DOMINIC E COSGROVE

Summary

Affiliation: Boys Town National Research Hospital
Country: USA

Publications

  1. ncbi Glomerular pathology in Alport syndrome: a molecular perspective
    Dominic Cosgrove
    Boys Town National Research Hospital, Omaha, NE 68131, USA
    Pediatr Nephrol 27:885-90. 2012
  2. ncbi Integrin alpha1beta1 regulates matrix metalloproteinases via P38 mitogen-activated protein kinase in mesangial cells: implications for Alport syndrome
    Dominic Cosgrove
    Boys Town National Research Hospital, 555 No 30th St, Omaha, NE 68131, USA
    Am J Pathol 172:761-73. 2008
  3. ncbi Choosing a mouse model to study the molecular pathobiology of Alport glomerulonephritis
    D Cosgrove
    Department of Genetics, Boys Town National Research Hospital, Omaha, Nebraska, USA
    Kidney Int 71:615-8. 2007
  4. ncbi Immunohistochemical localization of basement membrane collagens and associated proteins in the murine cochlea
    D Cosgrove
    Boys Town National Research Hospital, Department of Genetics, Omaha, NE 68131, USA
    Hear Res 97:54-65. 1996
  5. ncbi Ultrastructural, physiological, and molecular defects in the inner ear of a gene-knockout mouse model for autosomal Alport syndrome
    D Cosgrove
    Boys Town National Research Hospital, Omaha, NE 68131, USA
    Hear Res 121:84-98. 1998
  6. ncbi Expression of basement membrane type IV collagen chains during postnatal development in the murine cochlea
    D Cosgrove
    Boys Town National Research Hospital, Department of Genetics, Omaha, NE 68131, USA
    Hear Res 100:21-32. 1996
  7. ncbi Integrin alpha1beta1 and transforming growth factor-beta1 play distinct roles in alport glomerular pathogenesis and serve as dual targets for metabolic therapy
    D Cosgrove
    Department of Genetics, Boys Town National Research Hospital, Omaha, Nebraska, USA
    Am J Pathol 157:1649-59. 2000
  8. ncbi FAK and p38-MAP kinase-dependent activation of apoptosis and caspase-3 in retinal endothelial cells by alpha1(IV)NC1
    Chandra S Boosani
    Cell Signaling and Tumor Angiogenesis Laboratory, Department of Genetics, Boys Town National Research Hospital, Omaha, Nebraska 68131, USA
    Invest Ophthalmol Vis Sci 50:4567-75. 2009
  9. ncbi Regulation of COX-2 mediated signaling by alpha3 type IV noncollagenous domain in tumor angiogenesis
    Chandra Shekhar Boosani
    Cell Signaling and Tumor Angiogenesis Laboratory, Department of Genetics, Boys Town National Research Hospital, Omaha, NE 68131, USA
    Blood 110:1168-77. 2007
  10. ncbi Localization and expression of clarin-1, the Clrn1 gene product, in auditory hair cells and photoreceptors
    Marisa Zallocchi
    Boys Town National Research Hospital, Omaha, NE 68131, USA
    Hear Res 255:109-20. 2009

Collaborators

Detail Information

Publications21

  1. ncbi Glomerular pathology in Alport syndrome: a molecular perspective
    Dominic Cosgrove
    Boys Town National Research Hospital, Omaha, NE 68131, USA
    Pediatr Nephrol 27:885-90. 2012
    ....
  2. ncbi Integrin alpha1beta1 regulates matrix metalloproteinases via P38 mitogen-activated protein kinase in mesangial cells: implications for Alport syndrome
    Dominic Cosgrove
    Boys Town National Research Hospital, 555 No 30th St, Omaha, NE 68131, USA
    Am J Pathol 172:761-73. 2008
    ....
  3. ncbi Choosing a mouse model to study the molecular pathobiology of Alport glomerulonephritis
    D Cosgrove
    Department of Genetics, Boys Town National Research Hospital, Omaha, Nebraska, USA
    Kidney Int 71:615-8. 2007
    ....
  4. ncbi Immunohistochemical localization of basement membrane collagens and associated proteins in the murine cochlea
    D Cosgrove
    Boys Town National Research Hospital, Department of Genetics, Omaha, NE 68131, USA
    Hear Res 97:54-65. 1996
    ..These results indicate that an abundance of basement membrane collagen containing extracellular matrix exists in the murine cochlea and that the composition of these matrices are surprisingly varied and tissue specific...
  5. ncbi Ultrastructural, physiological, and molecular defects in the inner ear of a gene-knockout mouse model for autosomal Alport syndrome
    D Cosgrove
    Boys Town National Research Hospital, Omaha, NE 68131, USA
    Hear Res 121:84-98. 1998
    ..A closer look at this compartment in human Alport biopsy specimen may be warranted...
  6. ncbi Expression of basement membrane type IV collagen chains during postnatal development in the murine cochlea
    D Cosgrove
    Boys Town National Research Hospital, Department of Genetics, Omaha, NE 68131, USA
    Hear Res 100:21-32. 1996
    ..The complex developmental pattern of expression for the type IV collagen chains in the murine cochlea is similar to that observed in the murine kidney, which is the other major site for basement membrane pathology in Alport syndrome...
  7. ncbi Integrin alpha1beta1 and transforming growth factor-beta1 play distinct roles in alport glomerular pathogenesis and serve as dual targets for metabolic therapy
    D Cosgrove
    Department of Genetics, Boys Town National Research Hospital, Omaha, Nebraska, USA
    Am J Pathol 157:1649-59. 2000
    ..These data suggest that integrin alpha1beta1 and TGF-beta1 may provide useful targets for a dual therapy aimed at slowing disease progression in Alport glomerulonephritis...
  8. ncbi FAK and p38-MAP kinase-dependent activation of apoptosis and caspase-3 in retinal endothelial cells by alpha1(IV)NC1
    Chandra S Boosani
    Cell Signaling and Tumor Angiogenesis Laboratory, Department of Genetics, Boys Town National Research Hospital, Omaha, Nebraska 68131, USA
    Invest Ophthalmol Vis Sci 50:4567-75. 2009
    ..To determine the impact of the antiangiogenic factor alpha1(IV)NC1 on vascular endothelial growth factor-mediated proangiogenic activity in mouse retinal endothelial cells (MRECs)...
  9. ncbi Regulation of COX-2 mediated signaling by alpha3 type IV noncollagenous domain in tumor angiogenesis
    Chandra Shekhar Boosani
    Cell Signaling and Tumor Angiogenesis Laboratory, Department of Genetics, Boys Town National Research Hospital, Omaha, NE 68131, USA
    Blood 110:1168-77. 2007
    ..Our in vitro and in vivo findings demonstrate that alpha3beta1 integrin is critical for alpha3(IV)NC1-mediated inhibition of COX-2-dependent angiogenic signaling and inhibition of tumor progression...
  10. ncbi Localization and expression of clarin-1, the Clrn1 gene product, in auditory hair cells and photoreceptors
    Marisa Zallocchi
    Boys Town National Research Hospital, Omaha, NE 68131, USA
    Hear Res 255:109-20. 2009
    ..The protein co-localizes with microtubules and post-transgolgi vesicles. The subcellular localization of clarin-1 in hair cells and photoreceptors suggests it functions at both the basal and apical poles of neurosensoriepithelia...
  11. ncbi Human alpha1 type IV collagen NC1 domain exhibits distinct antiangiogenic activity mediated by alpha1beta1 integrin
    Akulapalli Sudhakar
    Cell Signaling and Angiogenesis Laboratory, Department of Genetics, Boys Town National Research Hospital, Omaha, Nebraska 68131, USA
    J Clin Invest 115:2801-10. 2005
    ..Collectively, the above data indicate that alpha1(IV)NC1 is a potential therapeutic candidate for targeting tumor angiogenesis...
  12. ncbi Progressive morphological and functional defects in retinas from alpha1 integrin-null mice
    You Wei Peng
    Boys Town National Research Hospital, Omaha, Nebraska 68131, USA
    Invest Ophthalmol Vis Sci 49:4647-54. 2008
    ..In this study the functional importance of alpha1beta1 integrin for retinal pigment epithelial cell homeostasis and retinal health was assessed by comparing alpha1 integrin knockout mice with strain- and age-matched wild-type mice...
  13. ncbi Biochemical characterization of native Usher protein complexes from a vesicular subfraction of tracheal epithelial cells
    Marisa Zallocchi
    Usher Syndrome Center, Boys Town National Research Hospital, 555 North 30th Street, Omaha, Nebraska 68131, USA
    Biochemistry 49:1236-47. 2010
    ..This complex(es) is present primarily in transport vesicles at the apical pole of tracheal epithelial cells, predicting that Usher proteins may be directionally transported as complexes in hair cells and photoreceptors...
  14. ncbi Biomechanical strain causes maladaptive gene regulation, contributing to Alport glomerular disease
    Daniel T Meehan
    Boys Town National Research Hospital, Omaha, Nebraska 68131, USA
    Kidney Int 76:968-76. 2009
    ..We suggest that MMP and cytokine dysregulation may constitute a maladaptive response to biomechanical strain in the podocytes of Alport patients, thus contributing to glomerular disease initiation and progression...
  15. ncbi Role for macrophage metalloelastase in glomerular basement membrane damage associated with alport syndrome
    Velidi H Rao
    Boys Town National Research Hospital, 555 No 30th St, Omaha, NE 68131, USA
    Am J Pathol 169:32-46. 2006
    ..Thus, MMP-12/CCR2 inhibitors may provide a novel and effective therapeutic stra-tegy for Alport glomerular disease...
  16. ncbi Strial marginal cells play a role in basement membrane homeostasis: in vitro and in vivo evidence
    Michael Anne Gratton
    Boys Town National Research Hospital, Omaha, NE 68131, USA
    Hear Res 163:27-36. 2002
    ..Moreover, these data suggest that a culture system using this marginal cell line will be useful to delineate mechanisms underlying the pathologic accumulation of extracellular matrix in the SCBM...
  17. ncbi Monocytes may promote myofibroblast accumulation and apoptosis in Alport renal fibrosis
    Kathyrn D Rodgers
    Department of Genetics, Boys Town National Research Hospital, Omaha, Nebraska 68131, USA
    Kidney Int 63:1338-55. 2003
    ..Elevated MMP expression and activity is associated with TBM destruction near monocytes clusters, suggesting an anoikis mechanism may contribute to apoptosis in this model...
  18. ncbi Increased expression of MMP-2, MMP-9 (type IV collagenases/gelatinases), and MT1-MMP in canine X-linked Alport syndrome (XLAS)
    Velidi H Rao
    Boys Town National Research Hospital, Omaha, Nebraska 68131, USA
    Kidney Int 63:1736-48. 2003
    ..These findings suggest that MMPs may play an important role in matrix accumulation associated with progressive renal scarring in this model...
  19. ncbi A domain-specific usherin/collagen IV interaction may be required for stable integration into the basement membrane superstructure
    Gautam Bhattacharya
    Usher Syndrome Center, Boys Town National Research Hospital, 555 No 30th Street, Omaha, Nebraska, 68131, USA
    J Cell Sci 117:233-42. 2004
    ..Thus, the domain-specific interaction between usherin and type IV collagen appears essential to usherin stability in vivo, and loss of this interaction may result in Usher pathology in humans...
  20. ncbi Dysregulation of renal MMP-3 and MMP-7 in canine X-linked Alport syndrome
    Velidi H Rao
    Department of Genetics, Boys Town National Research Hospital, Omaha, NE 68131, USA
    Pediatr Nephrol 20:732-9. 2005
    ..Thus, these data further implicate a role for the MMPs in progressive renal pathogenesis associated with AS...
  21. ncbi Localization and expression of usherin: a novel basement membrane protein defective in people with Usher's syndrome type IIa
    Gautam Bhattacharya
    Boys Town National Research Hospital, Omaha, NE, USA
    Hear Res 163:1-11. 2002
    ..Usherin is critical for normal development and tissue homeostasis in the inner ear and retina, illustrating yet another example of the importance of basement membranes in the development and function of tissues...