Robert J Glynn

Summary

Affiliation: Brigham and Women's Hospital
Country: USA

Publications

  1. pmc Indications for propensity scores and review of their use in pharmacoepidemiology
    Robert J Glynn
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Basic Clin Pharmacol Toxicol 98:253-9. 2006
  2. doi request reprint Number needed to treat with rosuvastatin to prevent first cardiovascular events and death among men and women with low low-density lipoprotein cholesterol and elevated high-sensitivity C-reactive protein: justification for the use of statins in prevention
    Paul M Ridker
    Center for Cardiovascular Disease Prevention and the Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Circ Cardiovasc Qual Outcomes 2:616-23. 2009
  3. pmc A randomized trial of rosuvastatin in the prevention of venous thromboembolism
    Robert J Glynn
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 360:1851-61. 2009
  4. doi request reprint Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 359:2195-207. 2008
  5. doi request reprint HDL cholesterol and residual risk of first cardiovascular events after treatment with potent statin therapy: an analysis from the JUPITER trial
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Lancet 376:333-9. 2010
  6. pmc Age-related cataract in a randomized trial of vitamins E and C in men
    William G Christen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215 1204, USA
    Arch Ophthalmol 128:1397-405. 2010
  7. pmc Emergency hospital admissions after income-based deductibles and prescription copayments in older users of inhaled medications
    Colin R Dormuth
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Clin Ther 30:1038-50. 2008
  8. pmc Increasing levels of restriction in pharmacoepidemiologic database studies of elderly and comparison with randomized trial results
    Sebastian Schneeweiss
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Med Care 45:S131-42. 2007
  9. pmc On-treatment non-high-density lipoprotein cholesterol, apolipoprotein B, triglycerides, and lipid ratios in relation to residual vascular risk after treatment with potent statin therapy: JUPITER (justification for the use of statins in prevention: an inte
    Samia Mora
    Center for Cardiovascular Disease Prevention, Divisions of Preventive and Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Am Coll Cardiol 59:1521-8. 2012
  10. pmc Vitamins E and C and medical record-confirmed age-related macular degeneration in a randomized trial of male physicians
    William G Christen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Ophthalmology 119:1642-9. 2012

Collaborators

Detail Information

Publications87

  1. pmc Indications for propensity scores and review of their use in pharmacoepidemiology
    Robert J Glynn
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Basic Clin Pharmacol Toxicol 98:253-9. 2006
    ..Use of propensity scores will not correct biases from unmeasured confounders, but can aid in understanding determinants of drug use and lead to improved estimates of drug effects in some settings...
  2. doi request reprint Number needed to treat with rosuvastatin to prevent first cardiovascular events and death among men and women with low low-density lipoprotein cholesterol and elevated high-sensitivity C-reactive protein: justification for the use of statins in prevention
    Paul M Ridker
    Center for Cardiovascular Disease Prevention and the Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Circ Cardiovasc Qual Outcomes 2:616-23. 2009
    ..However, whether the absolute risk reduction among such individuals justifies wide application of statin therapy in primary prevention is a controversial issue with broad policy and public health implications...
  3. pmc A randomized trial of rosuvastatin in the prevention of venous thromboembolism
    Robert J Glynn
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 360:1851-61. 2009
    ..Observational studies have yielded variable estimates of the effect of statin therapy on the risk of venous thromboembolism, and evidence from randomized trials is lacking...
  4. doi request reprint Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 359:2195-207. 2008
    ....
  5. doi request reprint HDL cholesterol and residual risk of first cardiovascular events after treatment with potent statin therapy: an analysis from the JUPITER trial
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Lancet 376:333-9. 2010
    ..We addressed, using the JUPITER trial cohort, whether this association remains when LDL-cholesterol concentrations are reduced to the very low ranges with high-dose statin treatment...
  6. pmc Age-related cataract in a randomized trial of vitamins E and C in men
    William G Christen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215 1204, USA
    Arch Ophthalmol 128:1397-405. 2010
    ..To test whether supplementation with alternate-day vitamin E or daily vitamin C affects the incidence of age-related cataract in a large cohort of men...
  7. pmc Emergency hospital admissions after income-based deductibles and prescription copayments in older users of inhaled medications
    Colin R Dormuth
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Clin Ther 30:1038-50. 2008
    ..Objective: The aim of this study was to compare the effects of 2 recent cost-sharing policies on emergency hospitalizations due to chronic obstructive pulmonary disease, asthma, or emphysema (CAE), and on physician visits...
  8. pmc Increasing levels of restriction in pharmacoepidemiologic database studies of elderly and comparison with randomized trial results
    Sebastian Schneeweiss
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Med Care 45:S131-42. 2007
    ..The goal of restricting study populations is to make patients more homogeneous regarding potential confounding factors and treatment effects and thereby achieve less biased effect estimates...
  9. pmc On-treatment non-high-density lipoprotein cholesterol, apolipoprotein B, triglycerides, and lipid ratios in relation to residual vascular risk after treatment with potent statin therapy: JUPITER (justification for the use of statins in prevention: an inte
    Samia Mora
    Center for Cardiovascular Disease Prevention, Divisions of Preventive and Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Am Coll Cardiol 59:1521-8. 2012
    ....
  10. pmc Vitamins E and C and medical record-confirmed age-related macular degeneration in a randomized trial of male physicians
    William G Christen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Ophthalmology 119:1642-9. 2012
    ..To test whether supplementation with alternate-day vitamin E or daily vitamin C affects the incidence of the diagnosis of age-related macular degeneration (AMD) in a large-scale randomized trial of male physicians...
  11. pmc Beneficiaries with cardiovascular disease and thePart D coverage gap
    Jennifer M Polinski
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Boston, MA 02120, USA
    Circ Cardiovasc Qual Outcomes 5:387-95. 2012
    ..The coverage gap remains the subject of Congressional debate; evidence regarding its impact on cardiovascular drug use and health outcomes is needed...
  12. pmc Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial
    J Michael Gaziano
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
    JAMA 301:52-62. 2009
    ..No previous trial in men at usual risk has examined vitamin C alone in the prevention of cancer...
  13. doi request reprint Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Lancet 373:1175-82. 2009
    ..8 mmol/L (<70 mg/dL). However, the benefit of lowering both LDL cholesterol and hsCRP after the start of statin therapy is controversial. We prospectively tested this hypothesis...
  14. pmc Adherence to beta-blocker therapy under drug cost-sharing in patients with and without acute myocardial infarction
    Sebastian Schneeweiss
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont St Ste 3030, Boston, MA 02120, USA
    Am J Manag Care 13:445-52. 2007
    ....
  15. doi request reprint Race, ethnicity, and the efficacy of rosuvastatin in primary prevention: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial
    Michelle A Albert
    Division of Cardiovascular Diseases, Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am Heart J 162:106-14.e2. 2011
    ..The aim of this study was to evaluate the effect of statin treatment in primary prevention of cardiovascular events in different race/ethnic groups...
  16. pmc Vascular risk factors, cardiovascular disease, and restless legs syndrome in men
    Anke C Winter
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Mass, USA
    Am J Med 126:228-35, 235.e1-2. 2013
    ..We therefore aim to evaluate the associations between prevalent vascular risk factors, prevalent cardiovascular disease, and restless legs syndrome...
  17. pmc Vascular risk factors, cardiovascular disease, and restless legs syndrome in women
    Anke C Winter
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Mass, USA
    Am J Med 126:220-7, 227.e1-2. 2013
    ..We therefore aimed to analyze the relationships between vascular risk factors, prevalent cardiovascular disease, and restless legs syndrome...
  18. pmc Multivitamins in the prevention of cancer in men: the Physicians' Health Study II randomized controlled trial
    J Michael Gaziano
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
    JAMA 308:1871-80. 2012
    ..Observational studies have not provided evidence regarding associations of multivitamin use with total and site-specific cancer incidence or mortality...
  19. pmc Consistency of performance ranking of comorbidity adjustment scores in Canadian and U.S. utilization data
    Sebastian Schneeweiss
    Division of Pharmacoepidemiology and Pharmacoeconomics, Gigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    J Gen Intern Med 19:444-50. 2004
    ..We sought to evaluate and rank the performance of comorbidity scores across selected U.S. and Canadian elderly populations using health care utilization databases...
  20. pmc Influence of systolic and diastolic blood pressure on the risk of incident atrial fibrillation in women
    David Conen
    Center for Arrhythmia Prevention, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Circulation 119:2146-52. 2009
    ..The influence of systolic and diastolic blood pressure (BP) on incident atrial fibrillation (AF) is not well studied among initially healthy, middle-aged women...
  21. doi request reprint Statins for the primary prevention of cardiovascular events in women with elevated high-sensitivity C-reactive protein or dyslipidemia: results from the Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin (JUP
    Samia Mora
    Center for Cardiovascular Disease Prevention, Divisions of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Circulation 121:1069-77. 2010
    ..We analyzed sex-specific outcomes in the Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) and synthesized the results with prior trials...
  22. doi request reprint Improvements in long-term mortality after myocardial infarction and increased use of cardiovascular drugs after discharge: a 10-year trend analysis
    Soko Setoguchi
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
    J Am Coll Cardiol 51:1247-54. 2008
    ..We sought to assess the relationship between increasing use of cardiovascular medications and trends in long-term prognosis after myocardial infarction (MI) in the elderly...
  23. pmc Rationale and design of the Post-MI FREEE trial: a randomized evaluation of first-dollar drug coverage for post-myocardial infarction secondary preventive therapies
    Niteesh K Choudhry
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    Am Heart J 156:31-6. 2008
    ..Removing patient out-of-pocket drug costs may increase adherence, improve clinical outcomes, and even reduce overall health costs for high-risk patients. The existing data are inadequate to assess whether this strategy is effective...
  24. pmc Beta carotene supplementation and age-related maculopathy in a randomized trial of US physicians
    William G Christen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215 1204, USA
    Arch Ophthalmol 125:333-9. 2007
    ..To test whether beta carotene supplementation affects the incidence of age-related maculopathy (ARM) in a large-scale randomized trial...
  25. pmc Subgroup analyses to determine cardiovascular risk associated with nonsteroidal antiinflammatory drugs and coxibs in specific patient groups
    Daniel H Solomon
    Brigham and Women s Hospital, 1620 Tremont Street, Boston, MA 02120, USA
    Arthritis Rheum 59:1097-104. 2008
    ..There is substantial concern regarding the potential cardiovascular adverse effects of selective coxibs and nonselective NSAIDs, but many patients with arthritis experience important clinical benefits from these agents...
  26. pmc Association of renin-angiotensin and endothelial nitric oxide synthase gene polymorphisms with blood pressure progression and incident hypertension: prospective cohort study
    David Conen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    J Hypertens 26:1780-6. 2008
    ..The aim of the present study was to assess the relationship of six previously characterized gene variants in the renin-angiotensin system and the NOS3 gene with blood pressure progression and incident hypertension...
  27. pmc Evaluation of risk factors for cataract types in a competing risks framework
    Robert J Glynn
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Ophthalmic Epidemiol 16:98-106. 2009
    ..One can compare the impact of risk factors on different types of cataract with methods of competing risk survival analysis that account for tied events...
  28. pmc Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial
    Howard D Sesso
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
    JAMA 300:2123-33. 2008
    ..However, few long-term trials have evaluated men at initially low risk of cardiovascular disease, and no previous trial in men has examined vitamin C alone in the prevention of cardiovascular disease...
  29. doi request reprint Instrumental variable analysis for estimation of treatment effects with dichotomous outcomes
    Jeremy A Rassen
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Boston, MA 02120, USA
    Am J Epidemiol 169:273-84. 2009
    ..Generalized method of moments estimation produced substantially the same results as the 2-stage logistic method. Few substantive differences among the methods were observed, despite their reliance on distinct assumptions...
  30. doi request reprint The comparative safety of opioids for nonmalignant pain in older adults
    Daniel H Solomon
    Division of Pharmacoepidemiology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Arch Intern Med 170:1979-86. 2010
    ..However, there is relatively little information about the comparative safety of opioids. Therefore, we sought to compare the safety of opioids commonly used for nonmalignant pain...
  31. pmc Risk factors for mortality in the nurses' health study: a competing risks analysis
    Heather J Baer
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Epidemiol 173:319-29. 2011
    ..In the future, this new model may be used to identify individuals at increased risk of mortality...
  32. ncbi request reprint Accuracy of Medicare claims-based diagnosis of acute myocardial infarction: estimating positive predictive value on the basis of review of hospital records
    Yuka Kiyota
    Division of Pharmacoepidemiology and Pharmacoeconomics, Boston, Mass USA
    Am Heart J 148:99-104. 2004
    ....
  33. pmc Effects of prescription coinsurance and income-based deductibles on net health plan spending for older users of inhaled medications
    Colin R Dormuth
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Med Care 47:508-16. 2009
    ..We analyzed the impact on health plan spending of a switch in public drug insurance from full coverage to a prescription copayment (copay), and then to income-based deductibles plus coinsurance (IBD)...
  34. doi request reprint The association between statin use and outcomes potentially attributable to an unhealthy lifestyle in older adults
    Amanda R Patrick
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Value Health 14:513-20. 2011
    ....
  35. pmc Excess weight and the risk of incident coronary heart disease among men and women
    Alan J Flint
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Obesity (Silver Spring) 18:377-83. 2010
    ..A substantial proportion of incident CHD may be attributed to excess weight...
  36. pmc Socioeconomic status and incident type 2 diabetes mellitus: data from the Women's Health Study
    Timothy C Lee
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 6:e27670. 2011
    ..We prospectively examined whether socioeconomic status (SES) predicts incident type II diabetes (diabetes), a cardiovascular risk equivalent and burgeoning public health epidemic among women...
  37. pmc Socioeconomic status, blood pressure progression, and incident hypertension in a prospective cohort of female health professionals
    David Conen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Eur Heart J 30:1378-84. 2009
    ..The aim of this study was to examine the association between socioeconomic status, blood pressure (BP) progression, and incident hypertension...
  38. pmc Folic acid, pyridoxine, and cyanocobalamin combination treatment and age-related macular degeneration in women: the Women's Antioxidant and Folic Acid Cardiovascular Study
    William G Christen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue E, Boston, MA 02215 1204, USA
    Arch Intern Med 169:335-41. 2009
    ..Our objective was to examine the incidence of AMD in a trial of combined folic acid, pyridoxine hydrochloride (vitamin B(6)), and cyanocobalamin (vitamin B(12)) therapy...
  39. pmc Low-dose aspirin and medical record-confirmed age-related macular degeneration in a randomized trial of women
    William G Christen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Ophthalmology 116:2386-92. 2009
    ..To test whether alternate-day low-dose aspirin affects incidence of age-related macular degeneration (AMD) in a large-scale randomized trial of women...
  40. doi request reprint Tracking of high-sensitivity C-reactive protein after an initially elevated concentration: the JUPITER Study
    Robert J Glynn
    Center for Cardiovascular Disease Prevention, Division of Preventive Medicine, Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Clin Chem 55:305-12. 2009
    ..Although studies of specific populations have suggested that hsCRP is a reliable longitudinal marker, it is unclear how strongly hsCRP tracks in individuals after a single increased concentration...
  41. pmc Rosuvastatin for primary prevention in older persons with elevated C-reactive protein and low to average low-density lipoprotein cholesterol levels: exploratory analysis of a randomized trial
    Robert J Glynn
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Ann Intern Med 152:488-96, W174. 2010
    ..Randomized data on statins for primary prevention in older persons are limited, and the relative hazard of cardiovascular disease associated with an elevated cholesterol level weakens with advancing age...
  42. doi request reprint Rosuvastatin for primary prevention among individuals with elevated high-sensitivity c-reactive protein and 5% to 10% and 10% to 20% 10-year risk. Implications of the Justification for Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvas
    Paul M Ridker
    Center for Cardiovascular Disease Prevention and Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Circ Cardiovasc Qual Outcomes 3:447-52. 2010
    ..However, trial data directly addressing whether this recommendation defines a patient population in which statin therapy is effective have not previously been published...
  43. ncbi request reprint Effects of noncardiovascular comorbidities on antihypertensive use in elderly hypertensives
    Philip S Wang
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Hypertension 46:273-9. 2005
    ..Highly prevalent, noncardiovascular conditions appear to deter use of antihypertensives in elderly with hypertension...
  44. pmc Adjustments for unmeasured confounders in pharmacoepidemiologic database studies using external information
    TIL STURMER
    Divisions of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Med Care 45:S158-65. 2007
    ..Nonexperimental studies of drug effects in large automated databases can provide timely assessment of real-life drug use, but are prone to confounding by variables that are not contained in these databases and thus cannot be controlled...
  45. doi request reprint The comparative safety of analgesics in older adults with arthritis
    Daniel H Solomon
    Division of Pharmacoepidemiology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Arch Intern Med 170:1968-76. 2010
    ..The safety of alternative analgesics is unclear. We examined the comparative safety of nonselective NSAIDs (nsNSAIDs), selective cyclooxygenase 2 inhibitors (coxibs), and opioids...
  46. doi request reprint Full coverage for preventive medications after myocardial infarction
    Niteesh K Choudhry
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    N Engl J Med 365:2088-97. 2011
    ..Adherence to medications that are prescribed after myocardial infarction is poor. Eliminating out-of-pocket costs may increase adherence and improve outcomes...
  47. ncbi request reprint Impact of two sequential drug cost-sharing policies on the use of inhaled medications in older patients with chronic obstructive pulmonary disease or asthma
    Colin R Dormuth
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Clin Ther 28:964-78; discussion 962-3. 2006
    ..Evaluations of drug cost-sharing policies within the same population are needed for a fair comparison of different options...
  48. ncbi request reprint Adherence to statin therapy under drug cost sharing in patients with and without acute myocardial infarction: a population-based natural experiment
    Sebastian Schneeweiss
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont St, Suite 3030, Boston, MA 02120, USA
    Circulation 115:2128-35. 2007
    ....
  49. pmc Supplementing claims data with outpatient laboratory test results to improve confounding adjustment in effectiveness studies of lipid-lowering treatments
    Sebastian Schneeweiss
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02120, USA
    BMC Med Res Methodol 12:180. 2012
    ..Adjusting for laboratory test results may result in better confounding control when added to administrative claims data in the study of treatment effects. However, missing values can arise through several mechanisms...
  50. pmc Multivitamins in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial
    Howard D Sesso
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    JAMA 308:1751-60. 2012
    ..Observational studies have shown inconsistent associations between regular multivitamin use and CVD, with no long-term clinical trials of multivitamin use...
  51. pmc Dietary ω-3 fatty acid and fish intake and incident age-related macular degeneration in women
    William G Christen
    Divisions of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Arch Ophthalmol 129:921-9. 2011
    ..To examine whether intake of ω-3 fatty acids and fish affects incidence of age-related macular degeneration (AMD) in women...
  52. ncbi request reprint Comparison of risk factors for the competing risks of coronary heart disease, stroke, and venous thromboembolism
    Robert J Glynn
    Division of Preventive Medicine and the Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Am J Epidemiol 162:975-82. 2005
    ..CHD and stroke have broadly comparable risk factor profiles that differ widely from the profile for VTE...
  53. pmc Vitamin E and age-related macular degeneration in a randomized trial of women
    William G Christen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Ophthalmology 117:1163-8. 2010
    ..To test whether alternate day vitamin E affects the incidence of age-related macular degeneration (AMD) in a large-scale randomized trial of women...
  54. pmc Risk of cardiovascular events among women with high normal blood pressure or blood pressure progression: prospective cohort study
    David Conen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue, Boston, MA 02215, USA
    BMJ 335:432. 2007
    ..To compare cardiovascular risk among women with high normal blood pressure (130-9/85-9 mm Hg) against those with normal blood pressure (120-9/75-84 mm Hg) and those with baseline hypertension...
  55. pmc High-dimensional propensity score adjustment in studies of treatment effects using health care claims data
    Sebastian Schneeweiss
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Epidemiology 20:512-22. 2009
    ..Here, we develop and test an algorithm that empirically identifies candidate covariates, prioritizes covariates, and integrates them into a propensity-score-based confounder adjustment model...
  56. ncbi request reprint Adjusting for unmeasured confounders in pharmacoepidemiologic claims data using external information: the example of COX2 inhibitors and myocardial infarction
    Sebastian Schneeweiss
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
    Epidemiology 16:17-24. 2005
    ..We show how to assess the impact of confounding by factors not measured in Medicare claims data in a study of the association between selective COX2 inhibitors and acute myocardial infarction (MI)...
  57. pmc Inflammation and progressive nephropathy in type 1 diabetes in the diabetes control and complications trial
    Julie Lin
    Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 31:2338-43. 2008
    ..Early albuminuria probably reflects vascular endothelial dysfunction, which may be mediated in part by chronic inflammation...
  58. doi request reprint NSAID switching and short-term gastrointestinal outcome rates after the withdrawal of rofecoxib
    Sebastian Schneeweiss
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street, Boston, MA 021205, USA
    Pharmacoepidemiol Drug Saf 18:1134-42. 2009
    ....
  59. ncbi request reprint Assessing health state utilities in elderly patients at cardiovascular risk
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Med Decis Making 26:247-54. 2006
    ..Health state preferences can be a crucial component of cost-effectiveness analyses, but off-the-shelf health state utilities specifically for older people are not available...
  60. ncbi request reprint Agreement of diagnosis and its date for hematologic malignancies and solid tumors between medicare claims and cancer registry data
    Soko Setoguchi
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Cancer Causes Control 18:561-9. 2007
    ..However, linkage between cancer registry and claims data including pharmacy-dispensing information is not always available. We examined the accuracy of claims-based definitions of incident cancers and their date of diagnosis...
  61. pmc Treatment effects in the presence of unmeasured confounding: dealing with observations in the tails of the propensity score distribution--a simulation study
    TIL STURMER
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Epidemiol 172:843-54. 2010
    ..Increasing validity based on PS trimming may be a unique advantage of PS's over conventional outcome models...
  62. pmc High-sensitivity C-reactive protein, other markers of inflammation, and the incidence of macular degeneration in women
    Debra A Schaumberg
    Division of Preventive Medicine, 900 Commonwealth Ave E, Boston, MA 02215, USA
    Arch Ophthalmol 125:300-5. 2007
    ..To investigate whether high-sensitivity C-reactive protein (hsCRP) and other biomarkers of inflammation predict age-related macular degeneration (AMD)...
  63. pmc A combined comorbidity score predicted mortality in elderly patients better than existing scores
    Joshua J Gagne
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
    J Clin Epidemiol 64:749-59. 2011
    ..To develop and validate a single numerical comorbidity score for predicting short- and long-term mortality, by combining conditions in the Charlson and Elixhauser measures...
  64. ncbi request reprint Combination therapy versus monotherapy as initial treatment for stage 2 hypertension: a prespecified subgroup analysis of a community-based, randomized, open-label trial
    Brendan M Everett
    The Center for Cardiovascular Disease Prevention, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Clin Ther 30:661-72. 2008
    ....
  65. pmc Evaluating uses of data mining techniques in propensity score estimation: a simulation study
    Soko Setoguchi
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02130, USA
    Pharmacoepidemiol Drug Saf 17:546-55. 2008
    ....
  66. ncbi request reprint Design of cluster-randomized trials of quality improvement interventions aimed at medical care providers
    Robert J Glynn
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    Med Care 45:S38-43. 2007
    ..Such trials are frequently embedded in health care systems with available automated records, which can be used to enhance the design of the trial...
  67. doi request reprint Relation of baseline high-sensitivity C-reactive protein level to cardiovascular outcomes with rosuvastatin in the Justification for Use of statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER)
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Boston, Massachusetts, USA
    Am J Cardiol 106:204-9. 2010
    ..In conclusion, as the absolute risk increased with increasing hs-CRP, the absolute risk reduction associated with rosuvastatin within JUPITER was also greatest among those with the greatest entry hs-CRP levels...
  68. pmc Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach
    Robert Y L Zee
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Clin Chim Acta 402:189-92. 2009
    ....
  69. ncbi request reprint Effect of low-dose aspirin on the occurrence of venous thromboembolism: a randomized trial
    Robert J Glynn
    Brigham and Women s Hospital, Harvard Medical School, and Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Ann Intern Med 147:525-33. 2007
    ..Short-term aspirin therapy can lower the risk for venous thromboembolism (VTE) in high-risk patients, but whether the long-term use of low-dose aspirin reduces risk in healthy adults is uncertain...
  70. doi request reprint Efficacy of rosuvastatin among men and women with moderate chronic kidney disease and elevated high-sensitivity C-reactive protein: a secondary analysis from the JUPITER (Justification for the Use of Statins in Prevention-an Intervention Trial Evaluating
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Am Coll Cardiol 55:1266-73. 2010
    ..We evaluated the efficacy of statin therapy in primary prevention among individuals with moderate chronic kidney disease (CKD)...
  71. pmc Colorectal cancer after start of nonsteroidal anti-inflammatory drug use
    TIL STURMER
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02215, USA
    Am J Med 119:494-502. 2006
    ....
  72. pmc A review of the application of propensity score methods yielded increasing use, advantages in specific settings, but not substantially different estimates compared with conventional multivariable methods
    TIL STURMER
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
    J Clin Epidemiol 59:437-47. 2006
    ..Such analyses have been proposed to address confounding by indication, but there is little empirical evidence that they achieve better control than conventional multivariate outcome modeling...
  73. ncbi request reprint A nonparametric test for observational non-normally distributed ophthalmic data with eye-specific exposures and outcomes
    Bernard Rosner
    Channing Laboratory, Harvard Medical School, Boston, Massachusetts 02115, USA
    Ophthalmic Epidemiol 14:243-50. 2007
    ....
  74. ncbi request reprint Extension of the rank sum test for clustered data: two-group comparisons with group membership defined at the subunit level
    Bernard Rosner
    Channing Laboratory, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biometrics 62:1251-9. 2006
    ..We also present comparisons between the clustered Wilcoxon test and each of the signed rank tests and mixed model approaches and show dramatic differences in power in favor of the clustered Wilcoxon test for some designs...
  75. pmc Insights into different results from different causal contrasts in the presence of effect-measure modification
    TIL STURMER
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Pharmacoepidemiol Drug Saf 15:698-709. 2006
    ..In the presence of effect-measure modification, different analytic approaches produce different summary estimates...
  76. ncbi request reprint Methods to evaluate risks for composite end points and their individual components
    Robert J Glynn
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Harvard School of Public Health, 900 Commonwealth Avenue East, Boston, MA 02215 1204, USA
    J Clin Epidemiol 57:113-22. 2004
    ..Both randomized and observational studies commonly examine composite end points, but the literature on model development and criticism in this setting is limited...
  77. ncbi request reprint Clinical and economic consequences of reference pricing for dihydropyridine calcium channel blockers
    Sebastian Schneeweiss
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02120, USA
    Clin Pharmacol Ther 74:388-400. 2003
    ....
  78. ncbi request reprint Incorporation of clustering effects for the Wilcoxon rank sum test: a large-sample approach
    Bernard Rosner
    Channing Laboratory, Harvard Medical School, 181 Longwood Avenue, Boston, Massachusetts, USA
    Biometrics 59:1089-98. 2003
    ..In this article, we present large-sample theory and simulation results for this test procedure and apply it to diabetic retinopathy data from type I diabetics in the Sorbinil Retinopathy Trial...
  79. pmc Variable selection for propensity score models
    M Alan Brookhart
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Am J Epidemiol 163:1149-56. 2006
    ..These simulation studies and other analytical results suggest that standard model-building tools designed to create good predictive models of the exposure will not always lead to optimal PS models, particularly in small studies...
  80. ncbi request reprint Stopping rules for surveys with multiple waves of nonrespondent follow-up
    R Sowmya Rao
    MGH Biostatistics Center and the Institute for Health Policy, Harvard Medical School, 50 Staniford Street, Suite 560, Boston, MA 02114, U S A
    Stat Med 27:2196-213. 2008
    ..The rules are not complicated and may be applied in a straightforward manner. Discontinuing follow-up would save time and possibly resources, and adjusting for the nonresponse in the analysis would reduce the impact of nonresponse bias...
  81. ncbi request reprint Interval estimation for rank correlation coefficients based on the probit transformation with extension to measurement error correction of correlated ranked data
    Bernard Rosner
    Channing Laboratory, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Stat Med 26:633-46. 2007
    ..This extends previous work by Rosner and Willett for obtaining point and interval estimates of measurement error corrected Pearson correlations...
  82. pmc Improved comorbidity adjustment for predicting mortality in Medicare populations
    Sebastian Schneeweiss
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Health Serv Res 38:1103-20. 2003
    ..To define and improve the performance of existing comorbidity scores in predicting mortality in Medicare enrollees...
  83. ncbi request reprint Explained variation in a model of therapeutic decision making is partitioned across patient, physician, and clinic factors
    M Alan Brookhart
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
    J Clin Epidemiol 59:18-25. 2006
    ..A statistical method is presented for attributing explained variation in patient care to different levels of aggregation in a multilevel model with the aim of prioritizing and targeting quality improvement interventions...
  84. ncbi request reprint Results of multivariable logistic regression, propensity matching, propensity adjustment, and propensity-based weighting under conditions of nonuniform effect
    Tobias Kurth
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Epidemiol 163:262-70. 2006
    ..Researchers need to be clear about the population for which an overall treatment estimate is most suitable...
  85. ncbi request reprint Aspirin and nonsteroidal anti-inflammatory drugs for the primary prevention of colorectal cancer: weighing the evidence
    TIL STURMER
    Ann Intern Med 147:674; author reply 674-5. 2007
  86. ncbi request reprint Low-intensity versus conventional-intensity warfarin for prevention of recurrent venous thromboembolism
    Paul M Ridker
    N Engl J Med 349:2164-7; author reply 2164-7. 2003
  87. ncbi request reprint Multiple imputation to estimate the association between eyes in disease progression with interval-censored data
    Robert J Glynn
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, USA
    Stat Med 23:3307-18. 2004
    ..A simulation study suggests that the method performs well. Results highlight the advantage of multiple imputation that data imputed under one model can be analysed under several alternative models...