D Cosgrove

Summary

Affiliation: Boys Town National Research Hospital
Country: USA

Publications

  1. ncbi request reprint Expression of the major basement membrane-associated proteins during postnatal development in the murine cochlea
    D Cosgrove
    Boys Town National Research Hospital, Omaha, NE 68131, USA
    Hear Res 105:159-70. 1997
  2. ncbi request reprint Expression of basement membrane type IV collagen chains during postnatal development in the murine cochlea
    D Cosgrove
    Boys Town National Research Hospital, Department of Genetics, Omaha, NE 68131, USA
    Hear Res 100:21-32. 1996
  3. ncbi request reprint Ultrastructural, physiological, and molecular defects in the inner ear of a gene-knockout mouse model for autosomal Alport syndrome
    D Cosgrove
    Boys Town National Research Hospital, Omaha, NE 68131, USA
    Hear Res 121:84-98. 1998
  4. ncbi request reprint Immunohistochemical localization of basement membrane collagens and associated proteins in the murine cochlea
    D Cosgrove
    Boys Town National Research Hospital, Department of Genetics, Omaha, NE 68131, USA
    Hear Res 97:54-65. 1996
  5. pmc Integrin alpha1beta1 and transforming growth factor-beta1 play distinct roles in alport glomerular pathogenesis and serve as dual targets for metabolic therapy
    D Cosgrove
    Department of Genetics, Boys Town National Research Hospital, Omaha, Nebraska, USA
    Am J Pathol 157:1649-59. 2000
  6. ncbi request reprint Role for transforming growth factor-beta1 in alport renal disease progression
    R Sayers
    Boystown National Research Hospital, 555 North 30th Street, Omaha, Nebrasa, 68131, USA
    Kidney Int 56:1662-73. 1999
  7. ncbi request reprint The laminins in the murine inner ear: developmental transitions and expression in cochlear basement membranes
    K D Rodgers
    Department of Genetics, Boys Town National Research Hospital, Omaha, NE 68131, USA
    Hear Res 158:39-50. 2001
  8. ncbi request reprint Choosing a mouse model to study the molecular pathobiology of Alport glomerulonephritis
    D Cosgrove
    Department of Genetics, Boys Town National Research Hospital, Omaha, Nebraska, USA
    Kidney Int 71:615-8. 2007
  9. ncbi request reprint Collagen COL4A3 knockout: a mouse model for autosomal Alport syndrome
    D Cosgrove
    Department of Genetics, Boys Town National Research Hospital, Omaha, Nebraska 68131, USA
    Genes Dev 10:2981-92. 1996
  10. ncbi request reprint Assembly of type IV collagen. Insights from alpha3(IV) collagen-deficient mice
    R Kalluri
    Renal Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 275:12719-24. 2000

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Expression of the major basement membrane-associated proteins during postnatal development in the murine cochlea
    D Cosgrove
    Boys Town National Research Hospital, Omaha, NE 68131, USA
    Hear Res 105:159-70. 1997
    ..The abundance and dynamic regulation of these major basement membrane-associated proteins suggests that they play an important role in postnatal cochlear development...
  2. ncbi request reprint Expression of basement membrane type IV collagen chains during postnatal development in the murine cochlea
    D Cosgrove
    Boys Town National Research Hospital, Department of Genetics, Omaha, NE 68131, USA
    Hear Res 100:21-32. 1996
    ..The complex developmental pattern of expression for the type IV collagen chains in the murine cochlea is similar to that observed in the murine kidney, which is the other major site for basement membrane pathology in Alport syndrome...
  3. ncbi request reprint Ultrastructural, physiological, and molecular defects in the inner ear of a gene-knockout mouse model for autosomal Alport syndrome
    D Cosgrove
    Boys Town National Research Hospital, Omaha, NE 68131, USA
    Hear Res 121:84-98. 1998
    ..A closer look at this compartment in human Alport biopsy specimen may be warranted...
  4. ncbi request reprint Immunohistochemical localization of basement membrane collagens and associated proteins in the murine cochlea
    D Cosgrove
    Boys Town National Research Hospital, Department of Genetics, Omaha, NE 68131, USA
    Hear Res 97:54-65. 1996
    ..These results indicate that an abundance of basement membrane collagen containing extracellular matrix exists in the murine cochlea and that the composition of these matrices are surprisingly varied and tissue specific...
  5. pmc Integrin alpha1beta1 and transforming growth factor-beta1 play distinct roles in alport glomerular pathogenesis and serve as dual targets for metabolic therapy
    D Cosgrove
    Department of Genetics, Boys Town National Research Hospital, Omaha, Nebraska, USA
    Am J Pathol 157:1649-59. 2000
    ..These data suggest that integrin alpha1beta1 and TGF-beta1 may provide useful targets for a dual therapy aimed at slowing disease progression in Alport glomerulonephritis...
  6. ncbi request reprint Role for transforming growth factor-beta1 in alport renal disease progression
    R Sayers
    Boystown National Research Hospital, 555 North 30th Street, Omaha, Nebrasa, 68131, USA
    Kidney Int 56:1662-73. 1999
    ..In this study, the model was exploited to demonstrate a potential role for transforming growth factor-beta1 (TGF-beta1) in Alport renal disease pathogenesis...
  7. ncbi request reprint The laminins in the murine inner ear: developmental transitions and expression in cochlear basement membranes
    K D Rodgers
    Department of Genetics, Boys Town National Research Hospital, Omaha, NE 68131, USA
    Hear Res 158:39-50. 2001
    ..Considering the well established role of laminins in regulating both embryonic and organ development in other systems, these data suggest a closer look at the role of the laminins in cochlear development and function may be warranted...
  8. ncbi request reprint Choosing a mouse model to study the molecular pathobiology of Alport glomerulonephritis
    D Cosgrove
    Department of Genetics, Boys Town National Research Hospital, Omaha, Nebraska, USA
    Kidney Int 71:615-8. 2007
    ....
  9. ncbi request reprint Collagen COL4A3 knockout: a mouse model for autosomal Alport syndrome
    D Cosgrove
    Department of Genetics, Boys Town National Research Hospital, Omaha, Nebraska 68131, USA
    Genes Dev 10:2981-92. 1996
    ..Thus, expression of these basement membrane-associated proteins may be involved in the progression of Alport renal disease pathogenesis. The levels of mRNAs encoding the basement membrane-associated proteins at 7 weeks were unchanged...
  10. ncbi request reprint Assembly of type IV collagen. Insights from alpha3(IV) collagen-deficient mice
    R Kalluri
    Renal Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 275:12719-24. 2000
    ..These findings support the notion that type IV collagen assembly may be regulated by tissue-specific factors...
  11. ncbi request reprint Global gene expression analysis reveals a role for the alpha 1 integrin in renal pathogenesis
    N S Sampson
    Biogen, Inc, Cambridge, Massachusetts 02142, USA
    J Biol Chem 276:34182-8. 2001
    ....
  12. pmc HLA-DQ8 transgenic mice are highly susceptible to collagen-induced arthritis: a novel model for human polyarthritis
    G H Nabozny
    Department of Immunology, Mayo Medical School, Rochester, Minnesota 55905, USA
    J Exp Med 183:27-37. 1996
    ..Therefore, these results strongly suggest that HLA-DQ8 molecules contribute to genetic susceptibility to arthritis and also establish a novel animal model for the study of human arthritis...