Daniel T Meehan

Summary

Affiliation: Boys Town National Research Hospital
Country: USA

Publications

  1. ncbi request reprint Dysregulation of renal MMP-3 and MMP-7 in canine X-linked Alport syndrome
    Velidi H Rao
    Department of Genetics, Boys Town National Research Hospital, Omaha, NE 68131, USA
    Pediatr Nephrol 20:732-9. 2005
  2. pmc Gene targeting in adult rhesus macaque fibroblasts
    Daniel T Meehan
    Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, 985805 Nebraska Medical Center, Omaha, NE 68198 5805, USA
    BMC Biotechnol 8:31. 2008
  3. pmc Localization and expression of clarin-1, the Clrn1 gene product, in auditory hair cells and photoreceptors
    Marisa Zallocchi
    Boys Town National Research Hospital, Omaha, NE 68131, USA
    Hear Res 255:109-20. 2009
  4. pmc Integrin alpha1beta1 regulates matrix metalloproteinases via P38 mitogen-activated protein kinase in mesangial cells: implications for Alport syndrome
    Dominic Cosgrove
    Boys Town National Research Hospital, 555 No 30th St, Omaha, NE 68131, USA
    Am J Pathol 172:761-73. 2008
  5. pmc Progressive morphological and functional defects in retinas from alpha1 integrin-null mice
    You Wei Peng
    Boys Town National Research Hospital, Omaha, Nebraska 68131, USA
    Invest Ophthalmol Vis Sci 49:4647-54. 2008
  6. pmc Biomechanical strain causes maladaptive gene regulation, contributing to Alport glomerular disease
    Daniel T Meehan
    Boys Town National Research Hospital, Omaha, Nebraska 68131, USA
    Kidney Int 76:968-76. 2009
  7. ncbi request reprint Monocytes may promote myofibroblast accumulation and apoptosis in Alport renal fibrosis
    Kathyrn D Rodgers
    Department of Genetics, Boys Town National Research Hospital, Omaha, Nebraska 68131, USA
    Kidney Int 63:1338-55. 2003
  8. pmc Role for macrophage metalloelastase in glomerular basement membrane damage associated with alport syndrome
    Velidi H Rao
    Boys Town National Research Hospital, 555 No 30th St, Omaha, NE 68131, USA
    Am J Pathol 169:32-46. 2006
  9. ncbi request reprint Increased expression of MMP-2, MMP-9 (type IV collagenases/gelatinases), and MT1-MMP in canine X-linked Alport syndrome (XLAS)
    Velidi H Rao
    Boys Town National Research Hospital, Omaha, Nebraska 68131, USA
    Kidney Int 63:1736-48. 2003
  10. ncbi request reprint Strial marginal cells play a role in basement membrane homeostasis: in vitro and in vivo evidence
    Michael Anne Gratton
    Boys Town National Research Hospital, Omaha, NE 68131, USA
    Hear Res 163:27-36. 2002

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Dysregulation of renal MMP-3 and MMP-7 in canine X-linked Alport syndrome
    Velidi H Rao
    Department of Genetics, Boys Town National Research Hospital, Omaha, NE 68131, USA
    Pediatr Nephrol 20:732-9. 2005
    ..Thus, these data further implicate a role for the MMPs in progressive renal pathogenesis associated with AS...
  2. pmc Gene targeting in adult rhesus macaque fibroblasts
    Daniel T Meehan
    Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, 985805 Nebraska Medical Center, Omaha, NE 68198 5805, USA
    BMC Biotechnol 8:31. 2008
    ..Our goal was to establish the protocols necessary to achieve gene targeting in primary culture of adult rhesus macaque fibroblasts as a first step in creating nonhuman primate models of genetic disease using nuclear transfer technology...
  3. pmc Localization and expression of clarin-1, the Clrn1 gene product, in auditory hair cells and photoreceptors
    Marisa Zallocchi
    Boys Town National Research Hospital, Omaha, NE 68131, USA
    Hear Res 255:109-20. 2009
    ..The protein co-localizes with microtubules and post-transgolgi vesicles. The subcellular localization of clarin-1 in hair cells and photoreceptors suggests it functions at both the basal and apical poles of neurosensoriepithelia...
  4. pmc Integrin alpha1beta1 regulates matrix metalloproteinases via P38 mitogen-activated protein kinase in mesangial cells: implications for Alport syndrome
    Dominic Cosgrove
    Boys Town National Research Hospital, 555 No 30th St, Omaha, NE 68131, USA
    Am J Pathol 172:761-73. 2008
    ....
  5. pmc Progressive morphological and functional defects in retinas from alpha1 integrin-null mice
    You Wei Peng
    Boys Town National Research Hospital, Omaha, Nebraska 68131, USA
    Invest Ophthalmol Vis Sci 49:4647-54. 2008
    ..In this study the functional importance of alpha1beta1 integrin for retinal pigment epithelial cell homeostasis and retinal health was assessed by comparing alpha1 integrin knockout mice with strain- and age-matched wild-type mice...
  6. pmc Biomechanical strain causes maladaptive gene regulation, contributing to Alport glomerular disease
    Daniel T Meehan
    Boys Town National Research Hospital, Omaha, Nebraska 68131, USA
    Kidney Int 76:968-76. 2009
    ..We suggest that MMP and cytokine dysregulation may constitute a maladaptive response to biomechanical strain in the podocytes of Alport patients, thus contributing to glomerular disease initiation and progression...
  7. ncbi request reprint Monocytes may promote myofibroblast accumulation and apoptosis in Alport renal fibrosis
    Kathyrn D Rodgers
    Department of Genetics, Boys Town National Research Hospital, Omaha, Nebraska 68131, USA
    Kidney Int 63:1338-55. 2003
    ..While much has been done to explore the role of these cell types individually in fibrosis, the interactive dependency of monocytes and myofibroblasts has been only marginally explored...
  8. pmc Role for macrophage metalloelastase in glomerular basement membrane damage associated with alport syndrome
    Velidi H Rao
    Boys Town National Research Hospital, 555 No 30th St, Omaha, NE 68131, USA
    Am J Pathol 169:32-46. 2006
    ..Thus, MMP-12/CCR2 inhibitors may provide a novel and effective therapeutic stra-tegy for Alport glomerular disease...
  9. ncbi request reprint Increased expression of MMP-2, MMP-9 (type IV collagenases/gelatinases), and MT1-MMP in canine X-linked Alport syndrome (XLAS)
    Velidi H Rao
    Boys Town National Research Hospital, Omaha, Nebraska 68131, USA
    Kidney Int 63:1736-48. 2003
    ..In this study, a well-characterized naturally occurring canine model was employed to demonstrate a potential role for matrix metalloproteinases (MMPs) in Alport renal disease pathogenesis...
  10. ncbi request reprint Strial marginal cells play a role in basement membrane homeostasis: in vitro and in vivo evidence
    Michael Anne Gratton
    Boys Town National Research Hospital, Omaha, NE 68131, USA
    Hear Res 163:27-36. 2002
    ..Moreover, these data suggest that a culture system using this marginal cell line will be useful to delineate mechanisms underlying the pathologic accumulation of extracellular matrix in the SCBM...
  11. pmc Matrix metalloproteinase dysregulation in the stria vascularis of mice with Alport syndrome: implications for capillary basement membrane pathology
    Michael Anne Gratton
    Department of Otolaryngology, Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Pathol 166:1465-74. 2005
    ..Further, these data suggest that the altered basement membrane composition in Alport stria influences the expression of genes involved in basement membrane metabolism...