J Brabender

Summary

Country: USA

Publications

  1. ncbi ERCC1 and thymidylate synthase mRNA levels predict survival for colorectal cancer patients receiving combination oxaliplatin and fluorouracil chemotherapy
    Y Shirota
    University of Southern California/Norris Comprehensive Cancer Center and Response Genetics Inc, Los Angeles, CA 90033, USA
    J Clin Oncol 19:4298-304. 2001
  2. ncbi High specificity of quantitative excision repair cross-complementing 1 messenger RNA expression for prediction of minor histopathological response to neoadjuvant radiochemotherapy in esophageal cancer
    Ute Warnecke-Eberz
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Clin Cancer Res 10:3794-9. 2004
  3. ncbi Epidermal growth factor receptor and HER2-neu mRNA expression in non-small cell lung cancer Is correlated with survival
    J Brabender
    Department of Biochemistry and Molecular Biology and Norris Comprehensive Cancer Center, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
    Clin Cancer Res 7:1850-5. 2001
  4. ncbi Increased c-myb mRNA expression in Barrett's esophagus and Barrett's-associated adenocarcinoma
    J Brabender
    Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA
    J Surg Res 99:301-6. 2001
  5. pmc Prognostic significance of cyclooxygenase 2 mRNA expression in non-small cell lung cancer
    Jan Brabender
    Department of Molecular Biology, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    Ann Surg 235:440-3. 2002
  6. ncbi Upregulation of ornithine decarboxylase mRNA expression in Barrett's esophagus and Barrett's-associated adenocarcinoma
    J Brabender
    Department of Biochemistry and Molecular Biology/Norris Comprehensive Cancer Research Center, University of Southern California Keck School of Medicine, Los Angeles, USA
    J Gastrointest Surg 5:174-81; discussion 182. 2001
  7. ncbi Adenomatous polyposis coli gene promoter hypermethylation in non-small cell lung cancer is associated with survival
    J Brabender
    Department of Biochemistry and Molecular Biology and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, CA 90033, USA
    Oncogene 20:3528-32. 2001
  8. ncbi Different lengths of a polymorphic repeat sequence in the thymidylate synthase gene affect translational efficiency but not its gene expression
    K Kawakami
    Department of Biochemistry and Molecular Biology, School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA
    Clin Cancer Res 7:4096-101. 2001
  9. doi TS and ERCC-1 mRNA expressions and clinical outcome in patients with metastatic colon cancer in CONFIRM-1 and -2 clinical trials
    P P Grimminger
    Department of Molecular Biology and Biochemistry, University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, CA, USA
    Pharmacogenomics J 12:404-11. 2012
  10. ncbi The role of retinoid X receptor messenger RNA expression in curatively resected non-small cell lung cancer
    Jan Brabender
    Department of Molecular Biology and Biochemistry, Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Clin Cancer Res 8:438-43. 2002

Collaborators

Detail Information

Publications25

  1. ncbi ERCC1 and thymidylate synthase mRNA levels predict survival for colorectal cancer patients receiving combination oxaliplatin and fluorouracil chemotherapy
    Y Shirota
    University of Southern California/Norris Comprehensive Cancer Center and Response Genetics Inc, Los Angeles, CA 90033, USA
    J Clin Oncol 19:4298-304. 2001
    ..Precise definition of the best TS cut point will require further analysis in a large, prospective study...
  2. ncbi High specificity of quantitative excision repair cross-complementing 1 messenger RNA expression for prediction of minor histopathological response to neoadjuvant radiochemotherapy in esophageal cancer
    Ute Warnecke-Eberz
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Clin Cancer Res 10:3794-9. 2004
    ....
  3. ncbi Epidermal growth factor receptor and HER2-neu mRNA expression in non-small cell lung cancer Is correlated with survival
    J Brabender
    Department of Biochemistry and Molecular Biology and Norris Comprehensive Cancer Center, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
    Clin Cancer Res 7:1850-5. 2001
    ..Testing of molecular marker coexpression (EGFR and HER2-neu) improves the estimation of prognosis and appears to define low- and high-risk groups for treatment failure in curatively resected NSCLC...
  4. ncbi Increased c-myb mRNA expression in Barrett's esophagus and Barrett's-associated adenocarcinoma
    J Brabender
    Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA
    J Surg Res 99:301-6. 2001
    ..The genetic basis of this process is increasingly well understood, but no studies have examined the role of the transcription factor c-myb in this disease...
  5. pmc Prognostic significance of cyclooxygenase 2 mRNA expression in non-small cell lung cancer
    Jan Brabender
    Department of Molecular Biology, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    Ann Surg 235:440-3. 2002
    ..To investigate cyclooxygenase-2 (COX-2) mRNA expression in curatively resected non-small cell lung cancer (NSCLC) and to determine its association with prognosis...
  6. ncbi Upregulation of ornithine decarboxylase mRNA expression in Barrett's esophagus and Barrett's-associated adenocarcinoma
    J Brabender
    Department of Biochemistry and Molecular Biology/Norris Comprehensive Cancer Research Center, University of Southern California Keck School of Medicine, Los Angeles, USA
    J Gastrointest Surg 5:174-81; discussion 182. 2001
    ..early event in the development and progression of Barrett's-associated adenocarcinoma of the esophagus, and they suggest that high ODC mRNA expression levels may be a clinically useful biomarker for the detection of occult adenocarcinoma..
  7. ncbi Adenomatous polyposis coli gene promoter hypermethylation in non-small cell lung cancer is associated with survival
    J Brabender
    Department of Biochemistry and Molecular Biology and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, CA 90033, USA
    Oncogene 20:3528-32. 2001
    ..High APC promoter methylation is significantly associated with inferior survival, showing promise as a biomarker of biologically aggressive disease in NSCLC...
  8. ncbi Different lengths of a polymorphic repeat sequence in the thymidylate synthase gene affect translational efficiency but not its gene expression
    K Kawakami
    Department of Biochemistry and Molecular Biology, School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA
    Clin Cancer Res 7:4096-101. 2001
    ..Recently, the TS gene has been shown to contain a polymorphic tandem repeat sequence. The aim of this study was to determine whether differences in the number of tandem repeats could affect gene expression or mRNA translation...
  9. doi TS and ERCC-1 mRNA expressions and clinical outcome in patients with metastatic colon cancer in CONFIRM-1 and -2 clinical trials
    P P Grimminger
    Department of Molecular Biology and Biochemistry, University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, CA, USA
    Pharmacogenomics J 12:404-11. 2012
    ..TS and ERCC-1 expression is associated with clinical outcome in mCRC. Baseline TS and ERCC-1 levels may allow the selection of patients who benefit from FOLFOX4 chemotherapy...
  10. ncbi The role of retinoid X receptor messenger RNA expression in curatively resected non-small cell lung cancer
    Jan Brabender
    Department of Molecular Biology and Biochemistry, Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Clin Cancer Res 8:438-43. 2002
    ..We hypothesized that suppressed RXR expression might be a prognostic factor of worse clinical outcome in patients with NSCLC...
  11. ncbi Sex differences in the predictive power of the molecular prognostic factor HER2/neu in patients with non-small-cell lung cancer
    Daniel Vallbohmer
    Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA
    Clin Lung Cancer 7:332-7. 2006
    ..Whereas considerable evidence indicates sex differences in epidemiologic, hormonal, biologic, and genetic factors in this disease, it has remained unknown whether HER2/neu has a diverse function as a prognostic factor in men and women...
  12. ncbi Comprehensive expression analysis of retinoic acid receptors and retinoid X receptors in non-small cell lung cancer: implications for tumor development and prognosis
    Jan Brabender
    Department of Visceral and Vascular Surgery, University of Cologne, Joseph Stelzmann Strasse 9, 50931 Cologne, Germany
    Carcinogenesis 26:525-30. 2005
    ..Quantitation of RAR and RXR mRNA expression levels in tumor tissue is a candidate prognostic marker and surrogate biomarker for chemopreventive trials in NSCLC...
  13. ncbi Osteopontin but not osteonectin messenger RNA expression is a prognostic marker in curatively resected non-small cell lung cancer
    Sylke Schneider
    Department of Molecular Biology, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    Clin Cancer Res 10:1588-96. 2004
    ....
  14. ncbi Quantitative O(6)-methylguanine DNA methyltransferase methylation analysis in curatively resected non-small cell lung cancer: associations with clinical outcome
    Jan Brabender
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne 50931, Germany
    Clin Cancer Res 9:223-7. 2003
    ..The purpose of this study was to determine the frequency and clinical relevance of MGMT gene promoter hypermethylation in curatively resected non-small cell lung cancer (NSCLC)...
  15. ncbi Low ERCC1 expression correlates with prolonged survival after cisplatin plus gemcitabine chemotherapy in non-small cell lung cancer
    Reginald V N Lord
    University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA
    Clin Cancer Res 8:2286-91. 2002
    ..We investigated whether ERCC1 mRNA expression levels were associated with clinical outcomes after treatment with a combination Gem/CDDP regimen for patients with advanced stage non-small cell lung cancer (NSCLC)...
  16. ncbi DNA methyltransferases messenger RNA expression and aberrant methylation of CpG islands in non-small-cell lung cancer: association and prognostic value
    Daniel Vallbohmer
    Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, USA
    Clin Lung Cancer 8:39-44. 2006
    ..The molecular events for this epigenetic alteration still remain unknown. Evidence suggests that overexpression of DNA methyltransferases (DNMTs) is one potential mechanism for hypermethylation...
  17. ncbi Down-regulation of Gadd45 expression is associated with tumor differentiation in non-small cell lung cancer
    Hiroshi Higashi
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Anticancer Res 26:2143-7. 2006
    ..The purpose of this study was to determine the gene expression patterns and clinical relevance of Gadd45 in tumor specimens of non-small cell lung cancer (NSCLC) patients...
  18. ncbi Quantitative adenomatous polyposis coli promoter methylation analysis in tumor tissue, serum, and plasma DNA of patients with lung cancer
    Henning Usadel
    Department of Otolaryngology Head and Neck Surgery, Head and Neck Cancer Research Division, Johns Hopkins University School of Medicine, Baltimore Maryland 21205 2196, USA
    Cancer Res 62:371-5. 2002
    ..015). APC methylation analysis appears to be promising as a prognostic factor in primary lung cancer and as a noninvasive tumor marker in plasma and/or serum DNA...
  19. ncbi High cyclooxygenase-2 expression following neoadjuvant radiochemotherapy is associated with minor histopathologic response and poor prognosis in esophageal cancer
    Huan Xi
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    Clin Cancer Res 11:8341-7. 2005
    ..We analyzed the association of COX-2 mRNA and protein expression with histomorphologic response to neoadjuvant radiochemotherapy in esophageal cancer...
  20. ncbi The molecular signature of normal squamous esophageal epithelium identifies the presence of a field effect and can discriminate between patients with Barrett's esophagus and patients with Barrett's-associated adenocarcinoma
    Jan Brabender
    Department of Visceral and Vascular Surgery, University of Cologne, Germany
    Cancer Epidemiol Biomarkers Prev 14:2113-7. 2005
    ....
  21. ncbi Overexpression of survivin mRNA is associated with a favorable prognosis following neoadjuvant radiochemotherapy in esophageal cancer
    Ute Warnecke-Eberz
    Department of Visceral and Vascular Surgery, University of Cologne, Joseph Stelzmann Strasse 9, 50931 Cologne, Germany
    Oncol Rep 13:1241-6. 2005
    ..However, overexpression of survivin mRNA in pretreatment biopsies (T/N ratio >1) was associated with superior survival probabilities...
  22. ncbi Downregulation of TS, DPD, ERCC1, GST-Pi, EGFR, and HER2 gene expression after neoadjuvant three-modality treatment in patients with esophageal cancer
    Sylke Schneider
    Department of Molecular Biology and Biochemistry and Norris Comprehensive Cancer Center, Los Angeles, CA 90033, USA
    J Am Coll Surg 200:336-44. 2005
    ....
  23. ncbi Glutathione S-transferase-pi expression is downregulated in patients with Barrett's esophagus and esophageal adenocarcinoma
    Jan Brabender
    Department of Biochemistry, USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    J Gastrointest Surg 6:359-67. 2002
    ..Loss of GSTPI expression may have an important role in the development and progression of this disease...
  24. ncbi A multigene expression panel for the molecular diagnosis of Barrett's esophagus and Barrett's adenocarcinoma of the esophagus
    Jan Brabender
    Department of Visceral and Vascular Surgery, University of Cologne, 50931 Germany
    Oncogene 23:4780-8. 2004
    ..Expression analysis of a limited number of highly selected genes may have clinical usefulness for the treatment of patients with this disease...
  25. ncbi Thymidylate synthase expression in advanced colorectal cancer predicts for response to raltitrexed
    David C Farrugia
    Section of Medicine and Cancer Research UK Centre for Cancer Therapeutics, Institute of Cancer Research, Sutton, Surrey SM2 5NG, United Kingdom
    Clin Cancer Res 9:792-801. 2003
    ..The purpose of this research was to evaluate the predictive value of expression of thymidylate synthase (TS) and other genes for response to raltitrexed (RTX)...