Research Topics
| Gina G TurrigianoSummaryAffiliation: Brandeis University Country: USA Publications
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Detail Information
Publications
Homeostatic plasticity in the developing nervous systemGina G Turrigiano
Department of Biology and Volen National Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
Nat Rev Neurosci 5:97-107. 2004- Activity deprivation reduces miniature IPSC amplitude by decreasing the number of postsynaptic GABA(A) receptors clustered at neocortical synapsesValerie Kilman
Department of Biology and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
J Neurosci 22:1328-37. 2002..Because excitatory and inhibitory synaptic currents are regulated in opposite directions by activity blockade, these data suggest that the balance between excitation and inhibition is dynamically regulated by ongoing activity... - Postsynaptic expression of homeostatic plasticity at neocortical synapsesCorette J Wierenga
Department of Biology and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454-9110, USA
J Neurosci 25:2895-905. 2005.... - Temporal regulation of the expression locus of homeostatic plasticityCorette J Wierenga
Department of Biology and Center for Complex Systems, Brandeis University, Waltham, MA 02454, USA
J Neurophysiol 96:2127-33. 2006.... - Multiple forms of long-term plasticity at unitary neocortical layer 5 synapsesPer Jesper Sjöström
Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA
Neuropharmacology 52:176-84. 2007..These data suggest that correlated high-frequency firing at layer-5 synapses simultaneously induces a mixture of presynaptic LTD, presynaptic LTP, and postsynaptic LTP... - Potentiation of cortical inhibition by visual deprivationArianna Maffei
Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02454, USA
Nature 443:81-4. 2006.... - More than a sidekick: glia and homeostatic synaptic plasticityGina G Turrigiano
Department of Biology, Brandeis University, Waltham, MA 02454, USA
Trends Mol Med 12:458-60. 2006..In addition to provide insight into the mechanisms of homeostatic plasticity, these data argue for the first time for an equal partnership between glial cells and neurons in the generation of an important form of synaptic plasticity... - Dynamics underlying synaptic gain between pairs of cortical pyramidal neuronsKara G Pratt
Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA
Dev Neurobiol 68:143-51. 2008..Our data suggest that activating CaMKII can increase synaptic connectivity through a CaM-dependent increase in contact formation, followed by stabilization of a constant fraction of new contacts... 
Rapid synaptic scaling induced by changes in postsynaptic firingKeiji Ibata
Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA
Neuron 57:819-26. 2008....
Multiple modes of network homeostasis in visual cortical layer 2/3Arianna Maffei
Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02454, USA
J Neurosci 28:4377-84. 2008..The existence of multiple, partially redundant forms of homeostatic plasticity may ensure that network compensation can be achieved in response to a wide range of sensory perturbations...- A proportional but slower NMDA potentiation follows AMPA potentiation in LTPAlanna J Watt
Department of Biology and Volen National Center for Complex Systems, MS 08, 415 South Street, Brandeis University, Waltham, Massachusetts 02454, USA
Nat Neurosci 7:518-24. 2004..This may ensure that LTP does not alter the relative contributions of these two receptors to synaptic transmission and information processing... - Long-term potentiation of intrinsic excitability in LV visual cortical neuronsRobert H Cudmore
Department of Biology, Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454-9110, USA
J Neurophysiol 92:341-8. 2004..This suggests that LTP-IE occurs through postsynaptic calcium influx and subsequent activation of PKA. Activity-dependent plasticity in intrinsic excitability could greatly expand the computational power of individual neurons... - Fast propagation of firing rates through layered networks of noisy neuronsMark C W van Rossum
Department of Biology, Brandeis University, Waltham, Massachusetts 02454 9110, USA
J Neurosci 22:1956-66. 2002..The proposed mode of propagation allows for fast computation with population coding based on firing rates, as is demonstrated with a local motion detector... - Neocortical LTD via coincident activation of presynaptic NMDA and cannabinoid receptorsPer Jesper Sjöström
Department of Biology, Volen Center for Complex Systems, Brandeis University, Mailstop 008, 415 South Street, Waltham, MA 02454, USA
Neuron 39:641-54. 2003..This novel form of coincidence detection may explain the temporal window of tLTD and may also impart synapse specificity to cannabinoid retrograde signaling... - Critical periods for experience-dependent synaptic scaling in visual cortexNiraj S Desai
Department of Biology and Volen National Center for Complex Systems, MS 008, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, USA
Nat Neurosci 5:783-9. 2002.... - Activity-dependent remodeling of presynaptic inputs by postsynaptic expression of activated CaMKIIKara G Pratt
Department of Biology, Volen National Center for Complex Systems, Brandeis University, Waltham, MA 02454, USA
Neuron 39:269-81. 2003..These data suggest that postsynaptic activation of CaMKII induces a structural remodeling of presynaptic inputs that favors the retention of active presynaptic partners... - A recipe for ridding synapses of the ubiquitous AMPA receptorGina G Turrigiano
Dept of Biology MS 08, Brandeis University, 415 South Street, Waltham, MA 02454, USA
Trends Neurosci 25:597-8. 2002..A recent study in Ceanorhabditis elegans suggests that ubiquitination of AMPA receptors is one important signal that targets these receptors for endocytosis... - Rate and timing in cortical synaptic plasticitySacha B Nelson
Department of Biology and Volen Center for Complex Systems, Brandeis University, Mailstop 008, 415 South Street, Waltham, MA 02454 9110, USA
Philos Trans R Soc Lond B Biol Sci 357:1851-7. 2002..The results hold important implications for which parts of the neural code are most readily stored for later retrieval... - The NMDA-to-AMPA ratio at synapses onto layer 2/3 pyramidal neurons is conserved across prefrontal and visual corticesChaelon I O Myme
Department of Biology, Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454-9110, USA
J Neurophysiol 90:771-9. 2003..We conclude that this basic property of excitatory transmission is conserved across PFC and VC synapses and is therefore unlikely to contribute to differences in firing patterns observed in vivo in the two regions... - Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndromeVardhan S Dani
Department of Biology and Volen Center for Complex Systems, Brandeis University, MS 008, Waltham, MA 02454 9110, USA
Proc Natl Acad Sci U S A 102:12560-5. 2005..These findings provide the first detailed electrophysiological analysis of Mecp2-mutant mice and provide a framework for understanding the pathophysiology of the disease and tools for studying the underlying disease mechanisms... - Selective reconfiguration of layer 4 visual cortical circuitry by visual deprivationArianna Maffei
Department of Biology and Volen National Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
Nat Neurosci 7:1353-9. 2004..These effects reversed when vision was restored. This dynamic adjustment of the excitation-inhibition balance may allow the networks within layer 4 to maintain stable levels of activity in the face of variable sensory input... - Endocannabinoid-dependent neocortical layer-5 LTD in the absence of postsynaptic spikingPer Jesper Sjöström
Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454 9110, USA
J Neurophysiol 92:3338-43. 2004....