Research Topics
Species | Anat BiegonSummaryAffiliation: Brookhaven National Laboratory Country: USA Publications
Research Grants
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Detail Information
Publications
Unique distribution of aromatase in the human brain: in vivo studies with PET and [N-methyl-11C]vorozoleAnat Biegon
Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
Synapse 64:801-7. 2010..These studies set the stage for the noninvasive assessment of aromatase involvement in various physiological and pathological processes affecting the human brain...- Nicotine blocks brain estrogen synthase (aromatase): in vivo positron emission tomography studies in female baboonsAnat Biegon
Brookhaven National Laboratory, Upton, New York, USA
Biol Psychiatry 67:774-7. 2010..We report the first in vivo primate study to determine whether there is a direct effect of nicotine administration on brain aromatase... - Dynamic changes in N-methyl-D-aspartate receptors after closed head injury in mice: Implications for treatment of neurological and cognitive deficitsAnat Biegon
Department of Functional Imaging, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
Proc Natl Acad Sci U S A 101:5117-22. 2004.... 
In vitro and in vivo characterization of [3H]CNS-5161--a use-dependent ligand for the N-methyl-D-aspartate receptor in rat brainAnat Biegon
Medical Department, Brookhaven National Laboratory, Upton, New York, USA
Synapse 61:577-86. 2007..Thus, CNS-5161 binds preferentially to the activated state of the NMDA receptor channel in vitro and in vivo. The high affinity and fast kinetics make it compatible with PET imaging of a carbon-11 labeled CNS-5161...- Cannabinoids as neuroprotective agents in traumatic brain injuryAnat Biegon
Department Functional Imaging, Lawrence Berkeley National Laboratory, Berkeley, CA, USA
Curr Pharm Des 10:2177-83. 2004.... - Gene x disease interaction on orbitofrontal gray matter in cocaine addictionNelly Alia-Klein
Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
Arch Gen Psychiatry 68:283-94. 2011..However, the concomitant use of other drugs and common genetic variability in monoamine regulation present additional structural variability... - Synthesis and PET studies of [(11)C-cyano]letrozole (Femara), an aromatase inhibitor drugKun Eek Kil
Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
Nucl Med Biol 36:215-23. 2009..5 nM) that has Food and Drug Administration approval for breast cancer treatment. Here we report the synthesis of carbon-11-labeled letrozole and its assessment as a radiotracer for brain aromatase in the baboon... 
Reinvestigation of the synthesis and evaluation of [N-methyl-(11)C]vorozole, a radiotracer targeting cytochrome P450 aromataseSung Won Kim
Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
Nucl Med Biol 36:323-34. 2009..Herein we report the preparation and positron emission tomography (PET) studies of pure [N-methyl-(11)C]vorozole...- Neural mechanisms of anger regulation as a function of genetic risk for violenceNelly Alia-Klein
Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
Emotion 9:385-96. 2009.... - Modeling and analysis of PET studies with norepinephrine transporter ligands: the search for a reference regionJean Logan
Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
Nucl Med Biol 32:531-42. 2005..The focus of this work is to identify a suitable reference region or means of normalizing data for the NET ligands investigated... - Maternal and fetal 11C-cocaine uptake and kinetics measured in vivo by combined PET and MRI in pregnant nonhuman primatesHelene Benveniste
Medical Department, Brookhaven National Laboratory, Upton, New York 11793, USA
J Nucl Med 46:312-20. 2005..Here, we evaluate the utility of PET to measure the uptake and distribution of (11)C-cocaine in the third-trimester fetus... - Brain monoamine oxidase A activity predicts trait aggressionNelly Alia-Klein
Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
J Neurosci 28:5099-104. 2008..Because trait aggression is a measure used to predict antisocial behavior, these results underscore the relevance of MAO A as a neurochemical substrate of aberrant aggression... - Evidence of gender differences in the ability to inhibit brain activation elicited by food stimulationGene Jack Wang
Medical Department, Brookhaven National Laboratory, Upton, NY, 11973, USA
Proc Natl Acad Sci U S A 106:1249-54. 2009..This finding suggests a mechanism by which cognitive inhibition decreases the desire for food and implicates lower ability to suppress hunger in women as a contributing factor to gender differences in obesity... - Serial microPET measures of the metabolic reaction to a microdialysis probe implantWynne K Schiffer
Graduate Program in Neuroscience, Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY 11794 5230, USA
J Neurosci Methods 155:272-84. 2006..Despite the extent and persistence of these reductions, 11C-raclopride binding and ECF DA concentrations remained stable... - 6-[18F]Fluoro-A-85380, a new PET tracer for the nicotinic acetylcholine receptor: studies in the human brain and in vivo demonstration of specific binding in white matterYu-Shin Ding
Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
Synapse 53:184-9. 2004 - Transient focal ischemia results in persistent and widespread neuroinflammation and loss of glutamate NMDA receptorsJasbeer Dhawan
Medical Department, Brookhaven National Laboratory, Building 490, Upton, NY 11973, USA
Neuroimage 51:599-605. 2010..Persistent, bilateral loss of NMDAR, probably reflecting receptor down regulation and internalization, may be responsible for some of the effects of stroke on cognitive function which cannot be explained by infarction alone... - D-cycloserine improves functional recovery and reinstates long-term potentiation (LTP) in a mouse model of closed head injuryRami Yaka
Department of Pharmacology, School of Pharmacy, The Hebrew University of Jerusalem, POB 12065, Jerusalem 91120, Israel
FASEB J 21:2033-41. 2007..Since DCS is in clinical use for other indications, the present study offers a novel approach to treat human brain injury... - Metabolic and behavioral deficits following a routine surgical procedure in ratsDavid B Frumberg
Cornell University, Ithaca NY 14853, USA
Brain Res 1144:209-18. 2007..Probe implantation in the striatum results in a widespread and long-lasting decline in cortical glucose metabolism together with a persistent, injury-related deficit in the performance of a cognitive (object recognition) task in rats... - The Ras inhibitor S-trans, trans-farnesylthiosalicylic acid exerts long-lasting neuroprotection in a mouse closed head injury modelEsther Shohami
Department of Pharmacology, School of Pharmacy, Hadassah Medical Center, The Hebrew University, Jerusalem, Israel
J Cereb Blood Flow Metab 23:728-38. 2003..These findings suggest that nontoxic Ras inhibitors such as FTS may qualify as neuroprotective drugs... - Dexanabinol (HU-211) in the treatment of severe closed head injury: a randomized, placebo-controlled, phase II clinical trialNachshon Knoller
Department of Neurosurgery, Sheba Medical Center, Tel-Hashomer, Israel
Crit Care Med 30:548-54. 2002..The treated patients achieved significantly better intracranial pressure/cerebral perfusion pressure control without jeopardizing blood pressure. A trend toward faster and better neurologic outcome was also observed... - Inhibition of NR2B phosphorylation restores alterations in NMDA receptor expression and improves functional recovery following traumatic brain injury in miceJohanna Schumann
Department of Pharmacology, School of Pharmacy, Hebrew University of Jerusalem, Jerusalem, Israel
J Neurotrauma 25:945-57. 2008.... - Sex-related differences in patients with severe head injury: greater susceptibility to brain swelling in female patients 50 years of age and youngerAzadeh Farin
Department of Family and Preventive Medicine, University of California School of Medicine, San Diego, La Jolla, California 92037, USA
J Neurosurg 98:32-6. 2003.... - Clinical trials in head injuryRaj K Narayan
Department of Neurosurgery, Temple University Hospital, Philadelphia, Pennsylvania 19140, USA
J Neurotrauma 19:503-57. 2002..This paper is an attempt to summarize the key points made at the workshop. It is hoped that these lessons will enhance the planning and design of future efforts in this important field of research...
Research Grants
- NMDA Receptor Dynamics After Brain InjuryAnat Biegon; Fiscal Year: 2007..The results may explain the failure of NMDAR antagonists in clinical trials and suggest novel strategies for treatment of brain injury. ..
- NMDA Receptor Dynamics After Brain InjuryAnat Biegon; Fiscal Year: 2009..The results may explain the failure of NMDAR antagonists in clinical trials and suggest novel strategies for treatment of brain injury. ..
- NMDA Receptor Dynamics After Brain InjuryAnat Biegon; Fiscal Year: 2011..The results may explain the failure of NMDAR antagonists in clinical trials and suggest novel strategies for treatment of brain injury. ..