D M Thomson

Summary

Affiliation: Brigham Young University
Country: USA

Publications

  1. pmc The effects of chronic AMPK activation on hepatic triglyceride accumulation and glycerol 3-phosphate acyltransferase activity with high fat feeding
    Bradley S Henriksen
    Diabetol Metab Syndr 5:29. 2013
  2. pmc Iron deficiency causes a shift in AMP-activated protein kinase (AMPK) subunit composition in rat skeletal muscle
    John F Merrill
    Department of Nutrition, Dietetics, and Food Science, Brigham Young University, Provo, Utah, USA
    Nutr Metab (Lond) 9:104. 2012
  3. pmc Skeletal muscle dysfunction in muscle-specific LKB1 knockout mice
    David M Thomson
    Department of Physiology and Developmental Biology, 589 WIDB, Brigham Young University, Provo, UT 84602, USA
    J Appl Physiol (1985) 108:1775-85. 2010
  4. pmc AMP-activated protein kinase response to contractions and treatment with the AMPK activator AICAR in young adult and old skeletal muscle
    D M Thomson
    Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA
    J Physiol 587:2077-86. 2009
  5. pmc AMP-activated protein kinase control of fat metabolism in skeletal muscle
    D M Thomson
    Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA
    Acta Physiol (Oxf) 196:147-54. 2009
  6. ncbi LKB1 and the regulation of malonyl-CoA and fatty acid oxidation in muscle
    D M Thomson
    Dept of Physiology and Developmental Biology, Brigham Young Univ, Provo, UT 84602, USA
    Am J Physiol Endocrinol Metab 293:E1572-9. 2007
  7. ncbi AMP-activated protein kinase phosphorylates transcription factors of the CREB family
    D M Thomson
    Dept of Physiology and Developmental Biology, 545 WIDB, Brigham Young Univ, Provo, UT 84602, USA
    J Appl Physiol (1985) 104:429-38. 2008
  8. ncbi Thyroid hormone effects on LKB1, MO25, phospho-AMPK, phospho-CREB, and PGC-1alpha in rat muscle
    D J Branvold
    Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA
    J Appl Physiol (1985) 105:1218-27. 2008
  9. pmc Effect of LKB1 deficiency on mitochondrial content, fibre type and muscle performance in the mouse diaphragm
    J D Brown
    Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT, USA
    Acta Physiol (Oxf) 201:457-66. 2011
  10. ncbi Skeletal muscle and heart LKB1 deficiency causes decreased voluntary running and reduced muscle mitochondrial marker enzyme expression in mice
    D M Thomson
    Dept of Physiology and Developmental Biology, Brigham Young Univ, Provo, UT 84602, USA
    Am J Physiol Endocrinol Metab 292:E196-202. 2007

Collaborators

  • Allen C Parcell
  • H Kim
  • W W Winder
  • J D Brown
  • Bradley S Henriksen
  • Chad R Hancock
  • John F Merrill
  • D J Branvold
  • Mary E Curtis
  • Natasha Fillmore
  • Brandon R Cardon
  • Shalene E Hardman
  • Squire D Hepworth
  • Shelby Willie
  • C R Hancock
  • A D Mongillo
  • R A Digiovanni
  • J Benjamin Barton
  • S N Sudweeks
  • D R Allred
  • D J Beckstead
  • N Fillmore
  • B M Condon

Detail Information

Publications10

  1. pmc The effects of chronic AMPK activation on hepatic triglyceride accumulation and glycerol 3-phosphate acyltransferase activity with high fat feeding
    Bradley S Henriksen
    Diabetol Metab Syndr 5:29. 2013
    ..CONCLUSIONS: These results suggest that chronic AMPK activation limits hepatic triglyceride accumulation independent of a reduction in total GPAT1 activity...
  2. pmc Iron deficiency causes a shift in AMP-activated protein kinase (AMPK) subunit composition in rat skeletal muscle
    John F Merrill
    Department of Nutrition, Dietetics, and Food Science, Brigham Young University, Provo, Utah, USA
    Nutr Metab (Lond) 9:104. 2012
    ..abstract:..
  3. pmc Skeletal muscle dysfunction in muscle-specific LKB1 knockout mice
    David M Thomson
    Department of Physiology and Developmental Biology, 589 WIDB, Brigham Young University, Provo, UT 84602, USA
    J Appl Physiol (1985) 108:1775-85. 2010
    ..These findings indicate that LKB1 plays a critical role in the maintenance of both skeletal and cardiac function...
  4. pmc AMP-activated protein kinase response to contractions and treatment with the AMPK activator AICAR in young adult and old skeletal muscle
    D M Thomson
    Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA
    J Physiol 587:2077-86. 2009
    ..Thus, AMPK hyperactivation in response to contractile activity in aged fast-twitch muscle may be the result of compromised cellular energetics and not necessarily due to an inherent defect in responsiveness of the AMPK molecule per se...
  5. pmc AMP-activated protein kinase control of fat metabolism in skeletal muscle
    D M Thomson
    Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA
    Acta Physiol (Oxf) 196:147-54. 2009
    ..Likewise, AMPK may regulate transport of FAs into the cell through FAT/CD36. AMPK may also regulate capacity for FA oxidation by phosphorylation of transcription factors such as CREB or coactivators such as PGC-1alpha...
  6. ncbi LKB1 and the regulation of malonyl-CoA and fatty acid oxidation in muscle
    D M Thomson
    Dept of Physiology and Developmental Biology, Brigham Young Univ, Provo, UT 84602, USA
    Am J Physiol Endocrinol Metab 293:E1572-9. 2007
    ..Regardless, our results suggest that LKB1 is an important regulator of malonyl-CoA levels and fatty acid oxidation in skeletal muscle...
  7. ncbi AMP-activated protein kinase phosphorylates transcription factors of the CREB family
    D M Thomson
    Dept of Physiology and Developmental Biology, 545 WIDB, Brigham Young Univ, Provo, UT 84602, USA
    J Appl Physiol (1985) 104:429-38. 2008
    ..We conclude that CREB and related proteins are direct downstream targets for AMPK and are therefore likely involved in mediating some effects of AMPK on expression of genes having a CRE in their promoters...
  8. ncbi Thyroid hormone effects on LKB1, MO25, phospho-AMPK, phospho-CREB, and PGC-1alpha in rat muscle
    D J Branvold
    Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA
    J Appl Physiol (1985) 105:1218-27. 2008
    ..These data provide evidence that thyroid hormones increase soleus muscle LKB1 and MO25 content with subsequent activation of AMPK, phosphorylation of CREB, and expression of mitochondrial protein genes having CRE in their promoters...
  9. pmc Effect of LKB1 deficiency on mitochondrial content, fibre type and muscle performance in the mouse diaphragm
    J D Brown
    Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT, USA
    Acta Physiol (Oxf) 201:457-66. 2011
    ..During exercise, LKB1-mediated phosphorylation of AMPK leads to its activation, promoting mitochondrial biogenesis and glucose transport, among other effects. The roles of LKB1 and AMPK have not been fully characterized in the diaphragm...
  10. ncbi Skeletal muscle and heart LKB1 deficiency causes decreased voluntary running and reduced muscle mitochondrial marker enzyme expression in mice
    D M Thomson
    Dept of Physiology and Developmental Biology, Brigham Young Univ, Provo, UT 84602, USA
    Am J Physiol Endocrinol Metab 292:E196-202. 2007
    ..Capacity for voluntary running is compromised with muscle and heart LKB1 deficiency...