Nelly Alia-Klein

Summary

Affiliation: Brookhaven National Laboratory
Country: USA

Publications

  1. pmc Neural mechanisms of anger regulation as a function of genetic risk for violence
    Nelly Alia-Klein
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Emotion 9:385-96. 2009
  2. pmc The MAO-A genotype does not modulate resting brain metabolism in adults
    Nelly Alia-Klein
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, United States
    Psychiatry Res 164:73-6. 2008
  3. pmc Gene x disease interaction on orbitofrontal gray matter in cocaine addiction
    Nelly Alia-Klein
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Arch Gen Psychiatry 68:283-94. 2011
  4. ncbi request reprint Insight into illness and adherence to psychotropic medications are separately associated with violence severity in a forensic sample
    Nelly Alia-Klein
    Brookhaven National Laboratory, Upton, New York 11973 5000, USA 11973 5000 E mail
    Aggress Behav 33:86-96. 2007
  5. pmc Brain monoamine oxidase A activity predicts trait aggression
    Nelly Alia-Klein
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurosci 28:5099-104. 2008
  6. pmc What is in a word? No versus Yes differentially engage the lateral orbitofrontal cortex
    Nelly Alia-Klein
    Brookhaven National Laboratory, Upton, NY, USA
    Emotion 7:649-59. 2007
  7. pmc Is decreased prefrontal cortical sensitivity to monetary reward associated with impaired motivation and self-control in cocaine addiction?
    Rita Z Goldstein
    State University of New York at Stony Brook, Brookhaven National Laboratory, P O Box 5000, Upton, NY 11973 5000, USA
    Am J Psychiatry 164:43-51. 2007
  8. pmc Motivated attention to cocaine and emotional cues in abstinent and current cocaine users--an ERP study
    Jonathan P Dunning
    Stony Brook University, Stony Brook, NY, USA
    Eur J Neurosci 33:1716-23. 2011
  9. pmc Oral methylphenidate normalizes cingulate activity in cocaine addiction during a salient cognitive task
    Rita Z Goldstein
    Department of Medical Research, Center for Translational Neuroimaging, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Proc Natl Acad Sci U S A 107:16667-72. 2010
  10. pmc A pattern of perseveration in cocaine addiction may reveal neurocognitive processes implicit in the Wisconsin Card Sorting Test
    Patricia A Woicik
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, United States
    Neuropsychologia 49:1660-9. 2011

Research Grants

  1. Genes, Brain, and Behavior in Human Aggression
    Nelly Alia Klein; Fiscal Year: 2010

Detail Information

Publications27

  1. pmc Neural mechanisms of anger regulation as a function of genetic risk for violence
    Nelly Alia-Klein
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Emotion 9:385-96. 2009
    ....
  2. pmc The MAO-A genotype does not modulate resting brain metabolism in adults
    Nelly Alia-Klein
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, United States
    Psychiatry Res 164:73-6. 2008
    ..Here we show no changes in baseline regional brain metabolism as a function of genotype indicating that, unchallenged, corticolimbic activity is not modulated by the MAO-A genotype...
  3. pmc Gene x disease interaction on orbitofrontal gray matter in cocaine addiction
    Nelly Alia-Klein
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Arch Gen Psychiatry 68:283-94. 2011
    ..However, the concomitant use of other drugs and common genetic variability in monoamine regulation present additional structural variability...
  4. ncbi request reprint Insight into illness and adherence to psychotropic medications are separately associated with violence severity in a forensic sample
    Nelly Alia-Klein
    Brookhaven National Laboratory, Upton, New York 11973 5000, USA 11973 5000 E mail
    Aggress Behav 33:86-96. 2007
    ..Treatment addressing medication adherence needs to concomitantly target substance use behaviors since the latter was responsible for a substantial increase in ODV...
  5. pmc Brain monoamine oxidase A activity predicts trait aggression
    Nelly Alia-Klein
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurosci 28:5099-104. 2008
    ..Because trait aggression is a measure used to predict antisocial behavior, these results underscore the relevance of MAO A as a neurochemical substrate of aberrant aggression...
  6. pmc What is in a word? No versus Yes differentially engage the lateral orbitofrontal cortex
    Nelly Alia-Klein
    Brookhaven National Laboratory, Upton, NY, USA
    Emotion 7:649-59. 2007
    ....
  7. pmc Is decreased prefrontal cortical sensitivity to monetary reward associated with impaired motivation and self-control in cocaine addiction?
    Rita Z Goldstein
    State University of New York at Stony Brook, Brookhaven National Laboratory, P O Box 5000, Upton, NY 11973 5000, USA
    Am J Psychiatry 164:43-51. 2007
    ..This study attempted to examine the brain's sensitivity to monetary rewards of different magnitudes in cocaine abusers and to study its association with motivation and self-control...
  8. pmc Motivated attention to cocaine and emotional cues in abstinent and current cocaine users--an ERP study
    Jonathan P Dunning
    Stony Brook University, Stony Brook, NY, USA
    Eur J Neurosci 33:1716-23. 2011
    ....
  9. pmc Oral methylphenidate normalizes cingulate activity in cocaine addiction during a salient cognitive task
    Rita Z Goldstein
    Department of Medical Research, Center for Translational Neuroimaging, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Proc Natl Acad Sci U S A 107:16667-72. 2010
    ..neutral) cue-reactivity condition in all subjects. The clinical application of such MPH-induced brain-behavior enhancements remains to be tested...
  10. pmc A pattern of perseveration in cocaine addiction may reveal neurocognitive processes implicit in the Wisconsin Card Sorting Test
    Patricia A Woicik
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, United States
    Neuropsychologia 49:1660-9. 2011
    ..Future studies should investigate whether dopaminergically innervated pathways alone, or in combination with other monoamines, underlie this implicit neurocognitive processes in the WCST...
  11. pmc Evidence that brain MAO A activity does not correspond to MAO A genotype in healthy male subjects
    Joanna S Fowler
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Biol Psychiatry 62:355-8. 2007
    ..We report the first in vivo human study to determine whether there is an association between MAO A genotype and brain MAO A activity in healthy male subjects...
  12. ncbi request reprint Anger and depression in cocaine addiction: association with the orbitofrontal cortex
    Rita Z Goldstein
    Medical Research, Brookhaven National Laboratory, Bldg 490, 30 Bell Ave, Upton, NY, 11973 5000, USA
    Psychiatry Res 138:13-22. 2005
    ....
  13. pmc Enhanced midbrain response at 6-month follow-up in cocaine addiction, association with reduced drug-related choice
    Scott J Moeller
    Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Addict Biol 17:1013-25. 2012
    ..Together, these results suggest that fMRI could be useful in sensitively tracking follow-up outcomes in drug addiction...
  14. pmc Sensitivity to monetary reward is most severely compromised in recently abstaining cocaine addicted individuals: a cross-sectional ERP study
    Muhammad A Parvaz
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Psychiatry Res 203:75-82. 2012
    ....
  15. pmc Dopaminergic response to drug words in cocaine addiction
    Rita Z Goldstein
    Department of Medical Research, Center for Translational Neuroimaging, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
    J Neurosci 29:6001-6. 2009
    ..The correlation between the brief verbal fluency test, which can be easily administered (crucial for clinical studies), and fMRI cue reactivity could be used as a biomarker of neurobiological changes in addiction...
  16. pmc The effect of practice on a sustained attention task in cocaine abusers
    Rita Z Goldstein
    Department of Medical Research, Center for Translational Neuroimaging, Brookhaven National Laboratory, P O Box 5000, Upton, NY 11973 5000, USA
    Neuroimage 35:194-206. 2007
    ....
  17. pmc Subjective sensitivity to monetary gradients is associated with frontolimbic activation to reward in cocaine abusers
    Rita Z Goldstein
    Brookhaven National Laboratory, P O Box 5000, Upton, NY 11973 5000, USA
    Drug Alcohol Depend 87:233-40. 2007
    ..These results provide for the first time evidence of restricted subjective sensitivity to gradients of reward in cocaine addiction and of the involvement of frontolimbic brain regions (including the orbitofrontal cortex) in this deficit...
  18. pmc Anterior cingulate cortex hypoactivations to an emotionally salient task in cocaine addiction
    Rita Z Goldstein
    Department of Medical Research, Center for Translational Neuroimaging, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Proc Natl Acad Sci U S A 106:9453-8. 2009
    ..Interventions to strengthen ACC reactivity or interconnectivity may be beneficial in enhancing top-down monitoring and emotion regulation as a strategy to reduce impulsive and compulsive behavior in addiction...
  19. pmc The neuropsychology of cocaine addiction: recent cocaine use masks impairment
    Patricia A Woicik
    Brookhaven National Laboratory, Medical Department, Upton, NY 11973 5000, USA
    Neuropsychopharmacology 34:1112-22. 2009
    ..These results call for development of pharmacological agents targeted to enhance cognition, without negatively impacting mood in individuals addicted to cocaine...
  20. pmc Compromised sensitivity to monetary reward in current cocaine users: an ERP study
    Rita Z Goldstein
    Brookhaven National Laboratory, Upton, New York 11973 5000, USA
    Psychophysiology 45:705-13. 2008
    ....
  21. pmc Structural and behavioral correlates of abnormal encoding of money value in the sensorimotor striatum in cocaine addiction
    Anna B Konova
    Medical Research, Brookhaven National Laboratory, Upton, NY, USA
    Eur J Neurosci 36:2979-88. 2012
    ....
  22. pmc Neuroimaging for drug addiction and related behaviors
    Muhammad A Parvaz
    Medical Department, Brookhaven National Laboratory, 30 Bell Ave, Bldg 490, Upton, NY 11973 5000, USA
    Rev Neurosci 22:609-24. 2011
    ..We begin with a brief account of drug addiction followed by a technical account of each of these imaging modalities. We then discuss how these techniques have uniquely contributed to a deeper understanding of addictive behaviors...
  23. pmc Thalamo-cortical dysfunction in cocaine abusers: implications in attention and perception
    Dardo Tomasi
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Psychiatry Res 155:189-201. 2007
    ..The development of therapies that diminish these thalamo-cortical deficits could improve the treatment of cocaine addiction...
  24. pmc Gene x abstinence effects on drug cue reactivity in addiction: multimodal evidence
    Scott J Moeller
    Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA
    J Neurosci 33:10027-36. 2013
    ..Because drug cues contribute to relapse, our results identify the DAT1R 9R-allele as a vulnerability allele for relapse especially during early abstinence (e.g., detoxification)...
  25. pmc Disrupted functional connectivity with dopaminergic midbrain in cocaine abusers
    Dardo Tomasi
    National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 5:e10815. 2010
    ....
  26. pmc Potential contribution of aromatase inhibition to the effects of nicotine and related compounds on the brain
    Anat Biegon
    Brookhaven National Laboratory Upton, NY, USA
    Front Pharmacol 3:185. 2012
    ..Additional research on the interaction between tobacco smoke, nicotine, and aromatase may help devise new, sex specific methods for prevention and treatment of smoking addiction...
  27. ncbi request reprint Exploiting temporal information in functional magnetic resonance imaging brain data
    Lei Zhang
    Department of Computer Science, SUNY at Stony Brook, NY, USA
    Med Image Comput Comput Assist Interv 8:679-87. 2005
    ....

Research Grants1

  1. Genes, Brain, and Behavior in Human Aggression
    Nelly Alia Klein; Fiscal Year: 2010
    ..Therefore, understanding the basic genetic, neurochemical and neuroanatomical processes associated with aggression is a public health concern. ..