Research Topics
Genomes and Genes
| Ming Hui ZouSummaryAffiliation: Boston University Country: USA Publications
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Detail Information
Publications
Peroxynitrite and protein tyrosine nitration of prostacyclin synthaseMing Hui Zou
BSEB 325, Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Science Center, 941 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
Prostaglandins Other Lipid Mediat 82:119-27. 2007....
Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitriteMing Hui Zou
Vascular Biology Unit, Whitaker Cardiovascular Institute, Department of Medicine, Boston University School of Medicine, 650 Albany Street, Boston, MA 02118, USA
J Clin Invest 109:817-26. 2002..in diabetes, contributing further to endothelial cell oxidant stress. Regulation of the zinc-thiolate center of NOS by ONOO(-) provides a novel mechanism for modulation of the enzyme function in disease...- Modulation by peroxynitrite of Akt- and AMP-activated kinase-dependent Ser1179 phosphorylation of endothelial nitric oxide synthaseMing Hui Zou
Vascular Biology Unit, Whitaker Cardiovascular Institute, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Biol Chem 277:32552-7. 2002..We conclude that ONOO(-) inhibits Akt and increases AMPK-dependent Ser(1179) phosphorylation of eNOS resulting in enhanced O(2)() release... - AMPKalpha2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo: role of 26S proteasomesShuangxi Wang
Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA
Circ Res 106:1117-28. 2010..Recent studies suggest that AMPK activation improves endothelial function by counteracting oxidative stress in endothelial cells. How AMPK suppresses oxidative stress remains to be established... - Activation of NAD(P)H oxidases by thromboxane A2 receptor uncouples endothelial nitric oxide synthaseMiao Zhang
Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA
Arterioscler Thromb Vasc Biol 31:125-32. 2011..How TPr stimulation causes vascular injury remains poorly defined. This study was conducted to investigate the mechanism by which TPr stimulation leads to vascular injury... - Proteasome-dependent degradation of guanosine 5'-triphosphate cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes mellitusJian Xu
Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Circulation 116:944-53. 2007.... - Acute inhibition of guanosine triphosphate cyclohydrolase 1 uncouples endothelial nitric oxide synthase and elevates blood pressureShuangxi Wang
Department of Medicine, Division of Endocrinology and Diabetes, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Hypertension 52:484-90. 2008..In conclusion, GTPCH1 via BH4 maintains normal BP and endothelial function in vivo by preserving NO synthesis by eNOS... - Reactive nitrogen species is required for the activation of the AMP-activated protein kinase by statin in vivoHyoung Chul Choi
Sections of Endocrinology and Nephrology, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
J Biol Chem 283:20186-97. 2008..Taken together, our data suggest that AMPK activation by statin is peroxynitrite-mediated but PKC-zeta-dependent... - Thromboxane receptor activates the AMP-activated protein kinase in vascular smooth muscle cells via hydrogen peroxideMiao Zhang
Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Science Center, 941 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
Circ Res 102:328-37. 2008..We conclude that TPr stimulation triggers reactive oxygen species-mediated LKB1-dependent AMPK activation, which in return inhibits cellular protein synthesis in VSMCs... - Phosphorylation of LKB1 at serine 428 by protein kinase C-zeta is required for metformin-enhanced activation of the AMP-activated protein kinase in endothelial cellsZhonglin Xie
Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Circulation 117:952-62. 2008..The objective of the present study was to determine how metformin activates AMPK in endothelial cells... - Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregulating phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in an LKB1-dependent mannerPing Song
Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA
Circulation 116:1585-95. 2007..Oxidative stress plays a causal role in vascular injury in diabetes mellitus, but the mechanisms and targets remain poorly understood... - Endothelial nitric oxide synthase-dependent tyrosine nitration of prostacyclin synthase in diabetes in vivoHong Nie
BSEB 325, Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA
Diabetes 55:3133-41. 2006..We conclude that diabetes increases PGIS nitration in vivo, likely via dysfunctional eNOS... - Activation of protease calpain by oxidized and glycated LDL increases the degradation of endothelial nitric oxide synthaseYunzhou Dong
Harold Hamm Oklahoma Diabetes Center, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
J Cell Mol Med 13:2899-910. 2009..HOG-LDL may impair endothelial function by inducing calpain-mediated eNOS degradation in a ROS- and Ca(2+)-dependent manner... - Activation of protein kinase C zeta by peroxynitrite regulates LKB1-dependent AMP-activated protein kinase in cultured endothelial cellsZhonglin Xie
Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73104, USA
J Biol Chem 281:6366-75. 2006..Taken together, we conclude that PKCzeta can regulate AMPK activity by increasing the Ser428 phosphorylation of LKB1, resulting in association of LKB1 with AMPK and consequent AMPK Thr172 phosphorylation by LKB1... - Protein kinase Czeta-dependent LKB1 serine 428 phosphorylation increases LKB1 nucleus export and apoptosis in endothelial cellsPing Song
Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA
J Biol Chem 283:12446-55. 2008..Finally, ONOO(-) enhanced PKCzeta nuclear import and LKB1 nuclear export. We conclude that PKCzeta mediates LKB1-dependent Akt inhibition in response to ONOO(-), resulting in endothelial apoptosis... - Identification of nitric oxide as an endogenous activator of the AMP-activated protein kinase in vascular endothelial cellsJunhua Zhang
Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
J Biol Chem 283:27452-61. 2008..Taken together, we conclude that NO might act as an endogenous AMPK activator... - Uncoupling of endothelial nitric oxidase synthase by hypochlorous acid: role of NAD(P)H oxidase-derived superoxide and peroxynitriteJian Xu
Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, 941 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
Arterioscler Thromb Vasc Biol 26:2688-95. 2006.... - Activation of protein phosphatase 2A by palmitate inhibits AMP-activated protein kinaseYong Wu
Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73104, USA
J Biol Chem 282:9777-88. 2007..Taken together, we conclude that palmitate inhibits the phosphorylation of both AMPK and endothelial nitric-oxide synthase in endothelial cells via ceramide-dependent PP2A activation... - High glucose via peroxynitrite causes tyrosine nitration and inactivation of prostacyclin synthase that is associated with thromboxane/prostaglandin H(2) receptor-mediated apoptosis and adhesion molecule expression in cultured human aortic endothelial celMing Hui Zou
Vascular Biology Unit, Whitaker Cardiovascular Institute, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Diabetes 51:198-203. 2002.... - Impaired expression of uncoupling protein 2 causes defective postischemic angiogenesis in mice deficient in AMP-activated protein kinase α subunitsMing jiang Xu
Section of Molecular Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, 73104, USA
Arterioscler Thromb Vasc Biol 31:1757-65. 2011..The aim of the present study was to determine whether mitochondrial uncoupling protein (UCP) 2 is required for AMPK-dependent angiogenesis in ischemia in vivo... - AMPKα2 deletion exacerbates neointima formation by upregulating Skp2 in vascular smooth muscle cellsPing Song
Section of Molecular Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, 73104, USA
Circ Res 109:1230-9. 2011..Whether AMPKα alters vascular neointima formation induced by vascular injury is unknown... - Activation of AMP-activated protein kinase alpha1 alleviates endothelial cell apoptosis by increasing the expression of anti-apoptotic proteins Bcl-2 and survivinChao Liu
Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
J Biol Chem 285:15346-55. 2010..Overall, our results suggest that AMPKalpha1, but not AMPKalpha2 activation, promotes cell survival by increasing NF-kappaB-mediated expression of anti-apoptotic proteins (Bcl-2 and Survivin) and intracellular ATP contents... - Upregulation of mitochondrial uncoupling protein-2 by the AMP-activated protein kinase in endothelial cells attenuates oxidative stress in diabetesZhonglin Xie
Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
Diabetes 57:3222-30. 2008..The present study was conducted to determine how AMPK activation suppressed tyrosine nitration of prostacyclin synthase in diabetes... - In vivo activation of AMP-activated protein kinase attenuates diabetes-enhanced degradation of GTP cyclohydrolase IShuangxi Wang
Division of Endocrinology and Diabetes, Department of Medicine, Herald Hamm Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
Diabetes 58:1893-901. 2009..The aim of this study was to test whether AMPK suppresses the degradation of GTP-cyclohydrolase (GTPCH I), a key event in vascular endothelial dysfunction in diabetes... - Estradiol-mediated endothelial nitric oxide synthase association with heat shock protein 90 requires adenosine monophosphate-dependent protein kinaseEberhard Schulz
Evans Memorial Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Mass 02118, USA
Circulation 111:3473-80. 2005..We therefore investigated whether AMPK is activated by estradiol in endothelial cells and plays a role in estradiol-induced eNOS activation... - Tyrosine nitration of prostacyclin synthase is associated with enhanced retinal cell apoptosis in diabetesMing Hui Zou
Section of Molecular Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
Am J Pathol 179:2835-44. 2011..In conclusion, oxidized LDL-mediated PGIS nitration and associated thromboxane receptor stimulation might be important in the initiation and progression of diabetic retinopathy... - Activation of AMP-activated protein kinase α2 by nicotine instigates formation of abdominal aortic aneurysms in mice in vivoShuangxi Wang
Department of Medicine, Division of Molecular Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
Nat Med 18:902-10. 2012..We conclude that smoking (through nicotine) instigates AAA through AMPK-α2–mediated AP-2α–dependent MMP2 expression in VSMCs... - Thromboxane A2 receptor activates a Rho-associated kinase/LKB1/PTEN pathway to attenuate endothelium insulin signalingPing Song
Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
J Biol Chem 284:17120-8. 2009..Importantly, administration of TP antagonist blocked these changes. We conclude that TP stimulation impairs insulin signaling in vascular endothelial cells by selectively activating the Rho/Rho-associated kinase/LKB1/PTEN pathway... - Identification of the serine 307 of LKB1 as a novel phosphorylation site essential for its nucleocytoplasmic transport and endothelial cell angiogenesisZhonglin Xie
Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Mol Cell Biol 29:3582-96. 2009.... - Inhibition of the AMP-activated protein kinase-α2 accentuates agonist-induced vascular smooth muscle contraction and high blood pressure in miceShuangxi Wang
Division of Molecular Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, BSEB 325, 941 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
Hypertension 57:1010-7. 2011.... - Regulation of NAD(P)H oxidases by AMPK in cardiovascular systemsPing Song
Section of Molecular Medicine, Department of Medicine, and Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Free Radic Biol Med 52:1607-19. 2012..In this review, we summarize our current understanding of how AMPK functions as a physiological repressor of NAD(P)H oxidase... - AMP-activated protein kinase activation as a strategy for protecting vascular endothelial functionMing Hui Zou
Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
Clin Exp Pharmacol Physiol 35:535-45. 2008..We further hypothesize that AMPK is a dual sensor for energy and redox status within a cell and AMPK may be a therapeutic target for protecting vascular endothelial function... - Vascular inflammation is a missing link for diabetes-enhanced atherosclerotic cardiovascular diseasesNajeeb A Shirwany
Section of Molecular Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Front Biosci 17:1140-64. 2012..This review aims to present the empirical underpinning of the hypothesis that inflammatory change in the vasculature might be the integrated mechanism that connects a diabetic phenotype with its attendant vascular complications... - AMP-activated protein kinase modulates cardiac autophagy in diabetic cardiomyopathyZhonglin Xie
Section of Molecular Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
Autophagy 7:1254-5. 2011..We conclude that AMPK activation protects cardiac structure and function by increasing cardiac autophagy in the diabetic heart... - Tyrosine nitration of PA700 activates the 26S proteasome to induce endothelial dysfunction in mice with angiotensin II-induced hypertensionJian Xu
Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, 941 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
Hypertension 54:625-32. 2009..We conclude that Ang II increases tyrosine nitration of PA700 resulting in accelerated GTP cyclohydrolase I degradation, BH4 deficiency, and consequent endothelial dysfunction in hypertension... - Arterial stiffness: a brief reviewNajeeb A Shirwany
Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, 73104, USA
Acta Pharmacol Sin 31:1267-76. 2010..A critical discussion of new techniques for assessing vascular stiffness is also presented... - Endothelial cell activation by endotoxin involves superoxide/NO-mediated nitration of prostacyclin synthase and thromboxane receptor stimulationMarkus Bachschmid
Faculty of Biology, University of Konstanz, 78457 Konstanz, Germany
FASEB J 17:914-6. 2003..PGE2 together with a lack of NO and PGI2 is known to promote the adhesion of white blood cells and their immigration to the inflammatory locus... - Quantitative assessment of tyrosine nitration of manganese superoxide dismutase in angiotensin II-infused rat kidneyWei Guo
Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University Medical Center, Boston, MA 02118, USA
Am J Physiol Heart Circ Physiol 285:H1396-403. 2003..Angiotensin II-induced hypertension is accompanied by increased tyrosine nitration of MnSOD, which, because it inactivates the enzyme, may contribute to increased oxidant stress in the kidney... - Activation of 5'-AMP-activated kinase is mediated through c-Src and phosphoinositide 3-kinase activity during hypoxia-reoxygenation of bovine aortic endothelial cells. Role of peroxynitriteMing Hui Zou
Vascular Research Laboratory, Department of Surgery, Graduate School of Medicine, The University of Tennessee, Knoxville, Tennessee 37920, USA
J Biol Chem 278:34003-10. 2003.... - Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen speciesMing Hui Zou
Vascular Research Laboratory, Graduate School of Medicine, University of Tennessee, Knoxville 37920, USA
J Biol Chem 279:43940-51. 2004.... - Peroxynitrite and vascular endothelial dysfunction in diabetes mellitusMing Hui Zou
Vascular Research Laboratory, Graduate School of Medicine, University of Tennessee, Knoxville, TN 37920, USA
Endothelium 11:89-97. 2004..The authors' studies indicate that in diabetes the synthetic enzymes of the two major endogenous vasodilators undergo oxidative inactivation by different mechanisms, which are, however, tightly interdependent... - CD40 ligand-dependent tyrosine nitration of prostacyclin synthase in vivoBradley Davis
Vascular Research Laboratory, Graduate School of Medicine, University of Tennessee, Knoxville, Tennessee, USA
Circulation 112:2184-92. 2005.... - Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthaseBradley J Davis
Vascular Research Laboratory, Department of Surgery, Graduate School of Medicine, University of Tennessee, Knoxville, USA
Diabetes 55:496-505. 2006..Taken together, our results indicate that metformin might improve vascular endothelial functions in diabetes by increasing AMPK-dependent, hsp90-mediated eNOS activation... - Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidationXueliang Du
Diabetes Research Center, Albert Einstein College of Medicine, New York, New York 10461, USA
J Clin Invest 116:1071-80. 2006..These studies identify what we believe to be a novel mechanism contributing to the accelerated atherogenesis and increased cardiovascular disease risk occurring in people with insulin resistance... - Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitusPhilip Wenzel
Second Medical Clinic, Department of Cardiology and Angiology, Johannes Gutenberg University, Langenbeckstrasse 1, 55131 Mainz, Germany
Atherosclerosis 198:65-76. 2008.... - Nicotine-induced activation of AMP-activated protein kinase inhibits fatty acid synthase in 3T3L1 adipocytes: a role for oxidant stressZhibo An
Vascular Biology Laboratory, Department of Surgery, Graduate School of Medicine, University of Tennessee, Knoxville, TN 37922, USA
J Biol Chem 282:26793-801. 2007..Taken together, our results strongly suggest that nicotine, via ONOO(-) activates AMPK, resulting in enhanced threonine phosphorylation and consequent inhibition of FAS... - Role for peroxynitrite in the inhibition of prostacyclin synthase in nitrate toleranceUlrich Hink
University Hospital Eppendorf, Division of Cardiology, Hamburg, Germany
J Am Coll Cardiol 42:1826-34. 2003..CONCLUSIONS: Nitroglycerin-induced vascular peroxynitrite formation inhibits the activity of PGI(2)-S as well as NO, cGMP, and cGK-I signaling, which may contribute to vascular dysfunction in the setting of tolerance...