- The use of mechanistic biomarkers for evaluating investigational CNS compounds in early drug developmentHolly D Soares
Bristol Myers Squibb Co, Wallingford, CT 06492, USA
Curr Opin Investig Drugs 11:795-801. 2010..This review focuses on recent advances in proof-of-pharmacology biomarkers, with an emphasis on biochemical measures and simple circuit platforms used to demonstrate target engagement in central compartments...
- Plasma biomarkers associated with the apolipoprotein E genotype and Alzheimer diseaseHolly D Soares
Bristol Myers Squibb, Wallingford, CT 06492, USA
Arch Neurol 69:1310-7. 2012..A blood-based test that could be used as a screen for Alzheimer disease (AD) may enable early intervention and better access to treatment...