D G Bostwick

Summary

Affiliation: Bostwick Laboratories
Country: USA

Publications

  1. doi request reprint Precursors of prostate cancer
    David G Bostwick
    Bostwick Laboratories, Glen Allen, VA 23060, USA
    Histopathology 60:4-27. 2012
  2. ncbi request reprint Diagnosis and classification of renal cell carcinoma
    D G Bostwick
    Department of Pathology, Mayo Clinic, Rochester, Minnesota, USA
    Urol Clin North Am 26:627-35. 1999
  3. ncbi request reprint Amphiregulin expression in prostatic intraepithelial neoplasia and adenocarcinoma: a study of 93 cases
    David G Bostwick
    Bostwick Laboratories, Richmond, Virginia 23294, USA
    Prostate 58:164-8. 2004
  4. ncbi request reprint Treatment changes in prostatic hyperplasia and cancer, including androgen deprivation therapy and radiotherapy
    D G Bostwick
    Department of Pathology, Mayo Clinic, Rochester, Minnesota, USA
    Urol Clin North Am 26:465-79. 1999
  5. ncbi request reprint Diagnosis and grading of bladder cancer and associated lesions
    D G Bostwick
    Department of Pathology, Mayo Clinic, Rochester, Minnesota, USA
    Urol Clin North Am 26:493-507. 1999
  6. ncbi request reprint Immunohistochemical changes in prostate cancer after androgen deprivation therapy
    D G Bostwick
    Bostwick Laboratories, Richmond, Virginia 23294, USA
    Mol Urol 4:101-6;discussion 107. 2000
  7. ncbi request reprint Phyllodes tumor of the prostate: long-term followup study of 23 cases
    David G Bostwick
    Bostwick Laboratories, 2807 North Parham Road, Richmond, VA 23294, USA
    J Urol 172:894-9. 2004
  8. ncbi request reprint Contemporary pathology of prostate cancer
    David G Bostwick
    Bostwick Laboratories, 2807 North Parham Road, Suite 114, Richmond, VA 23294, USA
    Urol Clin North Am 30:181-207. 2003
  9. ncbi request reprint Urothelial papillary (exophytic) neoplasms
    David G Bostwick
    Bostwick Laboratories, 2807 N Parham Rd Richmond, VA 23294, USA
    Virchows Arch 441:109-16. 2002
  10. ncbi request reprint Prostatic intraepithelial neoplasia
    D G Bostwick
    Bostwick Laboratories, 6722 Patterson Avenue, Richmond, VA 23226, USA
    Curr Urol Rep 1:65-70. 2000

Collaborators

Detail Information

Publications111 found, 100 shown here

  1. doi request reprint Precursors of prostate cancer
    David G Bostwick
    Bostwick Laboratories, Glen Allen, VA 23060, USA
    Histopathology 60:4-27. 2012
    ..Multiple clinical trials to date of men with PIN have had modest success in delaying or preventing subsequent cancer...
  2. ncbi request reprint Diagnosis and classification of renal cell carcinoma
    D G Bostwick
    Department of Pathology, Mayo Clinic, Rochester, Minnesota, USA
    Urol Clin North Am 26:627-35. 1999
    ....
  3. ncbi request reprint Amphiregulin expression in prostatic intraepithelial neoplasia and adenocarcinoma: a study of 93 cases
    David G Bostwick
    Bostwick Laboratories, Richmond, Virginia 23294, USA
    Prostate 58:164-8. 2004
    ..The purpose of this study was to compare the expression of AMP in benign prostatic epithelium, high-grade prostatic intraepithelial neoplasia (PIN), and adenocarcinoma...
  4. ncbi request reprint Treatment changes in prostatic hyperplasia and cancer, including androgen deprivation therapy and radiotherapy
    D G Bostwick
    Department of Pathology, Mayo Clinic, Rochester, Minnesota, USA
    Urol Clin North Am 26:465-79. 1999
    ..Pathologists must be aware of these distinct changes because of the reliance placed on nuclear and nucleolar size in the identification of prostate cancer, particularly in small specimens and lymph node metastases...
  5. ncbi request reprint Diagnosis and grading of bladder cancer and associated lesions
    D G Bostwick
    Department of Pathology, Mayo Clinic, Rochester, Minnesota, USA
    Urol Clin North Am 26:493-507. 1999
    ..Uniformity of pathologic reporting should improve the comparability of different studies and therapies and provide more accurate information to urologists in managing patients...
  6. ncbi request reprint Immunohistochemical changes in prostate cancer after androgen deprivation therapy
    D G Bostwick
    Bostwick Laboratories, Richmond, Virginia 23294, USA
    Mol Urol 4:101-6;discussion 107. 2000
    ..This report summarizes the existing literature regarding changes in tissue expression of proteins, as determined by immunohistochemistry, and the clinical implications of these changes...
  7. ncbi request reprint Phyllodes tumor of the prostate: long-term followup study of 23 cases
    David G Bostwick
    Bostwick Laboratories, 2807 North Parham Road, Richmond, VA 23294, USA
    J Urol 172:894-9. 2004
    ..Phyllodes tumor of the prostate is a rare neoplasm of uncertain malignant potential. We studied a large series of phyllodes tumors to define the combination of histological features that are most useful for predicting patient outcome...
  8. ncbi request reprint Contemporary pathology of prostate cancer
    David G Bostwick
    Bostwick Laboratories, 2807 North Parham Road, Suite 114, Richmond, VA 23294, USA
    Urol Clin North Am 30:181-207. 2003
    ..Numerous findings have proven to be of value, including simple quantitation of histopathologic features, cancer volume, perineural invasion, and others...
  9. ncbi request reprint Urothelial papillary (exophytic) neoplasms
    David G Bostwick
    Bostwick Laboratories, 2807 N Parham Rd Richmond, VA 23294, USA
    Virchows Arch 441:109-16. 2002
    ..Some pathologists may prefer additionally to report synonymous classification in other schemes, but this is discouraged owing to variations and difficulties in translations...
  10. ncbi request reprint Prostatic intraepithelial neoplasia
    D G Bostwick
    Bostwick Laboratories, 6722 Patterson Avenue, Richmond, VA 23226, USA
    Curr Urol Rep 1:65-70. 2000
    ..Androgen deprivation therapy decreases the prevalence and extent of PIN, suggesting that this form of treatment may play a role in chemoprevention...
  11. ncbi request reprint Over-diagnosis of high-grade prostatic intraepithelial neoplasia: a prospective study of 251 cases
    David G Bostwick
    Bostwick Laboratories, Richmond, Virginia, USA
    BJU Int 100:1036-9. 2007
    ..To assess the magnitude and causes of over-diagnosis of prostatic intraepithelial neoplasia (PIN), as large differences are reported in the incidence of high-grade PIN, probably because of the variance in diagnosis and interpretation...
  12. ncbi request reprint High-grade prostatic intraepithelial neoplasia
    David G Bostwick
    Bostwick Laboratories, Richmond, VA 23294, USA
    Mod Pathol 17:360-79. 2004
    ..Androgen deprivation therapy decreases the prevalence and extent of PIN, suggesting that this form of treatment may play a role in chemoprevention...
  13. doi request reprint Prostatic stromal hyperplasia with atypia: follow-up study of 18 cases
    Deloar Hossain
    Bostwick Laboratories, Glen Allen, VA 23060, USA
    Arch Pathol Lab Med 132:1729-33. 2008
    ..Prostatic stromal hyperplasia with atypia is a rare lesion that can be mistaken for sarcoma because of the presence of atypical, bizarre, degenerative myocyte nuclei...
  14. doi request reprint Group consensus reports from the Consensus Conference on Focal Treatment of Prostatic Carcinoma, Celebration, Florida, February 24, 2006
    David G Bostwick
    Bostwick Laboratories, Richmond, Virginia 23060, USA
    Urology 70:42-4. 2007
  15. ncbi request reprint Effect of androgen deprivation therapy on prostatic intraepithelial neoplasia
    D G Bostwick
    Bostwick Laboratories, Richmond, Virginia 23294, USA
    Urology 58:91-3. 2001
    ..Multiple chemoprevention trials are planned or under way to address this hypothesis...
  16. ncbi request reprint Prediction of individual patient outcome in cancer: comparison of artificial neural networks and Kaplan--Meier methods
    D G Bostwick
    Bostwick Laboratories, Richmond, Virginia 23294, USA
    Cancer 91:1643-6. 2001
    ..There is a great need for accurate treatment and outcome prediction in cancer. Two methods for prediction, artificial neural networks and Kaplan--Meier plots, have not, to the authors' knowledge, been compared previously...
  17. ncbi request reprint Glutathione S-transferase: differential expression of alpha, mu, and pi isoenzymes in benign prostate, prostatic intraepithelial neoplasia, and prostatic adenocarcinoma
    David G Bostwick
    Bostwick Laboratories, Glen Allen, VA 23060, USA
    Hum Pathol 38:1394-401. 2007
    ..We hypothesize that carcinogenesis in the prostate results from impaired cellular handling of mutagenic agents owing to reduction or loss of expression of multiple GST and other detoxifying and antimutagenesis agents...
  18. ncbi request reprint Human prostate cancer risk factors
    David G Bostwick
    Bostwick Laboratories, Richmond, Virginia 23294, USA
    Cancer 101:2371-490. 2004
    ..An understanding of the risk factors for prostate cancer has practical importance for public health research and policy, genetic and nutritional education and chemoprevention, and prevention strategies...
  19. ncbi request reprint 'Vanishing' prostate cancer in radical prostatectomy specimens: incidence and long-term follow-up in 38 cases
    David G Bostwick
    Mayo Clinic, Rochester, Minnesota, USA
    BJU Int 94:57-8. 2004
    ..To determine the incidence and long-term follow-up of the 'vanishing cancer' phenomenon, as complete sampling of some radical prostatectomy (RP) specimens reveals no residual cancer...
  20. ncbi request reprint Atypical small acinar proliferation in the prostate: clinical significance in 2006
    David G Bostwick
    Bostwick Laboratories, Richmond, VA 23060, USA
    Arch Pathol Lab Med 130:952-7. 2006
    ..Identification of atypical small acinar proliferation warrants repeat biopsy for concurrent or subsequent invasive carcinoma...
  21. ncbi request reprint Does finasteride alter the pathology of the prostate and cancer grading?
    David G Bostwick
    Bostwick Laboratories, Richmond, VA 23294, USA
    Clin Prostate Cancer 2:228-35. 2004
    ..Chemoprevention trials with agents such as finasteride that alter morphology should not rely on cancer grading as a secondary endpoint owing to grading bias...
  22. ncbi request reprint Extranodal extension in lymph node-positive prostate cancer
    L Cheng
    Department of Pathology, Indiana University School of Medicine, Indianapolis 46202, USA
    Mod Pathol 13:113-8. 2000
    ..In contrast, nodal cancer volume was predictive of distant metastasis-free survival and cancer-specific survival...
  23. ncbi request reprint Tumor size predicts the survival of patients with pathologic stage T2 bladder carcinoma: a critical evaluation of the depth of muscle invasion
    L Cheng
    Department of Pathology, Indiana University School of Medicine, Indianapolis 46202, USA
    Cancer 85:2638-47. 1999
    ..Evidence has accumulated that cancers invading the superficial muscle wall (T2a) behave similarly to those invading the deep muscle wall (T2b). Quantitative analysis of the depth of invasion in relation to patient outcome is needed...
  24. ncbi request reprint Cell proliferation in prostate cancer patients with lymph node metastasis: a marker for progression
    L Cheng
    Department of Pathology, Indiana University School of Medicine, Indianapolis 46202, USA
    Clin Cancer Res 5:2820-3. 1999
    ..52 and 0.17, respectively). Our data indicate that assessment of cell proliferation in nodal metastasis is predictive of clinical outcome in prostate cancer patients with regional lymph node metastasis...
  25. ncbi request reprint Diagnosis of prostate cancer in needle biopsies after radiation therapy
    L Cheng
    Department of Pathology, Indiana University School of Medicine, Indianapolis 46202, USA
    Am J Surg Pathol 23:1173-83. 1999
    ..Conversely, Gleason grade in postirradiation needle biopsy specimens appeared to provide useful predictive information and should be reported...
  26. ncbi request reprint Predictors of cancer progression in T1a prostate adenocarcinoma
    L Cheng
    Department of Pathology, Indiana University School of Medicine, Indianapolis 46202, USA
    Cancer 85:1300-4. 1999
    ..In the current study the authors attempted to identify such predictors of cancer progression in a large series of untreated patients with lengthy follow-up...
  27. ncbi request reprint Paraganglioma of the urinary bladder: can biologic potential be predicted?
    L Cheng
    Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Cancer 88:844-52. 2000
    ..Paraganglioma of the urinary bladder is rarely encountered and its biologic behavior is uncertain. The authors sought to determine the prognostic factors that would predict patient outcome...
  28. ncbi request reprint Risk of prostate carcinoma death in patients with lymph node metastasis
    L Cheng
    Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Cancer 91:66-73. 2001
    ..Results of published reports on survival among patients with lymph node metastasis are difficult to assess because of treatment selections. The extent to which lymph node status will have an impact on a patient's survival is uncertain...
  29. ncbi request reprint Mutation and expression analysis of the p73 gene in prostate cancer
    A Yokomizo
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA
    Prostate 39:94-100. 1999
    ..Recently, p73, a first homologue of p53, was identified and considered to be an imprinted tumor suppressor gene. Thus, we analyzed the possible role of p73 in human prostate cancers...
  30. ncbi request reprint Squamous papilloma of the urinary tract is unrelated to condyloma acuminata
    L Cheng
    Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Cancer 88:1679-86. 2000
    ..To the authors' knowledge, there is no previous report of squamous papilloma of the urinary tract. It is uncertain whether there is a correlation between squamous papilloma, condyloma acuminatum, and verrucous carcinoma...
  31. ncbi request reprint The cell cycle inhibitors p21WAF1 and p27KIP1 are associated with survival in patients treated by salvage prostatectomy after radiation therapy
    L Cheng
    Department of Pathology, Indiana University School of Medicine, Indianapolis 46202, USA
    Clin Cancer Res 6:1896-9. 2000
    ..06 and 0.01, respectively). These findings indicate that p21 and p27 expression levels are significant predictors of survival for patients selected for salvage prostatectomy for recurrent prostate cancer...
  32. ncbi request reprint Atypical nephrogenic metaplasia of the urinary tract: a precursor lesion?
    L Cheng
    Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Cancer 88:853-61. 2000
    ..Nephrogenic metaplasia with cytologic atypia (atypical nephrogenic metaplasia) is occasionally encountered and its biologic potential is uncertain...
  33. ncbi request reprint Predicting the survival of bladder carcinoma patients treated with radical cystectomy
    L Cheng
    Department of Pathology, Indiana University School of Medicine, Indianapolis 46202, USA
    Cancer 88:2326-32. 2000
    ..Clinical outcomes vary for patients treated with radical cystectomy. The authors sought to identify factors associated with the survival of patients treated with radical cystectomy for urothelial carcinoma of the urinary bladder...
  34. ncbi request reprint Predicting cancer progression in patients with stage T1 bladder carcinoma
    L Cheng
    Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Clin Oncol 17:3182-7. 1999
    ..We sought to identify factors associated with cancer progression in a series of patients with stage T1 bladder carcinoma treated with a contemporary therapeutic approach...
  35. ncbi request reprint Staging prostate cancer--1997: current methods and limitations
    D G Bostwick
    Department of Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Eur Urol 32:2-14. 1997
    ..Recent international agreement on the pathologic staging of prostate cancer should allow valid comparisons of surgical treatment from different institutions...
  36. ncbi request reprint Conserved genetic findings in metastatic bladder cancer: a possible utility of allelic loss of chromosomes 9p21 and 17p13 in diagnosis
    L Cheng
    Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Arch Pathol Lab Med 125:1197-9. 2001
    ..Molecular analysis of microsatellite alterations of biologically distinct tumor cell subpopulations from the same patient may aid in the determination of tumor origin and further our understanding of the genetic basis of cancer progression...
  37. ncbi request reprint Progression of prostatic intraepithelial neoplasia to early invasive adenocarcinoma
    D G Bostwick
    Department of Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Eur Urol 30:145-52. 1996
    ..This report describes the diagnostic criteria for prostatic intraepithelial neoplasia, its clinical significance, and the evidence suggesting that it progresses to prostatic adenocarcinoma...
  38. ncbi request reprint Natural history of urothelial dysplasia of the bladder
    L Cheng
    Department of Pathology, Indiana University School of Medicine, Indianapolis 46202, USA
    Am J Surg Pathol 23:443-7. 1999
    ..The authors conclude that urothelial dysplasia is a significant risk for the development of CIS and invasive urothelial carcinoma, and patients with urothelial dysplasia should be followed up closely...
  39. ncbi request reprint Molecular genetic evidence for different clonal origin of components of human renal angiomyolipomas
    L Cheng
    Department of Pathology, Indiana University School of Medicine, Indianapolis 46202, USA
    Am J Surg Pathol 25:1231-6. 2001
    ..The coexistence of tumor subclones with morphologic heterogeneity can lead to the formation of a clinically detectable tumor...
  40. ncbi request reprint Reversibility of prostatic intraepithelial neoplasia: implications for chemoprevention
    D G Bostwick
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minn 55905, USA
    Eur Urol 35:492-5. 1999
    ..Androgen deprivation therapy and radiation therapy decrease its prevalence and extent, suggesting a role in chemoprevention...
  41. ncbi request reprint Urothelial papilloma of the bladder. Clinical and biologic implications
    L Cheng
    Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Cancer 86:2098-101. 1999
    ..An international consensus has been reached regarding diagnostic criteria for papilloma of the urinary bladder. However, the incidences of recurrence and progression in patients with urothelial papilloma are uncertain...
  42. ncbi request reprint High grade prostatic intraepithelial neoplasia in military working dogs with and without prostate cancer
    J W Aquilina
    Mayo Clinic, Rochester, Minnesota 55905, USA
    Prostate 36:189-93. 1998
    ..This method will provide important data to determine whether a model of spontaneous PIN in elderly dogs may have clinical utility in developing strategies directed toward preventing and treating prostate...
  43. ncbi request reprint Criteria for biopsy diagnosis of minimal volume prostatic adenocarcinoma: analytic comparison with nondiagnostic but suspicious atypical small acinar proliferation
    K A Iczkowski
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
    Arch Pathol Lab Med 124:98-107. 2000
    ..We previously described the diagnostic category called atypical small acinar proliferation (ASAP), suspicious for but not diagnostic of malignancy, present in about 2.5% of routine prostatic needle biopsy specimens...
  44. ncbi request reprint Cancer heterogeneity and its biologic implications in the grading of urothelial carcinoma
    L Cheng
    Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Cancer 88:1663-70. 2000
    ..Urothelial carcinoma of the bladder often contains areas with different histologic grades. The influence of cancer heterogeneity on grading and its relation to patient outcome is uncertain...
  45. ncbi request reprint Distinguishing atrophy and high-grade prostatic intraepithelial neoplasia from prostatic adenocarcinoma with and without previous adjuvant hormone therapy with the aid of cytokeratin 5/6
    Neil A Abrahams
    Department of Pathology, Cleveland Clinic Foundation, Cleveland, OH, USA
    Am J Clin Pathol 120:368-76. 2003
    ..CK5/6 staining of the basal cells in foci of atrophy is sensitive and specific for excluding prostatic adenocarcinoma with and without androgen-deprivation effect...
  46. ncbi request reprint Molecular biology of prostatic intraepithelial neoplasia
    D G Bostwick
    Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Prostate 29:117-34. 1996
    ..Further studies are needed to evaluate the function and prognostic value of oncogene expression in the normal, preneoplastic, and neoplastic prostate...
  47. ncbi request reprint Expression of early growth response genes in human prostate cancer
    M A Eid
    Department of Urology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer Res 58:2461-8. 1998
    ..These results show that EGR-1 is overexpressed in prostate cancer and suggest a role for EGR-1 in prostate cancer growth...
  48. ncbi request reprint Steam heat with an EDTA buffer and protease digestion optimizes immunohistochemical expression of basal cell-specific antikeratin 34betaE12 to discriminate cancer in prostatic epithelium
    K A Iczkowski
    Department of Pathology, Mayo Clinic Rochester, Minnesota 55905, USA
    Mod Pathol 12:1-4. 1999
    ..This helps to prevent misinterpretation of histologic mimics of cancer, such as atrophic acini and high-grade prostatic intraepithelial neoplasia, that result from false-negative staining...
  49. ncbi request reprint Evaluating radical prostatectomy specimens: therapeutic and prognostic importance
    D G Bostwick
    Department of Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Virchows Arch 430:1-16. 1997
    ..Recent international agreement on pathologic staging of prostate cancer should allow valid comparisons of surgical treatment from different institutions. The vanishing cancer phenomenon is also briefly discussed...
  50. ncbi request reprint Prognostic factors for survival of patients with pathological Gleason score 7 prostate cancer: differences in outcome between primary Gleason grades 3 and 4
    W K Lau
    Department of Urology, Laboratory Medicine and Pathology, Section of Biostatistics, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Urol 166:1692-7. 2001
    ..However, primary Gleason grade does not provide any additional information than other known prognostic factors, such as preoperative PSA, seminal vesicle invasion and DNA ploidy...
  51. ncbi request reprint Human glandular kallikrein 2 (hK2) expression in prostatic intraepithelial neoplasia and adenocarcinoma: a novel prostate cancer marker
    M F Darson
    Department of Urology, Mayo Clinic, Rochester, MN 35905, USA
    Urology 49:857-62. 1997
    ..We describe the expression of a potentially new tumor marker, human glandular kallikrein 2 (hK2), that may be useful as an adjunct to prostate-specific antigen (PSA) in the diagnosis and monitoring of prostate cancer...
  52. ncbi request reprint Human acid ceramidase is overexpressed but not mutated in prostate cancer
    R S Seelan
    Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota
    Genes Chromosomes Cancer 29:137-46. 2000
    ..These results suggest that acid ceramidase may play an important role in prostate carcinogenesis...
  53. ncbi request reprint Identification of patients with low-risk for aneuploidy: comparative discriminatory models using linear and machine-learning classifiers in prostate cancer
    Girish Venkataraman
    Department of Pathology, Loyola University Medical Center, Maywood, Illinois 60153, USA
    Prostate 67:1524-36. 2007
    ..Prostate needle biopsy (PNB) ploidy status has proven utility to predict adverse outcomes after prostatectomy. We sought to develop models to predict ploidy status using clinicopathologic variables...
  54. ncbi request reprint Preoperative prediction of multifocal prostate cancer and application of focal therapy: review 2007
    Isabelle Meiers
    Bostwick Laboratories, Glen Allen, Virginia 23060, USA
    Urology 70:3-8. 2007
    ..This article reviews the importance of multifocal prostate cancer and the application of focal treatment...
  55. doi request reprint Androgen deprivation therapy for precancerous lesions of the prostate
    David Hull
    Bostwick Laboratories Inc, Glen Allen, VA 23060, USA
    Best Pract Res Clin Endocrinol Metab 22:285-91. 2008
    ....
  56. ncbi request reprint Cytokeratin 7 and cytokeratin 20 in primary urinary bladder carcinoma and matched lymph node metastasis
    J Jiang
    Department of Pathology, Indiana University School of Medicine, Indianapolis, Ind. 46202, USA
    Arch Pathol Lab Med 125:921-3. 2001
    ..All cases showed positive CK7 immunoreactivity in the primary cancers and matched lymph node metastases. CONCLUSIONS:-CK20 immunoreactivity is reliably observed in metastases from bladder cancer when the primary tumor expresses CK20...
  57. ncbi request reprint Corpora amylacea in adenocarcinoma of the prostate: incidence and histology within needle core biopsies
    James D Christian
    Bostwick Laboratories, Richmond, VA 23294, USA
    Mod Pathol 18:36-9. 2005
    ..Our results indicate that the incidence of corpora amylacea in adenocarcinoma is low, but the presence of such inclusions cannot be used to exclude malignancy...
  58. doi request reprint Prostatic leiomyoma with atypia: follow-up study of 10 cases
    Deloar Hossain
    Bostwick Laboratories, Glen Allen, VA 023060, USA
    Ann Diagn Pathol 12:328-32. 2008
    ..Four local recurrences were seen, with a follow-up for 3 to 16 years (mean, 7.4 years), but no evidence of sarcomatous transformation occurred. Despite worrisome histologic appearance, a benign clinical behavior was seen in all cases...
  59. ncbi request reprint Loss of p53 and c-myc overrepresentation in stage T(2-3)N(1-3)M(0) prostate cancer are potential markers for cancer progression
    Junqi Qian
    Department of Laboratory Medicine and Pathology, Section of Biostatistics, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    Mod Pathol 15:35-44. 2002
    ....
  60. ncbi request reprint Prostate cancer outcome: epidemiology and biostatistics
    Harry B Burke
    Bostwick Laboratories, Richmond, Virginia, USA
    Anal Quant Cytol Histol 27:211-7. 2005
    ..We must implement statistical approaches that integrate the new molecular biomarkers with existing prognostic biomarkers to accurately predict which patients require treatment and to determine the optimal therapy...
  61. ncbi request reprint Prostate cancer detected by uPM3: radical prostatectomy findings
    David G Bostwick
    Bostwick Laboratories, Glen Allen, VA 23060, USA
    Mod Pathol 19:630-3. 2006
    ..The uPM3 is an independent and specific biomarker that detects prostate cancers of similar volume, location, extent and grade as other tests for early detection. uPM3 does not preferentially identify large or aggressive prostate cancers...
  62. ncbi request reprint Diagnosis of prostatic carcinoma after therapy
    David G Bostwick
    Bostwick Laboratories, 4355 Innslake Dr, Glen Allen, VA 23060, USA
    Arch Pathol Lab Med 131:360-71. 2007
    ..Treatment changes in the benign and cancerous prostate create diagnostic challenges in pathologic interpretation, particularly in needle biopsy specimens and in evaluation of extraprostatic metastases...
  63. ncbi request reprint Characterization of prostate cancer in needle biopsy by cathepsin B, cell proliferation and DNA ploidy
    Junqi Qian
    Bostwick Laboratories, 4355 Innslake Drive, Glen Allen, VA 23060, USA
    Anticancer Res 30:719-25. 2010
    ....
  64. doi request reprint Detection of chromosomal anomalies in endometrial atypical hyperplasia and carcinoma by using fluorescence in situ hybridization
    Junqi Qian
    Bostwick Laboratories, 4355 Innslake Drive, Glen Allen, VA 23060, USA
    Cancer Cytopathol 118:97-104. 2010
    ..The authors sought to investigate the utility of chromosomal anomalies for the detection of endometrial hyperplasia and carcinoma using multitarget fluorescence in situ hybridization (FISH)...
  65. ncbi request reprint Workgroup I: rodent models of prostate cancer
    M S Lucia
    Department of Pathology, University of Colorado, Denver, USA
    Prostate 36:49-55. 1998
  66. ncbi request reprint Overexpression of the wild type p73 gene in human bladder cancer
    A Yokomizo
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55095, USA
    Oncogene 18:1629-33. 1999
    ..These data suggest that the p73 is unlikely to be a tumor suppressor gene, but that overexpression of p73 may contribute to tumorigenesis in bladder cancer...
  67. ncbi request reprint High-grade prostatic intraepithelial neoplasia and atypical small acinar proliferation: predictive value for cancer in current practice
    Cory Schlesinger
    Bostwick Laboratories, Richmond, VA, USA
    Am J Surg Pathol 29:1201-7. 2005
    ....
  68. doi request reprint Preoperative prediction of unifocal, unilateral, margin-negative, and small volume prostate cancer
    Kenneth A Iczkowski
    Department of Pathology, University of Colorado Health Science Center, Denver, Colorado 80045, USA
    Urology 71:1166-71. 2008
    ..Subtotal gland ablation by minimally invasive therapies such as cryotherapy demands preoperative prediction of unifocal, unilateral, margin-negative, and small volume (less than 0.5 mL) cancer...
  69. doi request reprint Precursor of prostate-specific antigen expression in prostatic intraepithelial neoplasia and adenocarcinoma: a study of 90 cases
    David Hull
    Bostwick Laboratories, Glen Allen, VA 23060, USA
    BJU Int 104:915-8. 2009
    ....
  70. ncbi request reprint Fast liquid ablation system for prostatic hyperplasia: a new minimally invasive thermal treatment
    Alberto G Corica
    Bostwick Laboratories, 2807 North Parham Road, Richmond, VA 23294, USA
    J Urol 170:874-8. 2003
    ..We determined patient tolerance and the sequence of histopathological changes of thermal injury and healing of the prostate after treatment with a novel, rapid, high temperature, liquid filled, flexible balloon thermotherapy system...
  71. ncbi request reprint Gadolinium-enhanced MRI in the evaluation of minimally invasive treatments of the prostate: correlation with histopathologic findings
    Benjamin T Larson
    Department of Radiology, Mayo Clinic, Scottsdale, Arizona, USA
    Urology 62:900-4. 2003
    ..As these devices enter the mainstream of patient care, imaging methods that verify the exact location, extent, and pattern of the ablation are needed...
  72. ncbi request reprint Mesonephric remnants of the prostate: incidence and histologic spectrum
    David G Bostwick
    Bostwick Laboratories, Richmond, Virginia 23294, USA
    Mod Pathol 16:630-5. 2003
    ..Immunohistochemical studies with antibodies to PSA and keratin 34BE12 are helpful in separating mesonephric remnants from adenocarcinoma, similar to the case of other benign mimics...
  73. ncbi request reprint Prostatic intraepithelial neoplasia (PIN): current concepts
    D G Bostwick
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905
    J Cell Biochem Suppl 16:10-9. 1992
    ..The clinical importance of recognizing PIN is based on its strong association with carcinoma; its identification in biopsy specimens of the prostate warrants further search for concurrent invasive carcinoma...
  74. ncbi request reprint Neuroendocrine expression in node positive prostate cancer: correlation with systemic progression and patient survival
    David G Bostwick
    Bostwick Laboratories, Richmond, USA
    J Urol 168:1204-11. 2002
    ....
  75. ncbi request reprint Histological changes of minimally invasive procedures for the treatment of benign prostatic hyperplasia and prostate cancer: clinical implications
    Benjamin T Larson
    Bostwick Laboratories, 2807 N Parham Road, Richmond, VA 23294, USA
    J Urol 170:12-9. 2003
    ..In the last decade numerous nonsurgical minimally invasive methods have emerged for ablation of prostatic tissue...
  76. doi request reprint Prostate needle biopsy quality in reduction by dutasteride of prostate cancer events study: worldwide comparison of improvement with investigator training and centralized laboratory processing
    David G Bostwick
    Bostwick Laboratories, Glen Allen, Virginia 23060, USA
    Urology 75:1406-10. 2010
    ..The accuracy of prostate cancer detection is influenced by the length and number of biopsy cores...
  77. ncbi request reprint Practical clinical application of predictive factors in prostate cancer. A review with an emphasis on quantitative methods in tissue specimens
    D G Bostwick
    Department of Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Anal Quant Cytol Histol 20:323-42. 1998
    ....
  78. ncbi request reprint Glutathione S-transferase pi (GSTP1) hypermethylation in prostate cancer: review 2007
    Isabelle Meiers
    Department of Pathology, Bostwick Laboratories, London, United Kingdom
    Pathology 39:299-304. 2007
    ..Inhibition of aberrant promoter methylation could theoretically prevent carcinogenesis...
  79. ncbi request reprint Intraepithelial and stromal lymphocytes in the normal human prostate
    David G Bostwick
    Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Prostate 55:187-93. 2003
    ..The distribution and significance of lymphocytes in the normal human prostate is uncertain. It may be important as a determinant of the immune response, playing a role in hyperplasia and carcinogenesis...
  80. ncbi request reprint Performance of urine test in patients monitored for recurrence of bladder cancer: a multicenter study in the United States
    Edward M Messing
    Department of Urology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Urol 174:1238-41. 2005
    ..We assessed the performance of the ImmunoCyt immunocytochemical test for detecting bladder cancer recurrence in patients with prior superficial bladder cancers compared with cystoscopic and histological findings...
  81. ncbi request reprint Immunohistochemical analysis of chromophobe renal cell carcinoma, renal oncocytoma, and clear cell carcinoma: an optimal and practical panel for differential diagnosis
    Lina Liu
    Bostwick Laboratories, Inc, 4355 Innslake Dr, Glen Allen, VA 23060, USA
    Arch Pathol Lab Med 131:1290-7. 2007
    ..The separation of chromophobe renal cell carcinoma, oncocytoma, and clear cell renal cell carcinoma using light microscopy remains problematic in some cases...
  82. ncbi request reprint Flutamide in men with prostatic intraepithelial neoplasia: a randomized, placebo-controlled chemoprevention trial
    Steven R Alberts
    Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA
    Am J Ther 13:291-7. 2006
    ..Quality-of-life measures did not show any differences between the 2 groups. This study showed no evidence of benefit from flutamide as a chemoprevention agent in men with HGPIN...
  83. ncbi request reprint Improved filter method for urine sediment detection of urothelial carcinoma by fluorescence in situ hybridization
    Isabelle Meiers
    Bostwick Laboratories, 4355 Innslake Dr, Glen Allen, VA 23060, USA
    Arch Pathol Lab Med 131:1574-7. 2007
    ..Fluorescence in situ hybridization (FISH) of voided urine sediment is a sensitive and specific test for the detection of urothelial carcinoma. The time required for slide preparation using the conventional cytospin method is lengthy...
  84. ncbi request reprint Tubulocystic carcinoma, mucinous tubular and spindle cell carcinoma, and other recently described rare renal tumors
    Gregory T MacLennan
    Department of Pathology, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH 44106, USA
    Clin Lab Med 25:393-416. 2005
    ..Most have been included in the 2004 edition of the WHO classification of tumors of the urinary system and male genital organs. Tubulocystic carcinoma needs to be studied and characterized more fully...
  85. doi request reprint Interobserver variability between expert urologic pathologists for extraprostatic extension and surgical margin status in radical prostatectomy specimens
    Andrew J Evans
    Department of Pathology and Laboratory Medicine, University Health Network, Toronto, Ontario, Canada
    Am J Surg Pathol 32:1503-12. 2008
    ..Interobserver variability for EPE and SM interpretation was principally related to the lack of a clearly definable prostatic capsule and crush/thermal artifact along the edge of the gland, respectively...
  86. ncbi request reprint Glycoprotein A-80 in the human prostate: immunolocalization in prostatic intraepithelial neoplasia, carcinoma, radiation failure, and after neoadjuvant hormonal therapy
    Christopher L Coogan
    Department of Urology, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    Urology 61:248-52. 2003
    ..A-80 is a glycoprotein linked to exocrine differentiation that shows little or no expression in normal exocrine cells, but is selectively overexpressed in dysplasias and adenocarcinomas...
  87. doi request reprint Is there a better way to biopsy the prostate? Prospects for a novel transrectal systematic biopsy approach
    Gerald L Andriole
    Division of Urologic Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Urology 70:22-6. 2007
    ..Its reproducibility from operator to operator suggests that it may be useful for guiding rebiopsy of specific locations within the prostate and for providing targeted focal prostate cancer therapy...
  88. ncbi request reprint Molecular differentiation of high- and moderate-grade human prostate cancer by cDNA microarray analysis
    Carolyn J M Best
    Pathogenetics Unit, Laboratory of Pathology and Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Diagn Mol Pathol 12:63-70. 2003
    ..We suggest that these data provide insight into the molecular nature of clinically aggressive prostate cancer...
  89. ncbi request reprint Needle core length in sextant biopsy influences prostate cancer detection rate
    Kenneth A Iczkowski
    Department of Pathology and Laboratory Medicine, Veterans Affairs Medical Center, Gainesville, Florida 32608 1197, USA
    Urology 59:698-703. 2002
    ..Prostate cancer detection in biopsies increases with the number of sites and total tissue sampled. Its dependence on needle core fragment length is uncertain...
  90. ncbi request reprint Subvisual changes in chromatin organization state are detected by karyometry in the histologically normal urothelium in patients with synchronous papillary carcinoma
    Rodolfo Montironi
    Institute of Pathological Anatomy and Histopathology, University of Ancona School of Medicine, Torrette, Italy
    Hum Pathol 34:893-901. 2003
    ..In conclusion, karyometry can detect an abnormal chromatin pattern and distribution in the normal-looking urothelium adjacent to papillary carcinoma. Such alterations correspond to the so-called "malignancy-associated change."..
  91. ncbi request reprint Amplifications of EGFR gene and protein expression of EGFR, Her-2/neu, c-kit, and androgen receptor in phyllodes tumor of the prostate
    Xiaoyan Wang
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Mod Pathol 20:175-82. 2007
    ..Anti-EGFR and/or antiandrogen agents may be potentially useful for management of patients with tumors expressing EGFR and/or androgen receptor...
  92. pmc Molecular genetic evidence for different clonal origins of epithelial and stromal components of phyllodes tumor of the prostate
    Ryan P McCarthy
    Department of Pathology and Laboratory Medicine, Indiana University Medical Center, University Hospital 3465, 550 North University Blvd, Indianapolis, IN 46202, USA
    Am J Pathol 165:1395-400. 2004
    ..While both epithelium and stroma are clonal proliferations, they appear to have different clonal origins...
  93. ncbi request reprint Prostate cancer in native Japanese and Japanese-American men: effects of dietary differences on prostatic tissue
    Leonard S Marks
    Department of Urology, University of California, Los Angeles, Geffen School of Medicine, Los Angeles, California, USA
    Urology 64:765-71. 2004
    ..To investigate the relationship between diet and prostate cancer (CaP) among native Japanese (NJ) and second-generation or third-generation Japanese-American (J-A) men--focusing on the effects of animal fat and soy on prostatic tissues...
  94. ncbi request reprint The dual 5-alpha-reductase inhibitor dutasteride induces atrophic changes and decreases relative cancer volume in human prostate
    Kenneth A Iczkowski
    Department of Pathology and Laboratory Medicine, Veterans Affairs Medical Center, Gainesville, Florida 32608 1197, USA
    Urology 65:76-82. 2005
    ..To perform the first evaluation of the effects of the 5-alpha-reductase inhibitor class of drugs on cancer histopathologic features at radical prostatectomy in a placebo-controlled multicenter trial...
  95. ncbi request reprint Effects of dietary selenium supplementation on DNA damage and apoptosis in canine prostate
    David J Waters
    Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, IN 47907, USA
    J Natl Cancer Inst 95:237-41. 2003
    ..7 (interquartile range = 0.2-2.8) for the control dogs ( P =.04, Mann-Whitney U test). These data suggest that dietary selenium supplementation decreases DNA damage and increases epithelial cell apoptosis within the aging canine prostate...
  96. ncbi request reprint Karyometry detects subvisual differences in chromatin organization state between cribriform and flat high-grade prostatic intraepithelial neoplasia
    Rodolfo Montironi
    Institute of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region, Ancona, Italy
    Mod Pathol 17:928-37. 2004
    ....
  97. ncbi request reprint Pleomorphic giant cell carcinoma of the prostate
    Antonio Lopez-Beltran
    Department of Pathology, Cordoba University Medical School, Cordoba, Spain
    Arch Pathol Lab Med 129:683-5. 2005
    ..Pleomorphic giant cell carcinoma is a rare variant of prostatic adenocarcinoma with a poor prognosis that should be considered in the differential diagnosis of prostatic pleomorphic tumors...
  98. ncbi request reprint Atypical adenomatous hyperplasia (adenosis) of the prostate: DNA ploidy analysis and immunophenotype
    Antonio Lopez-Beltran
    Department of Pathology, Cordoba University Medical School, Cordoba, Spain
    Int J Surg Pathol 13:167-73. 2005
    ..105) or carcinoma (p=0.0820). All foci of nodular hyperplasia, AAH, and carcinoma were diploid. Ploidy status and our selected panel of antibodies did not discriminate among these 3 entities reliably...
  99. ncbi request reprint Incidentally detected prostate cancer in cystoprostatectomies: pathological and morphometric comparison with clinically detected cancer in totally embedded specimens
    Rodolfo Montironi
    Polytechnic University of the Marche Region, School of Medicine, Umberto I Hospital, Torrette, Ancona, Italy
    Hum Pathol 36:646-54. 2005
    ..We conclude that incidentally detected cancer is less aggressive than clinically detected cancer...
  100. ncbi request reprint Examination of the relationship between symptoms of prostatitis and histological inflammation: baseline data from the REDUCE chemoprevention trial
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston General Hospital, Kingston, Ontario, Canada
    J Urol 178:896-900; discussion 900-1. 2007
    ..5 mg dutasteride daily decreases the risk of biopsy detectable prostate cancer. All men underwent biopsy before study entry, allowing review of the relationship between histological prostate inflammation and prostatitis symptoms...
  101. ncbi request reprint Prostate biopsy and optimization of cancer yield
    David G Bostwick
    Eur Urol 49:415-7. 2006