J E Lisman

Summary

Affiliation: Brandeis University
Country: USA

Publications

  1. pmc Questions about STDP as a General Model of Synaptic Plasticity
    John Lisman
    Department of Biology and Volen Center for Complex Systems, Brandeis University Waltham, MA, USA
    Front Synaptic Neurosci 2:140. 2010
  2. pmc A Biologically Plausible Transform for Visual Recognition that is Invariant to Translation, Scale, and Rotation
    Pavel Sountsov
    Department of Biology, Volen Center for Complex Systems, Brandeis University Waltham, MA, USA
    Front Comput Neurosci 5:53. 2011
  3. pmc NR2C in the thalamic reticular nucleus; effects of the NR2C knockout
    Yuchun Zhang
    Department of Biology, Brandeis University, Waltham, Massachusetts, United States of America
    PLoS ONE 7:e41908. 2012
  4. pmc The θ-γ neural code
    John E Lisman
    Brandeis University, Department of Biology and Volen Center for Complex Systems, 415 South Street MS 008, Waltham, MA 02454 9110, USA
    Neuron 77:1002-16. 2013
  5. pmc The CaMKII/NMDAR complex as a molecular memory
    Magdalena Sanhueza
    Department of Biology, Faculty of Sciences, University of Chile, Las Palmeras 3425, Santiago 7800024, Chile
    Mol Brain 6:10. 2013
  6. doi request reprint Habit and nonhabit systems for unconscious and conscious behavior: implications for multitasking
    John Lisman
    Brandeis University, Waltham, MA 02454 9110, USA
    J Cogn Neurosci 25:273-83. 2013
  7. pmc Excitation, inhibition, local oscillations, or large-scale loops: what causes the symptoms of schizophrenia?
    John Lisman
    Biology Department and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454 9110, USA
    Curr Opin Neurobiol 22:537-44. 2012
  8. pmc NMDAR antagonist action in thalamus imposes δ oscillations on the hippocampus
    Yuchun Zhang
    Dept of Biology, Brandeis University, Waltham, MA, USA
    J Neurophysiol 107:3181-9. 2012
  9. pmc Mechanisms of CaMKII action in long-term potentiation
    John Lisman
    Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
    Nat Rev Neurosci 13:169-82. 2012
  10. pmc Activity-dependent regulation of synaptic strength by PSD-95 in CA1 neurons
    Peng Zhang
    Biology Department and Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurophysiol 107:1058-66. 2012

Research Grants

  1. CRCNS: Quantitative description of initial biochemical steps in LTP
    John E Lisman; Fiscal Year: 2010
  2. CRCNS: Memory Mechanisms: Modifiability and Stability
    John Lisman; Fiscal Year: 2006
  3. CRCNS: Memory Mechanisms: Modifiability and Stability
    John Lisman; Fiscal Year: 2005
  4. MECHANISMS OF LONG-TERM POTENTIATION
    John Lisman; Fiscal Year: 2005
  5. CRCNS: Memory Mechanisms: Modifiability and Stability
    John Lisman; Fiscal Year: 2004
  6. MECHANISMS OF LONG-TERM POTENTIATION
    John Lisman; Fiscal Year: 2004
  7. MECHANISMS OF LONG-TERM POTENTIATION
    John Lisman; Fiscal Year: 2003
  8. MECHANISMS OF LONG-TERM POTENTIATION
    John Lisman; Fiscal Year: 2002
  9. MECHANISMS OF ADAPTATION AND EXCITATION
    John Lisman; Fiscal Year: 2002
  10. MECHANISMS OF LONG-TERM POTENTIATION
    John Lisman; Fiscal Year: 2001

Collaborators

Detail Information

Publications64

  1. pmc Questions about STDP as a General Model of Synaptic Plasticity
    John Lisman
    Department of Biology and Volen Center for Complex Systems, Brandeis University Waltham, MA, USA
    Front Synaptic Neurosci 2:140. 2010
    ..These often appear to be more important than the Na(+) spike in providing the depolarization necessary for plasticity. We thus feel that it is premature to accept STDP-like processes as the major determinant of LTP/LTD...
  2. pmc A Biologically Plausible Transform for Visual Recognition that is Invariant to Translation, Scale, and Rotation
    Pavel Sountsov
    Department of Biology, Volen Center for Complex Systems, Brandeis University Waltham, MA, USA
    Front Comput Neurosci 5:53. 2011
    ....
  3. pmc NR2C in the thalamic reticular nucleus; effects of the NR2C knockout
    Yuchun Zhang
    Department of Biology, Brandeis University, Waltham, Massachusetts, United States of America
    PLoS ONE 7:e41908. 2012
    ..In contrast, NR2C KO had no effect on the strongly rectifying NMDAR current in pyramidal cells of the prefrontal cortex. These results demonstrate that the low rectification normally observed in the nRT is due to NR2C...
  4. pmc The θ-γ neural code
    John E Lisman
    Brandeis University, Department of Biology and Volen Center for Complex Systems, 415 South Street MS 008, Waltham, MA 02454 9110, USA
    Neuron 77:1002-16. 2013
    ..Recent work suggests that this coding scheme coordinates communication between brain regions and is involved in sensory as well as memory processes...
  5. pmc The CaMKII/NMDAR complex as a molecular memory
    Magdalena Sanhueza
    Department of Biology, Faculty of Sciences, University of Chile, Las Palmeras 3425, Santiago 7800024, Chile
    Mol Brain 6:10. 2013
    ..These N-cadherin pairs have redundant storage that could provide informational stability in a manner analogous to the base-pairing in DNA...
  6. doi request reprint Habit and nonhabit systems for unconscious and conscious behavior: implications for multitasking
    John Lisman
    Brandeis University, Waltham, MA 02454 9110, USA
    J Cogn Neurosci 25:273-83. 2013
    ..The benefit of such a dual system is multitasking: The unconscious system can execute background tasks, leaving the conscious system to perform more difficult tasks...
  7. pmc Excitation, inhibition, local oscillations, or large-scale loops: what causes the symptoms of schizophrenia?
    John Lisman
    Biology Department and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454 9110, USA
    Curr Opin Neurobiol 22:537-44. 2012
    ..Evidence for these hypotheses will be reviewed...
  8. pmc NMDAR antagonist action in thalamus imposes δ oscillations on the hippocampus
    Yuchun Zhang
    Dept of Biology, Brandeis University, Waltham, MA, USA
    J Neurophysiol 107:3181-9. 2012
    ..Both mechanisms may be important in producing symptoms of schizophrenia...
  9. pmc Mechanisms of CaMKII action in long-term potentiation
    John Lisman
    Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
    Nat Rev Neurosci 13:169-82. 2012
    ..These processes are all localized to stimulated spines and account for the synapse-specificity of LTP. In the later stages of LTP, CaMKII has a structural role in enlarging and strengthening the synapse...
  10. pmc Activity-dependent regulation of synaptic strength by PSD-95 in CA1 neurons
    Peng Zhang
    Biology Department and Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurophysiol 107:1058-66. 2012
    ..We conclude that PSD-95 cannot itself increase synaptic strength simply by increasing the number of AMPAR slots; rather, PSD-95's effects on synaptic strength require an activity-dependent process involving mGluR and CaMKII...
  11. pmc The excitation cascade of Limulus ventral photoreceptors: guanylate cyclase as the link between InsP3-mediated Ca2+ release and the opening of cGMP-gated channels
    Alexander V Garger
    Department of Biology and Center for Complex Systems, Brandeis University, Waltham, MA 02454 9110, USA
    BMC Neurosci 5:7. 2004
    ..At the end of the cascade, cGMP-gated channels open and generate the depolarizing receptor potential. A major unresolved issue is the intermediate process by which Ca2+ elevation leads to channel opening...
  12. pmc Prediction, sequences and the hippocampus
    John Lisman
    Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454, USA
    Philos Trans R Soc Lond B Biol Sci 364:1193-201. 2009
    ..The mechanism of sequence retrieval and the usefulness of this retrieval to guide behaviour are discussed...
  13. pmc A neural coding scheme formed by the combined function of gamma and theta oscillations
    John Lisman
    Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454 9110, USA
    Schizophr Bull 34:974-80. 2008
    ..The same coding scheme may be used in certain cortical regions to encode multi-item short-term memory. The possibility that abnormalities in theta/gamma could underlie symptoms of schizophrenia is discussed...
  14. ncbi request reprint Recall of memory sequences by interaction of the dentate and CA3: a revised model of the phase precession
    John E Lisman
    Department of Biology, Brandeis University, Volen Center for Complex Systems, Waltham, MA 02454, USA
    Neural Netw 18:1191-201. 2005
    ..Our proposal is constrained by information regarding synaptic plasticity rules, network connectivity, timing delays and theta/gamma oscillations...
  15. pmc Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia
    John E Lisman
    Department of Biology, Brandeis University, 415 South Street, Waltham, MA 02454, USA
    Trends Neurosci 31:234-42. 2008
    ..iii) Nicotine enhances the output of interneurons, and might thereby contribute to its therapeutic effect in schizophrenia...
  16. ncbi request reprint Role of the dual entorhinal inputs to hippocampus: a hypothesis based on cue/action (non-self/self) couplets
    John E Lisman
    Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454, USA
    Prog Brain Res 163:615-25. 2007
    ....
  17. ncbi request reprint Postsynaptic depolarization requirements for LTP and LTD: a critique of spike timing-dependent plasticity
    John Lisman
    Volen Center for Complex Systems, Biology Department, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, USA
    Nat Neurosci 8:839-41. 2005
    ..New experimental work suggests, however, that other mechanisms can lead to dendritic depolarization, and that backpropagating action potentials may be neither necessary nor sufficient for synaptic plasticity in vivo...
  18. ncbi request reprint The hippocampal-VTA loop: controlling the entry of information into long-term memory
    John E Lisman
    Department of Biology, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, USA
    Neuron 46:703-13. 2005
    ..These findings support a model whereby the hippocampal-VTA loop regulates the entry of information into long-term memory...
  19. ncbi request reprint The sequence of events that underlie quantal transmission at central glutamatergic synapses
    John E Lisman
    Brandeis University, Department of Biology, MS 008, 415 South Street, Waltham, Massachusetts 02454 9110, USA
    Nat Rev Neurosci 8:597-609. 2007
    ..The results give insight into the factors that control the precision of quantal transmission and provide a framework for understanding synaptic plasticity...
  20. ncbi request reprint A unified model of the presynaptic and postsynaptic changes during LTP at CA1 synapses
    John Lisman
    Department of Biology, Brandeis University, Waltham, MA 02454, USA
    Sci STKE 2006:re11. 2006
    ..The model also provides a coherent explanation for the diverse effects of GluR1 knockout on basal transmission, LTP, and distance-dependent scaling...
  21. doi request reprint The pre/post LTP debate
    John E Lisman
    Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454 9110, USA
    Neuron 63:281-4. 2009
    ..This debate is increasingly constrained by technical advances that allow central synapses to be studied with increasing precision. A possible of way of reconciling conflicting evidence is suggested...
  22. ncbi request reprint A model of synaptic memory: a CaMKII/PP1 switch that potentiates transmission by organizing an AMPA receptor anchoring assembly
    J E Lisman
    Department of Biology, Brandeis University, Waltham, MA 02454, USA
    Neuron 31:191-201. 2001
    ..1/SAP97) linkages, additional sites for anchoring AMPARs at synapses. The proposed model has substantial experimental support and elucidates principles by which a local protein complex could produce stable information storage and readout...
  23. ncbi request reprint Simultaneous roles for Ca2+ in excitation and adaptation of Limulus ventral photoreceptors
    John E Lisman
    Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454 9110, USA
    Adv Exp Med Biol 514:507-38. 2002
    ..The question of how a single second messenger can produce these two opposing effects is of obvious interest and is a topic dealt with throughout this review...
  24. pmc A neoHebbian framework for episodic memory; role of dopamine-dependent late LTP
    John Lisman
    Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454 9110, USA
    Trends Neurosci 34:536-47. 2011
    ..In this Review we discuss recent experimental findings that support the view that this 'neoHebbian' framework can account for memory behavior in a variety of learning situations...
  25. pmc Long-term potentiation: outstanding questions and attempted synthesis
    John Lisman
    Department of Biology and Volen Center for Complex Systems, MS 008, 415 South Street, Waltham, MA 02454, USA
    Philos Trans R Soc Lond B Biol Sci 358:829-42. 2003
    ..A possible reconciliation is that a reversible CaMKII switch controls the construction of modules and hyperslot assemblies from newly synthesized proteins...
  26. pmc Formation of the non-functional and functional pools of granule cells in the dentate gyrus: role of neurogenesis, LTP and LTD
    John Lisman
    Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454, USA
    J Physiol 589:1905-9. 2011
    ..Recent experimental and theoretical work is providing a better understanding of the unique memory functions of the DG/CA3 unit. This will provide a behavioural framework for testing the ideas proposed here...
  27. ncbi request reprint Working memory: the importance of theta and gamma oscillations
    John Lisman
    Biology Department and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454, USA
    Curr Biol 20:R490-2. 2010
    ..Working memory is the ability to actively hold information in the mind. Recent results demonstrate that working memory is organized by oscillatory processes in the theta and gamma frequency range...
  28. ncbi request reprint The theta/gamma discrete phase code occuring during the hippocampal phase precession may be a more general brain coding scheme
    John Lisman
    Department of Biology, Brandeis University, Waltham, MA 02454, USA
    Hippocampus 15:913-22. 2005
    ....
  29. ncbi request reprint Storage, recall, and novelty detection of sequences by the hippocampus: elaborating on the SOCRATIC model to account for normal and aberrant effects of dopamine
    J E Lisman
    Volen Center for Complex Systems, Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
    Hippocampus 11:551-68. 2001
    ....
  30. ncbi request reprint Synaptic plasticity: a molecular memory switch
    J E Lisman
    Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02453, USA
    Curr Biol 11:R788-91. 2001
    ..This binding activates CaMKII and triggers its autophosphorylation. In this state, it may act as a memory switch and strengthen synapses through enzymatic and structural processes...
  31. ncbi request reprint Is persistent activity of calcium/calmodulin-dependent kinase required for the maintenance of LTP?
    H X Chen
    Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurophysiol 85:1368-76. 2001
    ..Thus we were unable to demonstrate a functional role of persistent Ca(2+)-independent CaMKII activity in LTP maintenance. Possible explanations of the data are discussed...
  32. ncbi request reprint Gating of human theta oscillations by a working memory task
    S Raghavachari
    Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurosci 21:3175-83. 2001
    ..These results suggest that theta oscillations could have an important role in organizing multi-item working memory...
  33. ncbi request reprint A labile component of AMPA receptor-mediated synaptic transmission is dependent on microtubule motors, actin, and N-ethylmaleimide-sensitive factor
    C H Kim
    Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurosci 21:4188-94. 2001
    ..A second, nonlabile pool resembles NMDA receptor channels in being nearly insensitive to any of these agents on the hour time scale of our experiments...
  34. pmc The high variance of AMPA receptor- and NMDA receptor-mediated responses at single hippocampal synapses: evidence for multiquantal release
    Rossella Conti
    Department of Biology and Volen Center for Complex Systems, MS 008, Brandeis University, 415 South Street, Waltham, MA 02454, USA
    Proc Natl Acad Sci U S A 100:4885-90. 2003
    ..The existence of multiquantal release has important implications for defining synaptic strength and understanding the mechanisms of synaptic plasticity...
  35. pmc Autonomous CaMKII can promote either long-term potentiation or long-term depression, depending on the state of T305/T306 phosphorylation
    Hyun Jae Pi
    Physics Department, Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurosci 30:8704-9. 2010
    ..Therefore, autonomous CaMKII can lead to either LTP or LTD, depending on the phosphorylation state of the control point, T305/T306...
  36. pmc A single brief burst induces GluR1-dependent associative short-term potentiation: a potential mechanism for short-term memory
    Martha A Erickson
    Brandeis University, Waltham, MA, USA
    J Cogn Neurosci 22:2530-40. 2010
    ..Enhanced long-term and impaired short-term spatial memory in GluA1 AMPA receptor subunit knockout mice: Evidence for a dual-process memory model. Learning and Memory, 2009], provide genetic evidence that STP is a likely mechanism of STM...
  37. ncbi request reprint Bursting neurons signal input slope
    Adam Kepecs
    Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454 9110, USA
    J Neurosci 22:9053-62. 2002
    ..This possibility could be further examined experimentally by looking for correlations between burst duration and stimulus variables...
  38. pmc CaMKII control of spine size and synaptic strength: role of phosphorylation states and nonenzymatic action
    Hyun Jae Pi
    Quantitative Biology Program, Physics Department, Brandeis University, Waltham, MA 02454, USA
    Proc Natl Acad Sci U S A 107:14437-42. 2010
    ..This form fails to enhance synaptic strength but increases spine size, presumably by a structural process. Thus very different mechanisms govern how CaMKII affects spine structure and synaptic function...
  39. ncbi request reprint Actin's actions in LTP-induced synapse growth
    John Lisman
    Biology Department, Brandeis University, Volen Center for Complex Systems, Waltham, MA 02454, USA
    Neuron 38:361-2. 2003
    ..Furthermore, these spines have large synapses, strongly suggesting that LTP involves synapse growth. This process appears to require LIMK-1 phosphorylation of the actin depolymerizing factor cofilin...
  40. ncbi request reprint Forskolin-induced LTP in the CA1 hippocampal region is NMDA receptor dependent
    Nikolai Otmakhov
    Brandeis University, Volen Center for Complex Systems, Waltham, Massachusetts 02454, USA
    J Neurophysiol 91:1955-62. 2004
    ..The method of inducing cLTP in slice cultures will be useful when it is desirable to produce NMDAR-dependent LTP in a large fraction of synapses...
  41. ncbi request reprint Synaptic strength of individual spines correlates with bound Ca2+-calmodulin-dependent kinase II
    Brent Asrican
    Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurosci 27:14007-11. 2007
    ..The results are consistent with the hypothesis that bound CaMKII serves as a structural organizer of postsynaptic molecules and thereby may be involved in maintaining spine size and synaptic strength...
  42. ncbi request reprint Information encoding and computation with spikes and bursts
    Adam Kepecs
    Volen Center for Complex Systems, Brandeis University, 415 South Street, Waltham, MA 02454, USA
    Network 14:103-18. 2003
    ..These findings lead us to propose that the biophysical mechanisms of spike generation enables individual neurons to encode different stimulus features into distinct spike patterns...
  43. ncbi request reprint A cGMP-gated channel subunit in Limulus photoreceptors
    F H Chen
    Volen Center for Complex Systems and Department of Biology, Brandeis University, Waltham, MA 02454, USA
    Vis Neurosci 18:517-26. 2001
    ..Preabsorption of the antiserum with antigen abolished the labeling, confirming specificity. The results lend support to the hypothesis that a cGMP-gated channel is directly involved in the phototransduction process...
  44. ncbi request reprint Inhibitors of guanylate cyclase inhibit phototransduction in limulus ventral photoreceptors
    A Garger
    Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454-9110, USA
    Vis Neurosci 18:625-32. 2001
    ..None of these agents had any substantial effect on phototransduction. Taken together, these results support a role for a particulate guanylate cyclase in Limulus photoreceptor excitation...
  45. ncbi request reprint Recognition by top-down and bottom-up processing in cortex: the control of selective attention
    Dan Graboi
    Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurophysiol 90:798-810. 2003
    ..More generally the model provides a physiologically plausible view of how bi-directional signal flow in cortex guides attention to produce efficient recognition...
  46. ncbi request reprint LTP: perils and progress
    John Lisman
    Department of Biology, Brandeis University, Waltham, Massachusetts, 02454, USA
    Nat Rev Neurosci 4:926-9. 2003
  47. ncbi request reprint Persistent accumulation of calcium/calmodulin-dependent protein kinase II in dendritic spines after induction of NMDA receptor-dependent chemical long-term potentiation
    Nikolai Otmakhov
    Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurosci 24:9324-31. 2004
    ..cLTP produced a persistent increase in the PSD-associated pool of CaMKIIalpha. These results are consistent with the hypothesis that CaMKIIalpha accumulation at synapses is a memory trace of past synaptic activity...
  48. ncbi request reprint Role of the neurogranin concentrated in spines in the induction of long-term potentiation
    Anatol M Zhabotinsky
    Department of Chemistry, Brandeis University, Waltham, Massachusetts 02454 9110, USA
    J Neurosci 26:7337-47. 2006
    ..Therefore, inducing LTP with a short tetanus requires calmodulin stored in spines in the form of rapidly dissociating calmodulin-neurogranin complexes...
  49. ncbi request reprint Testing the role of calmodulin in the excitation of Limulus photoreceptors
    Alexander V Garger
    Department of Biology, Brandeis University, Waltham, MA 02454 9110, USA
    Neurosci Lett 406:6-10. 2006
    ..We conclude that calmodulin should be considered a candidate to couple intermediate and late stages of the transduction cascade...
  50. ncbi request reprint Inhibition of perforant path input to the CA1 region by serotonin and noradrenaline
    Nonna A Otmakhova
    Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454, USA
    J Neurophysiol 94:1413-22. 2005
    ..We conclude that NE inhibits the PP fEPSP through postsynaptic action on alpha2-adrenoceptors and that 5-HT7, 5-HT2, and some other receptor may be involved in 5-HT action in PP...
  51. ncbi request reprint Reversal of synaptic memory by Ca2+/calmodulin-dependent protein kinase II inhibitor
    Magdalena Sanhueza
    Departamento de Biologia, Facultad de Ciencias, Universidad de Chile, Santiago 780 0024, Chile
    J Neurosci 27:5190-9. 2007
    ..The procedure also enhanced the LTP that could be induced in the control pathway, consistent with the idea that CaMKII is involved in controlling basal synaptic strength, perhaps as a result of LTP that occurred in vivo...
  52. ncbi request reprint Postsynaptic application of a cAMP analogue reverses long-term potentiation in hippocampal CA1 pyramidal neurons
    Nikolai Otmakhov
    Volen Center, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurophysiol 87:3018-32. 2002
    ..We conclude that there are postsynaptic cyclic nucleotide-dependent processes that can specifically alter the mechanisms that maintain LTP and that are not primarily dependent on PKA...
  53. ncbi request reprint Model for a robust neural integrator
    Alexei A Koulakov
    Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Neurosci 5:775-82. 2002
    ..Neither circuit requires fine tuning to perform robust integration, and the latter actually exploits the variability of neuronal conductances...
  54. ncbi request reprint Hippocampus, II: memory connections
    John E Lisman
    Am J Psychiatry 162:239. 2005
  55. pmc A structural mechanism for maintaining the 'on-state' of the CaMKII memory switch in the post-synaptic density
    Praseeda Mullasseril
    Department of Biology, Brandeis University, Waltham, Massachusetts, USA
    J Neurochem 103:357-64. 2007
    ....
  56. pmc Memory retrieval time and memory capacity of the CA3 network: role of gamma frequency oscillations
    Licurgo de Almeida
    Neuroscience Program, UFRGS, Porto Alegre, 90046 900, Brazil
    Learn Mem 14:795-806. 2007
    ..The recall process generates the phase precession in dentate, CA3, and entorhinal cortex...
  57. ncbi request reprint Pathway-specific properties of AMPA and NMDA-mediated transmission in CA1 hippocampal pyramidal cells
    Nonna A Otmakhova
    Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurosci 22:1199-207. 2002
    ..The difference in ratio thus cannot be attributed to regenerative currents. The higher NMDA component of the distal PP synapses could help to make these synapses more powerful under depolarizing conditions...
  58. ncbi request reprint Hippocampal sequence-encoding driven by a cortical multi-item working memory buffer
    Ole Jensen
    FC Donders Centre for Cognitive Neuroimaging, PO Box 9101, NL 6500 HB Nijmegen, The Netherlands
    Trends Neurosci 28:67-72. 2005
    ..In such a buffer, memory items that occurred seconds apart are represented with a temporal separation of 20-30 ms, thereby bringing them within the LTP window. The physiological and behavioral evidence for such a buffer will be reviewed...
  59. ncbi request reprint Contribution of Ih and GABAB to synaptically induced afterhyperpolarizations in CA1: a brake on the NMDA response
    Nonna A Otmakhova
    Department of Biology, Brandeis Univ, 415 South St, Waltham, MA 02454, USA
    J Neurophysiol 92:2027-39. 2004
    ..Blockade of the AHP converted a response that had a small NMDA component to one that had a large component. These results indicate that the Ih and postsynaptic GABAB conductances act as a brake on distally generated NMDA responses...
  60. ncbi request reprint Properties of quantal transmission at CA1 synapses
    Sridhar Raghavachari
    Dept of Biology and Volen Center for Complex Systems, Brandeis University MS 008, 415 South S, Waltham, MA 02454, USA
    J Neurophysiol 92:2456-67. 2004
    ....
  61. pmc The stability of a stochastic CaMKII switch: dependence on the number of enzyme molecules and protein turnover
    Paul Miller
    Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts, USA
    PLoS Biol 3:e107. 2005
    ..Our computational results show that, depending on the timescale of fluctuations in enzyme numbers, for a switch composed of about 15 CaMKII holoenzymes, the stable persistent activation can span from a few years to a human lifetime...
  62. ncbi request reprint Distribution of postsynaptic density (PSD)-95 and Ca2+/calmodulin-dependent protein kinase II at the PSD
    Jennifer D Petersen
    Laboratory of Neurobiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 23:11270-8. 2003
    ..This variability is significantly higher than that for PSD-95 and is consistent with an information storage role for CaMKII...

Research Grants49

  1. CRCNS: Quantitative description of initial biochemical steps in LTP
    John E Lisman; Fiscal Year: 2010
    ..There are also medical implications: understanding the early steps of synaptic plasticity may give insight into learning disorders. Ng, one of the proteins to be studied, is a risk gene for schizophrenia. ..
  2. CRCNS: Memory Mechanisms: Modifiability and Stability
    John Lisman; Fiscal Year: 2006
    ..The insights derived are likely to be of importance in understanding diseases of memory and suggest strategies for therapeutic intervention. ..
  3. CRCNS: Memory Mechanisms: Modifiability and Stability
    John Lisman; Fiscal Year: 2005
    ..The insights derived are likely to be of importance in understanding diseases of memory and suggest strategies for therapeutic intervention. ..
  4. MECHANISMS OF LONG-TERM POTENTIATION
    John Lisman; Fiscal Year: 2005
    ..abstract_text> ..
  5. CRCNS: Memory Mechanisms: Modifiability and Stability
    John Lisman; Fiscal Year: 2004
    ..The insights derived are likely to be of importance in understanding diseases of memory and suggest strategies for therapeutic intervention. ..
  6. MECHANISMS OF LONG-TERM POTENTIATION
    John Lisman; Fiscal Year: 2004
    ..abstract_text> ..
  7. MECHANISMS OF LONG-TERM POTENTIATION
    John Lisman; Fiscal Year: 2003
    ..Consistent with this view, preliminary results indicate that a microtubule-motor system and a vesicle fusion process is required for maintaining AMPA transmission. ..
  8. MECHANISMS OF LONG-TERM POTENTIATION
    John Lisman; Fiscal Year: 2002
    ..Consistent with this view, preliminary results indicate that a microtubule-motor system and a vesicle fusion process is required for maintaining AMPA transmission. ..
  9. MECHANISMS OF ADAPTATION AND EXCITATION
    John Lisman; Fiscal Year: 2002
    ....
  10. MECHANISMS OF LONG-TERM POTENTIATION
    John Lisman; Fiscal Year: 2001
    ..Consistent with this view, preliminary results indicate that a microtubule-motor system and a vesicle fusion process is required for maintaining AMPA transmission. ..
  11. MECHANISMS OF ADAPTATION AND EXCITATION
    John Lisman; Fiscal Year: 2001
    ....
  12. MECHANISMS OF LONG-TERM POTENTIATION
    John Lisman; Fiscal Year: 2006
    ..abstract_text> ..
  13. MECHANISMS OF LONG-TERM POTENTIATION
    John Lisman; Fiscal Year: 2006
    ..abstract_text> ..
  14. MECHANISMS OF LONG-TERM POTENTIATION
    John E Lisman; Fiscal Year: 2010
    ..Positive results would strongly argue that the CaMKII-NMDA complex is critical for the storage of synaptic memory and would set the stage for studying the role of this complex in the maintenance of behavioral memory. ..
  15. CRCNS: Quantitative description of initial biochemical steps in LTP
    John E Lisman; Fiscal Year: 2010
    ..There are also medical implications: understanding the early steps of synaptic plasticity may give insight into learning disorders. Ng, one of the proteins to be studied, is a risk gene for schizophrenia. ..
  16. MECHANISMS OF LONG-TERM POTENTIATION
    John Lisman; Fiscal Year: 2009
    ..abstract_text> ..
  17. Role of NMDA receptors in awake-state thalamocortical slow waves
    John E Lisman; Fiscal Year: 2010
    ..The cellular and molecular causes of this dysrhythmia in the thalamus will be investigated. A major clue appears to be the ability of NMDA recent antagonists to mimic the dysrhythmia. ..
  18. CRCNS: Quantitative description of initial biochemical steps in LTP
    John Lisman; Fiscal Year: 2009
    ..There are also medical implications: understanding the early steps of synaptic plasticity may give insight into learning disorders. Ng, one of the proteins to be studied, is a risk gene for schizophrenia. ..
  19. MECHANISMS OF LONG-TERM POTENTIATION
    John Lisman; Fiscal Year: 2009
    ..Positive results would strongly argue that the CaMKII-NMDA complex is critical for the storage of synaptic memory and would set the stage for studying the role of this complex in the maintenance of behavioral memory. ..
  20. MECHANISMS OF LONG-TERM POTENTIATION
    John Lisman; Fiscal Year: 2007
    ..abstract_text> ..
  21. NEUROSCIENCE: FROM CHANNELS TO BEHAVIOR
    John Lisman; Fiscal Year: 2007
    ..Our broad-based training environment and strengths in computational neuroscience provide a unique environment for teaching students how cognitively relevant brain computations emerge from molecular, cellular and network processes. ..
  22. CRCNS: Memory Mechanisms: Modifiability and Stability
    John Lisman; Fiscal Year: 2007
    ..The insights derived are likely to be of importance in understanding diseases of memory and suggest strategies for therapeutic intervention. ..
  23. MECHANISMS OF ADAPTATION AND EXCITATION
    John Lisman; Fiscal Year: 2000
    ....
  24. MECHANISMS OF LONG-TERM POTENTIATION
    John Lisman; Fiscal Year: 2000
    ..Consistent with this view, preliminary results indicate that a microtubule-motor system and a vesicle fusion process is required for maintaining AMPA transmission. ..
  25. MECHANISM OF LONG-TERM POTENTIATION
    John Lisman; Fiscal Year: 1990
    ..These studies will provide the first systematic test of the most explicit model of neuronal information storage yet proposed. The information acquired may well be relevant to the general questions of memory storage...
  26. MECHANISMS OF LONG-TERM POTENTIATION
    John Lisman; Fiscal Year: 1999
    ..The experiments are aimed at determining how phosphatases affect the synaptic response and how they contribute to the activity-dependent weakening of synapses. ..
  27. MECHANISMS OF ADAPTATION AND EXCITATION
    John Lisman; Fiscal Year: 1999
    ....
  28. MECHANISM OF LONG-TERM POTENTIATION
    John Lisman; Fiscal Year: 1991
    ..These studies will provide the first systematic test of the most explicit model of neuronal information storage yet proposed. The information acquired may well be relevant to the general questions of memory storage...
  29. MECHANISM OF LONG-TERM POTENTIATION
    John Lisman; Fiscal Year: 1992
    ..These studies will provide the first systematic test of the most explicit model of neuronal information storage yet proposed. The information acquired may well be relevant to the general questions of memory storage...
  30. MECHANISMS OF ADAPTATION
    John Lisman; Fiscal Year: 1980
    ....
  31. MECHANISM OF LONG-TERM POTENTIATION
    John Lisman; Fiscal Year: 1993
    ..These studies will provide the first systematic test of the most explicit model of neuronal information storage yet proposed. The information acquired may well be relevant to the general questions of memory storage...