Ramesh N Patel

Summary

Affiliation: Bristol-Myers Squibb
Country: USA

Publications

  1. ncbi Enzymatic synthesis of chiral intermediates for Omapatrilat, an antihypertensive drug
    R N Patel
    Enzyme Technology, Process Research and Development, Bristol Myers Squibb Pharmaceutical Research Institute, One Squibb Drive, P O Box 191, New Brunswick, NJ 08903, USA
    Biomol Eng 17:167-82. 2001
  2. ncbi Biocatalytic synthesis of intermediates for the synthesis of chiral drug substances
    R N Patel
    Process Research and Development, Bristol Myers Squibb Pharmaceutical Research, Institute New Brunswick, Brunswick, New Jersey 08903, USA
    Curr Opin Biotechnol 12:587-604. 2001
  3. ncbi Enzymatic synthesis of chiral intermediates for pharmaceuticals
    Ramesh Patel
    Process Research and Development, Bristol Myers Squibb Pharmaceutical Research Institute, New Brunswick, New Jersey, 08903, USA
    J Ind Microbiol Biotechnol 30:252-9. 2003
  4. ncbi Biocatalysis: synthesis of chiral intermediates for drugs
    Ramesh N Patel
    Process Research and Development, Pharmaceutical Research Institute, Bristol Myers Squibb, One Squibb Drive, New Brunswick, NJ 08903, USA
    Curr Opin Drug Discov Devel 9:741-64. 2006
  5. doi Microbial transformation of 2-amino-4-methyl-3-nitropyridine
    Thomas Tully
    Chemical Development, Bristol Myers Squibb, One Squibb Drive, New Brunswick, NJ 08903, USA
    J Ind Microbiol Biotechnol 39:1789-99. 2012
  6. doi Microbial N-demethylation: biotransformation and recovery of a drug metabolite
    Brian L Davis
    Process Research and Development, Bristol Myers Squibb Co, New Brunswick, NJ 08903, USA
    Biotechnol Appl Biochem 53:133-7. 2009
  7. ncbi Conversion of 7-deoxy-10-deacetylbaccatin-III into 6-alpha-hydroxy-7-deoxy-10-deacetylbaccatin-III by Nocardioides luteus
    Ronald L Hanson
    Process Research and Development, Bristol Myers Squibb Pharmaceutical Research Institute, 1 Squibb Drive, New Brunswick, NJ 08903, USA
    Biotechnol Appl Biochem 39:209-14. 2004
  8. doi Microbial hydroxylation of o-bromophenylacetic acid: synthesis of 4-substituted-2,3-dihydrobenzofurans
    Prashant P Deshpande
    Department of Process Research and Development, Bristol Myers Squibb Pharmaceutical Research Institute, New Brunswick, NJ 08903, USA
    J Ind Microbiol Biotechnol 35:901-6. 2008
  9. ncbi Enzymatic C-4 deacetylation of 10-deacetylbaccatin III
    Ronald L Hanson
    Department of Process Research and Development, Bristol Myers Squibb Pharmaceutical Research Institute, One Squibb Drive, New Brunswick, NJ 08903, USA
    Biotechnol Appl Biochem 45:81-5. 2006
  10. ncbi Microbial/enzymatic synthesis of chiral pharmaceutical intermediates
    Ramesh N Patel
    Bristol Myers Squibb, Process R and D, New Brunswick, NJ 08903, USA
    Curr Opin Drug Discov Devel 6:902-20. 2003

Collaborators

Detail Information

Publications12

  1. ncbi Enzymatic synthesis of chiral intermediates for Omapatrilat, an antihypertensive drug
    R N Patel
    Enzyme Technology, Process Research and Development, Bristol Myers Squibb Pharmaceutical Research Institute, One Squibb Drive, P O Box 191, New Brunswick, NJ 08903, USA
    Biomol Eng 17:167-82. 2001
    ..This enzyme was overexpressed in E. coli and a process was developed using the recombinant enzyme...
  2. ncbi Biocatalytic synthesis of intermediates for the synthesis of chiral drug substances
    R N Patel
    Process Research and Development, Bristol Myers Squibb Pharmaceutical Research, Institute New Brunswick, Brunswick, New Jersey 08903, USA
    Curr Opin Biotechnol 12:587-604. 2001
    ....
  3. ncbi Enzymatic synthesis of chiral intermediates for pharmaceuticals
    Ramesh Patel
    Process Research and Development, Bristol Myers Squibb Pharmaceutical Research Institute, New Brunswick, New Jersey, 08903, USA
    J Ind Microbiol Biotechnol 30:252-9. 2003
    ..In this review article, microbial/enzymatic processes for the synthesis of chiral intermediates for antihypertensive drugs, melatonin receptor agonists, and beta3-receptor receptor agonists are described...
  4. ncbi Biocatalysis: synthesis of chiral intermediates for drugs
    Ramesh N Patel
    Process Research and Development, Pharmaceutical Research Institute, Bristol Myers Squibb, One Squibb Drive, New Brunswick, NJ 08903, USA
    Curr Opin Drug Discov Devel 9:741-64. 2006
    ..In this article, biocatalytic processes are described for the synthesis of chiral intermediates for drugs...
  5. doi Microbial transformation of 2-amino-4-methyl-3-nitropyridine
    Thomas Tully
    Chemical Development, Bristol Myers Squibb, One Squibb Drive, New Brunswick, NJ 08903, USA
    J Ind Microbiol Biotechnol 39:1789-99. 2012
    ..13 % yield in multi-gram levels. A simple isolation process not requiring chromatography was developed to provide purified 2-amino-5-hydroxy-4-methyl-3-nitropyridine of excellent quality...
  6. doi Microbial N-demethylation: biotransformation and recovery of a drug metabolite
    Brian L Davis
    Process Research and Development, Bristol Myers Squibb Co, New Brunswick, NJ 08903, USA
    Biotechnol Appl Biochem 53:133-7. 2009
    ..Two Streptomyces species were found to carry out the desired N-demethylation. Bioconversion by Streptomyces griseus A.T.C.C. 13273 and product recovery were scaled up to the multi-gram level...
  7. ncbi Conversion of 7-deoxy-10-deacetylbaccatin-III into 6-alpha-hydroxy-7-deoxy-10-deacetylbaccatin-III by Nocardioides luteus
    Ronald L Hanson
    Process Research and Development, Bristol Myers Squibb Pharmaceutical Research Institute, 1 Squibb Drive, New Brunswick, NJ 08903, USA
    Biotechnol Appl Biochem 39:209-14. 2004
    ..Screening of microbial strains identified an enzyme activity in Nocardioides luteus SC 13912 (A.T.C.C. 55426) which converted 7-deoxy-10-deacetylbaccatin-III into 6-hydroxy-7-deoxy-10-deacetylbaccatin-III with a maximum yield of 44%...
  8. doi Microbial hydroxylation of o-bromophenylacetic acid: synthesis of 4-substituted-2,3-dihydrobenzofurans
    Prashant P Deshpande
    Department of Process Research and Development, Bristol Myers Squibb Pharmaceutical Research Institute, New Brunswick, NJ 08903, USA
    J Ind Microbiol Biotechnol 35:901-6. 2008
    ..Pd-mediated coupling reactions of 4-bromo-2,3-dihydrobenzofuran provided easy access to the 4-substituted-2,3-dihydrobenzofurans...
  9. ncbi Enzymatic C-4 deacetylation of 10-deacetylbaccatin III
    Ronald L Hanson
    Department of Process Research and Development, Bristol Myers Squibb Pharmaceutical Research Institute, One Squibb Drive, New Brunswick, NJ 08903, USA
    Biotechnol Appl Biochem 45:81-5. 2006
    ..218-fold from one of them. The activity of this enzyme was limited to 10-DAB, and the enzyme was not effective with paclitaxel or baccatin III...
  10. ncbi Microbial/enzymatic synthesis of chiral pharmaceutical intermediates
    Ramesh N Patel
    Bristol Myers Squibb, Process R and D, New Brunswick, NJ 08903, USA
    Curr Opin Drug Discov Devel 6:902-20. 2003
    ..In this article, biocatalytic processes for the synthesis of chiral pharmaceutical intermediates are described...
  11. ncbi Improvement of sordarin production through process optimization: combining traditional approaches with DOE
    Thomas P Tully
    Enzyme Technology, Process Research and Development, Bristol Myers Squibb Pharmaceutical Research Institute, P O Box 191, New Brunswick, NJ 08903, USA
    J Ind Microbiol Biotechnol 34:193-202. 2007
    ..The improved process was then successfully scaled to pilot plant tanks with the best batch producing 2,389 microg/g sordarin at the 250-l scale...
  12. ncbi Synthesis and activity of a C-8 keto pleuromutilin derivative
    Dane M Springer
    Department of Anti infective Chemistry, 5 Research Parkway, PO Box 5100, Wallingford, CT 06492, USA
    Bioorg Med Chem Lett 13:1751-3. 2003
    ..The presence of the C-8 keto group precipitated interesting intramolecular chemistry to afford a compound (10) with a novel pleuromutilin-derived ring system...