Nelson C Lau

Summary

Affiliation: Brandeis University
Country: USA

Publications

  1. pmc Abundant primary piRNAs, endo-siRNAs, and microRNAs in a Drosophila ovary cell line
    Nelson C Lau
    Department of Molecular Biology, Massachusetts General Hospital, Boston, 02114, USA
    Genome Res 19:1776-85. 2009
  2. pmc Small RNAs in the animal gonad: guarding genomes and guiding development
    Nelson C Lau
    Department of Biology, Brandeis University, 415 South Street, Waltham, MA 02454, USA
    Int J Biochem Cell Biol 42:1334-47. 2010
  3. pmc Most Caenorhabditis elegans microRNAs are individually not essential for development or viability
    Eric A Miska
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    PLoS Genet 3:e215. 2007
  4. ncbi Characterization of the piRNA complex from rat testes
    Nelson C Lau
    Department of Molecular Biology, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA
    Science 313:363-7. 2006
  5. ncbi The coming of age for Piwi proteins
    Anita G Seto
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Mol Cell 26:603-9. 2007
  6. doi Analysis of small endogenous RNAs
    Nelson C Lau
    Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Curr Protoc Mol Biol . 2008
  7. pmc RNAi pathways contribute to developmental history-dependent phenotypic plasticity in C. elegans
    Sarah E Hall
    Department of Biology and National Center for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02454, USA
    RNA 19:306-19. 2013
  8. pmc Diverse roles for RNA in gene regulation
    Nelson C Lau
    Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA
    Genome Biol 6:315. 2005
  9. pmc Systematic and single cell analysis of Xenopus Piwi-interacting RNAs and Xiwi
    Nelson C Lau
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA
    EMBO J 28:2945-58. 2009
  10. pmc The microRNAs of Caenorhabditis elegans
    Lee P Lim
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Genes Dev 17:991-1008. 2003

Collaborators

Detail Information

Publications12

  1. pmc Abundant primary piRNAs, endo-siRNAs, and microRNAs in a Drosophila ovary cell line
    Nelson C Lau
    Department of Molecular Biology, Massachusetts General Hospital, Boston, 02114, USA
    Genome Res 19:1776-85. 2009
    ..These data indicate that the restriction of certain TEs in somatic gonadal cells is largely mediated by a primary piRNA pathway...
  2. pmc Small RNAs in the animal gonad: guarding genomes and guiding development
    Nelson C Lau
    Department of Biology, Brandeis University, 415 South Street, Waltham, MA 02454, USA
    Int J Biochem Cell Biol 42:1334-47. 2010
    ..Progress in this area will likely impact biomedical goals of manipulating stem cells and preventing diseases caused by the transposition of mobile DNA elements...
  3. pmc Most Caenorhabditis elegans microRNAs are individually not essential for development or viability
    Eric A Miska
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    PLoS Genet 3:e215. 2007
    ..This study represents the first comprehensive genetic analysis of miRNA function in any organism and provides a unique, permanent resource for the systematic study of miRNAs...
  4. ncbi Characterization of the piRNA complex from rat testes
    Nelson C Lau
    Department of Molecular Biology, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA
    Science 313:363-7. 2006
    ..Piwi has been genetically linked to TGS in flies, and slicer activity cofractionates with the purified complex. These results are consistent with a gene-silencing role for piRC in mammals...
  5. ncbi The coming of age for Piwi proteins
    Anita G Seto
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Mol Cell 26:603-9. 2007
    ..Here, we highlight the recent progress in understanding Piwi function and the implications for germline and stem cell development...
  6. doi Analysis of small endogenous RNAs
    Nelson C Lau
    Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Curr Protoc Mol Biol . 2008
    ..This unit also outlines a cell-based reporter gene assay for assessing the regulatory potential of a microRNA on a candidate mRNA target...
  7. pmc RNAi pathways contribute to developmental history-dependent phenotypic plasticity in C. elegans
    Sarah E Hall
    Department of Biology and National Center for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02454, USA
    RNA 19:306-19. 2013
    ....
  8. pmc Diverse roles for RNA in gene regulation
    Nelson C Lau
    Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA
    Genome Biol 6:315. 2005
  9. pmc Systematic and single cell analysis of Xenopus Piwi-interacting RNAs and Xiwi
    Nelson C Lau
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA
    EMBO J 28:2945-58. 2009
    ..We suggest that in addition to regulating transposable elements, Xiwi may function in specifying RNA localization in vertebrate oocytes...
  10. pmc The microRNAs of Caenorhabditis elegans
    Lee P Lim
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Genes Dev 17:991-1008. 2003
    ..Our census of the worm miRNAs and their expression patterns helps define this class of noncoding RNAs, lays the groundwork for functional studies, and provides the tools for more comprehensive analyses of miRNA genes in other species...
  11. pmc Rem2 is an activity-dependent negative regulator of dendritic complexity in vivo
    Amy E Ghiretti
    Department of Biology, National Center for Behavioral Genomics, Rosenstiel Basic Medical Sciences Research Center, and Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, and Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710
    J Neurosci 34:392-407. 2014
    ..It is the balance of these opposing signals that leads to proper dendritic morphology. ..
  12. doi Small RNA library construction from minute biological samples
    Jessica A Matts
    Department of Biology, Rosenstiel Basic Medical Science Research Center, Brandeis University, Waltham, MA, USA
    Methods Mol Biol 1093:123-36. 2014
    ..Finally, our methodology generates libraries amenable to multiplex sequencing on the Illumina Hi-Seq platform...