Kap Sun Yeung

Summary

Affiliation: Bristol-Myers Squibb
Country: USA

Publications

  1. doi request reprint Inhibitors of HIV-1 attachment. Part 7: indole-7-carboxamides as potent and orally bioavailable antiviral agents
    Kap Sun Yeung
    Bristol Myers Squibb Research and Development, 5 Research Parkway, PO Box 5100, Wallingford, CT 06492, USA
    Bioorg Med Chem Lett 23:198-202. 2013
  2. doi request reprint Inhibitors of HIV-1 attachment. Part 8: the effect of C7-heteroaryl substitution on the potency, and in vitro and in vivo profiles of indole-based inhibitors
    Kap Sun Yeung
    Bristol Myers Squibb Research and Development, 5 Research Parkway, PO Box 5100, Wallingford, CT 06492, USA
    Bioorg Med Chem Lett 23:203-8. 2013
  3. doi request reprint Inhibitors of HIV-1 attachment. Part 9: an assessment of oral prodrug approaches to improve the plasma exposure of a tetrazole-containing derivative
    Kap Sun Yeung
    Bristol Myers Squibb Research and Development, 5 Research Parkway, PO Box 5100, Wallingford, CT 06492, USA
    Bioorg Med Chem Lett 23:209-12. 2013
  4. ncbi request reprint Recent developments in the virology and antiviral research of severe acute respiratory syndrome coronavirus
    Kap Sun Yeung
    Bristol Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, P O Box 5100, Wallingford, Connecticut 06492, USA
    Infect Disord Drug Targets 7:29-41. 2007
  5. ncbi request reprint Severe acute respiratory syndrome coronavirus entry into host cells: Opportunities for therapeutic intervention
    Kap Sun Yeung
    Department of Chemistry, The Bristol Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, P O Box 5100, Wallingford, Connecticut 06492, USA
    Med Res Rev 26:414-33. 2006
  6. ncbi request reprint Actin-binding marine macrolides: total synthesis and biological importance
    Kap Sun Yeung
    University Chemical Laboratory, Lensfield Road, Cambridge, CB2 1EW, UK
    Angew Chem Int Ed Engl 41:4632-53. 2002
  7. ncbi request reprint Structure-activity relationship studies of a bisbenzimidazole-based, Zn(2+)-dependent inhibitor of HCV NS3 serine protease
    K S Yeung
    Bristol Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, POBox 5100, Wallingford, CT 06492, USA
    Bioorg Med Chem Lett 11:2355-9. 2001
  8. doi request reprint Inhibitors of HIV-1 attachment. Part 2: An initial survey of indole substitution patterns
    Nicholas A Meanwell
    Department of Chemistry, Bristol Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, United States
    Bioorg Med Chem Lett 19:1977-81. 2009
  9. doi request reprint Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment 6. Preclinical and human pharmacokinetic profiling of BMS-663749, a phosphonooxymethyl prodrug of the HIV-1 attachment inhibitor 2-(4-benzoyl-1-piperazinyl)-1-(4,7-dimethoxy-1H-pyrrolo[2
    John F Kadow
    Bristol Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, USA
    J Med Chem 55:2048-56. 2012
  10. ncbi request reprint Advances in the total synthesis of biologically important marine macrolides
    Kap Sun Yeung
    University Chemical Laboratory, Cambridge, UK
    Chem Rev 105:4237-313. 2005

Detail Information

Publications13

  1. doi request reprint Inhibitors of HIV-1 attachment. Part 7: indole-7-carboxamides as potent and orally bioavailable antiviral agents
    Kap Sun Yeung
    Bristol Myers Squibb Research and Development, 5 Research Parkway, PO Box 5100, Wallingford, CT 06492, USA
    Bioorg Med Chem Lett 23:198-202. 2013
    ..The simple methyl amide analog 4 displayed a promising in vitro profile, with its favorable HLM stability and membrane permeability translating into favorable pharmacokinetic properties in preclinical species...
  2. doi request reprint Inhibitors of HIV-1 attachment. Part 8: the effect of C7-heteroaryl substitution on the potency, and in vitro and in vivo profiles of indole-based inhibitors
    Kap Sun Yeung
    Bristol Myers Squibb Research and Development, 5 Research Parkway, PO Box 5100, Wallingford, CT 06492, USA
    Bioorg Med Chem Lett 23:203-8. 2013
    ..Oral exposure in the rat correlated with membrane permeability as measured in a Caco-2 assay where the highly permeable 1,2,4-oxadiazole analog 13 exhibited the highest exposure...
  3. doi request reprint Inhibitors of HIV-1 attachment. Part 9: an assessment of oral prodrug approaches to improve the plasma exposure of a tetrazole-containing derivative
    Kap Sun Yeung
    Bristol Myers Squibb Research and Development, 5 Research Parkway, PO Box 5100, Wallingford, CT 06492, USA
    Bioorg Med Chem Lett 23:209-12. 2013
    ..This represents a novel example of a methyl tetrazole that acts as a prodrug for a free NH tetrazole-containing compound...
  4. ncbi request reprint Recent developments in the virology and antiviral research of severe acute respiratory syndrome coronavirus
    Kap Sun Yeung
    Bristol Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, P O Box 5100, Wallingford, Connecticut 06492, USA
    Infect Disord Drug Targets 7:29-41. 2007
    ....
  5. ncbi request reprint Severe acute respiratory syndrome coronavirus entry into host cells: Opportunities for therapeutic intervention
    Kap Sun Yeung
    Department of Chemistry, The Bristol Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, P O Box 5100, Wallingford, Connecticut 06492, USA
    Med Res Rev 26:414-33. 2006
    ..Opportunities for the design and development of anti-SARS agents based on the inhibition of receptor binding, the therapeutic uses of S-directed monoclonal antibodies and inhibitors of HR1-HR2 complex formation are presented...
  6. ncbi request reprint Actin-binding marine macrolides: total synthesis and biological importance
    Kap Sun Yeung
    University Chemical Laboratory, Lensfield Road, Cambridge, CB2 1EW, UK
    Angew Chem Int Ed Engl 41:4632-53. 2002
    ..Rather than detailing each individual step of these multistep total syntheses, the different synthetic strategies, key reactions, and methods adopted for controlling the stereochemistry are compared...
  7. ncbi request reprint Structure-activity relationship studies of a bisbenzimidazole-based, Zn(2+)-dependent inhibitor of HCV NS3 serine protease
    K S Yeung
    Bristol Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, POBox 5100, Wallingford, CT 06492, USA
    Bioorg Med Chem Lett 11:2355-9. 2001
    ....
  8. doi request reprint Inhibitors of HIV-1 attachment. Part 2: An initial survey of indole substitution patterns
    Nicholas A Meanwell
    Department of Chemistry, Bristol Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, United States
    Bioorg Med Chem Lett 19:1977-81. 2009
    ..These studies establish a basic understanding of the indole element of the HIV attachment inhibitor pharmacophore...
  9. doi request reprint Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment 6. Preclinical and human pharmacokinetic profiling of BMS-663749, a phosphonooxymethyl prodrug of the HIV-1 attachment inhibitor 2-(4-benzoyl-1-piperazinyl)-1-(4,7-dimethoxy-1H-pyrrolo[2
    John F Kadow
    Bristol Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, USA
    J Med Chem 55:2048-56. 2012
    ..These data provided guidance for further efforts to obtain an effective HIV-1 attachment inhibitor...
  10. ncbi request reprint Advances in the total synthesis of biologically important marine macrolides
    Kap Sun Yeung
    University Chemical Laboratory, Cambridge, UK
    Chem Rev 105:4237-313. 2005
  11. doi request reprint Inhibitors of HIV-1 attachment. Part 3: A preliminary survey of the effect of structural variation of the benzamide moiety on antiviral activity
    Nicholas A Meanwell
    Department of Chemistry, Bristol Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA
    Bioorg Med Chem Lett 19:5136-9. 2009
    ....
  12. ncbi request reprint Developments in antiviral drug design, discovery and development in 2004
    Nicholas A Meanwell
    Department of Chemistry, The Bristol Myers Squibb Pharmaceutical Research Institute, Wallingford, CT 06492, USA
    Curr Drug Targets Infect Disord 5:307-400. 2005
    ....
  13. ncbi request reprint To exploit the exploitation of actin by HIV?
    Kap Sun Yeung
    Drug Discov Today 9:2-4. 2004