K Ranade

Summary

Affiliation: Bristol-Myers Squibb
Country: USA

Publications

  1. ncbi Genetic variation in the human urea transporter-2 is associated with variation in blood pressure
    K Ranade
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305 5120, USA
    Hum Mol Genet 10:2157-64. 2001
  2. ncbi A genome scan for hypertension susceptibility loci in populations of Chinese and Japanese origins
    Koustubh Ranade
    Department of Genetics, Stanford University School of Medicine, Stanford, California, USA
    Am J Hypertens 16:158-62. 2003
  3. ncbi Tree-structured supervised learning and the genetics of hypertension
    Jing Huang
    Affymetrix Inc, 3380 Central Expressway, Santa Clara, CA 95051, USA
    Proc Natl Acad Sci U S A 101:10529-34. 2004
  4. ncbi Genetic analysis implicates resistin in HIV lipodystrophy
    Koustubh Ranade
    Bristol Myers Squibb R and D, Princeton, New Jersey 08543 5400, USA
    AIDS 22:1561-8. 2008
  5. ncbi Evaluation of the paraoxonases as candidate genes for stroke: Gln192Arg polymorphism in the paraoxonase 1 gene is associated with increased risk of stroke
    Koustubh Ranade
    Pharmaceutical Research Institute, Bristol Myers Squibb, Princeton, NJ 08543 5400, USA
    Stroke 36:2346-50. 2005
  6. ncbi A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate
    Koustubh Ranade
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Am J Hum Genet 70:935-42. 2002
  7. ncbi The glycine allele of a glycine/arginine polymorphism in the beta2-adrenergic receptor gene is associated with essential hypertension in a population of Chinese origin
    K Ranade
    Department of Genetics, Stanford University School of Medicine, California, USA
    Am J Hypertens 14:1196-200. 2001
  8. ncbi Genetic variation in aldosterone synthase predicts plasma glucose levels
    K Ranade
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305 5120, USA
    Proc Natl Acad Sci U S A 98:13219-24. 2001
  9. ncbi High-throughput genotyping with single nucleotide polymorphisms
    K Ranade
    Department of Genetics, Stanford University School of Medicine, Stanford, California 94305 5120, USA
    Genome Res 11:1262-8. 2001
  10. ncbi Lack of evidence for an association between alpha-adducin and blood pressure regulation in Asian populations
    K Ranade
    Department of Genetics, Stanford University School of Medicine, California 94305-5120, USA
    Am J Hypertens 13:704-9. 2000

Detail Information

Publications17

  1. ncbi Genetic variation in the human urea transporter-2 is associated with variation in blood pressure
    K Ranade
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305 5120, USA
    Hum Mol Genet 10:2157-64. 2001
    ..5 (95% CI 1.2-1.8, P < 0.001), respectively. There was a similar trend for systolic BP, and odds ratios for the Ile227 and Ala357 alleles were 1.7 (95% CI 1.2-2.3, P = 0.002) and 1.3 (95% CI 1.1-1.6, P = 0.007), respectively, in men...
  2. ncbi A genome scan for hypertension susceptibility loci in populations of Chinese and Japanese origins
    Koustubh Ranade
    Department of Genetics, Stanford University School of Medicine, Stanford, California, USA
    Am J Hypertens 16:158-62. 2003
    ..Our understanding of genes that predispose to essential hypertension is poor...
  3. ncbi Tree-structured supervised learning and the genetics of hypertension
    Jing Huang
    Affymetrix Inc, 3380 Central Expressway, Santa Clara, CA 95051, USA
    Proc Natl Acad Sci U S A 101:10529-34. 2004
    ..FlexTree and Logic Regression appear better than the others in terms of Bayes risk. However, the differences are not significant in the usual statistical sense...
  4. ncbi Genetic analysis implicates resistin in HIV lipodystrophy
    Koustubh Ranade
    Bristol Myers Squibb R and D, Princeton, New Jersey 08543 5400, USA
    AIDS 22:1561-8. 2008
    ..To investigate the role of genetic variation in influencing the risk of metabolic complications associated with highly active antiretroviral therapy (HAART)...
  5. ncbi Evaluation of the paraoxonases as candidate genes for stroke: Gln192Arg polymorphism in the paraoxonase 1 gene is associated with increased risk of stroke
    Koustubh Ranade
    Pharmaceutical Research Institute, Bristol Myers Squibb, Princeton, NJ 08543 5400, USA
    Stroke 36:2346-50. 2005
    ..We evaluated, in a comprehensive way, all 3 paraoxonase genes for association with stroke observed in the Cholesterol and Recurrent Events (CARE) trial...
  6. ncbi A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate
    Koustubh Ranade
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Am J Hum Genet 70:935-42. 2002
    ..Neither the Arg389Gly polymorphism in the beta1 adrenergic receptor nor polymorphisms in the beta2 and beta3 adrenergic receptors were associated with resting heart rate. The heritability of heart rate was 39.7% +/- 7.1% (P<10-7)...
  7. ncbi The glycine allele of a glycine/arginine polymorphism in the beta2-adrenergic receptor gene is associated with essential hypertension in a population of Chinese origin
    K Ranade
    Department of Genetics, Stanford University School of Medicine, California, USA
    Am J Hypertens 14:1196-200. 2001
    ..We sought to replicate these results in a population of Chinese origin primarily from Taiwan and the San Francisco Bay area...
  8. ncbi Genetic variation in aldosterone synthase predicts plasma glucose levels
    K Ranade
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305 5120, USA
    Proc Natl Acad Sci U S A 98:13219-24. 2001
    ..51; 95% confidence interval (C.I.) 1.39-3.92; P = 0.0015] and have impaired fasting glucose levels (odds ratio 3.53; 95% C.I. 2.02-5.5; P = 0.0000036). These results suggest a new role for aldosterone in glucose homeostasis...
  9. ncbi High-throughput genotyping with single nucleotide polymorphisms
    K Ranade
    Department of Genetics, Stanford University School of Medicine, Stanford, California 94305 5120, USA
    Genome Res 11:1262-8. 2001
    ..Indeed, large-scale genotyping has been accomplished for 23 other SNPs in 13 different genes using this method. In addition, we identified three "pseudo-SNPs" (WIAF1161, WIAF2566, and WIAF335) that are probably a result of duplication...
  10. ncbi Lack of evidence for an association between alpha-adducin and blood pressure regulation in Asian populations
    K Ranade
    Department of Genetics, Stanford University School of Medicine, California 94305-5120, USA
    Am J Hypertens 13:704-9. 2000
    ..30). In contrast, in the Japanese population, there was no evidence for a positive association under any model. For the combined Chinese and Japanese samples, the evidence for association with alpha-adducin was not significant...
  11. ncbi A locus for Fanconi anemia on 16q determined by homozygosity mapping
    M Gschwend
    Department of Genetics, Stanford University School of Medicine, CA 94305 5120, USA
    Am J Hum Genet 59:377-84. 1996
    ..We also demonstrate the strong effect of marker allele frequencies on LOD scores obtained in homozygosity mapping and discuss ways to avoid false positives arising from this effect...
  12. ncbi Genotyping using the TaqMan assay
    Lester Hui
    Bristol Myers Squibb, Princeton, New Jersey, USA
    Curr Protoc Hum Genet . 2008
    ..Moreover, because probes are included in the PCR, genotypes are determined without any post-PCR processing, a feature that is unavailable with most other genotyping methods. This unit describes probe and primer design and PCR conditions...
  13. ncbi Polymorphism in KIF6 gene and benefit from statins after acute coronary syndromes: results from the PROVE IT-TIMI 22 study
    Olga A Iakoubova
    Celera, Alameda, California 9450, USA
    J Am Coll Cardiol 51:449-55. 2008
    ..We explored whether the benefit of intensive versus moderate statin therapy would be greater in carriers of KIF6 719Arg than in noncarriers...
  14. ncbi Association between ADAMTS1 matrix metalloproteinase gene variation, coronary heart disease, and benefit of statin therapy
    Marc S Sabatine
    TIMI Study Group, Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Arterioscler Thromb Vasc Biol 28:562-7. 2008
    ..The purpose of this study was to investigate the association between the Ala227Pro polymorphism in the ADAMTS1 metalloproteinase gene and coronary heart disease and benefit from statin therapy in 2 independent cohorts...
  15. ncbi A meta-analysis of genome-wide linkage scans for hypertension: the National Heart, Lung and Blood Institute Family Blood Pressure Program
    Michael A Province
    Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Hypertens 16:144-7. 2003
    ..The networks used different family designs and targeted multiple ethnic groups, using standardized protocols and definitions. Linkage genome scans were done on samples within each network (N = 6245 relatives)...
  16. ncbi High-throughput genotyping of single nucleotide polymorphisms using new biplex invader technology
    Michael Olivier
    Stanford Human Genome Center, Stanford University School of Medicine, 975 California Avenue, Palo Alto, CA 94305, USA
    Nucleic Acids Res 30:e53. 2002
    ..The biplex invader assay with its automated set-up and analysis offers a new efficient high-throughput genotyping platform that is suitable for association studies in large study cohorts...
  17. ncbi Genetic and gene expression studies implicate renin and endothelin-1 in edema caused by peroxisome proliferator-activated receptor gamma agonists
    William J Geese
    R and D, Bristol Myers Squibb Co, Princeton, New Jersey 08543 5400, USA
    Pharmacogenet Genomics 18:903-10. 2008
    ....