Research Topics
| C A ManthousSummaryAffiliation: Bridgeport Hospital Country: USA Publications
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Detail Information
Publications
Informed consent for invasive procedures in a community hospital medical intensive care unitAngela DeGirolamo
Bridgeport Hospital, CT 06610, USA
Conn Med 68:223-9. 2004..5 to 4.1, P=0.01) and documentation of consent improved. CONCLUSIONS: These results suggest that informed consent can be obtained procedure-by-procedure, as needed, at a high frequency, and with reasonable consenter comprehension...
Fluid balance and weaning outcomesAnupama Upadya
Pulmonary and Critical Care, Bridgeport Hospital and Yale University School of Medicine, 267 Grant Street, Bridgeport, CT 06610, USA
Intensive Care Med 31:1643-7. 2005..To examine the relationship of fluid balance and weaning outcomes...
Why not physician-assisted death?Constantine A Manthous
Bridgeport Hospital and Yale University School of Medicine, Bridgeport, CT, USA
Crit Care Med 37:1206-9. 2009..This article explores contributions of religion, Western medical mores, law, and emerging concepts of moral neurocognition that may explain our inherent aversion to these ideas...
Why surgeons can say "no": exploring "unilateral withholding"Constantine A Manthous
Bridgeport Hospital, Bridgeport, CT, USA
J Hosp Med 7:249-53. 2012....
Critical care rationing: international comparisonsTimothy W Evans
Department of Critical Care, Imperial College School of Medicine, Royal Brompton Hospital, London, England, UK
Chest 140:1618-24. 2011....
Building effective critical care teamsConstantine Manthous
Bridgeport Hospital and Yale University School of Medicine, 267 Grant Street, Bridgeport, CT 06610, USA
Crit Care 15:307. 2011..Since critical care is a team endeavor, methods to maximize teamwork should be learned and mastered by critical care team members, and especially leaders...
Team science and critical careConstantine A Manthous
Bridgeport Hospital and Yale University School of Medicine, 267 Grant Street, Bridgeport, CT 06610, USA
Am J Respir Crit Care Med 184:17-25. 2011..The article highlights how team principles might be used to improve patient care and navigate hospital hierarchies, and concludes with implications for future educational and scientific efforts...
Critical care physicians' practices and attitudes and applicable statutes regarding withdrawal of life-sustaining therapiesConstantine A Manthous
Department of Internal Medicine, Bridgeport Hospital and Yale University School of Medicine, CT 06610, USA
Conn Med 69:395-400. 2005..To describe intensivist-educators' practices and opinions regarding the withdrawal of life-sustaining therapies, and to juxtapose these with applicable end-of-life statutes...
Leapfrog and critical care: evidence- and reality-based intensive care for the 21st centuryConstantine A Manthous
Pulmonary and Critical Care, Bridgeport Hospital, Bridgeport, Connecticut 06610, USA
Am J Med 116:188-93. 2004....
Negative fluid balance predicts survival in patients with septic shock: a retrospective pilot studyF Alsous
Division of Pulmonary and Critical Care, Bridgeport Hospital and Yale University School of Medicine, Bridgeport, CT 06610, USA
Chest 117:1749-54. 2000..We hypothesized that patients with septic shock who achieve negative fluid balance (< or =-500 mL) on any day in the first 3 days of management are more likely to survive than those who do not...
Summarizing the logistics of liberation from mechanical ventilationC A Manthous
Department of Medicine, Division of Pulmonary and Critical Care, Bridgeport Hospital, Bridgeport, Connecticut 06610, USA
Respir Care Clin N Am 6:463-8;vi. 2000..This article summarizes the principle themes for this issue of Respiratory Care Clinics of North America and distills the available data to two simple weaning algorithms...
Are living wills useful? In search of a new paradigmConstantine A Manthous
Bridgeport Hospital, Yale University School of Medicine, CT, USA
Conn Med 67:283-90; discussion 291-2. 2003..Potential solutions for current deficiencies in end-of-life care and decision-making are discussed...
Informed consent for medical procedures: local and national practicesConstantine A Manthous
Pulmonary and Critical Care Department, Bridgeport Hospital and Yale University School of Medicine, Bridgeport, CT 06610, USA
Chest 124:1978-84. 2003..No studies have assessed whether clinicians obtain informed consent for invasive medical procedures, and there are no explicit national standards to guide the process...
Predictors of extubation outcome in patients who have successfully completed a spontaneous breathing trialM Khamiees
Department of Pulmonary and Critical Care, Bridgeport Hospital, Bridgeport, CT 06610, USA
Chest 120:1262-70. 2001..Also, a majority (89%) of medically ill patients with P:F ratios of 120 to 200 (four of five patients with P:F ratios from 120 to 150), values sometimes used to preclude weaning, were extubated successfully...
Thyroid storm presenting as multiple organ dysfunction syndromeY Z Jiang
Department of Internal Medicine, Bridgeport Hospital, Yale New Haven Health, Bridgeport, CT 06610, USA
Chest 118:877-9. 2000..This case highlights both the multiple organ systems that can be involved in thyroid storm and the importance of recognizing atypical presentations of thyroid storm...
Liberation from mechanical ventilation: what monitoring matters?Jonathan M Siner
Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, P O Box 208057, New Haven, CT 06520 8057, USA
Crit Care Clin 23:613-38. 2007..We also suggest future study designs that would better inform the process of liberation from the ventilator and endotracheal extubation...
Medical professionalism in the new millennium: are there intercultural differences? Brief report and commentaryManasi M Shah
Bridgeport Hospital and Yale University School of Medicine, Bridgeport, USA
Conn Med 73:289-94. 2009..We use the results of this ostensibly "negative" study to comment on the foundations for the hypothesis and logistic difficulty of studying the question...
Patients' understanding of advance directives and cardiopulmonary resuscitationNatalya Thorevska
Pulmonary and Critical Care, Bridgeport Hospital and Yale University School of Medicine, Bridgeport, CT 06610, USA
J Crit Care 20:26-34. 2005..Most fail to involve physicians in creating directives. A significant number of those without living wills have end-of-life wishes that could be addressed by and appear open to the idea of creating advance directives...
Outcomes of critically ill patientsLisa Tilluckdharry
Pulmonary and Critical Care, Bridgeport Hospital, CT 06616, USA
Am J Emerg Med 23:336-9. 2005..Larger studies are required to examine this hypothesis...
Neurologic status, cough, secretions and extubation outcomesAdil Salam
Pulmonary and Critical Care, Bridgeport Hospital and Yale University School of Medicine, 267 Grant Street, Bridgeport, CT 06610, USA
Intensive Care Med 30:1334-9. 2004..8 times as likely to have any two risk factors compared to those who were successful. CONCLUSIONS: These simple, reproducible methods may provide a clinically useful approach to guiding the extubation of patients who have passed a SBT...
Cough peak flows and extubation outcomesMihai Smina
Pulmonary and Critical Care, Bridgeport Hospital and Yale University School of Medicine, Bridgeport, CT 06610, USA
Chest 124:262-8. 2003..CONCLUSION: These data suggest that cough strength, measured objectively, is a predictor of extubation outcome, morbidity, and mortality...
Age, duration of mechanical ventilation, and outcomes of patients who are critically illYan Feng
Bridgeport Hospital, Bridgeport, CT 06610 2870, USA
Chest 136:759-64. 2009..Age and duration of mechanical ventilation (MV) are strongly associated with mortality and hospital discharge disposition...
The 9-11 Commission's invitation to imagine: a pathophysiology-based approach to critical care of nuclear explosion victimsConstantine A Manthous
Pulmonary and Critical Care Department, Bridgeport Hospital and Yale University School of Medicine, Bridgeport, CT, USA
Crit Care Med 35:716-23. 2007..Documentation from previous bomb blasts and nuclear accidents is reviewed to assist in forecasting needs of both systems and patients in the event of an NDD in a major metropolitan area...
Outcomes of critically ill patients who received cardiopulmonary resuscitationJianmin Tian
Bridgeport Hospital and Yale University School of Medicine, Bridgeport, Connecticut 06610, USA
Am J Respir Crit Care Med 182:501-6. 2010..Studies examining survival outcomes after in-hospital cardiopulmonary arrest (CPA) among intensive care unit (ICU) patients requiring medications for hemodynamic support are limited...
Acute kidney injury predicts outcomes of non-critically ill patientsFidel Barrantes
Bridgeport Hospital, Bridgeport, CT 06610, USA
Mayo Clin Proc 84:410-6. 2009..To evaluate whether acute kidney injury (AKI), defined as an increase in the serum creatinine level of 0.3 mg/dL or more within 48 hours, predicts outcomes of non-critically ill patients...
Rapid reversal of acute kidney injury and hospital outcomes: a retrospective cohort studyJianmin Tian
Bridgeport Hospital and Yale University School of Medicine, Bridgeport, CT 06610, USA
Am J Kidney Dis 53:974-81. 2009..3 mg/dL or greater in 48 hours, is associated with poor outcomes. The prognosis associated with an increased creatinine level, either on admission or that develops in the hospital (ie, AKI), that rapidly returns to normal is not known...
Promoting a culture of patient safetyConstantine A Manthous
Bridgeport Hospital, USA
Conn Med 72:549-53. 2008
Patients' predilections regarding informed consent for hospital treatmentsShweta Upadhyay
Bridgeport Hospital and Yale University School of Medicine, Bridgeport, CT 06610, USA
J Hosp Med 3:6-11. 2008..Respect for patient autonomy is a core principle of American medicine. Informed consent is required for surgical procedures and blood transfusions but not for most medical treatments of hospitalized patients...
Enhanced end-of-life care associated with deploying a rapid response team: a pilot studyRodrigo Vazquez
Bridgeport Hospital and Yale University School of Medicine, Bridgeport, Connecticut 06610, USA
J Hosp Med 4:449-52. 2009..Institution of a rapid response team (RRT) improves patients' quality of death (QOD)...
The effect of arterial blood gas values on extubation decisionsAdil Salam
Department of Internal Medicine, Bridgeport Hospital, Yale University, CT 06610, USA
Respir Care 48:1033-7. 2003....
Informed consent for invasive medical procedures from the patient's perspectiveNatalya Thorevska
Department of Internal Medicine, Bridgeport Hospital, 267 Grant Street, Bridgeport, CT 06610, USA
Conn Med 68:101-5. 2004..A majority of patients do not want to have invasive procedures without first giving their informed consent...
Patient, physician, and family member understanding of living willsAnupama Upadya
Pulmonary and Critical Care, Bridgeport Hospital, Bridgeport, Connecticut 06610, USA
Am J Respir Crit Care Med 166:1430-5. 2002..These data suggest substantial differences of patient, physician, and family member understanding of living wills. Living wills did not reflect fully patients' expectations of receiving (or not receiving) life-sustaining modalities...
Propofol infusion is associated with a higher rapid shallow breathing index in patients preparing to wean from mechanical ventilationMohammad Khamiees
Bridgeport Hospital, West Tower 6, 267 Grant Street, Bridgeport, CT 06610, USA
Respir Care 47:150-3. 2002..Since this effect has also been noted following benzodiazepine infusion, the clinician should consider the patient's "sedation history" when using RSBI to guide weaning decisions...
If asked, hospitalized patients will choose whether to receive life-sustaining therapiesNelson Nicolasora
Department of Internal Medicine, Bridgeport Hospital and Yale University School of Medicine, New Haven, Connecticut, USA
J Hosp Med 1:161-7. 2006..Only a minority drafted advance directives during hospitalization. Larger studies that include patients at other centers are required to determine whether these findings are reproducible and whether this approach is clinically feasible...
An official ATS statement: grading the quality of evidence and strength of recommendations in ATS guidelines and recommendationsHolger J Schunemann
Am J Respir Crit Care Med 174:605-14. 2006
Beta-agonists for patients with chronic obstructive pulmonary disease and heart disease?Hugh Parker
Am J Emerg Med 26:104-5. 2008
The anarchy of weaning techniquesConstantine A Manthous
Chest 121:1738-40. 2002
Weaning by protocolConstantine A Manthous
Am J Respir Crit Care Med 170:98-9; author reply 99-100. 2004
A concussive clinical coincidenceConstantine A Manthous
Chest 125:1593-4. 2004
Medical errors and quality of care in Connecticut hospitals. Grappling with the implications of the IOM reportsConstantine A Manthous
Conn Med 69:29-32. 2005
Toward solving the critical care manpower crisisConstantine A Manthous
Respir Care 51:1224-5. 2006
The sound and the furyConstantine A Manthous
Am J Respir Crit Care Med 173:1414. 2006
Counterpoint: is it ethical to order "do not resuscitate" without patient consent?Constantine A Manthous
Chest 132:751-4; discussion 754-5. 2007
