Gregory M Rose

Summary

Affiliation: Bristol-Myers Squibb
Country: USA

Publications

  1. ncbi Phosphodiesterase inhibitors for cognitive enhancement
    Gregory M Rose
    Memory Pharmaceuticals Corp, 100 Philips Parkway, Montvale, NJ 07645, USA
    Curr Pharm Des 11:3329-34. 2005
  2. ncbi Efficacy of MEM 1003, a novel calcium channel blocker, in delay and trace eyeblink conditioning in older rabbits
    Gregory M Rose
    Memory Pharmaceuticals Corp, Montvale, NJ, United States
    Neurobiol Aging 28:766-73. 2007
  3. ncbi Hippocampal expression analyses reveal selective association of immediate-early, neuroenergetic, and myelinogenic pathways with cognitive impairment in aged rats
    Wayne B Rowe
    Department of Functional Neuroscience, Memory Pharmaceuticals Corporation, Montvale, New Jersey 07645, USA
    J Neurosci 27:3098-110. 2007
  4. ncbi The slow afterhyperpolarization in hippocampal CA1 neurons covaries with spatial learning ability in aged Fisher 344 rats
    Geoffrey C Tombaugh
    Memory Pharmaceuticals Corporation, Montvale, New Jersey 07645, USA
    J Neurosci 25:2609-16. 2005
  5. ncbi Donepezil primarily attenuates scopolamine-induced deficits in psychomotor function, with moderate effects on simple conditioning and attention, and small effects on working memory and spatial mapping
    Mark D Lindner
    Department 401, Neuroscience Drug Discovery, Bristol Myers Squibb Pharmaceutical Research Institute, Wallingford, CT 06492, USA
    Psychopharmacology (Berl) 188:629-40. 2006
  6. ncbi Soluble Abeta and cognitive function in aged F-344 rats and Tg2576 mice
    Mark D Lindner
    Neuroscience Drug Discovery, Bristol Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492, USA
    Behav Brain Res 173:62-75. 2006
  7. ncbi Theta-frequency synaptic potentiation in CA1 in vitro distinguishes cognitively impaired from unimpaired aged Fischer 344 rats
    Geoffrey C Tombaugh
    Memory Pharmaceuticals Corporation, Montvale, New Jersey 07645, USA
    J Neurosci 22:9932-40. 2002
  8. ncbi Effects of the novel PDE4 inhibitors MEM1018 and MEM1091 on memory in the radial-arm maze and inhibitory avoidance tests in rats
    Han Ting Zhang
    Department of Pharmacology, University of Tennessee Health Science Center, 874 Union Avenue, Memphis, TN 38163, USA
    Psychopharmacology (Berl) 179:613-9. 2005
  9. ncbi Exogenous NGF restores endogenous NGF distribution in the brain of the cognitively impaired aged rat
    Dave Albeck
    Department of Psychology, University of Colorado at Denver, Campus Box 173, P O Box 173364, 80217 3364, USA
    Brain Res 967:306-10. 2003
  10. ncbi Antidepressant-like effects of PDE4 inhibitors mediated by the high-affinity rolipram binding state (HARBS) of the phosphodiesterase-4 enzyme (PDE4) in rats
    Han Ting Zhang
    Departments of Behavioral Medicine and Psychiatry and Neurobiology and Anatomy, West Virginia University Health Sciences Center, Morgantown, WV 26506, USA
    Psychopharmacology (Berl) 186:209-17. 2006

Collaborators

Detail Information

Publications10

  1. ncbi Phosphodiesterase inhibitors for cognitive enhancement
    Gregory M Rose
    Memory Pharmaceuticals Corp, 100 Philips Parkway, Montvale, NJ 07645, USA
    Curr Pharm Des 11:3329-34. 2005
    ....
  2. ncbi Efficacy of MEM 1003, a novel calcium channel blocker, in delay and trace eyeblink conditioning in older rabbits
    Gregory M Rose
    Memory Pharmaceuticals Corp, Montvale, NJ, United States
    Neurobiol Aging 28:766-73. 2007
    ..However, higher or lower doses were ineffective. These results support previous work demonstrating that modulation of Ca2+ channel activity can reduce age-related cognitive impairments...
  3. ncbi Hippocampal expression analyses reveal selective association of immediate-early, neuroenergetic, and myelinogenic pathways with cognitive impairment in aged rats
    Wayne B Rowe
    Department of Functional Neuroscience, Memory Pharmaceuticals Corporation, Montvale, New Jersey 07645, USA
    J Neurosci 27:3098-110. 2007
    ..Together, the findings suggest a new model, in which deficient neuroenergetics leads to downregulated neuronal signaling and increased glial activation, resulting in aging-related cognitive dysfunction...
  4. ncbi The slow afterhyperpolarization in hippocampal CA1 neurons covaries with spatial learning ability in aged Fisher 344 rats
    Geoffrey C Tombaugh
    Memory Pharmaceuticals Corporation, Montvale, New Jersey 07645, USA
    J Neurosci 25:2609-16. 2005
    ..Our findings also indicate that multiple processes, in addition to elevated calcium influx, conspire to induce cognitive decline during aging...
  5. ncbi Donepezil primarily attenuates scopolamine-induced deficits in psychomotor function, with moderate effects on simple conditioning and attention, and small effects on working memory and spatial mapping
    Mark D Lindner
    Department 401, Neuroscience Drug Discovery, Bristol Myers Squibb Pharmaceutical Research Institute, Wallingford, CT 06492, USA
    Psychopharmacology (Berl) 188:629-40. 2006
    ....
  6. ncbi Soluble Abeta and cognitive function in aged F-344 rats and Tg2576 mice
    Mark D Lindner
    Neuroscience Drug Discovery, Bristol Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492, USA
    Behav Brain Res 173:62-75. 2006
    ....
  7. ncbi Theta-frequency synaptic potentiation in CA1 in vitro distinguishes cognitively impaired from unimpaired aged Fischer 344 rats
    Geoffrey C Tombaugh
    Memory Pharmaceuticals Corporation, Montvale, New Jersey 07645, USA
    J Neurosci 22:9932-40. 2002
    ..These findings reinforce the idea that distinct types of hippocampal LTP offer mechanistic insight into age-associated cognitive decline...
  8. ncbi Effects of the novel PDE4 inhibitors MEM1018 and MEM1091 on memory in the radial-arm maze and inhibitory avoidance tests in rats
    Han Ting Zhang
    Department of Pharmacology, University of Tennessee Health Science Center, 874 Union Avenue, Memphis, TN 38163, USA
    Psychopharmacology (Berl) 179:613-9. 2005
    ..Inhibition of cyclic AMP (cAMP)-specific phosphodiesterase (PDE4) enhances memory in rodents. MEM1018 and MEM1091 are newly developed PDE4 inhibitors that had not been evaluated as yet for their effects on working and reference memory...
  9. ncbi Exogenous NGF restores endogenous NGF distribution in the brain of the cognitively impaired aged rat
    Dave Albeck
    Department of Psychology, University of Colorado at Denver, Campus Box 173, P O Box 173364, 80217 3364, USA
    Brain Res 967:306-10. 2003
    ..These data suggest that NGF administration restores utilization of endogenous growth factor in the brain of cognitively impaired aged rats...
  10. ncbi Antidepressant-like effects of PDE4 inhibitors mediated by the high-affinity rolipram binding state (HARBS) of the phosphodiesterase-4 enzyme (PDE4) in rats
    Han Ting Zhang
    Departments of Behavioral Medicine and Psychiatry and Neurobiology and Anatomy, West Virginia University Health Sciences Center, Morgantown, WV 26506, USA
    Psychopharmacology (Berl) 186:209-17. 2006
    ..Phosphodiesterase-4 (PDE4) has two conformation states based on rolipram binding, the high-affinity rolipram binding state (HARBS) and the low-affinity rolipram binding state (LARBS); their functions remain to be fully explained...