Xinkang Wang

Summary

Affiliation: Bristol-Myers Squibb
Country: USA

Publications

  1. ncbi request reprint Deficiency in thrombin-activatable fibrinolysis inhibitor (TAFI) protected mice from ferric chloride-induced vena cava thrombosis
    Xinkang Wang
    Department of Thrombosis Biology, Bristol Myers Squibb Company, 311 Pennington Rocky Hill Road, Pennington, NJ 08534, USA
    J Thromb Thrombolysis 23:41-9. 2007
  2. ncbi request reprint Quantification of platelet composition in experimental venous thrombosis by real-time polymerase chain reaction
    Xinkang Wang
    Department of Thrombosis Biology, Bristol Myers Squibb Company, Pennington, NJ 08534, USA
    Thromb Res 119:593-600. 2007
  3. ncbi request reprint Murine model of ferric chloride-induced vena cava thrombosis: evidence for effect of potato carboxypeptidase inhibitor
    X Wang
    Department of Thrombosis Biology, Bristol Myers Squibb Company, Pennington, NJ 08534, USA
    J Thromb Haemost 4:403-10. 2006
  4. ncbi request reprint Investigational anti-inflammatory agents for the treatment of ischaemic brain injury
    Xinkang Wang
    Bristol Myers Squibb Company, Discovery Biology, 311 Pennington Rocky Hill Road, Pennington, NJ 08534, USA
    Expert Opin Investig Drugs 14:393-409. 2005
  5. ncbi request reprint Inhibition of tumor necrosis factor-alpha-converting enzyme by a selective antagonist protects brain from focal ischemic injury in rats
    Xinkang Wang
    Department of Thrombosis Research, Bristol Myers Squibb Company, P O Box 5400, Princeton, NJ 08543 5400, USA
    Mol Pharmacol 65:890-6. 2004
  6. ncbi request reprint Up-regulation of secretory leukocyte protease inhibitor (SLPI) in the brain after ischemic stroke: adenoviral expression of SLPI protects brain from ischemic injury
    Xinkang Wang
    Department of Thrombosis Research, Bristol Myers Squibb Company, 311 Pennington Rocky Hill Road, Pennington, NJ 08534, USA
    Mol Pharmacol 64:833-40. 2003
  7. ncbi request reprint Inhibition of factor Xa reduces ischemic brain damage after thromboembolic stroke in rats
    Xinkang Wang
    Department of Cardiovascular Sciences, Bristol Myers Squibb Company, Wilmington, Del, USA
    Stroke 34:468-74. 2003
  8. ncbi request reprint Comparative analysis of various platelet glycoprotein IIb/IIIa antagonists on shear-induced platelet activation and adhesion
    Xinkang Wang
    Department of Cardiovascular Sciences, Bristol Myers Squibb Company, Experimental Station, Wilmington, Delaware 19880 0400, USA
    J Pharmacol Exp Ther 303:1114-20. 2002
  9. ncbi request reprint CD44 deficiency in mice protects brain from cerebral ischemia injury
    Xinkang Wang
    Departments of Cardiovascular Sciences and Neurosciences, Bristol Myers Squibb Company, Wilmington, Delaware 19880 0400, USA
    J Neurochem 83:1172-9. 2002
  10. ncbi request reprint Mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 deficiency protects brain from ischemic injury in mice
    Xinkang Wang
    Department of Cardiovascular Sciences, Bristol Myers Squibb Company, Wilmington, Delaware 19880 0400, USA
    J Biol Chem 277:43968-72. 2002

Detail Information

Publications24

  1. ncbi request reprint Deficiency in thrombin-activatable fibrinolysis inhibitor (TAFI) protected mice from ferric chloride-induced vena cava thrombosis
    Xinkang Wang
    Department of Thrombosis Biology, Bristol Myers Squibb Company, 311 Pennington Rocky Hill Road, Pennington, NJ 08534, USA
    J Thromb Thrombolysis 23:41-9. 2007
    ..The strong ex vivo fibrinolytic activity of TAFI deficiency or TAFIa inhibition by PCI provides a biomarker of TAFIa inhibition that tracks in vivo antithrombotic efficacy...
  2. ncbi request reprint Quantification of platelet composition in experimental venous thrombosis by real-time polymerase chain reaction
    Xinkang Wang
    Department of Thrombosis Biology, Bristol Myers Squibb Company, Pennington, NJ 08534, USA
    Thromb Res 119:593-600. 2007
    ..In this study a sensitive and reliable method to characterize the cellular components of experimental thrombi was developed using real-time polymerase chain reaction (PCR)...
  3. ncbi request reprint Murine model of ferric chloride-induced vena cava thrombosis: evidence for effect of potato carboxypeptidase inhibitor
    X Wang
    Department of Thrombosis Biology, Bristol Myers Squibb Company, Pennington, NJ 08534, USA
    J Thromb Haemost 4:403-10. 2006
    ..In the present study, we describe the development of a murine model of vena cava thrombosis and its use to characterize the antithrombotic activity of potato carboxypeptidase inhibitor (PCI) of TAFIa (activated TAFI) in mice...
  4. ncbi request reprint Investigational anti-inflammatory agents for the treatment of ischaemic brain injury
    Xinkang Wang
    Bristol Myers Squibb Company, Discovery Biology, 311 Pennington Rocky Hill Road, Pennington, NJ 08534, USA
    Expert Opin Investig Drugs 14:393-409. 2005
    ....
  5. ncbi request reprint Inhibition of tumor necrosis factor-alpha-converting enzyme by a selective antagonist protects brain from focal ischemic injury in rats
    Xinkang Wang
    Department of Thrombosis Research, Bristol Myers Squibb Company, P O Box 5400, Princeton, NJ 08543 5400, USA
    Mol Pharmacol 65:890-6. 2004
    ..Our data suggest that inhibition of TACE might be a potential therapeutic strategy for neuroprotection after focal ischemic stroke...
  6. ncbi request reprint Up-regulation of secretory leukocyte protease inhibitor (SLPI) in the brain after ischemic stroke: adenoviral expression of SLPI protects brain from ischemic injury
    Xinkang Wang
    Department of Thrombosis Research, Bristol Myers Squibb Company, 311 Pennington Rocky Hill Road, Pennington, NJ 08534, USA
    Mol Pharmacol 64:833-40. 2003
    ..01). These data suggest that the ischemia-induced expression of SLPI might play a neuroprotective role in focal stroke, possibly because of rapid inhibition of activated proteases and its suppression in inflammatory response...
  7. ncbi request reprint Inhibition of factor Xa reduces ischemic brain damage after thromboembolic stroke in rats
    Xinkang Wang
    Department of Cardiovascular Sciences, Bristol Myers Squibb Company, Wilmington, Del, USA
    Stroke 34:468-74. 2003
    ..In the present study we describe the effect of a novel, potent, and selective FXa inhibitor, DPC602, on brain damage and neurobehavioral consequence in a rat thromboembolic model of stroke...
  8. ncbi request reprint Comparative analysis of various platelet glycoprotein IIb/IIIa antagonists on shear-induced platelet activation and adhesion
    Xinkang Wang
    Department of Cardiovascular Sciences, Bristol Myers Squibb Company, Experimental Station, Wilmington, Delaware 19880 0400, USA
    J Pharmacol Exp Ther 303:1114-20. 2002
    ..The clinical significance of this phenomenon awaits further investigation...
  9. ncbi request reprint CD44 deficiency in mice protects brain from cerebral ischemia injury
    Xinkang Wang
    Departments of Cardiovascular Sciences and Neurosciences, Bristol Myers Squibb Company, Wilmington, Delaware 19880 0400, USA
    J Neurochem 83:1172-9. 2002
    ..Our data provide new evidence on the potential role of CD44 in brain tissue in response to ischemia and may suggest that this effect might be associated with selective reduction in inflammatory cytokines such as interleukin-1beta...
  10. ncbi request reprint Mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 deficiency protects brain from ischemic injury in mice
    Xinkang Wang
    Department of Cardiovascular Sciences, Bristol Myers Squibb Company, Wilmington, Delaware 19880 0400, USA
    J Biol Chem 277:43968-72. 2002
    ..Our data provide new evidence for the involvement of MAP kinase pathway in focal ischemic brain injury and suggest that this effect might be associated with the expression of interleukin-1beta in the ischemic brain tissue...
  11. ncbi request reprint Significant neuroprotection against ischemic brain injury by inhibition of the MEK1 protein kinase in mice: exploration of potential mechanism associated with apoptosis
    Xinkang Wang
    Department of Cardiovascular Sciences, Bristol Myers Squibb Company, Wilmington, Delaware 19880 0400, USA
    J Pharmacol Exp Ther 304:172-8. 2003
    ..Our data suggest that the inhibition of MEK1/2 results in neuroprotection from reperfusion injury and that this protection may be associated with the reduction in apoptosis...
  12. doi request reprint A platelet target for venous thrombosis? P2Y1 deletion or antagonism protects mice from vena cava thrombosis
    J Eileen Bird
    Department of Thrombosis Biology, Bristol Myers Squibb, 311 Pennington Rocky Hill Road, Pennington, NJ 08534, USA
    J Thromb Thrombolysis 34:199-207. 2012
    ..However as with many antithrombotic agents the benefit comes at the potential price of an increase in provoked bleeding times...
  13. doi request reprint Effects of plasma kallikrein deficiency on haemostasis and thrombosis in mice: murine ortholog of the Fletcher trait
    J Eileen Bird
    Department of Thrombosis Biology, Bristol Myers Squibb, Pennington, New Jersey 08534, USA
    Thromb Haemost 107:1141-50. 2012
    ..Additional support for the significance of the intrinsic pathway in the coagulation cascade is provided, as well as for a potential new anti-thrombotic approach...
  14. ncbi request reprint An optimized murine model of ferric chloride-induced arterial thrombosis for thrombosis research
    Xinkang Wang
    Department of Thrombosis Research, Bristol Myers Squibb Company, Princeton, NJ 08543, USA
    Thromb Res 115:95-100. 2005
    ..Thus, the purpose of this study was to refine the ferric-chloride-induced thrombosis model to be better suited for thrombosis research...
  15. ncbi request reprint Effects of orally active glycoprotein IIb/IIIa antagonists on platelet CD40 ligand (CD154) expression and platelet-heteroaggregate formation
    Susan Carr Zondlo
    Cardiovascular Department, Bristol Myers Squibb Company, Experimental Station, Bldg 400 3352, Route 141 and Henry Clay Road, 19880, Wilmington, DE, USA
    Thromb Res 106:35-40. 2002
  16. ncbi request reprint Recombinant adenoviral expression of dominant negative IkappaBalpha protects brain from cerebral ischemic injury
    Lin Xu
    Department of Cardiovascular Sciences, Bristol Myers Squibb Company, Experimental Station, E400 3418, Wilmington, DE 19880 0400, USA
    Biochem Biophys Res Commun 299:14-7. 2002
    ..01, n=8). These data provide further evidence for the role of NF-kappaB/IkappaB in ischemic brain injury and suggest that inhibition of NF-kappaB is neuroprotective in focal stroke...
  17. ncbi request reprint Effects of factor XI deficiency on ferric chloride-induced vena cava thrombosis in mice
    X Wang
    Department of Thrombosis Research, Bristol Myers Squibb Company, Pennington, NJ 08534, USA
    J Thromb Haemost 4:1982-8. 2006
    ..Increased plasma levels of coagulation factor (F) XI are a risk factor for venous thrombosis...
  18. ncbi request reprint Effects of factor IX or factor XI deficiency on ferric chloride-induced carotid artery occlusion in mice
    X Wang
    Department of Thrombosis Research, Bristol Myers Squibb Company, Pennington, NJ 08534, USA
    J Thromb Haemost 3:695-702. 2005
    ..8-fold increase, P < 0.01). Given the relatively mild bleeding diathesis associated with FXI deficiency, therapeutic inhibition of FXI may be a reasonable strategy for treating or preventing thrombus formation...
  19. ncbi request reprint Technologies of disease-related gene discovery using preclinical models of stroke
    Xinkang Wang
    Department of Thrombosis Research, Bristol Myers Squibb Company, Princeton, NJ, USA
    Methods Mol Med 104:253-64. 2005
    ..Identification of stroke-related gene expression will facilitate the understanding of the molecular basis of stroke pathogenesis and may provide a novel therapeutic intervention of the disease...
  20. ncbi request reprint Assessment of cardiac safety for PPARĪ³ agonists in rodent models of heart failure: a translational medicine perspective
    Xinkang Wang
    Translational Science, Agennix Incorporated, Princeton, NJ 08540, USA
    Curr Mol Pharmacol 5:264-71. 2012
    ..The data and strategic approach are discussed from translational medicine perspectives...
  21. ncbi request reprint Differential regulation of IL-1beta and TNF-alpha RNA expression by MEK1 inhibitor after focal cerebral ischemia in mice
    H Wang
    Department of Cardiovascular Sciences, DuPont Pharmaceuticals Company, Experimental Station, Wilmington, Delaware 19880, USA
    Biochem Biophys Res Commun 286:869-74. 2001
    ..The study also demonstrates for the first time that these two cytokines are differentially regulated by kinase mediated signaling pathways...
  22. ncbi request reprint Use of suppression subtractive hybridization for differential gene expression in stroke: discovery of CD44 gene expression and localization in permanent focal stroke in rats
    H Wang
    Departments of Cardiovascular Sciences and General Pharmacology, DuPont Pharmaceuticals Company, Wilmington, Deleware, USA
    Stroke 32:1020-7. 2001
    ....
  23. ncbi request reprint Cocaine-induced intracellular signaling and gene expression are oppositely regulated by the dopamine D1 and D3 receptors
    Lu Zhang
    Department of Cell Biology, Neurobiology, and Anatomy, University of Cincinnati Medical Center, Cincinnati, Ohio 45267, USA
    J Neurosci 24:3344-54. 2004
    ..These results suggest that the D1 and D3 receptors elicit opposite regulation of target gene expression by regulating ERK activation and c-fos induction after acute and chronic cocaine treatment...
  24. ncbi request reprint Missing steps in the STAIR case: a Translational Medicine perspective on the development of NXY-059 for treatment of acute ischemic stroke
    Giora Z Feuerstein
    Wyeth Research, Collegeville, Pennsylvania 19426, USA
    J Cereb Blood Flow Metab 28:217-9. 2008
    ..Finally, rational patient selection and new outcome scales tailored in an adaptive design model must be evaluated...