Research Topics
Genomes and GenesSpecies | Piali SenguptaSummaryAffiliation: Brandeis University Country: USA Publications
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Publications
Sensing temperaturePiali Sengupta
Department of Biology and National Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA Electronic address
Curr Biol 23:R304-7. 2013....
The belly rules the nose: feeding state-dependent modulation of peripheral chemosensory responsesPiali Sengupta
Department of Biology and the National Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, United States
Curr Opin Neurobiol 23:68-75. 2013..Focusing primarily on recent work in C. elegans and Drosophila, I describe the neuromodulatory mechanisms that translate feeding state information into changes in chemosensory neuron response properties and behavioral output...- Left-right olfactory asymmetry results from antagonistic functions of voltage-activated calcium channels and the Raw repeat protein OLRN-1 in C. elegansSarah L Bauer Huang
Howard Hughes Medical Institute and Rockefeller University, New York, NY 10065, USA
Neural Dev 2:24. 2007..Signaling between AWC neurons induces left-right asymmetry through a gap junction network and a claudin-related protein, which inhibit a calcium-regulated MAP kinase pathway in the neuron that becomes AWCON... 
Generation and modulation of chemosensory behaviors in C. elegansPiali Sengupta
Department of Biology and National Center for Behavioral Genomics, Brandeis University, 415 South Street, Waltham, MA 02454, USA
Pflugers Arch 454:721-34. 2007..This review summarizes the current knowledge on the molecular and neuronal substrates of chemosensory behaviors and chemosensory behavioral plasticity in C. elegans...- Chemosensation: tasting with the tailPiali Sengupta
Department of Biology, Brandeis University, Waltham, MA 02454, USA
Curr Biol 12:R386-8. 2002..Recent work suggests that Caenorhabditis elegans uses chemosensory information provided by spatially distinct sensilla to generate a sensory map of its environment and to avoid noxious compounds... - Cellular reprogramming: chromatin puts on the brakePiali Sengupta
Department of Biology and National Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA
Curr Biol 21:R157-9. 2011..A recent study demonstrates that efficient reprogramming of Caenorhabditis elegans germ cells into neurons can be achieved by knocking down a histone chaperone gene and ectopic expression of a terminal selector transcription factor... - Caenorhabditis elegans: a model system for systems neurosciencePiali Sengupta
Department of Biology and National Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, United States
Curr Opin Neurobiol 19:637-43. 2009.... - Sensory signaling-dependent remodeling of olfactory cilia architecture in C. elegansSaikat Mukhopadhyay
Department of Biology and National Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA
Dev Cell 14:762-74. 2008..Our results suggest that compensatory mechanisms in response to altered levels of sensory activity modulate AWB cilia architecture, revealing remarkable plasticity in the regulation of cilia structure... - The HMX/NKX homeodomain protein MLS-2 specifies the identity of the AWC sensory neuron type via regulation of the ceh-36 Otx gene in C. elegansKyuhyung Kim
Department of Biology and National Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA
Development 137:963-74. 2010.... - KIN-29 SIK regulates chemoreceptor gene expression via an MEF2 transcription factor and a class II HDACAlexander M van der Linden
Department of Biology and National Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA
EMBO J 26:358-70. 2007..elegans... - The EGL-4 PKG acts with KIN-29 salt-inducible kinase and protein kinase A to regulate chemoreceptor gene expression and sensory behaviors in Caenorhabditis elegansAlexander M van der Linden
Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
Genetics 180:1475-91. 2008..Our results suggest that integration of complex sensory inputs via multiple signaling pathways allows animals to precisely regulate sensory gene expression, thereby appropriately modulating physiology and behavior... - Identification of thermosensory and olfactory neuron-specific genes via expression profiling of single neuron typesMarc E Colosimo
Department of Biology, Brandeis University, Waltham, MA 02454, USA
Curr Biol 14:2245-51. 2004..Expression profiling of single neuron types provides a rapid, powerful, and unbiased method for identifying neuron-specific genes whose functions can then be investigated in vivo... - Otx/otd homeobox genes specify distinct sensory neuron identities in C. elegansAnne Lanjuin
Department of Biology and Volen Center for Complex Systems, Brandeis University, 415 South Street, Waltham, MA 02454, USA
Dev Cell 5:621-33. 2003..Misexpression experiments indicate that although the specific identity adopted upon expression of an Otx gene may be constrained by the cellular context, individual Otx genes preferentially promote distinct neuronal identities... - The UNC-3 Olf/EBF protein represses alternate neuronal programs to specify chemosensory neuron identityKyuhyung Kim
Department of Biology and Volen Center for Complex Systems, Brandeis University, 415 South Street, Waltham, MA 02454, USA
Dev Biol 286:136-48. 2005.... - Regulation of neuronal lineage decisions by the HES-related bHLH protein REF-1Anne Lanjuin
Department of Biology, Brandeis University, Waltham, MA 02454, USA
Dev Biol 290:139-51. 2006..These results indicate that REF-1 functions in both Notch-dependent and independent pathways to regulate multiple developmental decisions in different neuronal sublineages... - Two chemoreceptors mediate developmental effects of dauer pheromone in C. elegansKyuhyung Kim
Department of Biology and National Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA
Science 326:994-8. 2009..Identification of dauer pheromone receptors will allow a better understanding of the signaling cascades that transduce the context-dependent effects of ecologically important chemical signals... - Cis-regulatory mechanisms of gene expression in an olfactory neuron type in Caenorhabditis elegansEva B Nokes
Department of Biology and National Center for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02454, USA
Dev Dyn 238:3080-92. 2009..Our results provide insights into the cis-regulatory logic driving cell-specific gene expression, and suggest that variations in this logic contribute to the generation of functional diversity... - An olfactory neuron responds stochastically to temperature and modulates Caenorhabditis elegans thermotactic behaviorDavid Biron
Department of Biology and National Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA
Proc Natl Acad Sci U S A 105:11002-7. 2008..Our observations suggest that the AFD and AWC neurons encode thermal stimuli via distinct strategies to regulate C. elegans thermotactic behavior... - Regulation of response properties and operating range of the AFD thermosensory neurons by cGMP signalingSara M Wasserman
Department of Biology, Brandeis University, Waltham, MA 02454, USA
Curr Biol 21:353-62. 2011..However, because AFD thermosensory responses appear to be similar at all examined temperatures above T∗(AFD), the mechanisms that generate specific behaviors in defined temperature ranges remain to be determined... - Genome-wide analysis of light- and temperature-entrained circadian transcripts in Caenorhabditis elegansAlexander M van der Linden
Department of Biology and National Center for Behavioral Genomics, Brandeis University, Waltham, Massachusetts, United States of America
PLoS Biol 8:e1000503. 2010..Together, these findings demonstrate circadian-regulated transcriptional rhythms in C. elegans and suggest that further analyses in this organism will provide new information about the evolution and function of this biological clock... - Regulation of chemosensory and GABAergic motor neuron development by the C. elegans Aristaless/Arx homolog alr-1Tali Melkman
Department of Biology, Brandeis University, 415 South Street, Brandeis, MA 02454, USA
Development 132:1935-49. 2005..Investigating ALR-1 functions in C. elegans may yield insights into the role of this important protein in neuronal development and the etiology of mental retardation... - RNAi pathways contribute to developmental history-dependent phenotypic plasticity in C. elegansSarah E Hall
Department of Biology and National Center for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02454, USA
RNA 19:306-19. 2013.... - The DAF-7 TGF-beta signaling pathway regulates chemosensory receptor gene expression in C. elegansKatherine M Nolan
Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
Genes Dev 16:3061-73. 2002..elegans is subject to multiple modes of regulation, thereby ensuring that animals exhibit the responses most appropriate for their developmental stage and environmental conditions... - The divergent orphan nuclear receptor ODR-7 regulates olfactory neuron gene expression via multiple mechanisms in Caenorhabditis elegansMarc E Colosimo
Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
Genetics 165:1779-91. 2003..The odr-7 ortholog in the closely related nematode C. briggsae can fully substitute for all ODR-7-mediated functions, indicating conservation of function across 25-120 million years of divergence... - Distinct IFT mechanisms contribute to the generation of ciliary structural diversity in C. elegansSaikat Mukhopadhyay
Department of Biology and National Center for Behavioral Genomics, Brandeis University, 415 South Street, Waltham, MA 2454, USA
EMBO J 26:2966-80. 2007..Our results suggest that cell-specific regulation of IFT contributes to the generation of ciliary diversity, and provide insights into the networks coupling the acquisition of ciliary specializations with other aspects of cell fate... - Specification of chemosensory neuron subtype identities in Caenorhabditis elegansAnne Lanjuin
Department of Biology, Brandeis University, MS008, 415 South Street, Waltham, MA 02454, USA
Curr Opin Neurobiol 14:22-30. 2004..Additional cellular complexity is generated by novel mechanisms that further diversify the identities of the left and right members of a bilateral sensory neuron pair... - Degeneracy and neuromodulation among thermosensory neurons contribute to robust thermosensory behaviors in Caenorhabditis elegansMatthew Beverly
Department of Biology and National Center for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02454, USA
J Neurosci 31:11718-27. 2011.... - The CMK-1 CaMKI and the TAX-4 Cyclic nucleotide-gated channel regulate thermosensory neuron gene expression and function in C. elegansJohn S Satterlee
Department of Biology and Volen Center for Complex Systems, Brandeis University, MS 008, Waltham, Massachusetts 02454, USA
Curr Biol 14:62-8. 2004..We propose that the activation of distinct programs of AFD-specific gene expression at different temperatures by CMK-1 and TAX-4 enables C. elegans to sense and/or encode a memory for the T(c)... - The worm's sense of smell. Development of functional diversity in the chemosensory system of Caenorhabditis elegansTali Melkman
Department of Biology, Brandeis University, Waltham, MA 02454, USA
Dev Biol 265:302-19. 2004..Such a complete description may be possible in C. elegans... - Regulation of chemosensory receptor expression and sensory signaling by the KIN-29 Ser/Thr kinaseAnne Lanjuin
Department of Biology and Volen Center for Complex Systems, Brandeis University, MS 008, 415 South Street, Waltham, MA 02454, USA
Neuron 33:369-81. 2002.... - A cellular memory of developmental history generates phenotypic diversity in C. elegansSarah E Hall
Department of Biology and National Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA
Curr Biol 20:149-55. 2010..Modifications to the epigenome as a consequence of early experience may contribute in part to a memory of early experience and generate phenotypic variation in an isogenic population... - Running hot and cold: behavioral strategies, neural circuits, and the molecular machinery for thermotaxis in C. elegans and DrosophilaPaul A Garrity
Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
Genes Dev 24:2365-82. 2010..Here, we discuss the role of thermosensation in the development and survival of C. elegans and Drosophila, and review the behavioral strategies, neuronal circuits, and molecular networks responsible for thermotaxis behavior... - The AFD sensory neurons encode multiple functions underlying thermotactic behavior in Caenorhabditis elegansDamon A Clark
Department of Physics, Harvard University, Cambridge, Massachusetts 02138, USA
J Neurosci 26:7444-51. 2006..Encoding multiple functions in individual sensory neurons may enable C. elegans to perform complex behaviors with simple neuronal circuits... - Regulation of body size and behavioral state of C. elegans by sensory perception and the EGL-4 cGMP-dependent protein kinaseManabi Fujiwara
Ernest Gallo Clinic and Research Center and Department of Neurology, Programs in Neuroscience and Biomedical Science, University of California, San Francisco, 5858 Horton Street, Suite 200, Emeryville, CA 94608, USA
Neuron 36:1091-102. 2002..elegans to regulate multiple developmental and behavioral processes including the orchestrated growth of the animal and the expression of particular behavioral states... - A diacylglycerol kinase modulates long-term thermotactic behavioral plasticity in C. elegansDavid Biron
Department of Physics, Harvard University, 17 Oxford Street, Cambridge, Massachusetts 02138, USA
Nat Neurosci 9:1499-505. 2006..These results provide the first mechanistic insight into the basis of experience-dependent plasticity in this complex behavior... - Temperature and food mediate long-term thermotactic behavioral plasticity by association-independent mechanisms in C. elegansCynthia A Chi
Department of Physics, Harvard University, Cambridge, MA 02138, USA
J Exp Biol 210:4043-52. 2007..Mutation in the tax-6 calcineurin gene abolishes thermotactic behavior altogether. In summary, we do not find evidence that long-term plasticity requires association between temperature and the presence or absence of bacterial food... - Elipsa is an early determinant of ciliogenesis that links the IFT particle to membrane-associated small GTPase Rab8Yoshihiro Omori
Department of Ophthalmology, Harvard Medical School, MEEI, R513, 243 Charles St Boston, MA 02114, USA
Nat Cell Biol 10:437-44. 2008..We show that Rabaptin5 binds to both Elipsa and Rab8, suggesting that these proteins provide a bridging mechanism between the IFT particle and protein complexes that assemble at the ciliary membrane... - From eye of newt to chemical structurePiali Sengupta
Nat Chem Biol 3:368-9. 2007 - Sensorimotor integration: locating locomotion in neural circuitsAravinthan D T Samuel
Department of Physics, Harvard University, Cambridge, Massachusetts 02138, USA
Curr Biol 15:R341-3. 2005..Several recent studies have now functionally mapped the sensorimotor circuits responsible for locomotion behaviors under defined environmental conditions in the nematode Caenorhabditis elegans... - Taking sides in the nervous system with miRNAPiali Sengupta
Nat Neurosci 7:100-2. 2004 - Identification of guanylyl cyclases that function in thermosensory neurons of Caenorhabditis elegansHitoshi Inada
Group of Molecular Neurobiology, Department of Molecular Biology, Graduate School of Science, Nagoya University, Japan
Genetics 172:2239-52. 2006..These results suggest that three guanylyl cyclases function redundantly in the AFD neurons to mediate thermosensation by C. elegans... - Smell: the worm turnsPiali Sengupta
Nature 450:35-6. 2007
Research Grants
- GENETIC ANALYSIS OF SENSORY SPECIFICATION IN C ELEGANSPiali Sengupta; Fiscal Year: 2001..Our long-term goals are to elucidate the pathways in which odr-7-like genes act in the development and function of sensory neuron types. ..
- Genetic analysis of sensory specification in C.elegansPiali Sengupta; Fiscal Year: 2009..elegans model system. We expect that this information will inform experiments aimed at driving the differentiation of defined cell types from multipotent precursors such as stem cells. ..
- Genetic analysis of sensory specification in C.elegansPiali Sengupta; Fiscal Year: 2009..elegans model system. We expect that this information will inform experiments aimed at driving the differentiation of defined cell types from multipotent precursors such as stem cells. ..
- Molecular and neuronal mechanisms of thermosensory behaviorPiali Sengupta; Fiscal Year: 2009..elegans model system. Many of these genes are expected to be conserved in other organisms including humans, and to play important roles in regulating neuron functions. ..
- Genetic analyses of Arx homeobox gene function in neurodevelopmental disordersPiali Sengupta; Fiscal Year: 2007..elegans, to investigate how Arx gene mutations affect brain development. This work may allow us to rapidly identify potential new targets for rational drug design. ..
- Genetic analysis of sensory specification in C.elegansPiali Sengupta; Fiscal Year: 2005....
- Molecular and neuronal mechanisms of thermosensory behaviorPiali Sengupta; Fiscal Year: 2010..elegans model system. Many of these genes are expected to be conserved in other organisms including humans, and to play important roles in regulating neuron functions. ..