users is consistent with previous results. The increased rCBF in the white matter of cocaine users may be due to the presence of reactive glia...
  46. pmc Overlap between functional GI disorders and other functional syndromes: what are the underlying mechanisms?
    S E Kim
    Oppenheimer Family Center of Neurobiology of Stress, Los Angeles, CA, USA
    Neurogastroenterol Motil 24:895-913. 2012
    ..They commonly coexist within the same individual. The pathophysiologic mechanisms of these disorders are not well understood, but it has been hypothesized that they share a common pathogenesis...
  47. ncbi request reprint Basic pathophysiologic mechanisms in irritable bowel syndrome
    E A Mayer
    UCLA CURE Neuroenteric Disease Program, Department of Medicine, Physiology and Biobehavioral Sciences, UCLA School of Medicine, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Dig Dis 19:212-8. 2001
    ..IBS patients show an enhanced responsiveness of this system manifesting in altered modulation of gastrointestinal motility, secretion, immune function and in alterations in the perceptual and emotional response to visceral events...
  48. ncbi request reprint Gender-related differences in IBS symptoms
    O Y Lee
    CURE Digestive Diseases Research Center/Neuroenteric Disease Program, Department of Medicine and Physiology, UCLA School of Medicine, Los Angeles, California, USA
    Am J Gastroenterol 96:2184-93. 2001
    ..The apparent differences in sensitivity to nonpainful visceral sensations, medications, and food may represent altered sensory processes, autonomic responses, and/or cognitive hypervigilance...
  49. ncbi request reprint Memantine and HIV-associated cognitive impairment: a neuropsychological and proton magnetic resonance spectroscopy study
    Giovanni Schifitto
    University of Rochester, Rochester, New York 14620, USA
    AIDS 21:1877-86. 2007
    ..To assess the safety and efficacy of memantine, an uncompetitive antagonist of the N-methyl-D-aspartate receptor as treatment of HIV-associated cognitive impairment...
  50. pmc Is decreased prefrontal cortical sensitivity to monetary reward associated with impaired motivation and self-control in cocaine addiction?
    Rita Z Goldstein
    State University of New York at Stony Brook, Brookhaven National Laboratory, P O Box 5000, Upton, NY 11973 5000, USA
    Am J Psychiatry 164:43-51. 2007
    ..This study attempted to examine the brain's sensitivity to monetary rewards of different magnitudes in cocaine abusers and to study its association with motivation and self-control...
  51. ncbi request reprint Unified structural equation modeling approach for the analysis of multisubject, multivariate functional MRI data
    Jieun Kim
    Department of Applied Mathematics and Statistics, State University of New York at Stony Brook, Stony Brook, New York, USA
    Hum Brain Mapp 28:85-93. 2007
    ....
  52. ncbi request reprint Structural and metabolic brain changes in the striatum associated with methamphetamine abuse
    Linda Chang
    Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA
    Addiction 102:16-32. 2007
    ..To review structural, chemical and metabolic brain changes, particularly those in the basal ganglia, in individuals who used methamphetamine, as well as in children with prenatal methamphetamine exposure...
  53. pmc Imaging the addicted human brain
    Joanna S Fowler
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Sci Pract Perspect 3:4-16. 2007
    ..The authors give examples of key findings illustrating how each technique has extended and deepened our knowledge of the neurobiological bases of drug abuse and addiction, and they address potential clinical and therapeutic applications...
  54. ncbi request reprint Relationships between white matter metabolite abnormalities, cognitive and social functioning in elderly schizophrenic subjects
    Joseph I Friedman
    Schizophr Res 100:356-8. 2008
  55. pmc Regional variations and the effects of age and gender on glutamate concentrations in the human brain
    Napapon Sailasuta
    Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA
    Magn Reson Imaging 26:667-75. 2008
    ..Our results also highlight the importance of brain region, age and gender matching in clinical studies...
  56. ncbi request reprint Proton MRS and neuropsychological correlates in AIDS dementia complex: evidence of subcortical specificity
    Robert H Paul
    Department of Behavioral Neuroscience, University of Missouri, St Louis, St Louis, MO 63121, USA
    J Neuropsychiatry Clin Neurosci 19:283-92. 2007
    ..Prospective studies are needed to elucidate the evolution of these changes in the setting of antiretroviral therapy...
  57. pmc Brain metabolite abnormalities in the white matter of elderly schizophrenic subjects: implication for glial dysfunction
    Linda Chang
    Department of Medicine, John A Burns School of Medicine, Honolulu, Hawaii 96813, USA
    Biol Psychiatry 62:1396-404. 2007
    ....
  58. pmc Correlations between Diffusion Tensor Imaging (DTI) and Magnetic Resonance Spectroscopy (1H MRS) in schizophrenic patients and normal controls
    Cheuk Y Tang
    Department of Radiology, Mount Sinai School of Medicine NY, NY 10029, USA
    BMC Psychiatry 7:25. 2007
    ..DTI is thus sensitive to demyelination and other structural abnormalities. DTI has also shown abnormalities in these regions...
  59. ncbi request reprint The effects of tamoxifen and estrogen on brain metabolism in elderly women
    Thomas Ernst
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    J Natl Cancer Inst 94:592-7. 2002
    ..Consequently, we assessed the effects of tamoxifen and estrogen on the brain chemistry of elderly women...
  60. pmc The orbitofrontal cortex in methamphetamine addiction: involvement in fear
    Rita Z Goldstein
    Department of Human Development, Laboratory of Neurobiology of Personality and Emotion, Cornell University, Ithaca, NY 14853, USA
    Neuroreport 13:2253-7. 2002
    ..051). These results suggest that the role of the orbitofrontal cortex in inhibitory control can be manifested in stable personality predispositions and further implicate this region in the core characteristics of drug addiction...
  61. ncbi request reprint A multi-center 1H MRS study of the AIDS dementia complex: validation and preliminary analysis
    Patricia Lani Lee
    NMR Center, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02111, USA
    J Magn Reson Imaging 17:625-33. 2003
    ....
  62. ncbi request reprint k-Space based summary motion detection for functional magnetic resonance imaging
    Elisabeth C Caparelli
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuroimage 20:1411-8. 2003
    ..This method makes it possible to evaluate brain motion within seconds after a scan and to decide whether a study needs to be repeated...
  63. ncbi request reprint Partial recovery of brain metabolism in methamphetamine abusers after protracted abstinence
    Gene Jack Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Am J Psychiatry 161:242-8. 2004
    ..In this study, the authors assessed whether metabolism recovers with protracted abstinence...
  64. ncbi request reprint Effect of aging on brain metabolism in antiretroviral-naive HIV patients
    Thomas Ernst
    Medical Department, Brookhaven National Laboratory, Upton, NY, USA
    AIDS 18:S61-7. 2004
    ..The goal of this pilot study was to evaluate the interaction between aging and HIV infection in the brain using proton magnetic resonance spectroscopy (H-MRS)...
  65. ncbi request reprint Antiretroviral treatment alters relationship between MCP-1 and neurometabolites in HIV patients
    Linda Chang
    Department of Medicine, John A Burns School of Medicine, University of Hawai, Honolulu, HI, USA
    Antivir Ther 9:431-40. 2004
    ..The relationships between neurometabolites and macrophage chemoattractant protein (MCP-1) in serum and cerebrospinal fluid (CSF) were evaluated in HIV patients before and after antiretroviral treatment...
  66. ncbi request reprint Adaptation of the attention network in human immunodeficiency virus brain injury
    Linda Chang
    Medical Department, Brookhaven National Laboratory, Upton, NY, USA
    Ann Neurol 56:259-72. 2004
    ..Exceeding the brain reserve capacity may lead to attention deficits and cognitive impairment in HIV patients...
  67. ncbi request reprint Decreased brain dopaminergic transporters in HIV-associated dementia patients
    Gene Jack Wang
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, NY, USA
    Brain 127:2452-8. 2004
    ..The inverse relationship between viral burden and DAT availability further supports HIV-mediated neurotoxicity to dopaminergic terminals...
  68. ncbi request reprint Regional patterns of brain metabolites in AIDS dementia complex
    Constantin T Yiannoutsos
    Division of Biostatistics, Indiana University School of Medicine, 1050 Wishard Boulevard, RG 4101, Indianapolis, IN 46202, USA
    Neuroimage 23:928-35. 2004
    ..We conclude that by using factor analysis, we are able to combine multiple metabolites across brain regions in a biologically plausible manner and construct a predictive model of ADC adjusting for relevant factors such as age...
  69. ncbi request reprint Smaller subcortical volumes and cognitive deficits in children with prenatal methamphetamine exposure
    Linda Chang
    Department of Medicine, John A Burns School of Medicine, University of Hawai i, HI 96813, USA
    Psychiatry Res 132:95-106. 2004
    ..These preliminary findings suggest prenatal Meth exposure may be neurotoxic to the developing brain...
  70. pmc The human immunodeficiency virus reduces network capacity: acoustic noise effect
    Dardo Tomasi
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Ann Neurol 59:419-23. 2006
    ..Increased acoustic noise (AN) during working memory leads to increased brain activation in healthy individuals and may have greater impact in human immunodeficiency virus (HIV) patients...
  71. pmc Common deactivation patterns during working memory and visual attention tasks: an intra-subject fMRI study at 4 Tesla
    Dardo Tomasi
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Hum Brain Mapp 27:694-705. 2006
    ..The task-dependent balance of activation and deactivation might allow maximization of resources for the activated network...
  72. ncbi request reprint Enlarged striatum in abstinent methamphetamine abusers: a possible compensatory response
    Linda Chang
    Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu 96813, USA
    Biol Psychiatry 57:967-74. 2005
    ....
  73. ncbi request reprint A multicenter study of two magnetic resonance spectroscopy techniques in individuals with HIV dementia
    Ned Sacktor
    Department of Neurology, Johns Hopkins Bayview Medical Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Magn Reson Imaging 21:325-33. 2005
    ..To evaluate single-voxel proton magnetic resonance spectroscopy (SV-MRS) and magnetic resonance spectroscopic imaging (MRSI) metabolite results in individuals with HIV dementia...
  74. ncbi request reprint Additive effects of HIV and chronic methamphetamine use on brain metabolite abnormalities
    Linda Chang
    Department of Medicine, John A Burns School of Medicine, University of Hawaii, 1356 Lusitana St, 7th Floor, Honolulu, HI 96813, USA
    Am J Psychiatry 162:361-9. 2005
    ..The authors sought to determine whether HIV and a history of chronic methamphetamine use might have additive or interactive effects on brain metabolite abnormalities...
  75. ncbi request reprint Neuropsychological effects of 3,4-methylenedioxymethamphetamine (MDMA or ecstasy) in recreational users
    Carla Back-Madruga
    Department of Psychiatry, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Clin Neuropsychol 17:446-59. 2003
    ..Our results suggest that a subgroup of MDMA patients, specifically heavy MDMA users, evidence declines in nonverbal (visual) memory, however, other cognitive areas appear to be spared...
  76. pmc Response: images and interventions
    Linda Chang
    Sci Pract Perspect 3:17-9. 2007
  77. ncbi request reprint The effects of repeated endotoxin exposure on rat brain metabolites as measured by ex vivo 1HMRS
    Sulie L Chang
    Department of Biology, Seton Hall University, 400 South Orange Avenue, South Orange, NJ 07079, USA
    J Neuroimmunol 166:39-46. 2005
    ..These findings suggest that chronic inflammation induced by LPS could lead to cell loss/dysfunction, and hence, desensitization of the HPA axis, particularly in the hypothalamus...
  78. ncbi request reprint NeuroAIDS, drug abuse, and inflammation: building collaborative research activities
    Joan W Berman
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Neuroimmune Pharmacol 1:351-99. 2006
    ..Research priorities were identified. Additional information about this meeting is available through links from the NIDA AIDS Research Program website ( http://www.nida.nih.gov/about/organization/arp/arp-websites.htm )...
  79. ncbi request reprint Treatment of hyperlipidemia
    Eric Henley
    Department of Family and Community Medicine, University of Illinois College of Medicine at Rockford, 1601 Parkview Ave, Robkford, IL 61107, USA
    J Fam Pract 51:370-6. 2002
    ....
  80. ncbi request reprint Insights from recent positron emission tomographic studies of drug abuse and dependence
    Linda Chang
    Department of Medicine, Division of Neurology, John A Burns School of Medicine, University of Hawaii, Queen s University Tower, 7th Floor, 1356 Lusitana St, Honolulu, HI 96813, USA
    Curr Opin Psychiatry 19:246-52. 2006
    ..Recent positron emission tomographic studies demonstrate a variety of abnormalities in the brains of addicted individuals. This review aims to discuss and highlight these findings...