Research Topics
| David L AlexoffSummaryAffiliation: Brookhaven National Laboratory Country: USA Publications
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Detail Information
Publications
PET imaging of thin objects: measuring the effects of positron range and partial-volume averaging in the leaf of Nicotiana tabacumDavid L Alexoff
Medical Department, Brookhaven National Laboratory, Upton, New York, USA
Nucl Med Biol 38:191-200. 2011..Although these limitations are acknowledged by researchers, little data have been published on them...
Reproducibility of 11C-raclopride binding in the rat brain measured with the microPET R4: effects of scatter correction and tracer specific activityDavid L Alexoff
Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
J Nucl Med 44:815-22. 2003..Here we investigate the reproducibility of microPET imaging of (11)C-raclopride in the rat brain and the effects of tracer-specific activity and photon scatter correction on measures of D2 receptor (D2R) availability...
Unique distribution of aromatase in the human brain: in vivo studies with PET and [N-methyl-11C]vorozoleAnat Biegon
Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
Synapse 64:801-7. 2010..These studies set the stage for the noninvasive assessment of aromatase involvement in various physiological and pathological processes affecting the human brain...- Imaging dopamine release with Positron Emission Tomography (PET) and (11)C-raclopride in freely moving animalsVinal D Patel
Medical Department, Brookhaven National Laboratory, Upton NY 11973, USA
Neuroimage 41:1051-66. 2008..This imaging strategy extends the applicability of small animal PET to include functional neurotransmitter imaging and the neurochemical correlates of behavioral tasks... - The effects of inhaled acetone on place conditioning in adolescent ratsDianne E Lee
Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
Pharmacol Biochem Behav 89:101-5. 2008..Therefore, we systematically investigated the conditioned response to inhaled acetone in a place conditioning apparatus... - Imaging dopamine receptors in the rat striatum with the MicroPET R4: kinetic analysis of [11C]raclopride binding using graphical methodsDavid L Alexoff
Department of Chemistry, Brookhaven National Laboratory, Upton, NY 11973, USA
Methods Enzymol 385:213-28. 2004 - Development of a simultaneous PET/microdialysis method to identify the optimal dose of 11C-raclopride for small animal imagingWynne K Schiffer
Department of Neurobiology and Behavior, State University of New York at Stony Brook, NY 11794 5230, USA
J Neurosci Methods 144:25-34. 2005..0 and 3.5 pmol/ml, around which the measured BP can be compromised by system sensitivity, endogenous DA, or excessive competition with unlabeled compound... - Reproducibility of intraperitoneal 2-deoxy-2-[18F]-fluoro-D-glucose cerebral uptake in rodents through timeDouglas A Marsteller
Graduate Program in Molecular and Cellular Pharmacology, SUNY Stony Brook, NY 11794 8651, USA
Nucl Med Biol 33:71-9. 2006..However, the variability of within-rodent brain glucose uptake after an intraperitoneal injection across an extended time has not been measured... - Serial microPET measures of the metabolic reaction to a microdialysis probe implantWynne K Schiffer
Graduate Program in Neuroscience, Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY 11794 5230, USA
J Neurosci Methods 155:272-84. 2006..Despite the extent and persistence of these reductions, 11C-raclopride binding and ECF DA concentrations remained stable... - Metabolic correlates of toluene abuse: decline and recovery of function in adolescent animalsWynne K Schiffer
Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
Psychopharmacology (Berl) 186:159-67. 2006..Children and adolescents will readily abuse household products that contain solvents such as toluene. It is likely that reinforcing exposures to toluene alter brain glucose metabolism... - Quantitative imaging with the micro-PET small-animal PET tomographPaul Vaska
Medical Department and Center for Translational Neuroimaging, Brookhaven National Laboratory, Upton, New York 11973, USA
Int Rev Neurobiol 73:191-218. 2006 - Reinvestigation of the synthesis and evaluation of [N-methyl-(11)C]vorozole, a radiotracer targeting cytochrome P450 aromataseSung Won Kim
Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
Nucl Med Biol 36:323-34. 2009..Herein we report the preparation and positron emission tomography (PET) studies of pure [N-methyl-(11)C]vorozole... - Acute handling stress modulates methylphenidate-induced catecholamine overflow in the medial prefrontal cortexDouglas A Marsteller
Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
Neuropsychopharmacology 27:163-70. 2002..These findings suggest that persistent alterations in mesocorticolimbic DA-ergic activity are induced by a short exposure to restraint stress as evidenced by the altered response to MP challenge... - MicroPET imaging in an animal model of anorexia nervosaNicole C Barbarich-Marsteller
Graduate Program in Neuroscience, Department of Neurobiology and Behavior, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
Synapse 57:85-90. 2005..This is the first study to establish support for the use of microPET imaging in an animal model of anorexia nervosa as a means for studying the neurobiological changes that occur due to chronic food restriction...