Ramesh N Patel

Summary

Affiliation: Bristol-Myers Squibb
Country: USA

Publications

  1. ncbi request reprint Enzymatic synthesis of chiral intermediates for Omapatrilat, an antihypertensive drug
    R N Patel
    Enzyme Technology, Process Research and Development, Bristol Myers Squibb Pharmaceutical Research Institute, One Squibb Drive, P O Box 191, New Brunswick, NJ 08903, USA
    Biomol Eng 17:167-82. 2001
  2. ncbi request reprint Biocatalytic synthesis of intermediates for the synthesis of chiral drug substances
    R N Patel
    Process Research and Development, Bristol Myers Squibb Pharmaceutical Research, Institute New Brunswick, Brunswick, New Jersey 08903, USA
    Curr Opin Biotechnol 12:587-604. 2001
  3. ncbi request reprint Enzymatic synthesis of chiral intermediates for pharmaceuticals
    Ramesh Patel
    Process Research and Development, Bristol Myers Squibb Pharmaceutical Research Institute, New Brunswick, New Jersey, 08903, USA
    J Ind Microbiol Biotechnol 30:252-9. 2003
  4. ncbi request reprint Biocatalysis: synthesis of chiral intermediates for drugs
    Ramesh N Patel
    Process Research and Development, Pharmaceutical Research Institute, Bristol Myers Squibb, One Squibb Drive, New Brunswick, NJ 08903, USA
    Curr Opin Drug Discov Devel 9:741-64. 2006
  5. doi request reprint Microbial N-demethylation: biotransformation and recovery of a drug metabolite
    Brian L Davis
    Process Research and Development, Bristol Myers Squibb Co, New Brunswick, NJ 08903, USA
    Biotechnol Appl Biochem 53:133-7. 2009
  6. ncbi request reprint Conversion of 7-deoxy-10-deacetylbaccatin-III into 6-alpha-hydroxy-7-deoxy-10-deacetylbaccatin-III by Nocardioides luteus
    Ronald L Hanson
    Process Research and Development, Bristol Myers Squibb Pharmaceutical Research Institute, 1 Squibb Drive, New Brunswick, NJ 08903, USA
    Biotechnol Appl Biochem 39:209-14. 2004
  7. doi request reprint Microbial transformation of 2-amino-4-methyl-3-nitropyridine
    Thomas Tully
    Chemical Development, Bristol Myers Squibb, One Squibb Drive, New Brunswick, NJ, 08903, USA
    J Ind Microbiol Biotechnol 39:1789-99. 2012
  8. doi request reprint Microbial hydroxylation of o-bromophenylacetic acid: synthesis of 4-substituted-2,3-dihydrobenzofurans
    Prashant P Deshpande
    Department of Process Research and Development, Bristol Myers Squibb Pharmaceutical Research Institute, New Brunswick, NJ 08903, USA
    J Ind Microbiol Biotechnol 35:901-6. 2008
  9. ncbi request reprint Enzymatic C-4 deacetylation of 10-deacetylbaccatin III
    Ronald L Hanson
    Department of Process Research and Development, Bristol Myers Squibb Pharmaceutical Research Institute, One Squibb Drive, New Brunswick, NJ 08903, USA
    Biotechnol Appl Biochem 45:81-5. 2006
  10. ncbi request reprint Microbial/enzymatic synthesis of chiral pharmaceutical intermediates
    Ramesh N Patel
    Bristol Myers Squibb, Process R and D, New Brunswick, NJ 08903, USA
    Curr Opin Drug Discov Devel 6:902-20. 2003

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Enzymatic synthesis of chiral intermediates for Omapatrilat, an antihypertensive drug
    R N Patel
    Enzyme Technology, Process Research and Development, Bristol Myers Squibb Pharmaceutical Research Institute, One Squibb Drive, P O Box 191, New Brunswick, NJ 08903, USA
    Biomol Eng 17:167-82. 2001
    ..This enzyme was overexpressed in E. coli and a process was developed using the recombinant enzyme...
  2. ncbi request reprint Biocatalytic synthesis of intermediates for the synthesis of chiral drug substances
    R N Patel
    Process Research and Development, Bristol Myers Squibb Pharmaceutical Research, Institute New Brunswick, Brunswick, New Jersey 08903, USA
    Curr Opin Biotechnol 12:587-604. 2001
    ....
  3. ncbi request reprint Enzymatic synthesis of chiral intermediates for pharmaceuticals
    Ramesh Patel
    Process Research and Development, Bristol Myers Squibb Pharmaceutical Research Institute, New Brunswick, New Jersey, 08903, USA
    J Ind Microbiol Biotechnol 30:252-9. 2003
    ..In this review article, microbial/enzymatic processes for the synthesis of chiral intermediates for antihypertensive drugs, melatonin receptor agonists, and beta3-receptor receptor agonists are described...
  4. ncbi request reprint Biocatalysis: synthesis of chiral intermediates for drugs
    Ramesh N Patel
    Process Research and Development, Pharmaceutical Research Institute, Bristol Myers Squibb, One Squibb Drive, New Brunswick, NJ 08903, USA
    Curr Opin Drug Discov Devel 9:741-64. 2006
    ..In this article, biocatalytic processes are described for the synthesis of chiral intermediates for drugs...
  5. doi request reprint Microbial N-demethylation: biotransformation and recovery of a drug metabolite
    Brian L Davis
    Process Research and Development, Bristol Myers Squibb Co, New Brunswick, NJ 08903, USA
    Biotechnol Appl Biochem 53:133-7. 2009
    ..Two Streptomyces species were found to carry out the desired N-demethylation. Bioconversion by Streptomyces griseus A.T.C.C. 13273 and product recovery were scaled up to the multi-gram level...
  6. ncbi request reprint Conversion of 7-deoxy-10-deacetylbaccatin-III into 6-alpha-hydroxy-7-deoxy-10-deacetylbaccatin-III by Nocardioides luteus
    Ronald L Hanson
    Process Research and Development, Bristol Myers Squibb Pharmaceutical Research Institute, 1 Squibb Drive, New Brunswick, NJ 08903, USA
    Biotechnol Appl Biochem 39:209-14. 2004
    ..Screening of microbial strains identified an enzyme activity in Nocardioides luteus SC 13912 (A.T.C.C. 55426) which converted 7-deoxy-10-deacetylbaccatin-III into 6-hydroxy-7-deoxy-10-deacetylbaccatin-III with a maximum yield of 44%...
  7. doi request reprint Microbial transformation of 2-amino-4-methyl-3-nitropyridine
    Thomas Tully
    Chemical Development, Bristol Myers Squibb, One Squibb Drive, New Brunswick, NJ, 08903, USA
    J Ind Microbiol Biotechnol 39:1789-99. 2012
    ..13 % yield in multi-gram levels. A simple isolation process not requiring chromatography was developed to provide purified 2-amino-5-hydroxy-4-methyl-3-nitropyridine of excellent quality...
  8. doi request reprint Microbial hydroxylation of o-bromophenylacetic acid: synthesis of 4-substituted-2,3-dihydrobenzofurans
    Prashant P Deshpande
    Department of Process Research and Development, Bristol Myers Squibb Pharmaceutical Research Institute, New Brunswick, NJ 08903, USA
    J Ind Microbiol Biotechnol 35:901-6. 2008
    ..Pd-mediated coupling reactions of 4-bromo-2,3-dihydrobenzofuran provided easy access to the 4-substituted-2,3-dihydrobenzofurans...
  9. ncbi request reprint Enzymatic C-4 deacetylation of 10-deacetylbaccatin III
    Ronald L Hanson
    Department of Process Research and Development, Bristol Myers Squibb Pharmaceutical Research Institute, One Squibb Drive, New Brunswick, NJ 08903, USA
    Biotechnol Appl Biochem 45:81-5. 2006
    ..218-fold from one of them. The activity of this enzyme was limited to 10-DAB, and the enzyme was not effective with paclitaxel or baccatin III...
  10. ncbi request reprint Microbial/enzymatic synthesis of chiral pharmaceutical intermediates
    Ramesh N Patel
    Bristol Myers Squibb, Process R and D, New Brunswick, NJ 08903, USA
    Curr Opin Drug Discov Devel 6:902-20. 2003
    ..In this article, biocatalytic processes for the synthesis of chiral pharmaceutical intermediates are described...
  11. ncbi request reprint Improvement of sordarin production through process optimization: combining traditional approaches with DOE
    Thomas P Tully
    Enzyme Technology, Process Research and Development, Bristol Myers Squibb Pharmaceutical Research Institute, P O Box 191, New Brunswick, NJ 08903, USA
    J Ind Microbiol Biotechnol 34:193-202. 2007
    ..The improved process was then successfully scaled to pilot plant tanks with the best batch producing 2,389 microg/g sordarin at the 250-l scale...
  12. ncbi request reprint Synthesis and activity of a C-8 keto pleuromutilin derivative
    Dane M Springer
    Department of Anti infective Chemistry, 5 Research Parkway, PO Box 5100, Wallingford, CT 06492, USA
    Bioorg Med Chem Lett 13:1751-3. 2003
    ..The presence of the C-8 keto group precipitated interesting intramolecular chemistry to afford a compound (10) with a novel pleuromutilin-derived ring system...