David L Alexoff

Summary

Affiliation: Brookhaven National Laboratory
Country: USA

Publications

  1. ncbi request reprint Reproducibility of 11C-raclopride binding in the rat brain measured with the microPET R4: effects of scatter correction and tracer specific activity
    David L Alexoff
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
    J Nucl Med 44:815-22. 2003
  2. doi request reprint PET imaging of thin objects: measuring the effects of positron range and partial-volume averaging in the leaf of Nicotiana tabacum
    David L Alexoff
    Medical Department, Brookhaven National Laboratory, Upton, New York, USA
    Nucl Med Biol 38:191-200. 2011
  3. pmc Unique distribution of aromatase in the human brain: in vivo studies with PET and [N-methyl-11C]vorozole
    Anat Biegon
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 64:801-7. 2010
  4. doi request reprint Aromatase Imaging with [N-Methyl-11C]Vorozole PET in Healthy Men and Women
    Anat Biegon
    Stony Brook University School of Medicine, Stony Brook, New York Brookhaven National Laboratory, Upton, New York
    J Nucl Med 56:580-5. 2015
  5. doi request reprint Imaging dopamine release with Positron Emission Tomography (PET) and (11)C-raclopride in freely moving animals
    Vinal D Patel
    Medical Department, Brookhaven National Laboratory, Upton NY 11973, USA
    Neuroimage 41:1051-66. 2008
  6. pmc Evidence that formulations of the selective MAO-B inhibitor, selegiline, which bypass first-pass metabolism, also inhibit MAO-A in the human brain
    Joanna S Fowler
    Biological, Environmental and Climate Sciences Department, Brookhaven National Laboratory, Upton, NY, USA
    Neuropsychopharmacology 40:650-7. 2015
  7. doi request reprint The design and performance of a portable handheld (11)CO2 delivery system
    Dohyun Kim
    Biosciences Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA Electronic address
    Appl Radiat Isot 94:338-43. 2014
  8. ncbi request reprint The effects of inhaled acetone on place conditioning in adolescent rats
    Dianne E Lee
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Pharmacol Biochem Behav 89:101-5. 2008
  9. ncbi request reprint Serial microPET measures of the metabolic reaction to a microdialysis probe implant
    Wynne K Schiffer
    Graduate Program in Neuroscience, Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY 11794 5230, USA
    J Neurosci Methods 155:272-84. 2006
  10. ncbi request reprint Reproducibility of intraperitoneal 2-deoxy-2-[18F]-fluoro-D-glucose cerebral uptake in rodents through time
    Douglas A Marsteller
    Graduate Program in Molecular and Cellular Pharmacology, SUNY Stony Brook, NY 11794 8651, USA
    Nucl Med Biol 33:71-9. 2006

Detail Information

Publications18

  1. ncbi request reprint Reproducibility of 11C-raclopride binding in the rat brain measured with the microPET R4: effects of scatter correction and tracer specific activity
    David L Alexoff
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
    J Nucl Med 44:815-22. 2003
    ..Here we investigate the reproducibility of microPET imaging of (11)C-raclopride in the rat brain and the effects of tracer-specific activity and photon scatter correction on measures of D2 receptor (D2R) availability...
  2. doi request reprint PET imaging of thin objects: measuring the effects of positron range and partial-volume averaging in the leaf of Nicotiana tabacum
    David L Alexoff
    Medical Department, Brookhaven National Laboratory, Upton, New York, USA
    Nucl Med Biol 38:191-200. 2011
    ..Although these limitations are acknowledged by researchers, little data have been published on them...
  3. pmc Unique distribution of aromatase in the human brain: in vivo studies with PET and [N-methyl-11C]vorozole
    Anat Biegon
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 64:801-7. 2010
    ..These studies set the stage for the noninvasive assessment of aromatase involvement in various physiological and pathological processes affecting the human brain...
  4. doi request reprint Aromatase Imaging with [N-Methyl-11C]Vorozole PET in Healthy Men and Women
    Anat Biegon
    Stony Brook University School of Medicine, Stony Brook, New York Brookhaven National Laboratory, Upton, New York
    J Nucl Med 56:580-5. 2015
    ..The present study aimed to provide baseline information defining aromatase distribution in healthy men and women, against which its perturbation in pathologic situations can be studied...
  5. doi request reprint Imaging dopamine release with Positron Emission Tomography (PET) and (11)C-raclopride in freely moving animals
    Vinal D Patel
    Medical Department, Brookhaven National Laboratory, Upton NY 11973, USA
    Neuroimage 41:1051-66. 2008
    ..This imaging strategy extends the applicability of small animal PET to include functional neurotransmitter imaging and the neurochemical correlates of behavioral tasks...
  6. pmc Evidence that formulations of the selective MAO-B inhibitor, selegiline, which bypass first-pass metabolism, also inhibit MAO-A in the human brain
    Joanna S Fowler
    Biological, Environmental and Climate Sciences Department, Brookhaven National Laboratory, Upton, NY, USA
    Neuropsychopharmacology 40:650-7. 2015
    ..Our results provide the first direct evidence of brain MAO-A inhibition in humans by formulations of selegiline, which are currently postulated but not verified to target brain MAO-A in addition to MAO-B. ..
  7. doi request reprint The design and performance of a portable handheld (11)CO2 delivery system
    Dohyun Kim
    Biosciences Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA Electronic address
    Appl Radiat Isot 94:338-43. 2014
    ..1kg. The overall [(11)C]CO2 delivery efficiency of the device is ~82% (> 99% trapping efficiency). Radiation dose rates measured at 30cm from the surface of the pig are <43.5µSv/h (5mR/h) up to 2.59GBq (70mCi). ..
  8. ncbi request reprint The effects of inhaled acetone on place conditioning in adolescent rats
    Dianne E Lee
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Pharmacol Biochem Behav 89:101-5. 2008
    ..Therefore, we systematically investigated the conditioned response to inhaled acetone in a place conditioning apparatus...
  9. ncbi request reprint Serial microPET measures of the metabolic reaction to a microdialysis probe implant
    Wynne K Schiffer
    Graduate Program in Neuroscience, Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY 11794 5230, USA
    J Neurosci Methods 155:272-84. 2006
    ..Despite the extent and persistence of these reductions, 11C-raclopride binding and ECF DA concentrations remained stable...
  10. ncbi request reprint Reproducibility of intraperitoneal 2-deoxy-2-[18F]-fluoro-D-glucose cerebral uptake in rodents through time
    Douglas A Marsteller
    Graduate Program in Molecular and Cellular Pharmacology, SUNY Stony Brook, NY 11794 8651, USA
    Nucl Med Biol 33:71-9. 2006
    ..However, the variability of within-rodent brain glucose uptake after an intraperitoneal injection across an extended time has not been measured...
  11. pmc Development of a simultaneous PET/microdialysis method to identify the optimal dose of 11C-raclopride for small animal imaging
    Wynne K Schiffer
    Department of Neurobiology and Behavior, State University of New York at Stony Brook, NY 11794 5230, USA
    J Neurosci Methods 144:25-34. 2005
    ..0 and 3.5 pmol/ml, around which the measured BP can be compromised by system sensitivity, endogenous DA, or excessive competition with unlabeled compound...
  12. ncbi request reprint Imaging dopamine receptors in the rat striatum with the MicroPET R4: kinetic analysis of [11C]raclopride binding using graphical methods
    David L Alexoff
    Department of Chemistry, Brookhaven National Laboratory, Upton, NY 11973, USA
    Methods Enzymol 385:213-28. 2004
  13. doi request reprint Radiosynthesis of 3-indolyl[1-¹¹C]acetic acid for phyto-PET-imaging: an improved production procedure and formulation method
    Youwen Xu
    Biosciences Department, Brookhaven National Laboratory, Upton, NY 11973, USA Electronic address
    Appl Radiat Isot 91:155-60. 2014
    ..This integrated system facilitated routine high radiation level production of [(11)C]IAA while minimizing radiation exposure to the production chemists...
  14. ncbi request reprint Metabolic correlates of toluene abuse: decline and recovery of function in adolescent animals
    Wynne K Schiffer
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Psychopharmacology (Berl) 186:159-67. 2006
    ..Children and adolescents will readily abuse household products that contain solvents such as toluene. It is likely that reinforcing exposures to toluene alter brain glucose metabolism...
  15. ncbi request reprint Quantitative imaging with the micro-PET small-animal PET tomograph
    Paul Vaska
    Medical Department and Center for Translational Neuroimaging, Brookhaven National Laboratory, Upton, New York 11973, USA
    Int Rev Neurobiol 73:191-218. 2006
  16. ncbi request reprint Acute handling stress modulates methylphenidate-induced catecholamine overflow in the medial prefrontal cortex
    Douglas A Marsteller
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuropsychopharmacology 27:163-70. 2002
    ..These findings suggest that persistent alterations in mesocorticolimbic DA-ergic activity are induced by a short exposure to restraint stress as evidenced by the altered response to MP challenge...
  17. pmc Reinvestigation of the synthesis and evaluation of [N-methyl-(11)C]vorozole, a radiotracer targeting cytochrome P450 aromatase
    Sung Won Kim
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 36:323-34. 2009
    ..Herein we report the preparation and positron emission tomography (PET) studies of pure [N-methyl-(11)C]vorozole...
  18. ncbi request reprint MicroPET imaging in an animal model of anorexia nervosa
    Nicole C Barbarich-Marsteller
    Graduate Program in Neuroscience, Department of Neurobiology and Behavior, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
    Synapse 57:85-90. 2005
    ..This is the first study to establish support for the use of microPET imaging in an animal model of anorexia nervosa as a means for studying the neurobiological changes that occur due to chronic food restriction...