Laura Bridgewater

Summary

Affiliation: Brigham Young University
Country: USA

Publications

  1. pmc Nuclear variants of bone morphogenetic proteins
    Jenny E Felin
    Department of Microbiology and Molecular Biology, Brigham Young University, Provo, Utah, USA
    BMC Cell Biol 11:20. 2010
  2. pmc Adjacent DNA sequences modulate Sox9 transcriptional activation at paired Sox sites in three chondrocyte-specific enhancer elements
    Laura C Bridgewater
    Department of Microbiology and Molecular Biology, Brigham Young University, 591 WIDB, Provo, UT 84602, USA
    Nucleic Acids Res 31:1541-53. 2003
  3. pmc The heterozygous disproportionate micromelia (dmm) mouse: morphological changes in fetal cartilage precede postnatal dwarfism and compared with lethal homozygotes can explain the mild phenotype
    Robert E Seegmiller
    Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA
    J Histochem Cytochem 56:1003-11. 2008
  4. ncbi request reprint Altered mandibular development precedes the time of palate closure in mice homozygous for disproportionate micromelia: an oral clefting model supporting the Pierre-Robin sequence
    James E Ricks
    Department of Zoology, Brigham Young University, Provo, Utah 84602, USA
    Teratology 65:116-20. 2002
  5. pmc A novel retinoic acid-response element requires an enhancer element mediator for transcriptional activation
    Laura R Harris
    Department of Microbiology and Molecular Biology, Brigham Young University, 591 WIDB, Provo, UT 84602, USA
    Biochem J 383:37-43. 2004
  6. pmc A Col9a1 enhancer element activated by two interdependent SOX9 dimers
    Mary Ann Genzer
    Department of Microbiology and Molecular Biology, Brigham Young University, Provo, Utah 84602, USA
    Nucleic Acids Res 35:1178-86. 2007
  7. pmc The new collagen gene COL27A1 contains SOX9-responsive enhancer elements
    Elizabeth Jenkins
    Department of Microbiology and Molecular Biology, Brigham Young University, 591 WIDB, Provo, Utah 84602, USA
    Matrix Biol 24:177-84. 2005
  8. pmc The transcription factor Lc-Maf participates in Col27a1 regulation during chondrocyte maturation
    Jaime L Mayo
    Department of Microbiology and Molecular Biology, Brigham Young University, 591 WIDB, Provo, UT 84602, USA
    Exp Cell Res 315:2293-300. 2009
  9. ncbi request reprint The transcription factor Sox9 is degraded by the ubiquitin-proteasome system and stabilized by a mutation in a ubiquitin-target site
    Haruhiko Akiyama
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Matrix Biol 23:499-505. 2005

Research Grants

  1. Chondrocyte-Specific Transcriptional Regulation
    Laura Bridgewater; Fiscal Year: 2006

Collaborators

Detail Information

Publications9

  1. pmc Nuclear variants of bone morphogenetic proteins
    Jenny E Felin
    Department of Microbiology and Molecular Biology, Brigham Young University, Provo, Utah, USA
    BMC Cell Biol 11:20. 2010
    ..They have previously been recognized only as secreted growth factors, but the present study detected Bmp2, Bmp4, and Gdf5/CDMP1 in the nuclei of cultured cells using immunocytochemistry and immunoblotting of nuclear extracts...
  2. pmc Adjacent DNA sequences modulate Sox9 transcriptional activation at paired Sox sites in three chondrocyte-specific enhancer elements
    Laura C Bridgewater
    Department of Microbiology and Molecular Biology, Brigham Young University, 591 WIDB, Provo, UT 84602, USA
    Nucleic Acids Res 31:1541-53. 2003
    ..The data suggest a new model in which adjacently bound proteins affect the DNA bend angle produced by Sox9, which in turn determines whether an active transcriptional enhancer complex is assembled...
  3. pmc The heterozygous disproportionate micromelia (dmm) mouse: morphological changes in fetal cartilage precede postnatal dwarfism and compared with lethal homozygotes can explain the mild phenotype
    Robert E Seegmiller
    Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA
    J Histochem Cytochem 56:1003-11. 2008
    ..Thus, intracellular entrapment of proalpha1(II) seems to be primarily responsible for the dominant-negative effect of the Dmm mutation in the expression of dwarfism...
  4. ncbi request reprint Altered mandibular development precedes the time of palate closure in mice homozygous for disproportionate micromelia: an oral clefting model supporting the Pierre-Robin sequence
    James E Ricks
    Department of Zoology, Brigham Young University, Provo, Utah 84602, USA
    Teratology 65:116-20. 2002
    ..The present study was conducted in embryonic day 14 (E14) mice, 1 day before palate closure, to describe the relationship between growth of the lower jaw/tongue complex versus genotype of the embryo...
  5. pmc A novel retinoic acid-response element requires an enhancer element mediator for transcriptional activation
    Laura R Harris
    Department of Microbiology and Molecular Biology, Brigham Young University, 591 WIDB, Provo, UT 84602, USA
    Biochem J 383:37-43. 2004
    ..Such a system of regulation, particularly if found to be operating in other cartilage genes, could explain the conflicting responses RA produces in chondrocytes under different experimental conditions...
  6. pmc A Col9a1 enhancer element activated by two interdependent SOX9 dimers
    Mary Ann Genzer
    Department of Microbiology and Molecular Biology, Brigham Young University, Provo, Utah 84602, USA
    Nucleic Acids Res 35:1178-86. 2007
    ....
  7. pmc The new collagen gene COL27A1 contains SOX9-responsive enhancer elements
    Elizabeth Jenkins
    Department of Microbiology and Molecular Biology, Brigham Young University, 591 WIDB, Provo, Utah 84602, USA
    Matrix Biol 24:177-84. 2005
    ..In summary, these results suggest that SOX9 may play an important role in the transcriptional activation of the newest collagen gene, COL27A1...
  8. pmc The transcription factor Lc-Maf participates in Col27a1 regulation during chondrocyte maturation
    Jaime L Mayo
    Department of Microbiology and Molecular Biology, Brigham Young University, 591 WIDB, Provo, UT 84602, USA
    Exp Cell Res 315:2293-300. 2009
    ..The work presented here suggests that Lc-Maf may affect the process of endochondral ossification by participating in the regulation of Col27a1 expression...
  9. ncbi request reprint The transcription factor Sox9 is degraded by the ubiquitin-proteasome system and stabilized by a mutation in a ubiquitin-target site
    Haruhiko Akiyama
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Matrix Biol 23:499-505. 2005
    ..Our in vitro studies indicate that the ubiquitin-proteasome proteolytic system degrades Sox9 and regulates its transcriptional activity...

Research Grants5

  1. Chondrocyte-Specific Transcriptional Regulation
    Laura Bridgewater; Fiscal Year: 2006
    ..Finally, the genes for the proteins identified can be examined in future linkage analysis studies to see if they participate in a genetic predisposition to osteoarthritis. ..