Michele Agler

Summary

Affiliation: Bristol-Myers Squibb
Country: USA

Publications

  1. doi Multiplexing a high-throughput liability assay to leverage efficiencies
    John Herbst
    Lead Discovery, Profiling and Compound Management, Research and Development, Bristol Myers Squibb, 5 Research Parkway, Wallingford, CT 06492, USA
    Assay Drug Dev Technol 7:294-303. 2009
  2. ncbi A high-content glucocorticoid receptor translocation assay for compound mechanism-of-action evaluation
    Michele Agler
    Bristol Myers Squibb, Lead Discovery and Profiling, Wallingford, Connecticut 06492, USA
    J Biomol Screen 12:1029-41. 2007
  3. doi Protection against HIV-envelope-induced neuronal cell destruction by HIV attachment inhibitors
    Sharon Zhang
    Department of Virology, Bristol Myers Squibb, 5 Research Parkway, Wallingford, CT 06492, USA
    Arch Virol 155:777-81. 2010
  4. ncbi Coactivators in assay design for nuclear hormone receptor drug discovery
    Taosheng Chen
    Lead Discovery and Profiling, Bristol Myers Squibb Company, Wallingford, CT 06492, USA
    Assay Drug Dev Technol 1:835-42. 2003
  5. doi HCS road: an enterprise system for integrated HCS data management and analysis
    Donald Jackson
    Applied Genomics Group, Applied Biotechnology Department, Bristol Myers Squibb Research and Development, Princeton, NJ, USA
    J Biomol Screen 15:882-91. 2010
  6. ncbi Analysis of cellular events using CellCard System in cell-based high-content multiplexed assays
    Taosheng Chen
    Bristol Myers Squibb Company, Lead Discovery and Profiling, 5 Research Parkway, Wallingford, CT 06492, USA
    Expert Rev Mol Diagn 5:817-29. 2005
  7. pmc Inhibition of envelope-mediated CD4+-T-cell depletion by human immunodeficiency virus attachment inhibitors
    Louis Alexander
    Department of Virology, Bristol Myers Squibb, 5 Research Parkway, Wallingford, CT 06492, USA
    Antimicrob Agents Chemother 53:4726-32. 2009
  8. ncbi Identification of a pharmaceutical compound that partially corrects the Niemann-Pick C phenotype in cultured cells
    Laura Liscum
    Department of Physiology, Tufts University School of Medicine, Boston, MA 02111, USA
    J Lipid Res 43:1708-17. 2002

Collaborators

  • Mary Ellen Cvijic
  • Taosheng Chen
  • Tao Wang
  • Louis Alexander
  • Oren Beske
  • Wen Xie
  • Laura Liscum
  • Sharon Zhang
  • Donald Jackson
  • John Herbst
  • Paul Clapham
  • Mahesh Nawade
  • John Kadow
  • Normand J Cloutier
  • Christopher Miller
  • Nannon Zhou
  • Mohammad Shaikh
  • Alexander Zelensky
  • Hua Fang
  • Qi Guo
  • Judith Wardwell-Swanson
  • James V Scharpf
  • James Gill
  • Myles Fennell
  • Pin fang Lin
  • Richard Shaginaw
  • Michael Lenard
  • Dandan Zhao
  • Yingjie Zhu
  • Monique Anthony
  • Martyn Banks
  • David Connors
  • Edward W Petrillo
  • Jeremy Stewart

Detail Information

Publications8

  1. doi Multiplexing a high-throughput liability assay to leverage efficiencies
    John Herbst
    Lead Discovery, Profiling and Compound Management, Research and Development, Bristol Myers Squibb, 5 Research Parkway, Wallingford, CT 06492, USA
    Assay Drug Dev Technol 7:294-303. 2009
    ..Implementation of the multiplexed assay for routine compound profiling provides improved data quality, sample conservation, cost savings, and resource efficiencies...
  2. ncbi A high-content glucocorticoid receptor translocation assay for compound mechanism-of-action evaluation
    Michele Agler
    Bristol Myers Squibb, Lead Discovery and Profiling, Wallingford, Connecticut 06492, USA
    J Biomol Screen 12:1029-41. 2007
    ..Using a high-content imaging system, ligand-induced, dose-dependent GR nuclear translocation was quantified and a correlation with other conventional assays established...
  3. doi Protection against HIV-envelope-induced neuronal cell destruction by HIV attachment inhibitors
    Sharon Zhang
    Department of Virology, Bristol Myers Squibb, 5 Research Parkway, Wallingford, CT 06492, USA
    Arch Virol 155:777-81. 2010
    ..This antiretroviral class may therefore have the potential to inhibit HIV-induced neuron damage, thereby curtailing the increasing incidence of HIV-associated cognitive impairment...
  4. ncbi Coactivators in assay design for nuclear hormone receptor drug discovery
    Taosheng Chen
    Lead Discovery and Profiling, Bristol Myers Squibb Company, Wallingford, CT 06492, USA
    Assay Drug Dev Technol 1:835-42. 2003
    ..This minireview discusses various aspects of NHR drug discovery, with a focus on the application of NHR coactivators in assay design for NHR ligand identification...
  5. doi HCS road: an enterprise system for integrated HCS data management and analysis
    Donald Jackson
    Applied Genomics Group, Applied Biotechnology Department, Bristol Myers Squibb Research and Development, Princeton, NJ, USA
    J Biomol Screen 15:882-91. 2010
    ..Data can be exported to third-party applications for further analysis and exploration. HCS Road provides a single source for high-content results across the organization, regardless of the group or instrument that produced them...
  6. ncbi Analysis of cellular events using CellCard System in cell-based high-content multiplexed assays
    Taosheng Chen
    Bristol Myers Squibb Company, Lead Discovery and Profiling, 5 Research Parkway, Wallingford, CT 06492, USA
    Expert Rev Mol Diagn 5:817-29. 2005
    ..In this technology review, the authors discuss personal experience with assay validation, data analysis, results such as cell type-specific compound effects, and the potential application of the CellCard System in drug discovery...
  7. pmc Inhibition of envelope-mediated CD4+-T-cell depletion by human immunodeficiency virus attachment inhibitors
    Louis Alexander
    Department of Virology, Bristol Myers Squibb, 5 Research Parkway, Wallingford, CT 06492, USA
    Antimicrob Agents Chemother 53:4726-32. 2009
    ....
  8. ncbi Identification of a pharmaceutical compound that partially corrects the Niemann-Pick C phenotype in cultured cells
    Laura Liscum
    Department of Physiology, Tufts University School of Medicine, Boston, MA 02111, USA
    J Lipid Res 43:1708-17. 2002
    ..In addition to making NPC cells more sensitive to amphotericin B, NP-27 stimulated two separate cholesterol transport pathways and restored LDL stimulation of cholesterol esterification to near normal levels...