E D Lephart

Summary

Affiliation: Brigham Young University
Country: USA

Publications

  1. pmc Equol an isoflavonoid: potential for improved prostate health, in vitro and in vivo evidence
    Trent D Lund
    Stoelting Co, Wood Dale, IL 60191, USA
    Reprod Biol Endocrinol 9:4. 2011
  2. pmc Influences of dietary soy isoflavones on metabolism but not nociception and stress hormone responses in ovariectomized female rats
    Lihong Bu
    Physiology and Developmental Biology Department, Neuroscience Center, Brigham Young University, Provo, Utah 84602, USA
    Reprod Biol Endocrinol 3:58. 2005
  3. pmc Diets high in selenium and isoflavones decrease androgen-regulated gene expression in healthy rat dorsolateral prostate
    Russell L Legg
    Department of Nutrition, Dietetics and Food Science, Brigham Young University, Provo, UT 84602, USA
    Reprod Biol Endocrinol 6:57. 2008
  4. pmc Androgen receptor expression in the rat prostate is down-regulated by dietary phytoestrogens
    Trent D Lund
    Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA
    Reprod Biol Endocrinol 2:5. 2004
  5. pmc Timing of supplementation of selenium and isoflavones determines prostate cancer risk factor reduction in rats
    Jessica R Tolman
    Department of Nutrition, Dietetics and Food Science, Brigham Young University, Provo, Utah 84602, USA
    Nutr Metab (Lond) 5:31. 2008
  6. pmc Neuromodulation by soy diets or equol: anti-depressive & anti-obesity-like influences, age- & hormone-dependent effects
    Crystal Blake
    Department of Physiology and Developmental Biology and the Neuroscience Center, Brigham Young University, Provo, Utah 84602, USA
    BMC Neurosci 12:28. 2011
  7. pmc AVPV neurons containing estrogen receptor-beta in adult male rats are influenced by soy isoflavones
    Lihong Bu
    Physiology and Developmental Biology Department and Neuroscience Center Brigham Young University, Provo, UT, USA
    BMC Neurosci 8:13. 2007
  8. ncbi request reprint Maternal separation: hypothalamic-preoptic area and hippocampal calbindin-D28K and calretinin in male and female infantile rats
    E D Lephart
    Department of Zoology, Brigham Young University, Provo, UT 84602, USA
    Neurosci Lett 267:41-4. 1999
  9. ncbi request reprint Phytoestrogens decrease brain calcium-binding proteins but do not alter hypothalamic androgen metabolizing enzymes in adult male rats
    E D Lephart
    Neuroscience Center, 633 WIDB, Brigham Young University, Provo, UT 84602, USA
    Brain Res 859:123-31. 2000
  10. ncbi request reprint Neurobehavioral effects of dietary soy phytoestrogens
    Edwin D Lephart
    Neuroscience Center, 633 WIDB, Brigham Young University, Provo, UT 86402, USA
    Neurotoxicol Teratol 24:5-16. 2002

Collaborators

Detail Information

Publications32

  1. pmc Equol an isoflavonoid: potential for improved prostate health, in vitro and in vivo evidence
    Trent D Lund
    Stoelting Co, Wood Dale, IL 60191, USA
    Reprod Biol Endocrinol 9:4. 2011
    ....
  2. pmc Influences of dietary soy isoflavones on metabolism but not nociception and stress hormone responses in ovariectomized female rats
    Lihong Bu
    Physiology and Developmental Biology Department, Neuroscience Center, Brigham Young University, Provo, Utah 84602, USA
    Reprod Biol Endocrinol 3:58. 2005
    ..Isoflavones, the most abundant phytoestrogens in soy foods, are structurally similar to 17beta-estradiol. Few studies have examined the nociception and stress hormone responses after consumption of soy isoflavones...
  3. pmc Diets high in selenium and isoflavones decrease androgen-regulated gene expression in healthy rat dorsolateral prostate
    Russell L Legg
    Department of Nutrition, Dietetics and Food Science, Brigham Young University, Provo, UT 84602, USA
    Reprod Biol Endocrinol 6:57. 2008
    ..These components each affect androgen-regulated gene expression. The objective of this work was to determine the combined effects of selenium and isoflavones on androgen-regulated gene expression in rat prostate...
  4. pmc Androgen receptor expression in the rat prostate is down-regulated by dietary phytoestrogens
    Trent D Lund
    Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA
    Reprod Biol Endocrinol 2:5. 2004
    ..Proliferation of prostate cells is, at least in part, under control of estrogen receptor beta (ER-beta). Phytoestrogens bind ER-beta with high affinity and therefore may have antiproliferative effects in the prostate...
  5. pmc Timing of supplementation of selenium and isoflavones determines prostate cancer risk factor reduction in rats
    Jessica R Tolman
    Department of Nutrition, Dietetics and Food Science, Brigham Young University, Provo, Utah 84602, USA
    Nutr Metab (Lond) 5:31. 2008
    ..We tested whether combined supplementation of these two dietary components would reduce prostate cancer risk factors in rats more than supplementation of each component individually...
  6. pmc Neuromodulation by soy diets or equol: anti-depressive & anti-obesity-like influences, age- & hormone-dependent effects
    Crystal Blake
    Department of Physiology and Developmental Biology and the Neuroscience Center, Brigham Young University, Provo, Utah 84602, USA
    BMC Neurosci 12:28. 2011
    ....
  7. pmc AVPV neurons containing estrogen receptor-beta in adult male rats are influenced by soy isoflavones
    Lihong Bu
    Physiology and Developmental Biology Department and Neuroscience Center Brigham Young University, Provo, UT, USA
    BMC Neurosci 8:13. 2007
    ..Therefore, in this study, we examined the influence of dietary soy isoflavones on apoptosis in AVPV of 150 day-old male rats fed either a soy isoflavone-free diet (Phyto-free) or a soy isoflavone-rich diet (Phyto-600)...
  8. ncbi request reprint Maternal separation: hypothalamic-preoptic area and hippocampal calbindin-D28K and calretinin in male and female infantile rats
    E D Lephart
    Department of Zoology, Brigham Young University, Provo, UT 84602, USA
    Neurosci Lett 267:41-4. 1999
    ....
  9. ncbi request reprint Phytoestrogens decrease brain calcium-binding proteins but do not alter hypothalamic androgen metabolizing enzymes in adult male rats
    E D Lephart
    Neuroscience Center, 633 WIDB, Brigham Young University, Provo, UT 84602, USA
    Brain Res 859:123-31. 2000
    ....
  10. ncbi request reprint Neurobehavioral effects of dietary soy phytoestrogens
    Edwin D Lephart
    Neuroscience Center, 633 WIDB, Brigham Young University, Provo, UT 86402, USA
    Neurotoxicol Teratol 24:5-16. 2002
    ....
  11. ncbi request reprint Neuroendocrine regulation of sexually dimorphic brain structure and associated sexual behavior in male rats is genetically controlled
    E D Lephart
    Neuroscience Center, 633 WIDB, Brigham Young University, Provo, UT 84602, USA
    Biol Reprod 64:571-8. 2001
    ..e., structure) and reproductive hormone patterns and mating behavior (i.e., function) of WF/NCr versus NB/Cr males is regulated by potentially E2-mediated mechanisms that are genetically controlled...
  12. ncbi request reprint Brain androgen and progesterone metabolizing enzymes: biosynthesis, distribution and function
    E D Lephart
    Neuroscience Center, Brigham Young University, 633 WIDB, Provo, UT 84602, USA
    Brain Res Brain Res Rev 37:25-37. 2001
    ..a low phytoestrogen diet on visual spatial memory in male and female rats is presented...
  13. ncbi request reprint Altered sexually dimorphic nucleus of the preoptic area (SDN-POA) volume in adult Long-Evans rats by dietary soy phytoestrogens
    T D Lund
    The Neuroscience Center, Brigham Young University, Provo, UT 84602, USA
    Brain Res 914:92-9. 2001
    ..These data suggest that consumption of phytoestrogens via a soy diet, significantly: (1) decreases body and prostate weight, (2) delays puberty onset, and (3) alters SDN-POA volumes during adulthood...
  14. pmc Manipulation of prenatal hormones and dietary phytoestrogens during adulthood alter the sexually dimorphic expression of visual spatial memory
    T D Lund
    The Neuroscience Center Brigham Young University, Provo, Utah 84602, USA
    BMC Neurosci 2:21. 2001
    ..Additionally, the influence of dietary soy phytoestrogens (i.e., the presence of high or low estrogen-like compounds present in the animal's diet) on VSM was examined in combination with the prenatal hormonal manipulations...
  15. pmc Visual spatial memory is enhanced in female rats (but inhibited in males) by dietary soy phytoestrogens
    T D Lund
    The Neuroscience Center Brigham Young University, Provo, Utah 84602, USA
    BMC Neurosci 2:20. 2001
    ..Additionally, brain phytoestrogen, calbindin (CALB), and cyclooxygenase-2 (COX-2) levels were determined...
  16. ncbi request reprint Dietary soy phytoestrogens produce anxiolytic effects in the elevated plus-maze
    T D Lund
    Neuroscience Center, Brigham Young University, Provo, UT 84602, USA
    Brain Res 913:180-4. 2001
    ..Phytoestrogens produced anxiolytic effects in both male and female Long-Evans rats. Additionally, phytoestrogens decreased body weight but increased consumption of food and/or water...
  17. ncbi request reprint Maternal and perinatal brain aromatase: effects of dietary soy phytoestrogens
    K S Weber
    633 WIDB, Neuroscience Center, Brigham Young University, Provo, UT 84602, USA
    Brain Res Dev Brain Res 126:217-21. 2001
    ..Dietary phytoestrogens, however, do not alter brain aromatase during pregnancy/lactation or perinatal development...
  18. ncbi request reprint Dietary soy-phytoestrogens decrease testosterone levels and prostate weight without altering LH, prostate 5alpha-reductase or testicular steroidogenic acute regulatory peptide levels in adult male Sprague-Dawley rats
    K S Weber
    Neuroscience Center, Brigham Young University, Provo, Utah 86402, USA
    J Endocrinol 170:591-9. 2001
    ....
  19. ncbi request reprint Dietary soy phytoestrogen effects on brain structure and aromatase in Long-Evans rats
    E D Lephart
    Neuroscience Center, Brigham Young University, Provo, UT 84602, USA
    Neuroreport 12:3451-5. 2001
    ..e. anteroventral periventricular nucleus; AVPV) in male, but not in female rats. Since most commercial animal diets contain significant concentrations of phytoestrogens their influence on brain structure should be considered...
  20. ncbi request reprint Effects of testosterone and progesterone on brain 5alpha-reductase and aromatase in Long-Evans males and comparison of aromatase in Long-Evans vs. Sprague-Dawley rats
    E D Lephart
    Department of Psychology, Brigham Young University, Provo, UT 84602, USA
    Brain Res 789:327-30. 1998
    ..The activity in castrated S-D (but again, not in L-E) rats significantly decreased compared to control values. These data suggest that the absence of gonads does not decrease MBH-POA aromatase in adult L-E rats...
  21. ncbi request reprint Relationship between sexual behavior and sexually dimorphic structures in the anterior hypothalamus in control and prenatally stressed male rats
    R W Rhees
    Department of Zoology, Brigham Young University, Provo, UT 84602, USA
    Brain Res Bull 50:193-9. 1999
    ..The results obtained in this study provide a strong positive relationship between sexual behavior and the morphology of the two sexually dimorphic structures measured...
  22. ncbi request reprint Pre- or postnatal testosterone and flutamide effects on sexually dimorphic nuclei of the rat hypothalamus
    T D Lund
    Department of Psychology, Brigham Young University, Provo, UT 84602, USA
    Brain Res Dev Brain Res 120:261-6. 2000
    ..The present findings establish that pre- or postnatal hormonal environments are crucial in influencing sexual morphology on the developing brain...
  23. ncbi request reprint Dimorphic expression of calbindin-D28K in the medial basal hypothalamus from perinatal male and female rats
    E D Lephart
    Department of Zoology, Brigham Young University, Provo, UT 84602, USA
    Brain Res Dev Brain Res 96:281-4. 1996
    ..These data imply that androgens or other hormonal factors regulate MBH CALB expression which in turn may modulate sexually dimorphic brain structures by preventing cell loss during neuronal development...
  24. ncbi request reprint Steroid hormone influence on brain calbindin-D(28K) in male prepubertal and ovariectomized rats
    E B Stuart
    Neuroscience Center, 633 WIDB, Brigham Young University, Provo, UT 84602, USA
    Brain Res Dev Brain Res 129:125-33. 2001
    ....
  25. ncbi request reprint Developmental expression of calretinin in the medial basal hypothalamus and amygdala from male and female rats
    E D Lephart
    Department of Zoology, Brigham Young University, Provo, UT 84602, USA
    Neurosci Res 28:269-73. 1997
    ....
  26. ncbi request reprint Inhibition of brain 5 alpha-reductase in pregnant rats: effects on enzymatic and behavioral activity
    E D Lephart
    Department of Zoology, Brigham Young University, Provo, UT 84602, USA
    Brain Res 739:356-60. 1996
    ....
  27. ncbi request reprint Estrogens and phytoestrogens: brain plasticity of sexually dimorphic brain volumes
    E D Lephart
    The Neuroscience Center, 633 WIDB, Brigham Young University, Provo, UT 84602, USA
    J Steroid Biochem Mol Biol 85:299-309. 2003
    ..In summary, consumption of dietary phytoestrogens (estrogen mimics) can alter hormone-sensitive hypothalamic brain volumes in rodents during adulthood...
  28. ncbi request reprint Effects of maternal separation during early postnatal development on male sexual behavior and female reproductive function
    R W Rhees
    Department of Zoology and Neuroscience Center, Brigham Young University, Provo, UT 84602, USA
    Behav Brain Res 123:1-10. 2001
    ..Thus, significant gender differences in response to Sep (during the dark phase of the circadian cycle) were observed in the paradigm used in the present study...
  29. ncbi request reprint Effects of prenatal testosterone on sexual behavior, reproductive morphology and LH secretion in the female rat
    R W Rhees
    Department of Zoology, Brigham Young University, Provo, Utah 84602, USA
    Dev Neurosci 19:430-7. 1997
    ....
  30. ncbi request reprint Calbindin-D28k is regulated by adrenal steroids in hypothalamic tissue during prenatal development
    E D Lephart
    Department of Zoology, Brigham Young University, Provo, UT 84062, USA
    Brain Res Dev Brain Res 100:117-20. 1997
    ..These data indicate that corticosterone regulates MBH CALB expression during prenatal development and CALB may be implicated in modulating the sexual differentiation of neural structures within the MBH during perinatal development...
  31. ncbi request reprint Molecular aspects of brain aromatase cytochrome P450
    E D Lephart
    Department of Zoology, Brigham Young University, Provo, UT 84602, U S A
    J Steroid Biochem Mol Biol 61:375-80. 1997
    ..However, further study is necessary to understand the molecular basis of this complex developmental pattern of brain P450arom expression...