Research Topics
Species | J E LismanSummaryAffiliation: Brandeis University Country: USA Publications
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Publications
The theta-gamma neural codeJohn E Lisman
Brandeis University, Department of Biology and Volen Center for Complex Systems, 415 South Street MS 008, Waltham, MA 02454 9110, USA
Neuron 77:1002-16. 2013..Recent work suggests that this coding scheme coordinates communication between brain regions and is involved in sensory as well as memory processes...- The CaMKII/NMDAR complex as a molecular memoryMagdalena Sanhueza
Volen Center for Complex Systems, Biology Department, Brandeis University, 415 South Street, MS 008, Waltham, MA 02454 9110, USA
Mol Brain 6:10. 2013..These N-cadherin pairs have redundant storage that could provide informational stability in a manner analogous to the base-pairing in DNA... 
Habit and nonhabit systems for unconscious and conscious behavior: implications for multitaskingJohn Lisman
Brandeis University, Waltham, MA 02454 9110, USA
J Cogn Neurosci 25:273-83. 2013..The benefit of such a dual system is multitasking: The unconscious system can execute background tasks, leaving the conscious system to perform more difficult tasks...- Excitation, inhibition, local oscillations, or large-scale loops: what causes the symptoms of schizophrenia?John Lisman
Biology Department and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454 9110, USA
Curr Opin Neurobiol 22:537-44. 2012..Evidence for these hypotheses will be reviewed... - NMDAR antagonist action in thalamus imposes δ oscillations on the hippocampusYuchun Zhang
Dept of Biology, Brandeis University, Waltham, MA, USA
J Neurophysiol 107:3181-9. 2012..Both mechanisms may be important in producing symptoms of schizophrenia... - Mechanisms of CaMKII action in long-term potentiationJohn Lisman
Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
Nat Rev Neurosci 13:169-82. 2012..These processes are all localized to stimulated spines and account for the synapse-specificity of LTP. In the later stages of LTP, CaMKII has a structural role in enlarging and strengthening the synapse... - Activity-dependent regulation of synaptic strength by PSD-95 in CA1 neuronsPeng Zhang
Biology Department and Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
J Neurophysiol 107:1058-66. 2012..We conclude that PSD-95 cannot itself increase synaptic strength simply by increasing the number of AMPAR slots; rather, PSD-95's effects on synaptic strength require an activity-dependent process involving mGluR and CaMKII... - The excitation cascade of Limulus ventral photoreceptors: guanylate cyclase as the link between InsP3-mediated Ca2+ release and the opening of cGMP-gated channelsAlexander V Garger
Department of Biology and Center for Complex Systems, Brandeis University, Waltham, MA 02454 9110, USA
BMC Neurosci 5:7. 2004..At the end of the cascade, cGMP-gated channels open and generate the depolarizing receptor potential. A major unresolved issue is the intermediate process by which Ca2+ elevation leads to channel opening... - A neural coding scheme formed by the combined function of gamma and theta oscillationsJohn Lisman
Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454 9110, USA
Schizophr Bull 34:974-80. 2008..The same coding scheme may be used in certain cortical regions to encode multi-item short-term memory. The possibility that abnormalities in theta/gamma could underlie symptoms of schizophrenia is discussed... 
Postsynaptic depolarization requirements for LTP and LTD: a critique of spike timing-dependent plasticityJohn Lisman
Volen Center for Complex Systems, Biology Department, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, USA
Nat Neurosci 8:839-41. 2005..New experimental work suggests, however, that other mechanisms can lead to dendritic depolarization, and that backpropagating action potentials may be neither necessary nor sufficient for synaptic plasticity in vivo...- The hippocampal-VTA loop: controlling the entry of information into long-term memoryJohn E Lisman
Department of Biology, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, USA
Neuron 46:703-13. 2005..These findings support a model whereby the hippocampal-VTA loop regulates the entry of information into long-term memory... - Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophreniaJohn E Lisman
Department of Biology, Brandeis University, 415 South Street, Waltham, MA 02454, USA
Trends Neurosci 31:234-42. 2008..iii) Nicotine enhances the output of interneurons, and might thereby contribute to its therapeutic effect in schizophrenia... - Role of the dual entorhinal inputs to hippocampus: a hypothesis based on cue/action (non-self/self) coupletsJohn E Lisman
Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454, USA
Prog Brain Res 163:615-25. 2007.... - The sequence of events that underlie quantal transmission at central glutamatergic synapsesJohn E Lisman
Brandeis University, Department of Biology, MS 008, 415 South Street, Waltham, Massachusetts 02454 9110, USA
Nat Rev Neurosci 8:597-609. 2007..The results give insight into the factors that control the precision of quantal transmission and provide a framework for understanding synaptic plasticity... - A unified model of the presynaptic and postsynaptic changes during LTP at CA1 synapsesJohn Lisman
Department of Biology, Brandeis University, Waltham, MA 02454, USA
Sci STKE 2006:re11. 2006..The model also provides a coherent explanation for the diverse effects of GluR1 knockout on basal transmission, LTP, and distance-dependent scaling... - Recall of memory sequences by interaction of the dentate and CA3: a revised model of the phase precessionJohn E Lisman
Department of Biology, Brandeis University, Volen Center for Complex Systems, Waltham, MA 02454, USA
Neural Netw 18:1191-201. 2005..Our proposal is constrained by information regarding synaptic plasticity rules, network connectivity, timing delays and theta/gamma oscillations... - The theta/gamma discrete phase code occuring during the hippocampal phase precession may be a more general brain coding schemeJohn Lisman
Department of Biology, Brandeis University, Waltham, MA 02454, USA
Hippocampus 15:913-22. 2005.... - The pre/post LTP debateJohn E Lisman
Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454 9110, USA
Neuron 63:281-4. 2009..This debate is increasingly constrained by technical advances that allow central synapses to be studied with increasing precision. A possible of way of reconciling conflicting evidence is suggested... - Working memory: the importance of theta and gamma oscillationsJohn Lisman
Biology Department and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454, USA
Curr Biol 20:R490-2. 2010..Working memory is the ability to actively hold information in the mind. Recent results demonstrate that working memory is organized by oscillatory processes in the theta and gamma frequency range... - Long-term potentiation: outstanding questions and attempted synthesisJohn Lisman
Department of Biology and Volen Center for Complex Systems, MS 008, 415 South Street, Waltham, MA 02454, USA
Philos Trans R Soc Lond B Biol Sci 358:829-42. 2003..A possible reconciliation is that a reversible CaMKII switch controls the construction of modules and hyperslot assemblies from newly synthesized proteins... - Formation of the non-functional and functional pools of granule cells in the dentate gyrus: role of neurogenesis, LTP and LTDJohn Lisman
Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454, USA
J Physiol 589:1905-9. 2011..Recent experimental and theoretical work is providing a better understanding of the unique memory functions of the DG/CA3 unit. This will provide a behavioural framework for testing the ideas proposed here... - Simultaneous roles for Ca2+ in excitation and adaptation of Limulus ventral photoreceptorsJohn E Lisman
Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454 9110, USA
Adv Exp Med Biol 514:507-38. 2002..The question of how a single second messenger can produce these two opposing effects is of obvious interest and is a topic dealt with throughout this review... - A neoHebbian framework for episodic memory; role of dopamine-dependent late LTPJohn Lisman
Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454 9110, USA
Trends Neurosci 34:536-47. 2011..In this Review we discuss recent experimental findings that support the view that this 'neoHebbian' framework can account for memory behavior in a variety of learning situations... - Prediction, sequences and the hippocampusJohn Lisman
Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454, USA
Philos Trans R Soc Lond B Biol Sci 364:1193-201. 2009..The mechanism of sequence retrieval and the usefulness of this retrieval to guide behaviour are discussed... - A model of synaptic memory: a CaMKII/PP1 switch that potentiates transmission by organizing an AMPA receptor anchoring assemblyJ E Lisman
Department of Biology, Brandeis University, Waltham, MA 02454, USA
Neuron 31:191-201. 2001..1/SAP97) linkages, additional sites for anchoring AMPARs at synapses. The proposed model has substantial experimental support and elucidates principles by which a local protein complex could produce stable information storage and readout... - Synaptic plasticity: a molecular memory switchJ E Lisman
Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02453, USA
Curr Biol 11:R788-91. 2001..This binding activates CaMKII and triggers its autophosphorylation. In this state, it may act as a memory switch and strengthen synapses through enzymatic and structural processes... - Storage, recall, and novelty detection of sequences by the hippocampus: elaborating on the SOCRATIC model to account for normal and aberrant effects of dopamineJ E Lisman
Volen Center for Complex Systems, Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
Hippocampus 11:551-68. 2001.... - Gating of human theta oscillations by a working memory taskS Raghavachari
Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
J Neurosci 21:3175-83. 2001..These results suggest that theta oscillations could have an important role in organizing multi-item working memory... - Is persistent activity of calcium/calmodulin-dependent kinase required for the maintenance of LTP?H X Chen
Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
J Neurophysiol 85:1368-76. 2001..Thus we were unable to demonstrate a functional role of persistent Ca(2+)-independent CaMKII activity in LTP maintenance. Possible explanations of the data are discussed... - A labile component of AMPA receptor-mediated synaptic transmission is dependent on microtubule motors, actin, and N-ethylmaleimide-sensitive factorC H Kim
Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
J Neurosci 21:4188-94. 2001..A second, nonlabile pool resembles NMDA receptor channels in being nearly insensitive to any of these agents on the hour time scale of our experiments... - The high variance of AMPA receptor- and NMDA receptor-mediated responses at single hippocampal synapses: evidence for multiquantal releaseRossella Conti
Department of Biology and Volen Center for Complex Systems, MS 008, Brandeis University, 415 South Street, Waltham, MA 02454, USA
Proc Natl Acad Sci U S A 100:4885-90. 2003..The existence of multiquantal release has important implications for defining synaptic strength and understanding the mechanisms of synaptic plasticity... - A single brief burst induces GluR1-dependent associative short-term potentiation: a potential mechanism for short-term memoryMartha A Erickson
Brandeis University, Waltham, MA, USA
J Cogn Neurosci 22:2530-40. 2010..Enhanced long-term and impaired short-term spatial memory in GluA1 AMPA receptor subunit knockout mice: Evidence for a dual-process memory model. Learning and Memory, 2009], provide genetic evidence that STP is a likely mechanism of STM... - Autonomous CaMKII can promote either long-term potentiation or long-term depression, depending on the state of T305/T306 phosphorylationHyun Jae Pi
Physics Department, Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
J Neurosci 30:8704-9. 2010..Therefore, autonomous CaMKII can lead to either LTP or LTD, depending on the phosphorylation state of the control point, T305/T306... - CaMKII control of spine size and synaptic strength: role of phosphorylation states and nonenzymatic actionHyun Jae Pi
Quantitative Biology Program, Physics Department, Brandeis University, Waltham, MA 02454, USA
Proc Natl Acad Sci U S A 107:14437-42. 2010..This form fails to enhance synaptic strength but increases spine size, presumably by a structural process. Thus very different mechanisms govern how CaMKII affects spine structure and synaptic function... - Actin's actions in LTP-induced synapse growthJohn Lisman
Biology Department, Brandeis University, Volen Center for Complex Systems, Waltham, MA 02454, USA
Neuron 38:361-2. 2003..Furthermore, these spines have large synapses, strongly suggesting that LTP involves synapse growth. This process appears to require LIMK-1 phosphorylation of the actin depolymerizing factor cofilin... - Bursting neurons signal input slopeAdam Kepecs
Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454-9110, USA
J Neurosci 22:9053-62. 2002..This possibility could be further examined experimentally by looking for correlations between burst duration and stimulus variables... - Information encoding and computation with spikes and burstsAdam Kepecs
Volen Center for Complex Systems, Brandeis University, 415 South Street, Waltham, MA 02454, USA
Network 14:103-18. 2003..These findings lead us to propose that the biophysical mechanisms of spike generation enables individual neurons to encode different stimulus features into distinct spike patterns... - Forskolin-induced LTP in the CA1 hippocampal region is NMDA receptor dependentNikolai Otmakhov
Brandeis University, Volen Center for Complex Systems, Waltham, Massachusetts 02454, USA
J Neurophysiol 91:1955-62. 2004..The method of inducing cLTP in slice cultures will be useful when it is desirable to produce NMDAR-dependent LTP in a large fraction of synapses... - Synaptic strength of individual spines correlates with bound Ca2+-calmodulin-dependent kinase IIBrent Asrican
Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
J Neurosci 27:14007-11. 2007..The results are consistent with the hypothesis that bound CaMKII serves as a structural organizer of postsynaptic molecules and thereby may be involved in maintaining spine size and synaptic strength... - Inhibitors of guanylate cyclase inhibit phototransduction in limulus ventral photoreceptorsA Garger
Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454-9110, USA
Vis Neurosci 18:625-32. 2001..None of these agents had any substantial effect on phototransduction. Taken together, these results support a role for a particulate guanylate cyclase in Limulus photoreceptor excitation... - A cGMP-gated channel subunit in Limulus photoreceptorsF H Chen
Volen Center for Complex Systems and Department of Biology, Brandeis University, Waltham, MA 02454, USA
Vis Neurosci 18:517-26. 2001..Preabsorption of the antiserum with antigen abolished the labeling, confirming specificity. The results lend support to the hypothesis that a cGMP-gated channel is directly involved in the phototransduction process... - Recognition by top-down and bottom-up processing in cortex: the control of selective attentionDan Graboi
Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
J Neurophysiol 90:798-810. 2003..More generally the model provides a physiologically plausible view of how bi-directional signal flow in cortex guides attention to produce efficient recognition... - LTP: perils and progressJohn Lisman
Department of Biology, Brandeis University, Waltham, Massachusetts, 02454, USA
Nat Rev Neurosci 4:926-9. 2003 - Persistent accumulation of calcium/calmodulin-dependent protein kinase II in dendritic spines after induction of NMDA receptor-dependent chemical long-term potentiationNikolai Otmakhov
Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
J Neurosci 24:9324-31. 2004..cLTP produced a persistent increase in the PSD-associated pool of CaMKIIalpha. These results are consistent with the hypothesis that CaMKIIalpha accumulation at synapses is a memory trace of past synaptic activity... - Pathway-specific properties of AMPA and NMDA-mediated transmission in CA1 hippocampal pyramidal cellsNonna A Otmakhova
Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
J Neurosci 22:1199-207. 2002..The difference in ratio thus cannot be attributed to regenerative currents. The higher NMDA component of the distal PP synapses could help to make these synapses more powerful under depolarizing conditions... - Postsynaptic application of a cAMP analogue reverses long-term potentiation in hippocampal CA1 pyramidal neuronsNikolai Otmakhov
Volen Center, Brandeis University, Waltham, Massachusetts 02454, USA
J Neurophysiol 87:3018-32. 2002..We conclude that there are postsynaptic cyclic nucleotide-dependent processes that can specifically alter the mechanisms that maintain LTP and that are not primarily dependent on PKA... - Model for a robust neural integratorAlexei A Koulakov
Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Nat Neurosci 5:775-82. 2002..Neither circuit requires fine tuning to perform robust integration, and the latter actually exploits the variability of neuronal conductances... - Inhibition of perforant path input to the CA1 region by serotonin and noradrenalineNonna A Otmakhova
Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454, USA
J Neurophysiol 94:1413-22. 2005..We conclude that NE inhibits the PP fEPSP through postsynaptic action on alpha2-adrenoceptors and that 5-HT7, 5-HT2, and some other receptor may be involved in 5-HT action in PP... - Role of the neurogranin concentrated in spines in the induction of long-term potentiationAnatol M Zhabotinsky
Department of Chemistry, Brandeis University, Waltham, Massachusetts 02454 9110, USA
J Neurosci 26:7337-47. 2006..Therefore, inducing LTP with a short tetanus requires calmodulin stored in spines in the form of rapidly dissociating calmodulin-neurogranin complexes... - Properties of quantal transmission at CA1 synapsesSridhar Raghavachari
Dept. of Biology and Volen Center for Complex Systems, Brandeis University MS 008, 415 South S, Waltham, MA 02454, USA
J Neurophysiol 92:2456-67. 2004.... - Memory retrieval time and memory capacity of the CA3 network: role of gamma frequency oscillationsLicurgo de Almeida
Neuroscience Program, UFRGS, Porto Alegre, 90046 900, Brazil
Learn Mem 14:795-806. 2007..The recall process generates the phase precession in dentate, CA3, and entorhinal cortex... - Testing the role of calmodulin in the excitation of Limulus photoreceptorsAlexander V Garger
Department of Biology, Brandeis University, Waltham, MA 02454-9110, USA
Neurosci Lett 406:6-10. 2006..We conclude that calmodulin should be considered a candidate to couple intermediate and late stages of the transduction cascade... - Hippocampus, II: memory connectionsJohn E Lisman
Am J Psychiatry 162:239. 2005 - Reversal of synaptic memory by Ca2+/calmodulin-dependent protein kinase II inhibitorMagdalena Sanhueza
Departamento de Biologia, Facultad de Ciencias, Universidad de Chile, Santiago 780 0024, Chile
J Neurosci 27:5190-9. 2007..The procedure also enhanced the LTP that could be induced in the control pathway, consistent with the idea that CaMKII is involved in controlling basal synaptic strength, perhaps as a result of LTP that occurred in vivo... - Hippocampal sequence-encoding driven by a cortical multi-item working memory bufferOle Jensen
FC Donders Centre for Cognitive Neuroimaging, PO Box 9101, NL-6500 HB Nijmegen, The Netherlands
Trends Neurosci 28:67-72. 2005..In such a buffer, memory items that occurred seconds apart are represented with a temporal separation of 20-30 ms, thereby bringing them within the LTP window. The physiological and behavioral evidence for such a buffer will be reviewed... - A structural mechanism for maintaining the 'on-state' of the CaMKII memory switch in the post-synaptic densityPraseeda Mullasseril
Department of Biology, Brandeis University, Waltham, Massachusetts, USA
J Neurochem 103:357-64. 2007.... - Contribution of Ih and GABAB to synaptically induced afterhyperpolarizations in CA1: a brake on the NMDA responseNonna A Otmakhova
Department of Biology, Brandeis Univ, 415 South St, Waltham, MA 02454, USA
J Neurophysiol 92:2027-39. 2004..Blockade of the AHP converted a response that had a small NMDA component to one that had a large component. These results indicate that the Ih and postsynaptic GABAB conductances act as a brake on distally generated NMDA responses... - The stability of a stochastic CaMKII switch: dependence on the number of enzyme molecules and protein turnoverPaul Miller
Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts, USA
PLoS Biol 3:e107. 2005..Our computational results show that, depending on the timescale of fluctuations in enzyme numbers, for a switch composed of about 15 CaMKII holoenzymes, the stable persistent activation can span from a few years to a human lifetime... - Distribution of postsynaptic density (PSD)-95 and Ca2+/calmodulin-dependent protein kinase II at the PSDJennifer D Petersen
Laboratory of Neurobiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 23:11270-8. 2003..This variability is significantly higher than that for PSD-95 and is consistent with an information storage role for CaMKII...
Research Grants
- CRCNS: Quantitative description of initial biochemical steps in LTPJohn E Lisman; Fiscal Year: 2010..There are also medical implications: understanding the early steps of synaptic plasticity may give insight into learning disorders. Ng, one of the proteins to be studied, is a risk gene for schizophrenia. ..
- MECHANISMS OF LONG-TERM POTENTIATIONJohn Lisman; Fiscal Year: 2003..Consistent with this view, preliminary results indicate that a microtubule-motor system and a vesicle fusion process is required for maintaining AMPA transmission. ..
- MECHANISMS OF ADAPTATION AND EXCITATIONJohn Lisman; Fiscal Year: 2002....
- MECHANISMS OF LONG-TERM POTENTIATIONJohn E Lisman; Fiscal Year: 2010..Positive results would strongly argue that the CaMKII-NMDA complex is critical for the storage of synaptic memory and would set the stage for studying the role of this complex in the maintenance of behavioral memory. ..
- CRCNS: Quantitative description of initial biochemical steps in LTPJohn E Lisman; Fiscal Year: 2010..There are also medical implications: understanding the early steps of synaptic plasticity may give insight into learning disorders. Ng, one of the proteins to be studied, is a risk gene for schizophrenia. ..
- MECHANISMS OF LONG-TERM POTENTIATIONJohn Lisman; Fiscal Year: 2009..abstract_text> ..
- Role of NMDA receptors in awake-state thalamocortical slow wavesJohn E Lisman; Fiscal Year: 2010..The cellular and molecular causes of this dysrhythmia in the thalamus will be investigated. A major clue appears to be the ability of NMDA recent antagonists to mimic the dysrhythmia. ..
- CRCNS: Quantitative description of initial biochemical steps in LTPJohn Lisman; Fiscal Year: 2009..There are also medical implications: understanding the early steps of synaptic plasticity may give insight into learning disorders. Ng, one of the proteins to be studied, is a risk gene for schizophrenia. ..
- NEUROSCIENCE: FROM CHANNELS TO BEHAVIORJohn Lisman; Fiscal Year: 2007..Our broad-based training environment and strengths in computational neuroscience provide a unique environment for teaching students how cognitively relevant brain computations emerge from molecular, cellular and network processes. ..
- CRCNS: Memory Mechanisms: Modifiability and StabilityJohn Lisman; Fiscal Year: 2007..The insights derived are likely to be of importance in understanding diseases of memory and suggest strategies for therapeutic intervention. ..
- MECHANISMS OF LONG-TERM POTENTIATIONJohn Lisman; Fiscal Year: 1999..The experiments are aimed at determining how phosphatases affect the synaptic response and how they contribute to the activity-dependent weakening of synapses. ..
- MECHANISMS OF ADAPTATIONJohn Lisman; Fiscal Year: 1980....
- MECHANISM OF LONG-TERM POTENTIATIONJohn Lisman; Fiscal Year: 1993..These studies will provide the first systematic test of the most explicit model of neuronal information storage yet proposed. The information acquired may well be relevant to the general questions of memory storage...