Anat Biegon

Summary

Affiliation: Brookhaven National Laboratory
Country: USA

Publications

  1. pmc Hippocampal glutamate NMDA receptor loss tracks progression in Alzheimer's disease: quantitative autoradiography in postmortem human brain
    Efrat Kravitz
    J Sagol Neuroscience Center, Sheba Medical Center, Ramat Gan, Israel
    PLoS ONE 8:e81244. 2013
  2. pmc Potential contribution of aromatase inhibition to the effects of nicotine and related compounds on the brain
    Anat Biegon
    Brookhaven National Laboratory Upton, NY, USA
    Front Pharmacol 3:185. 2012
  3. ncbi request reprint Cannabinoids as neuroprotective agents in traumatic brain injury
    Anat Biegon
    Department Functional Imaging, Lawrence Berkeley National Laboratory, Berkeley, CA, USA
    Curr Pharm Des 10:2177-83. 2004
  4. pmc Nicotine blocks brain estrogen synthase (aromatase): in vivo positron emission tomography studies in female baboons
    Anat Biegon
    Brookhaven National Laboratory, Upton, New York, USA
    Biol Psychiatry 67:774-7. 2010
  5. pmc Dynamic changes in N-methyl-D-aspartate receptors after closed head injury in mice: Implications for treatment of neurological and cognitive deficits
    Anat Biegon
    Department of Functional Imaging, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 101:5117-22. 2004
  6. pmc Unique distribution of aromatase in the human brain: in vivo studies with PET and [N-methyl-11C]vorozole
    Anat Biegon
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 64:801-7. 2010
  7. ncbi request reprint In vitro and in vivo characterization of [3H]CNS-5161--a use-dependent ligand for the N-methyl-D-aspartate receptor in rat brain
    Anat Biegon
    Medical Department, Brookhaven National Laboratory, Upton, New York, USA
    Synapse 61:577-86. 2007
  8. pmc Gene x disease interaction on orbitofrontal gray matter in cocaine addiction
    Nelly Alia-Klein
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Arch Gen Psychiatry 68:283-94. 2011
  9. pmc Reinvestigation of the synthesis and evaluation of [N-methyl-(11)C]vorozole, a radiotracer targeting cytochrome P450 aromatase
    Sung Won Kim
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 36:323-34. 2009
  10. pmc Synthesis and PET studies of [(11)C-cyano]letrozole (Femara), an aromatase inhibitor drug
    Kun Eek Kil
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 36:215-23. 2009

Research Grants

  1. NMDA Receptor Dynamics After Brain Injury
    Anat Biegon; Fiscal Year: 2007
  2. NMDA Receptor Dynamics After Brain Injury
    Anat Biegon; Fiscal Year: 2009
  3. NMDA Receptor Dynamics After Brain Injury
    Anat Biegon; Fiscal Year: 2010
  4. NMDA Receptor Dynamics After Brain Injury
    Anat Biegon; Fiscal Year: 2011

Collaborators

Detail Information

Publications26

  1. pmc Hippocampal glutamate NMDA receptor loss tracks progression in Alzheimer's disease: quantitative autoradiography in postmortem human brain
    Efrat Kravitz
    J Sagol Neuroscience Center, Sheba Medical Center, Ramat Gan, Israel
    PLoS ONE 8:e81244. 2013
    ....
  2. pmc Potential contribution of aromatase inhibition to the effects of nicotine and related compounds on the brain
    Anat Biegon
    Brookhaven National Laboratory Upton, NY, USA
    Front Pharmacol 3:185. 2012
    ..Additional research on the interaction between tobacco smoke, nicotine, and aromatase may help devise new, sex specific methods for prevention and treatment of smoking addiction...
  3. ncbi request reprint Cannabinoids as neuroprotective agents in traumatic brain injury
    Anat Biegon
    Department Functional Imaging, Lawrence Berkeley National Laboratory, Berkeley, CA, USA
    Curr Pharm Des 10:2177-83. 2004
    ....
  4. pmc Nicotine blocks brain estrogen synthase (aromatase): in vivo positron emission tomography studies in female baboons
    Anat Biegon
    Brookhaven National Laboratory, Upton, New York, USA
    Biol Psychiatry 67:774-7. 2010
    ..We report the first in vivo primate study to determine whether there is a direct effect of nicotine administration on brain aromatase...
  5. pmc Dynamic changes in N-methyl-D-aspartate receptors after closed head injury in mice: Implications for treatment of neurological and cognitive deficits
    Anat Biegon
    Department of Functional Imaging, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 101:5117-22. 2004
    ....
  6. pmc Unique distribution of aromatase in the human brain: in vivo studies with PET and [N-methyl-11C]vorozole
    Anat Biegon
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 64:801-7. 2010
    ..These studies set the stage for the noninvasive assessment of aromatase involvement in various physiological and pathological processes affecting the human brain...
  7. ncbi request reprint In vitro and in vivo characterization of [3H]CNS-5161--a use-dependent ligand for the N-methyl-D-aspartate receptor in rat brain
    Anat Biegon
    Medical Department, Brookhaven National Laboratory, Upton, New York, USA
    Synapse 61:577-86. 2007
    ..Thus, CNS-5161 binds preferentially to the activated state of the NMDA receptor channel in vitro and in vivo. The high affinity and fast kinetics make it compatible with PET imaging of a carbon-11 labeled CNS-5161...
  8. pmc Gene x disease interaction on orbitofrontal gray matter in cocaine addiction
    Nelly Alia-Klein
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Arch Gen Psychiatry 68:283-94. 2011
    ..However, the concomitant use of other drugs and common genetic variability in monoamine regulation present additional structural variability...
  9. pmc Reinvestigation of the synthesis and evaluation of [N-methyl-(11)C]vorozole, a radiotracer targeting cytochrome P450 aromatase
    Sung Won Kim
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 36:323-34. 2009
    ..Herein we report the preparation and positron emission tomography (PET) studies of pure [N-methyl-(11)C]vorozole...
  10. pmc Synthesis and PET studies of [(11)C-cyano]letrozole (Femara), an aromatase inhibitor drug
    Kun Eek Kil
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 36:215-23. 2009
    ..5 nM) that has Food and Drug Administration approval for breast cancer treatment. Here we report the synthesis of carbon-11-labeled letrozole and its assessment as a radiotracer for brain aromatase in the baboon...
  11. pmc Neural mechanisms of anger regulation as a function of genetic risk for violence
    Nelly Alia-Klein
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Emotion 9:385-96. 2009
    ....
  12. ncbi request reprint Maternal and fetal 11C-cocaine uptake and kinetics measured in vivo by combined PET and MRI in pregnant nonhuman primates
    Helene Benveniste
    Medical Department, Brookhaven National Laboratory, Upton, New York 11793, USA
    J Nucl Med 46:312-20. 2005
    ..Here, we evaluate the utility of PET to measure the uptake and distribution of (11)C-cocaine in the third-trimester fetus...
  13. ncbi request reprint Modeling and analysis of PET studies with norepinephrine transporter ligands: the search for a reference region
    Jean Logan
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 32:531-42. 2005
    ..The focus of this work is to identify a suitable reference region or means of normalizing data for the NET ligands investigated...
  14. pmc Brain monoamine oxidase A activity predicts trait aggression
    Nelly Alia-Klein
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurosci 28:5099-104. 2008
    ..Because trait aggression is a measure used to predict antisocial behavior, these results underscore the relevance of MAO A as a neurochemical substrate of aberrant aggression...
  15. ncbi request reprint 6-[18F]Fluoro-A-85380, a new PET tracer for the nicotinic acetylcholine receptor: studies in the human brain and in vivo demonstration of specific binding in white matter
    Yu Shin Ding
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 53:184-9. 2004
  16. pmc Evidence of gender differences in the ability to inhibit brain activation elicited by food stimulation
    Gene Jack Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY, 11973, USA
    Proc Natl Acad Sci U S A 106:1249-54. 2009
    ..This finding suggests a mechanism by which cognitive inhibition decreases the desire for food and implicates lower ability to suppress hunger in women as a contributing factor to gender differences in obesity...
  17. ncbi request reprint Serial microPET measures of the metabolic reaction to a microdialysis probe implant
    Wynne K Schiffer
    Graduate Program in Neuroscience, Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY 11794 5230, USA
    J Neurosci Methods 155:272-84. 2006
    ..Despite the extent and persistence of these reductions, 11C-raclopride binding and ECF DA concentrations remained stable...
  18. pmc Transient focal ischemia results in persistent and widespread neuroinflammation and loss of glutamate NMDA receptors
    Jasbeer Dhawan
    Medical Department, Brookhaven National Laboratory, Building 490, Upton, NY 11973, USA
    Neuroimage 51:599-605. 2010
    ..Persistent, bilateral loss of NMDAR, probably reflecting receptor down regulation and internalization, may be responsible for some of the effects of stroke on cognitive function which cannot be explained by infarction alone...
  19. pmc Regional sensitivity to neuroinflammation: in vivo and in vitro studies
    Sigal Liraz-Zaltsman
    The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat Gan, Israel Department of Pharmacology, School of Pharmacy, Hebrew University, Jerusalem, Israel
    Synapse 65:634-42. 2011
    ....
  20. ncbi request reprint Dexanabinol (HU-211) in the treatment of severe closed head injury: a randomized, placebo-controlled, phase II clinical trial
    Nachshon Knoller
    Department of Neurosurgery, Sheba Medical Center, Tel Hashomer, Israel
    Crit Care Med 30:548-54. 2002
    ..To establish the safety of intravenous dexanabinol in severe head injury...
  21. pmc Metabolic and behavioral deficits following a routine surgical procedure in rats
    David B Frumberg
    Cornell University, Ithaca NY 14853, USA
    Brain Res 1144:209-18. 2007
    ..Probe implantation in the striatum results in a widespread and long-lasting decline in cortical glucose metabolism together with a persistent, injury-related deficit in the performance of a cognitive (object recognition) task in rats...
  22. ncbi request reprint The Ras inhibitor S-trans, trans-farnesylthiosalicylic acid exerts long-lasting neuroprotection in a mouse closed head injury model
    Esther Shohami
    Department of Pharmacology, School of Pharmacy, Hadassah Medical Center, The Hebrew University, Jerusalem, Israel
    J Cereb Blood Flow Metab 23:728-38. 2003
    ..These findings suggest that nontoxic Ras inhibitors such as FTS may qualify as neuroprotective drugs...
  23. ncbi request reprint D-cycloserine improves functional recovery and reinstates long-term potentiation (LTP) in a mouse model of closed head injury
    Rami Yaka
    Department of Pharmacology, School of Pharmacy, The Hebrew University of Jerusalem, POB 12065, Jerusalem 91120, Israel
    FASEB J 21:2033-41. 2007
    ..Since DCS is in clinical use for other indications, the present study offers a novel approach to treat human brain injury...
  24. ncbi request reprint Sex-related differences in patients with severe head injury: greater susceptibility to brain swelling in female patients 50 years of age and younger
    Azadeh Farin
    Department of Family and Preventive Medicine, University of California School of Medicine, San Diego, La Jolla, California 92037, USA
    J Neurosurg 98:32-6. 2003
    ..The goal of this study was to study the influence of sex and age on factors affecting patient outcome in severe head injury...
  25. pmc Clinical trials in head injury
    Raj K Narayan
    Department of Neurosurgery, Temple University Hospital, Philadelphia, Pennsylvania 19140, USA
    J Neurotrauma 19:503-57. 2002
    ..This paper is an attempt to summarize the key points made at the workshop. It is hoped that these lessons will enhance the planning and design of future efforts in this important field of research...
  26. pmc Inhibition of NR2B phosphorylation restores alterations in NMDA receptor expression and improves functional recovery following traumatic brain injury in mice
    Johanna Schumann
    Department of Pharmacology, School of Pharmacy, Hebrew University of Jerusalem, Jerusalem, Israel
    J Neurotrauma 25:945-57. 2008
    ....

Research Grants5

  1. NMDA Receptor Dynamics After Brain Injury
    Anat Biegon; Fiscal Year: 2007
    ..The results may explain the failure of NMDAR antagonists in clinical trials and suggest novel strategies for treatment of brain injury. ..
  2. NMDA Receptor Dynamics After Brain Injury
    Anat Biegon; Fiscal Year: 2009
    ..The results may explain the failure of NMDAR antagonists in clinical trials and suggest novel strategies for treatment of brain injury. ..
  3. NMDA Receptor Dynamics After Brain Injury
    Anat Biegon; Fiscal Year: 2010
    ..The results may explain the failure of NMDAR antagonists in clinical trials and suggest novel strategies for treatment of brain injury. ..
  4. NMDA Receptor Dynamics After Brain Injury
    Anat Biegon; Fiscal Year: 2011
    ..The results may explain the failure of NMDAR antagonists in clinical trials and suggest novel strategies for treatment of brain injury. ..