WILLIAM WINDER

Summary

Affiliation: Brigham Young University
Country: USA

Publications

  1. ncbi request reprint Long-term regulation of AMP-activated protein kinase and acetyl-CoA carboxylase in skeletal muscle
    W W Winder
    Department of Physiology and Developmental Biology, 545 WIDB, Brigham Young University, Provo, UT 84602, USA
    Biochem Soc Trans 31:182-5. 2003
  2. ncbi request reprint Role of AMP-activated protein kinase in the molecular adaptation to endurance exercise
    William W Winder
    Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA
    Med Sci Sports Exerc 38:1945-9. 2006
  3. ncbi request reprint Cellular energy sensing and signaling by AMP-activated protein kinase
    William W Winder
    Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA
    Cell Biochem Biophys 47:332-47. 2007
  4. ncbi request reprint Energy-sensing and signaling by AMP-activated protein kinase in skeletal muscle
    W W Winder
    Department of Zoology, Brigham Young University, Provo, Utah 84602, USA
    J Appl Physiol 91:1017-28. 2001
  5. ncbi request reprint AMP-activated protein kinase: possible target for treatment of type 2 diabetes
    W W Winder
    Department of Zoology, Brigham Young University, Provo, Utah 84602, USA
    Diabetes Technol Ther 2:441-8. 2000
  6. ncbi request reprint Insulin stimulation of glucose uptake fails to decrease palmitate oxidation in muscle if AMPK is activated
    W W Winder
    Brigham Young University, Provo, Utah 84602, USA
    J Appl Physiol 89:2430-7. 2000
  7. ncbi request reprint Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle
    W W Winder
    Department of Zoology, Brigham Young University, Provo, Utah 84602, USA
    J Appl Physiol 88:2219-26. 2000
  8. ncbi request reprint AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes
    W W Winder
    Department of Zoology, Brigham Young University, Provo, Utah 84602, USA
    Am J Physiol 277:E1-10. 1999
  9. pmc Characterization of the liver kinase B1-mouse protein-25 -Ste-20-related adaptor protein complex in adult mouse skeletal muscle
    Cody D Smith
    Department of Physiology and Developmental Biology, Brigham Young University, Provo, Utah, USA
    J Appl Physiol 111:1622-8. 2011
  10. ncbi request reprint LKB1 and the regulation of malonyl-CoA and fatty acid oxidation in muscle
    D M Thomson
    Dept of Physiology and Developmental Biology, Brigham Young Univ, Provo, UT 84602, USA
    Am J Physiol Endocrinol Metab 293:E1572-9. 2007

Research Grants

  1. Physiology of Malonyl-CoA in Muscle during Exercise
    WILLIAM WINDER; Fiscal Year: 2006
  2. Regulation of Skeletal Muscle LKB1
    WILLIAM WINDER; Fiscal Year: 2007
  3. PHYSIOLOGY OF MALONYL COA IN MUSCLE DURING EXERCISE
    WILLIAM WINDER; Fiscal Year: 2001
  4. PHYSIOLOGY OF MALONYL COA IN MUSCLE DURING EXERCISE
    WILLIAM WINDER; Fiscal Year: 1993
  5. Regulation of Skeletal Muscle LKB1
    WILLIAM WINDER; Fiscal Year: 2010

Collaborators

  • D G Hardie
  • D M Thomson
  • H T Yang
  • J O Holloszy
  • B B Rasmussen
  • M Chen
  • H Kim
  • Burton F Holmes
  • GERALD L DOHM
  • Eric B Taylor
  • E B Taylor
  • D S Rubink
  • W J Ellingson
  • S H Park
  • Jeremy D Lamb
  • S R Paulsen
  • Cody D Smith
  • D J Branvold
  • D G Chesser
  • S N Sudweeks
  • David G Chesser
  • Cori L Compton
  • William J Ellingson
  • Denise Hurst
  • Lyle J Greenwood
  • J D Lamb
  • Paula E Durante
  • S R Gammon
  • Joshua S Bowler
  • Richard A Compton
  • Sterling N Sudweeks
  • Jonathan T Kemp
  • D R Allred
  • J D Brown
  • B M Condon
  • D J Beckstead
  • N Fillmore
  • Richard W Hurst
  • Troy D Cline
  • Seth T Herway
  • Brian B Porter
  • T D Cline
  • D Hurst
  • L J Greenwood
  • Kirsty J Mustard
  • J D Knippers
  • Soo Hyun Park
  • K J Mustard

Detail Information

Publications31

  1. ncbi request reprint Long-term regulation of AMP-activated protein kinase and acetyl-CoA carboxylase in skeletal muscle
    W W Winder
    Department of Physiology and Developmental Biology, 545 WIDB, Brigham Young University, Provo, UT 84602, USA
    Biochem Soc Trans 31:182-5. 2003
    ..Thyroid state therefore appears to be one important factor controlling expression of these proteins in skeletal muscle...
  2. ncbi request reprint Role of AMP-activated protein kinase in the molecular adaptation to endurance exercise
    William W Winder
    Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA
    Med Sci Sports Exerc 38:1945-9. 2006
    ..These observations lend credence to the hypothesis that AMPK activation induced by muscle contraction is responsible in part for adaptations to endurance exercise training...
  3. ncbi request reprint Cellular energy sensing and signaling by AMP-activated protein kinase
    William W Winder
    Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA
    Cell Biochem Biophys 47:332-47. 2007
    ..Because AMPK enhances both glucose uptake and fatty acid oxidation in skeletal muscle, it has become a target for prevention and treatment of type 2 diabetes and obesity...
  4. ncbi request reprint Energy-sensing and signaling by AMP-activated protein kinase in skeletal muscle
    W W Winder
    Department of Zoology, Brigham Young University, Provo, Utah 84602, USA
    J Appl Physiol 91:1017-28. 2001
    ..In addition, this system may have the capability of enhancing capacity for ATP production when the muscle is exposed to endurance training...
  5. ncbi request reprint AMP-activated protein kinase: possible target for treatment of type 2 diabetes
    W W Winder
    Department of Zoology, Brigham Young University, Provo, Utah 84602, USA
    Diabetes Technol Ther 2:441-8. 2000
    ..These observations open the door to the possibility of treatment of patients with type 2 diabetes with AMPK activators...
  6. ncbi request reprint Insulin stimulation of glucose uptake fails to decrease palmitate oxidation in muscle if AMPK is activated
    W W Winder
    Brigham Young University, Provo, Utah 84602, USA
    J Appl Physiol 89:2430-7. 2000
    ..6 nmol/g. We conclude that AMPK activation can prevent high rates of glucose uptake and glycolytic flux from inhibiting palmitate oxidation in predominantly fast-twitch muscle under these conditions...
  7. ncbi request reprint Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle
    W W Winder
    Department of Zoology, Brigham Young University, Provo, Utah 84602, USA
    J Appl Physiol 88:2219-26. 2000
    ..These results suggest that chronic AMPK activation may mediate the effects of muscle contraction on some, but not all, biochemical adaptations of muscle to endurance exercise training...
  8. ncbi request reprint AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes
    W W Winder
    Department of Zoology, Brigham Young University, Provo, Utah 84602, USA
    Am J Physiol 277:E1-10. 1999
    ....
  9. pmc Characterization of the liver kinase B1-mouse protein-25 -Ste-20-related adaptor protein complex in adult mouse skeletal muscle
    Cody D Smith
    Department of Physiology and Developmental Biology, Brigham Young University, Provo, Utah, USA
    J Appl Physiol 111:1622-8. 2011
    ..Quantitative PCR revealed significantly reduced LKB1, MO25╬▒, and STRAD╬▓ mRNA in LKB1(-/-) muscle. These findings demonstrate that the LKB1-MO25-STRAD complex is the principal AMPKK in skeletal muscle...
  10. ncbi request reprint LKB1 and the regulation of malonyl-CoA and fatty acid oxidation in muscle
    D M Thomson
    Dept of Physiology and Developmental Biology, Brigham Young Univ, Provo, UT 84602, USA
    Am J Physiol Endocrinol Metab 293:E1572-9. 2007
    ..Regardless, our results suggest that LKB1 is an important regulator of malonyl-CoA levels and fatty acid oxidation in skeletal muscle...
  11. ncbi request reprint AMP-activated protein kinase phosphorylates transcription factors of the CREB family
    D M Thomson
    Dept of Physiology and Developmental Biology, 545 WIDB, Brigham Young Univ, Provo, UT 84602, USA
    J Appl Physiol 104:429-38. 2008
    ..We conclude that CREB and related proteins are direct downstream targets for AMPK and are therefore likely involved in mediating some effects of AMPK on expression of genes having a CRE in their promoters...
  12. ncbi request reprint AMP-activated protein kinase activation prevents denervation-induced decline in gastrocnemius GLUT-4
    S R Paulsen
    Department of Zoology, Brigham Young University, Provo, Utah 84602, USA
    J Appl Physiol 91:2102-8. 2001
    ..saline-treated rats. These studies provide evidence that some effects of denervation may be prevented by chemical activation of the appropriate signaling pathways...
  13. ncbi request reprint Long-chain acyl-CoA esters inhibit phosphorylation of AMP-activated protein kinase at threonine-172 by LKB1/STRAD/MO25
    E B Taylor
    Department of Physiology and Developmental Biology, Brigham Young Univ, Provo, Utah 84602, USA
    Am J Physiol Endocrinol Metab 288:E1055-61. 2005
    ..These results suggest that the AMPK signaling cascade may directly sense and respond to the lipid energy charge of the cell...
  14. ncbi request reprint Phosphorylation-activity relationships of AMPK and acetyl-CoA carboxylase in muscle
    S H Park
    Department of Zoology, Brigham Young University, Provo, Utah 84602, USA
    J Appl Physiol 92:2475-82. 2002
    ....
  15. ncbi request reprint Effects of thyroid state on AMP-activated protein kinase and acetyl-CoA carboxylase expression in muscle
    S H Park
    Department of Physiology and Developmental Biology, Brigham Young University, Provo, Utah 84602, USA
    J Appl Physiol 93:2081-8. 2002
    ..These data provide evidence that skeletal muscle AMPK subunit and ACC expression is partially under the control of thyroid hormones...
  16. ncbi request reprint Effect of phosphorylation by AMP-activated protein kinase on palmitoyl-CoA inhibition of skeletal muscle acetyl-CoA carboxylase
    D S Rubink
    Dept of Physiology and Developmental Biology, 545 WIDB, Brigham Young Univ, Provo, UT 84602, USA
    J Appl Physiol 98:1221-7. 2005
    ..This may contribute to low-muscle malonyl-CoA values and increasing fatty acid oxidation rates during long-term exercise when plasma fatty acid concentrations are elevated...
  17. ncbi request reprint Skeletal muscle and heart LKB1 deficiency causes decreased voluntary running and reduced muscle mitochondrial marker enzyme expression in mice
    D M Thomson
    Dept of Physiology and Developmental Biology, Brigham Young Univ, Provo, UT 84602, USA
    Am J Physiol Endocrinol Metab 292:E196-202. 2007
    ..Capacity for voluntary running is compromised with muscle and heart LKB1 deficiency...
  18. ncbi request reprint Phosphorylation of rat muscle acetyl-CoA carboxylase by AMP-activated protein kinase and protein kinase A
    W W Winder
    Department of Zoology, Brigham Young University, Provo, Utah 84602, USA
    J Appl Physiol 82:219-25. 1997
    ..Thus muscle ACC can be phosphorylated by PKA but with no apparent functional effects on the enzyme. AMPK appears to be the more important regulator of muscle ACC...
  19. doi request reprint Thyroid hormone effects on LKB1, MO25, phospho-AMPK, phospho-CREB, and PGC-1alpha in rat muscle
    D J Branvold
    Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA
    J Appl Physiol 105:1218-27. 2008
    ..These data provide evidence that thyroid hormones increase soleus muscle LKB1 and MO25 content with subsequent activation of AMPK, phosphorylation of CREB, and expression of mitochondrial protein genes having CRE in their promoters...
  20. pmc AMP-activated protein kinase control of fat metabolism in skeletal muscle
    D M Thomson
    Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA
    Acta Physiol (Oxf) 196:147-54. 2009
    ..Likewise, AMPK may regulate transport of FAs into the cell through FAT/CD36. AMPK may also regulate capacity for FA oxidation by phosphorylation of transcription factors such as CREB or coactivators such as PGC-1alpha...
  21. pmc AMP-activated protein kinase response to contractions and treatment with the AMPK activator AICAR in young adult and old skeletal muscle
    D M Thomson
    Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA
    J Physiol 587:2077-86. 2009
    ..Thus, AMPK hyperactivation in response to contractile activity in aged fast-twitch muscle may be the result of compromised cellular energetics and not necessarily due to an inherent defect in responsiveness of the AMPK molecule per se...
  22. ncbi request reprint Effects of 3-phosphoglycerate and other metabolites on the activation of AMP-activated protein kinase by LKB1-STRAD-MO25
    W J Ellingson
    Department of Physiology and Developmental Biology, Brigham Young University, Provo, Utah 84602, USA
    Am J Physiol Endocrinol Metab 292:E400-7. 2007
    ..3-PG did not stimulate LKB1-STRAD-MO25 activity toward the peptide substrate LKB1tide. These results have identified 3-PG as an AMPK-specific regulator of AMPK phosphorylation and activation by LKB1-STRAD-MO25...
  23. ncbi request reprint Endurance training increases LKB1 and MO25 protein but not AMP-activated protein kinase kinase activity in skeletal muscle
    E B Taylor
    Department of Physiology and Developmental Biology, Brigham Young University, Provo, Utah 84602, USA
    Am J Physiol Endocrinol Metab 287:E1082-9. 2004
    ..05). In conclusion, endurance training markedly increased skeletal muscle LKB1 and MO25 protein without increasing AMPKK activity. LKB1 may be playing multiple roles in skeletal muscle adaptation to endurance training...
  24. ncbi request reprint Liver fructose 2,6-bisphosphate in rats running at different treadmill speeds
    W W Winder
    Department of Zoology, Brigham Young University, Provo, Utah 84602
    Am J Physiol 255:R38-41. 1988
    ..The rapid decline in fructose 2,6-P2 probably plays a role in decreasing hepatic glycolysis, thereby ensuring that glucose 6-phosphate derived from glycogenolysis is diverted to blood glucose...
  25. ncbi request reprint Adrenodemedullation affects endurance but not hepatic fructose 2,6-bisphosphate
    H T Yang
    Department of Zoology, Brigham Young University, Provo, Utah 84602
    Am J Physiol 254:R572-7. 1988
    ..After liver glycogen is depleted, epinephrine from the adrenal medulla prevents hypoglycemia and is essential for allowing continuation of exercise...
  26. ncbi request reprint Evidence against regulation of AMP-activated protein kinase and LKB1/STRAD/MO25 activity by creatine phosphate
    Eric B Taylor
    Department of Physiology and Developmental Biology, Brigham Young University, Provo, Utah 84602, USA
    Am J Physiol Endocrinol Metab 290:E661-9. 2006
    ..In conclusion, these results suggest that creatine phosphate is not a direct regulator of LKB1 or AMPK activity. Creatine phosphate may indirectly modulate AMPK activity by replenishing ATP at the onset of muscle contraction...
  27. ncbi request reprint Regulation of muscle GLUT4 enhancer factor and myocyte enhancer factor 2 by AMP-activated protein kinase
    Burton F Holmes
    Department of Exercise and Sport Science, Human Performance Laboratory, Brody School of Medicine, East Carolina University, Greenville, NC, USA
    Am J Physiol Endocrinol Metab 289:E1071-6. 2005
    ..AMPK can phosphorylate GEF and in response to AICAR, GEF, and MEF2 translocate to the nucleus and have increased binding to the GLUT4 promoter...
  28. ncbi request reprint Endurance training increases skeletal muscle LKB1 and PGC-1alpha protein abundance: effects of time and intensity
    Eric B Taylor
    Department of Physiology and Developmental Biology, 545 WIDB, Brigham Young University, Provo, UT 84602, USA
    Am J Physiol Endocrinol Metab 289:E960-8. 2005
    ..The increase in LKB1 and PGC-1alpha with endurance and interval training may function to maintain the training-induced increases in mitochondrial mass...
  29. ncbi request reprint AMP-activated protein kinase kinase activity and phosphorylation of AMP-activated protein kinase in contracting muscle of sedentary and endurance-trained rats
    Denise Hurst
    Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA
    Am J Physiol Endocrinol Metab 289:E710-5. 2005
    ..These results suggest that AMPKK is activated during electrical stimulation of both trained and nontrained muscle by mechanisms other than covalent modification...
  30. ncbi request reprint Effects of endurance training on activity and expression of AMP-activated protein kinase isoforms in rat muscles
    Paula E Durante
    Division of Molecular Physiology, School of Life Sciences, Dundee University, Wellcome Trust Biocentre, Dundee, DD1 5EH Scotland, UK
    Am J Physiol Endocrinol Metab 283:E178-86. 2002
    ..There was a threefold increase in expression of gamma 3 after training in red quadriceps only. Our results suggest that gamma 3 might have a special role in the adaptation to endurance exercise in muscles utilizing oxidative metabolism...
  31. doi request reprint Regulation of the AMPK-related protein kinases by ubiquitination
    David M Thomson
    Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA
    Biochem J 411:e9-10. 2008
    ....

Research Grants20

  1. Physiology of Malonyl-CoA in Muscle during Exercise
    WILLIAM WINDER; Fiscal Year: 2006
    ..The results will provide additional rationale for the use of regular exercise in preventing and treating type 2 diabetes and obesity. ..
  2. Regulation of Skeletal Muscle LKB1
    WILLIAM WINDER; Fiscal Year: 2007
    ..The proposed studies will provide additional rationale for convincing a predominantly sedentary population of the importance of regular exercise in combating inactivity-related diseases. ..
  3. PHYSIOLOGY OF MALONYL COA IN MUSCLE DURING EXERCISE
    WILLIAM WINDER; Fiscal Year: 2001
    ..These studies will contribute to our understanding of the mechanisms responsible for increasing fat utilization during exercise. ..
  4. PHYSIOLOGY OF MALONYL COA IN MUSCLE DURING EXERCISE
    WILLIAM WINDER; Fiscal Year: 1993
    ..This information will be important for better understanding the metabolic derangements of diabetes mellitus and for understanding regulation of fat utilization during exercise...
  5. Regulation of Skeletal Muscle LKB1
    WILLIAM WINDER; Fiscal Year: 2010
    ..The proposed studies will provide additional rationale for convincing a predominantly sedentary population of the importance of regular exercise in combating inactivity-related diseases. ..