R Preston Mason

Summary

Affiliation: Brigham and Women's Hospital
Country: USA

Publications

  1. ncbi request reprint Effect of nebivolol on endothelial nitric oxide and peroxynitrite release in hypertensive animals: Role of antioxidant activity
    R Preston Mason
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Cardiovasc Pharmacol 48:862-9. 2006
  2. ncbi request reprint X-ray diffraction analysis of membrane structure changes with oxidative stress
    R Preston Mason
    Cardiovascular Division, Department of Medicine, Harvard Medical School, Boston, MA, USA
    Methods Mol Biol 196:69-78. 2002
  3. ncbi request reprint Cholesterol crystallization and macrophage apoptosis: implication for atherosclerotic plaque instability and rupture
    Yong Jian Geng
    Center for Cardiovascular Biology and Atherosclerosis, University of Texas Health Science Center at Houston School of Medicine, 6431 Fannin Street, MSB 6 001, Houston, TX 77030, USA
    Biochem Pharmacol 66:1485-92. 2003
  4. ncbi request reprint Active metabolite of atorvastatin inhibits membrane cholesterol domain formation by an antioxidant mechanism
    R Preston Mason
    Elucida Research, Beverly, Massachusetts 01915 0091, USA
    J Biol Chem 281:9337-45. 2006
  5. ncbi request reprint A rationale for combined therapy with a calcium channel blocker and a statin: evaluation of basic and clinical evidence
    R Preston Mason
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Curr Drug Targets Cardiovasc Haematol Disord 5:489-501. 2005
  6. pmc The favorable kinetics and balance of nebivolol-stimulated nitric oxide and peroxynitrite release in human endothelial cells
    R Preston Mason
    Department of Chemistry and Biochemistry, Ohio University, 45701 Athens, OH, USA
    BMC Pharmacol Toxicol 14:48. 2013
  7. doi request reprint Dipeptidyl peptidase-4 inhibition with saxagliptin enhanced nitric oxide release and reduced blood pressure and sICAM-1 levels in hypertensive rats
    R Preston Mason
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Cardiovasc Pharmacol 60:467-73. 2012
  8. pmc Pleiotropic effects of calcium channel blockers
    R Preston Mason
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, PO Box 7100, 100 Cummings Center, Suite 135L, Beverly, MA 01915, USA
    Curr Hypertens Rep 14:293-303. 2012
  9. ncbi request reprint Intermolecular differences of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors contribute to distinct pharmacologic and pleiotropic actions
    R Preston Mason
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 96:11F-23F. 2005
  10. ncbi request reprint Atheroprotective effects of long-acting dihydropyridine-type calcium channel blockers: evidence from clinical trials and basic scientific research
    R Preston Mason
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Cerebrovasc Dis 16:11-7. 2003

Collaborators

Detail Information

Publications50

  1. ncbi request reprint Effect of nebivolol on endothelial nitric oxide and peroxynitrite release in hypertensive animals: Role of antioxidant activity
    R Preston Mason
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Cardiovasc Pharmacol 48:862-9. 2006
    ..These results demonstrate that nebivolol inhibits endothelial dysfunction through a potent antioxidant mechanism attributed to its physicochemical interactions with the membrane, independent of beta1-blockade activity...
  2. ncbi request reprint X-ray diffraction analysis of membrane structure changes with oxidative stress
    R Preston Mason
    Cardiovascular Division, Department of Medicine, Harvard Medical School, Boston, MA, USA
    Methods Mol Biol 196:69-78. 2002
  3. ncbi request reprint Cholesterol crystallization and macrophage apoptosis: implication for atherosclerotic plaque instability and rupture
    Yong Jian Geng
    Center for Cardiovascular Biology and Atherosclerosis, University of Texas Health Science Center at Houston School of Medicine, 6431 Fannin Street, MSB 6 001, Houston, TX 77030, USA
    Biochem Pharmacol 66:1485-92. 2003
    ..These results suggest that hyperthermia inhibits cholesterol crystallization and promotes apoptotic effects of oxysterols on macrophages...
  4. ncbi request reprint Active metabolite of atorvastatin inhibits membrane cholesterol domain formation by an antioxidant mechanism
    R Preston Mason
    Elucida Research, Beverly, Massachusetts 01915 0091, USA
    J Biol Chem 281:9337-45. 2006
    ..These findings indicate an atheroprotective effect of ATM on membrane lipid organization through a potent antioxidant mechanism...
  5. ncbi request reprint A rationale for combined therapy with a calcium channel blocker and a statin: evaluation of basic and clinical evidence
    R Preston Mason
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Curr Drug Targets Cardiovasc Haematol Disord 5:489-501. 2005
    ....
  6. pmc The favorable kinetics and balance of nebivolol-stimulated nitric oxide and peroxynitrite release in human endothelial cells
    R Preston Mason
    Department of Chemistry and Biochemistry, Ohio University, 45701 Athens, OH, USA
    BMC Pharmacol Toxicol 14:48. 2013
    ..The vasodilation properties of nebivolol have been attributed to nitric oxide (NO) release. However, the kinetics and mechanism of nebivolol-stimulated bioavailable NO are not fully understood...
  7. doi request reprint Dipeptidyl peptidase-4 inhibition with saxagliptin enhanced nitric oxide release and reduced blood pressure and sICAM-1 levels in hypertensive rats
    R Preston Mason
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Cardiovasc Pharmacol 60:467-73. 2012
    ..001) and decreased sICAM-1 levels by 37% (P < 0.01). The results of this study suggest that DPP4 inhibition reduces blood pressure and inflammation in hypertensive rats while increasing NO bioavailability...
  8. pmc Pleiotropic effects of calcium channel blockers
    R Preston Mason
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, PO Box 7100, 100 Cummings Center, Suite 135L, Beverly, MA 01915, USA
    Curr Hypertens Rep 14:293-303. 2012
    ..Furthermore, by elucidating the biological mechanisms by which cardiovascular risk factors lead to vascular injury, we may highlight common pathways and identify novel therapeutic targets...
  9. ncbi request reprint Intermolecular differences of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors contribute to distinct pharmacologic and pleiotropic actions
    R Preston Mason
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 96:11F-23F. 2005
    ..To understand the biochemical basis for such differences among statins, this article reviews their physicochemical properties and pharmacology at the molecular level...
  10. ncbi request reprint Atheroprotective effects of long-acting dihydropyridine-type calcium channel blockers: evidence from clinical trials and basic scientific research
    R Preston Mason
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Cerebrovasc Dis 16:11-7. 2003
    ..These findings support a broader therapeutic role for third-generation dihydropyridine-type CCBs in the treatment of atherosclerosis...
  11. ncbi request reprint Targeting nitric oxide with drug therapy
    R Preston Mason
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Clin Hypertens (Greenwich) 8:40-52. 2006
    ..The NO-promoting actions of these established drugs provide some insight into their known benefits and suggest possible therapeutic potential...
  12. ncbi request reprint Molecular basis of differences among statins and a comparison with antioxidant vitamins
    R Preston Mason
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 98:34P-41P. 2006
    ..In addition, the possibility that statin benefits on stroke reflect pleiotropic effects is reviewed. Finally, possible reasons for differences between the effects of atorvastatin metabolites and antioxidant vitamins are considered...
  13. ncbi request reprint Effects of HMG-CoA reductase inhibitors on endothelial function: role of microdomains and oxidative stress
    R Preston Mason
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Circulation 109:II34-41. 2004
    ..The relationships between membrane microdomains, cholesterol biosynthesis, and endothelial function will be discussed...
  14. ncbi request reprint Nitric oxide mechanisms in the pathogenesis of global risk
    R Preston Mason
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Clin Hypertens (Greenwich) 8:31-8; quiz 40. 2006
    ..This effect may help explain the cardioprotective benefits of these agents and may stimulate further use of nitric oxide modulation for the treatment of cardiovascular risk factors and manifestations of cardiovascular disease...
  15. ncbi request reprint A rationale for combination therapy in risk factor management: a mechanistic perspective
    R Preston Mason
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Med 118:54-61. 2005
    ..The clinical implications of these observations are discussed in this article in the context of cardiovascular risk factor management strategies...
  16. ncbi request reprint Membrane microdomains and vascular biology: emerging role in atherogenesis
    R Preston Mason
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, USA
    Circulation 107:2270-3. 2003
  17. doi request reprint Evolving mechanisms of action of beta blockers: focus on nebivolol
    R Preston Mason
    Cardiovascular Division, Department of Medicine Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Cardiovasc Pharmacol 54:123-8. 2009
    ..As a result, its hemodynamic profile is clearly different from those of traditional beta-blockers. This review will evaluate this class of agents and the basis for their differences in clinical use...
  18. ncbi request reprint Rofecoxib increases susceptibility of human LDL and membrane lipids to oxidative damage: a mechanism of cardiotoxicity
    R Preston Mason
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Cardiovasc Pharmacol 47:S7-14. 2006
    ..These findings provide a mechanistic rationale for differences in cardiovascular risk among COX-selective inhibitors because of their intrinsic physicochemical properties...
  19. ncbi request reprint Mechanisms of atherosclerotic plaque stabilization for a lipophilic calcium antagonist amlodipine
    R P Mason
    Membrane Biophysics Laboratory, Division of Cardiology, Department of Medicine and Biochemistry, Medical College of Pennsylvania Hahnemann University School of Medicine, Pittsburgh, Pennsylvania, USA
    Am J Cardiol 88:2M-6M. 2001
    ..In this article, cellular and molecular mechanisms of action that may contribute to a beneficial role for a calcium antagonist in the treatment of atherosclerosis will be reviewed...
  20. pmc Optimal therapeutic strategy for treating patients with hypertension and atherosclerosis: focus on olmesartan medoxomil
    R Preston Mason
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Vasc Health Risk Manag 7:405-16. 2011
    ....
  21. ncbi request reprint Mechanisms of plaque stabilization for the dihydropyridine calcium channel blocker amlodipine: review of the evidence
    R Preston Mason
    Membrane Biophysics Laboratory, Division of Cardiology, Department of Medicine and Biochemistry, MCP Hahnemann University School of Medicine, Allegheny Campus, Pittsburgh, PA, USA
    Atherosclerosis 165:191-9. 2002
    ....
  22. ncbi request reprint Antioxidant and cytoprotective activities of the calcium channel blocker mibefradil
    R P Mason
    Department of Biochemistry, MCP Hahnemann School of Medicine, Allegheny University of the Health Sciences, Pittsburgh, PA 15212 4772, USA
    Biochem Pharmacol 55:1843-52. 1998
    ..These findings indicate that the chemical structure of mibefradil contributes to biophysical interactions with the cell membrane that underlie antioxidant and cytoprotective activities in models of oxidative stress...
  23. ncbi request reprint Neuroprotective activities of carvedilol and a hydroxylated derivative: role of membrane biophysical interactions
    P G Lysko
    Department of Cardiovascular Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA, USA
    Biochem Pharmacol 56:1645-56. 1998
    ....
  24. ncbi request reprint [Membrane biophysical interaction of amlodipine and antioxidant properties]
    R P Mason
    D├ępartement de M├ędecine et de Biochimie, MCP Hahnemann University School of Medicine, Pittsburg, Pennsylvania, USA
    Drugs 59:9-16. 2000
    ....
  25. ncbi request reprint Direct evidence for cholesterol crystalline domains in biological membranes: role in human pathobiology
    R Preston Mason
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 01915, USA
    Biochim Biophys Acta 1610:198-207. 2003
    ..These findings support a model of the membrane in which cholesterol aggregates into structurally distinct regions that regulate the function of the cell membrane...
  26. ncbi request reprint Mechanisms of plaque stabilization for a charged calcium channel blocker in coronary artery disease
    R P Mason
    Department of Medicine, MCP Hahnemann University School of Medicine, Pittsburgh, Pennsylvania, USA
    Pharmacotherapy 21:209S-215S. 2001
    ..These results have renewed interest in potential plaque stabilization properties of third-generation calcium channel blockers and their possible therapeutic role in CAD...
  27. ncbi request reprint Antioxidant activity of the monoamine oxidase B inhibitor lazabemide
    R P Mason
    Membrane Biophysics Laboratory, Departments of Biochemistry and Medicine, MCP Hahnemann University School of Medicine, Allegheny Campus, Pittsburgh, PA, USA
    Biochem Pharmacol 60:709-16. 2000
    ..These findings indicate that lazabemide is a potent and concentration-dependent inhibitor of membrane oxy-radical damage as a result of inhibiting membrane lipid peroxidation, independent of MAO-B interactions...
  28. ncbi request reprint Inhibition of oxidized LDL aggregation with the calcium channel blocker amlodipine: role of electrostatic interactions
    Jane Ellen Phillips
    Department of Medicine, MCP Hahnemann University School of Medicine, Allegheny Campus, Pittsburgh, PA, USA
    Atherosclerosis 168:239-44. 2003
    ..These effects of amlodipine on LDL lipid aggregation and electrostatic properties may represent a novel antiatherosclerotic mechanism of action...
  29. ncbi request reprint Evidence for distinct cholesterol domains in fiber cell membranes from cataractous human lenses
    R F Jacob
    Membrane Biophysics Laboratory, Department of Medicine, MCP Hahnemann University School of Medicine, Allegheny Campus, Pittsburgh, Pennsylvania 15212 4772, USA
    J Biol Chem 276:13573-8. 2001
    ....
  30. ncbi request reprint 7-Ketocholesterol forms crystalline domains in model membranes and murine aortic smooth muscle cells
    J E Phillips
    Membrane Biophysics Laboratory, Department of Medicine, Division of Cardiology, MCP Hahnemann University, Allegheny Campus, 320 East North Avenue, Pittsburgh, PA 15212-4772, USA
    Atherosclerosis 159:125-35. 2001
    ..While these domains may decrease its cytotoxicity by inducing the formation of sterol crystals in smooth muscle cells, they may, in a broader capacity, contribute to the sterol crystals found in advanced atherosclerotic lesions...
  31. ncbi request reprint Novel vascular biology of third-generation L-type calcium channel antagonists: ancillary actions of amlodipine
    R P Mason
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Arterioscler Thromb Vasc Biol 23:2155-63. 2003
    ....
  32. ncbi request reprint Alzheimer's disease amyloid beta peptide 25-35 inhibits lipid peroxidation as a result of its membrane interactions
    M F Walter
    Laboratory for Membrane Structure Studies, MCP Hahnemann School of Medicine, Allegheny University of the Health Sciences, Pittsburgh, Pennsylvania 15212 4772, USA
    Biochem Biophys Res Commun 233:760-4. 1997
    ..These findings indicate that the amphiphilic A beta(25-35) peptide inhibits lipid peroxidation at low concentrations as a result of physicochemical interactions with the membrane lipid bilayer...
  33. ncbi request reprint Calcium channel blockers, apoptosis and cancer: is there a biologic relationship?
    R P Mason
    Cardiovascular and Pulmonary Research Institute, Department of Biochemistry, MCP Hahnemann University School of Medicine, Pittsburgh, Pennsylvania, USA
    J Am Coll Cardiol 34:1857-66. 1999
    ..A comprehensive analysis of the basic and clinical evidence does not support a causal relationship between the therapeutic use of CCBs and an increased incidence of cancer development as a result of interfering with apoptosis...
  34. ncbi request reprint The editor's roundtable: revisiting the role of beta blockers in hypertension
    William C Roberts
    Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, Texas, USA
    Am J Cardiol 100:253-67. 2007
  35. ncbi request reprint Synergistic effect of amlodipine and atorvastatin in reversing LDL-induced endothelial dysfunction
    R Preston Mason
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Pharm Res 25:1798-806. 2008
    ..Statins and certain calcium channel blockers may improve nitric oxide (NO) release and endothelial function through various mechanisms, but their combined effects are not well understood...
  36. doi request reprint Effect of beta-blockers on endothelial function during biological aging: a nanotechnological approach
    Philip Funovic
    Department of Orthopaedics, Medical University of Vienna, Vienna, Austria
    J Cardiovasc Pharmacol 51:208-15. 2008
    ..This effect was not observed with atenolol, but L-arginine, sepiapterin, and superoxide dismutase were beneficial...
  37. ncbi request reprint Scientific rationale for combination of a calcium channel antagonist and an HMG-CoA reductase inhibitor: a new approach to risk factor management
    R Preston Mason
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Drugs 68:885-900. 2008
    ..This article provides an overview of the evidence for this new approach and recommends applications for use in clinical settings...
  38. ncbi request reprint A biological rationale for the cardiotoxic effects of rofecoxib: comparative analysis with other COX-2 selective agents and NSAids
    R Preston Mason
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Subcell Biochem 42:175-90. 2007
    ..These findings provide a compelling rationale for distinguishing the differences in cardiovascular risk among COX-selective inhibitors on the basis of their intrinsic physico-chemical properties...
  39. ncbi request reprint Differential effects of carotenoids on lipid peroxidation due to membrane interactions: X-ray diffraction analysis
    Hyesun P McNulty
    Elucida Research, 100 Cummings Center, Suite 135L, P O Box 7100, Beverly, MA 01915 0091, USA
    Biochim Biophys Acta 1768:167-74. 2007
    ..These findings indicate distinct effects of carotenoids on lipid peroxidation due to membrane structure changes. These contrasting effects of carotenoids on lipid peroxidation may explain differences in their biological activity...
  40. ncbi request reprint The antioxidant effects of statins
    Jean Davignon
    Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, and University of Montreal Hospital Medical Centre, Montreal, QC, Canada
    Coron Artery Dis 15:251-8. 2004
    ..The antioxidant properties of statins extend to organ protection especially the myocardium and the lungs...
  41. ncbi request reprint Lipid peroxidation induces cholesterol domain formation in model membranes
    Robert F Jacob
    Elucida Research, Beverly, Massachusetts 01915 0091, USA
    J Biol Chem 280:39380-7. 2005
    ....
  42. ncbi request reprint Influence of serum cholesterol on atherogenesis and intimal hyperplasia after angioplasty: inhibition by amlodipine
    Mark B Kahn
    Department of Surgery, Thomas Jefferson University College of Medicine, Philadelphia, Pennsylvania 19107, USA
    Am J Physiol Heart Circ Physiol 288:H591-600. 2005
    ..This study establishes a causal role between serum HC and the development of spontaneous and angioplasty-induced lesions and the ability of amlodipine to disrupt this action by a novel remodelling action on the SMC membrane...
  43. ncbi request reprint Sulfone COX-2 inhibitors increase susceptibility of human LDL and plasma to oxidative modification: comparison to sulfonamide COX-2 inhibitors and NSAIDs
    Mary F Walter
    Elucida Research LLC, 100 Cummings Center, Suite 135L, Beverly, MA 01915, USA
    Atherosclerosis 177:235-43. 2004
    ..These findings may provide mechanistic insight into reported differences in cardiovascular risk for COX-2 inhibitors...
  44. ncbi request reprint Nebivolol reduces nitroxidative stress and restores nitric oxide bioavailability in endothelium of black Americans
    R Preston Mason
    Elucida Research, Beverly, Massachusetts, USA
    Circulation 112:3795-801. 2005
    ..The ability to pharmacologically reverse endothelial dysfunction in blacks was tested with nebivolol, a beta1-selective agent with vasodilating and antioxidant properties...
  45. doi request reprint Biologic activity of carotenoids related to distinct membrane physicochemical interactions
    Hyesun McNulty
    Elucida Research, Beverly, MA 01915, USA
    Am J Cardiol 101:20D-29D. 2008
    ..This relation of structure and function may explain the differences in biologic activity reported for various carotenoids, with important therapeutic implications...
  46. doi request reprint Circulating lipid hydroperoxides predict cardiovascular events in patients with stable coronary artery disease: the PREVENT study
    Mary F Walter
    Elucida Research, Beverly, Massachusetts, USA
    J Am Coll Cardiol 51:1196-202. 2008
    ..This study was designed to determine the predictive value of lipid hydroperoxide (LOOH) levels for adverse cardiovascular outcomes in patients with stable coronary artery disease (CAD)...
  47. ncbi request reprint A membrane defect in the pathogenesis of the Smith-Lemli-Opitz syndrome
    Thomas N Tulenko
    Departments of Surgery and Biochemistry and Molecular Pharmacology, Thomas Jefferson University College of Medicine, Philadelphia, PA, USA
    J Lipid Res 47:134-43. 2006
    ..These data indicate that the disturbance in membrane sterol content in SLOS, likely at the level of membrane caveolae, directly contributes to the widespread tissue abnormalities in this disease...
  48. ncbi request reprint Direct perturbation of lens membrane structure may contribute to cataracts caused by U18666A, an oxidosqualene cyclase inhibitor
    Richard J Cenedella
    Department of Biochemistry, Kirksville College of Osteopathic Medicine, Kirksville, MO 63501, USA
    J Lipid Res 45:1232-41. 2004
    ..Induction of apoptosis may begin by intercalation of U18666A into cell membranes. By increasing membrane structural order, U18666A may also increase light scatter, thus directly contributing to lens opacification...
  49. ncbi request reprint Serum levels of thiobarbituric acid reactive substances predict cardiovascular events in patients with stable coronary artery disease: a longitudinal analysis of the PREVENT study
    Mary F Walter
    Elucida Research, Beverly, Massachusetts, USA
    J Am Coll Cardiol 44:1996-2002. 2004
    ..The objective of this study was to test the predictive value of an oxidative stress biomarker in 634 patients from the Prospective Randomized Evaluation of the Vascular Effects of Norvasc Trial (PREVENT)...
  50. ncbi request reprint Regulation of the gating of BKCa channel by lipid bilayer thickness
    Chunbo Yuan
    Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01604, USA
    J Biol Chem 282:7276-86. 2007
    ..We suggest a simple mechanical model that combines forces of lateral stress within the lipid bilayer with local hydrophobic mismatch between lipids and the protein to account for the biphasic modulation of BK(Ca) gating...