Research Topics
Species | Nelly Alia-KleinSummaryAffiliation: Brookhaven National Laboratory Country: USA Publications
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Publications
The MAO-A genotype does not modulate resting brain metabolism in adultsNelly Alia-Klein
Medical Department, Brookhaven National Laboratory, Upton, New York 11973, United States
Psychiatry Res 164:73-6. 2008..Here we show no changes in baseline regional brain metabolism as a function of genotype indicating that, unchallenged, corticolimbic activity is not modulated by the MAO-A genotype...- Neural mechanisms of anger regulation as a function of genetic risk for violenceNelly Alia-Klein
Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
Emotion 9:385-96. 2009.... - Brain monoamine oxidase A activity predicts trait aggressionNelly Alia-Klein
Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
J Neurosci 28:5099-104. 2008..Because trait aggression is a measure used to predict antisocial behavior, these results underscore the relevance of MAO A as a neurochemical substrate of aberrant aggression... - What is in a word? No versus Yes differentially engage the lateral orbitofrontal cortexNelly Alia-Klein
Brookhaven National Laboratory, Upton, NY, USA
Emotion 7:649-59. 2007.... 
Insight into illness and adherence to psychotropic medications are separately associated with violence severity in a forensic sampleNelly Alia-Klein
Brookhaven National Laboratory, Upton, New York 11973 5000, USA 11973 5000 E mail
Aggress Behav 33:86-96. 2007..Treatment addressing medication adherence needs to concomitantly target substance use behaviors since the latter was responsible for a substantial increase in ODV...- Gene x disease interaction on orbitofrontal gray matter in cocaine addictionNelly Alia-Klein
Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
Arch Gen Psychiatry 68:283-94. 2011..However, the concomitant use of other drugs and common genetic variability in monoamine regulation present additional structural variability... - Is decreased prefrontal cortical sensitivity to monetary reward associated with impaired motivation and self-control in cocaine addiction?Rita Z Goldstein
State University of New York at Stony Brook, Brookhaven National Laboratory, P O Box 5000, Upton, NY 11973 5000, USA
Am J Psychiatry 164:43-51. 2007..This study attempted to examine the brain's sensitivity to monetary rewards of different magnitudes in cocaine abusers and to study its association with motivation and self-control... - Motivated attention to cocaine and emotional cues in abstinent and current cocaine users--an ERP studyJonathan P Dunning
Stony Brook University, Stony Brook, NY, USA
Eur J Neurosci 33:1716-23. 2011.... - Oral methylphenidate normalizes cingulate activity in cocaine addiction during a salient cognitive taskRita Z Goldstein
Department of Medical Research, Center for Translational Neuroimaging, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
Proc Natl Acad Sci U S A 107:16667-72. 2010..neutral) cue-reactivity condition in all subjects. The clinical application of such MPH-induced brain-behavior enhancements remains to be tested... - Evidence that brain MAO A activity does not correspond to MAO A genotype in healthy male subjectsJoanna S Fowler
Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
Biol Psychiatry 62:355-8. 2007..We report the first in vivo human study to determine whether there is an association between MAO A genotype and brain MAO A activity in healthy male subjects... - A pattern of perseveration in cocaine addiction may reveal neurocognitive processes implicit in the Wisconsin Card Sorting TestPatricia A Woicik
Medical Department, Brookhaven National Laboratory, Upton, NY 11973, United States
Neuropsychologia 49:1660-9. 2011..Future studies should investigate whether dopaminergically innervated pathways alone, or in combination with other monoamines, underlie this implicit neurocognitive processes in the WCST... - Anger and depression in cocaine addiction: association with the orbitofrontal cortexRita Z Goldstein
Medical Research, Brookhaven National Laboratory, Bldg 490, 30 Bell Ave, Upton, NY, 11973 5000, USA
Psychiatry Res 138:13-22. 2005.... - Dopaminergic response to drug words in cocaine addictionRita Z Goldstein
Department of Medical Research, Center for Translational Neuroimaging, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
J Neurosci 29:6001-6. 2009..The correlation between the brief verbal fluency test, which can be easily administered (crucial for clinical studies), and fMRI cue reactivity could be used as a biomarker of neurobiological changes in addiction... - The effect of practice on a sustained attention task in cocaine abusersRita Z Goldstein
Department of Medical Research, Center for Translational Neuroimaging, Brookhaven National Laboratory, P O Box 5000, Upton, NY 11973 5000, USA
Neuroimage 35:194-206. 2007.... - Compromised sensitivity to monetary reward in current cocaine users: an ERP studyRita Z Goldstein
Brookhaven National Laboratory, Upton, New York 11973 5000, USA
Psychophysiology 45:705-13. 2008.... - Subjective sensitivity to monetary gradients is associated with frontolimbic activation to reward in cocaine abusersRita Z Goldstein
Brookhaven National Laboratory, P O Box 5000, Upton, NY 11973 5000, USA
Drug Alcohol Depend 87:233-40. 2007..These results provide for the first time evidence of restricted subjective sensitivity to gradients of reward in cocaine addiction and of the involvement of frontolimbic brain regions (including the orbitofrontal cortex) in this deficit... - The neuropsychology of cocaine addiction: recent cocaine use masks impairmentPatricia A Woicik
Brookhaven National Laboratory, Medical Department, Upton, NY 11973 5000, USA
Neuropsychopharmacology 34:1112-22. 2009..These results call for development of pharmacological agents targeted to enhance cognition, without negatively impacting mood in individuals addicted to cocaine... - Anterior cingulate cortex hypoactivations to an emotionally salient task in cocaine addictionRita Z Goldstein
Department of Medical Research, Center for Translational Neuroimaging, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
Proc Natl Acad Sci U S A 106:9453-8. 2009..Interventions to strengthen ACC reactivity or interconnectivity may be beneficial in enhancing top-down monitoring and emotion regulation as a strategy to reduce impulsive and compulsive behavior in addiction... - Structural and behavioral correlates of abnormal encoding of money value in the sensorimotor striatum in cocaine addictionAnna B Konova
Medical Research, Brookhaven National Laboratory, Upton, NY, USA
Eur J Neurosci 36:2979-88. 2012.... - Sensitivity to monetary reward is most severely compromised in recently abstaining cocaine addicted individuals: a cross-sectional ERP studyMuhammad A Parvaz
Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
Psychiatry Res 203:75-82. 2012.... - Enhanced midbrain response at 6-month follow-up in cocaine addiction, association with reduced drug-related choiceScott J Moeller
Brookhaven National Laboratory, Upton, NY 11973 5000, USA
Addict Biol 17:1013-25. 2012..Together, these results suggest that fMRI could be useful in sensitively tracking follow-up outcomes in drug addiction... - Neuroimaging for drug addiction and related behaviorsMuhammad A Parvaz
Medical Department, Brookhaven National Laboratory, 30 Bell Ave, Bldg 490, Upton, NY 11973 5000, USA
Rev Neurosci 22:609-24. 2011..We begin with a brief account of drug addiction followed by a technical account of each of these imaging modalities. We then discuss how these techniques have uniquely contributed to a deeper understanding of addictive behaviors... - Thalamo-cortical dysfunction in cocaine abusers: implications in attention and perceptionDardo Tomasi
Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
Psychiatry Res 155:189-201. 2007..The development of therapies that diminish these thalamo-cortical deficits could improve the treatment of cocaine addiction... - Disrupted functional connectivity with dopaminergic midbrain in cocaine abusersDardo Tomasi
National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
PLoS ONE 5:e10815. 2010.... - Potential contribution of aromatase inhibition to the effects of nicotine and related compounds on the brainAnat Biegon
Brookhaven National Laboratory Upton, NY, USA
Front Pharmacol 3:185. 2012..Additional research on the interaction between tobacco smoke, nicotine, and aromatase may help devise new, sex specific methods for prevention and treatment of smoking addiction... - Exploiting temporal information in functional magnetic resonance imaging brain dataLei Zhang
Department of Computer Science, SUNY at Stony Brook, NY, USA
Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv 8:679-87. 2005....
Research Grants
- Genes, Brain, and Behavior in Human AggressionNelly Alia Klein; Fiscal Year: 2010..Therefore, understanding the basic genetic, neurochemical and neuroanatomical processes associated with aggression is a public health concern. ..