Gina G Turrigiano

Summary

Affiliation: Brandeis University
Country: USA

Publications

  1. ncbi request reprint Homeostatic plasticity in the developing nervous system
    Gina G Turrigiano
    Department of Biology and Volen National Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
    Nat Rev Neurosci 5:97-107. 2004
  2. pmc Synaptic scaling requires the GluR2 subunit of the AMPA receptor
    Melanie A Gainey
    Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurosci 29:6479-89. 2009
  3. ncbi request reprint Postsynaptic expression of homeostatic plasticity at neocortical synapses
    Corette J Wierenga
    Department of Biology and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454 9110, USA
    J Neurosci 25:2895-905. 2005
  4. ncbi request reprint A proportional but slower NMDA potentiation follows AMPA potentiation in LTP
    Alanna J Watt
    Department of Biology and Volen National Center for Complex Systems, MS 08, 415 South Street, Brandeis University, Waltham, Massachusetts 02454, USA
    Nat Neurosci 7:518-24. 2004
  5. doi request reprint Rapid synaptic scaling induced by changes in postsynaptic firing
    Keiji Ibata
    Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA
    Neuron 57:819-26. 2008
  6. ncbi request reprint Dynamics underlying synaptic gain between pairs of cortical pyramidal neurons
    Kara G Pratt
    Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA
    Dev Neurobiol 68:143-51. 2008
  7. ncbi request reprint Multiple forms of long-term plasticity at unitary neocortical layer 5 synapses
    Per Jesper Sjöström
    Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA
    Neuropharmacology 52:176-84. 2007
  8. ncbi request reprint Activity-dependent remodeling of presynaptic inputs by postsynaptic expression of activated CaMKII
    Kara G Pratt
    Department of Biology, Volen National Center for Complex Systems, Brandeis University, Waltham, MA 02454, USA
    Neuron 39:269-81. 2003
  9. pmc Critical period for inhibitory plasticity in rodent binocular V1
    Arianna Maffei
    Department of Biology and National Center for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurosci 30:3304-9. 2010
  10. pmc Tumor necrosis factor-α signaling maintains the ability of cortical synapses to express synaptic scaling
    Celine C Steinmetz
    Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurosci 30:14685-90. 2010

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Homeostatic plasticity in the developing nervous system
    Gina G Turrigiano
    Department of Biology and Volen National Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
    Nat Rev Neurosci 5:97-107. 2004
  2. pmc Synaptic scaling requires the GluR2 subunit of the AMPA receptor
    Melanie A Gainey
    Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurosci 29:6479-89. 2009
    ..Together, our results suggest that synaptic scaling and LTP use different trafficking pathways, making these two forms of plasticity both functionally and molecularly distinct...
  3. ncbi request reprint Postsynaptic expression of homeostatic plasticity at neocortical synapses
    Corette J Wierenga
    Department of Biology and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454 9110, USA
    J Neurosci 25:2895-905. 2005
    ....
  4. ncbi request reprint A proportional but slower NMDA potentiation follows AMPA potentiation in LTP
    Alanna J Watt
    Department of Biology and Volen National Center for Complex Systems, MS 08, 415 South Street, Brandeis University, Waltham, Massachusetts 02454, USA
    Nat Neurosci 7:518-24. 2004
    ..This may ensure that LTP does not alter the relative contributions of these two receptors to synaptic transmission and information processing...
  5. doi request reprint Rapid synaptic scaling induced by changes in postsynaptic firing
    Keiji Ibata
    Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA
    Neuron 57:819-26. 2008
    ....
  6. ncbi request reprint Dynamics underlying synaptic gain between pairs of cortical pyramidal neurons
    Kara G Pratt
    Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA
    Dev Neurobiol 68:143-51. 2008
    ..Our data suggest that activating CaMKII can increase synaptic connectivity through a CaM-dependent increase in contact formation, followed by stabilization of a constant fraction of new contacts...
  7. ncbi request reprint Multiple forms of long-term plasticity at unitary neocortical layer 5 synapses
    Per Jesper Sjöström
    Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA
    Neuropharmacology 52:176-84. 2007
    ..These data suggest that correlated high-frequency firing at layer-5 synapses simultaneously induces a mixture of presynaptic LTD, presynaptic LTP, and postsynaptic LTP...
  8. ncbi request reprint Activity-dependent remodeling of presynaptic inputs by postsynaptic expression of activated CaMKII
    Kara G Pratt
    Department of Biology, Volen National Center for Complex Systems, Brandeis University, Waltham, MA 02454, USA
    Neuron 39:269-81. 2003
    ..These data suggest that postsynaptic activation of CaMKII induces a structural remodeling of presynaptic inputs that favors the retention of active presynaptic partners...
  9. pmc Critical period for inhibitory plasticity in rodent binocular V1
    Arianna Maffei
    Department of Biology and National Center for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurosci 30:3304-9. 2010
    ..Inhibitory plasticity is thus fundamental in modulating cortical circuit refinement and might be one of the mechanisms promoting ocular dominance shifts...
  10. pmc Tumor necrosis factor-α signaling maintains the ability of cortical synapses to express synaptic scaling
    Celine C Steinmetz
    Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurosci 30:14685-90. 2010
    ..Together, these data suggest that TNFα is not an instructive signal for scaling but rather is critical for maintaining synapses in a plastic state in which synaptic scaling can be expressed...
  11. pmc A critical and cell-autonomous role for MeCP2 in synaptic scaling up
    Melissa P Blackman
    Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurosci 32:13529-36. 2012
    ..Our results establish MeCP2 as a critical mediator of synaptic scaling and raise the possibility that some of the neurological defects of Rett arise from a disruption of homeostatic plasticity...
  12. pmc Synaptic and intrinsic homeostatic mechanisms cooperate to increase L2/3 pyramidal neuron excitability during a late phase of critical period plasticity
    Mary E Lambo
    Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurosci 33:8810-9. 2013
    ....
  13. ncbi request reprint Temporal regulation of the expression locus of homeostatic plasticity
    Corette J Wierenga
    Department of Biology and Center for Complex Systems, Brandeis University, Waltham, MA 02454, USA
    J Neurophysiol 96:2127-33. 2006
    ....
  14. ncbi request reprint Neocortical LTD via coincident activation of presynaptic NMDA and cannabinoid receptors
    Per Jesper Sjöström
    Department of Biology, Volen Center for Complex Systems, Brandeis University, Mailstop 008, 415 South Street, Waltham, MA 02454, USA
    Neuron 39:641-54. 2003
    ..This novel form of coincidence detection may explain the temporal window of tLTD and may also impart synapse specificity to cannabinoid retrograde signaling...
  15. pmc How to scale down postsynaptic strength
    Vedakumar Tatavarty
    Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02453, USA
    J Neurosci 33:13179-89. 2013
    ..These data demonstrate that scaling down is accomplished through a regulated increase in Koff, which in turn reduces the fractional occupancy of synaptic scaffolds to proportionally reduce synaptic strength. ..
  16. pmc Multiple modes of network homeostasis in visual cortical layer 2/3
    Arianna Maffei
    Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurosci 28:4377-84. 2008
    ..The existence of multiple, partially redundant forms of homeostatic plasticity may ensure that network compensation can be achieved in response to a wide range of sensory perturbations...
  17. pmc Experience-dependent regulation of TrkB isoforms in rodent visual cortex
    Bethany K Bracken
    Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
    Dev Neurobiol 69:267-78. 2009
    ..Our data indicate that TrkB isoform expression can be selectively regulated by visual experience, and may contribute to experience-dependent cortical plasticity...
  18. pmc PSD-95 and PSD-93 play critical but distinct roles in synaptic scaling up and down
    Qian Sun
    Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurosci 31:6800-8. 2011
    ....
  19. ncbi request reprint Critical periods for experience-dependent synaptic scaling in visual cortex
    Niraj S Desai
    Department of Biology and Volen National Center for Complex Systems, MS 008, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, USA
    Nat Neurosci 5:783-9. 2002
    ....
  20. ncbi request reprint Potentiation of cortical inhibition by visual deprivation
    Arianna Maffei
    Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02454, USA
    Nature 443:81-4. 2006
    ....
  21. pmc Firing rate homeostasis in visual cortex of freely behaving rodents
    Keith B Hengen
    Department of Biology, Brandeis University, Waltham, MA 02454, USA
    Neuron 80:335-42. 2013
    ..These data establish that homeostatic mechanisms within the intact CNS act to stabilize neuronal firing rates in the face of sustained sensory perturbations...
  22. ncbi request reprint Long-term potentiation of intrinsic excitability in LV visual cortical neurons
    Robert H Cudmore
    Department of Biology, Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454 9110, USA
    J Neurophysiol 92:341-8. 2004
    ..This suggests that LTP-IE occurs through postsynaptic calcium influx and subsequent activation of PKA. Activity-dependent plasticity in intrinsic excitability could greatly expand the computational power of individual neurons...
  23. doi request reprint Strength through diversity
    Sacha B Nelson
    Department of Biology and National Center for Behavioral Genomics, Brandeis University, MS 008, 415 South Street, Waltham, Massachusetts 02454 9110, USA
    Neuron 60:477-82. 2008
    ..A fundamental challenge for the field is to assemble our detailed knowledge of these specific mechanisms into a coherent picture of how plasticity within cortical circuits works to tune network properties...
  24. ncbi request reprint The NMDA-to-AMPA ratio at synapses onto layer 2/3 pyramidal neurons is conserved across prefrontal and visual cortices
    Chaelon I O Myme
    Department of Biology, Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454 9110, USA
    J Neurophysiol 90:771-9. 2003
    ..We conclude that this basic property of excitatory transmission is conserved across PFC and VC synapses and is therefore unlikely to contribute to differences in firing patterns observed in vivo in the two regions...
  25. pmc Rate and timing in cortical synaptic plasticity
    Sacha B Nelson
    Department of Biology and Volen Center for Complex Systems, Brandeis University, Mailstop 008, 415 South Street, Waltham, MA 02454 9110, USA
    Philos Trans R Soc Lond B Biol Sci 357:1851-7. 2002
    ..The results hold important implications for which parts of the neural code are most readily stored for later retrieval...
  26. pmc Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome
    Vardhan S Dani
    Department of Biology and Volen Center for Complex Systems, Brandeis University, MS 008, Waltham, MA 02454 9110, USA
    Proc Natl Acad Sci U S A 102:12560-5. 2005
    ..These findings provide the first detailed electrophysiological analysis of Mecp2-mutant mice and provide a framework for understanding the pathophysiology of the disease and tools for studying the underlying disease mechanisms...
  27. ncbi request reprint Endocannabinoid-dependent neocortical layer-5 LTD in the absence of postsynaptic spiking
    Per Jesper Sjöström
    Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454 9110, USA
    J Neurophysiol 92:3338-43. 2004
    ....
  28. ncbi request reprint Selective reconfiguration of layer 4 visual cortical circuitry by visual deprivation
    Arianna Maffei
    Department of Biology and Volen National Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
    Nat Neurosci 7:1353-9. 2004
    ..These effects reversed when vision was restored. This dynamic adjustment of the excitation-inhibition balance may allow the networks within layer 4 to maintain stable levels of activity in the face of variable sensory input...
  29. pmc Deprivation-induced strengthening of presynaptic and postsynaptic inhibitory transmission in layer 4 of visual cortex during the critical period
    Marc Nahmani
    Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02454
    J Neurosci 34:2571-82. 2014
    ..These coordinated changes in FS→SP synaptic strength define an expression pathway modulating excitatory output during CP plasticity in visual cortex. ..
  30. pmc Long-term inhibitory plasticity in visual cortical layer 4 switches sign at the opening of the critical period
    Sandrine Lefort
    Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454
    Proc Natl Acad Sci U S A 110:E4540-7. 2013
    ..Thus, at the opening of the CP, there are coordinated changes in plasticity that allow specific patterns of activity within layer 4 to potentiate feedback inhibition by boosting the strength of FS ↔ SP connections...
  31. pmc The self-tuning neuron: synaptic scaling of excitatory synapses
    Gina G Turrigiano
    Department of Biology, Volen Center for Complex Systems, and National Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA
    Cell 135:422-35. 2008
    ..Additional mechanisms may allow local or network-wide changes in activity to be sensed through parallel pathways, generating a nested set of homeostatic mechanisms that operate over different temporal and spatial scales...
  32. ncbi request reprint More than a sidekick: glia and homeostatic synaptic plasticity
    Gina G Turrigiano
    Department of Biology, Brandeis University, Waltham, MA 02454, USA
    Trends Mol Med 12:458-60. 2006
    ..In addition to provide insight into the mechanisms of homeostatic plasticity, these data argue for the first time for an equal partnership between glial cells and neurons in the generation of an important form of synaptic plasticity...
  33. ncbi request reprint Fast propagation of firing rates through layered networks of noisy neurons
    Mark C W van Rossum
    Department of Biology, Brandeis University, Waltham, Massachusetts 02454 9110, USA
    J Neurosci 22:1956-66. 2002
    ..The proposed mode of propagation allows for fast computation with population coding based on firing rates, as is demonstrated with a local motion detector...
  34. ncbi request reprint A recipe for ridding synapses of the ubiquitous AMPA receptor
    Gina G Turrigiano
    Dept of Biology MS 08, Brandeis University, 415 South Street, Waltham, MA 02454, USA
    Trends Neurosci 25:597-8. 2002
    ..A recent study in Ceanorhabditis elegans suggests that ubiquitination of AMPA receptors is one important signal that targets these receptors for endocytosis...
  35. pmc PSD-95 promotes the stabilization of young synaptic contacts
    Christine E Taft
    Department of Biology, Brandeis University, Waltham, MA 02454, USA
    Philos Trans R Soc Lond B Biol Sci 369:20130134. 2014
    ..Taken together, these data show that synaptic protein composition is highly variable over a time-scale of hours, and that PSD-95 is probably a key synaptic protein that promotes synapse stability. ..
  36. ncbi request reprint Activity deprivation reduces miniature IPSC amplitude by decreasing the number of postsynaptic GABA(A) receptors clustered at neocortical synapses
    Valerie Kilman
    Department of Biology and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurosci 22:1328-37. 2002
    ..Because excitatory and inhibitory synaptic currents are regulated in opposite directions by activity blockade, these data suggest that the balance between excitation and inhibition is dynamically regulated by ongoing activity...