Ming Hui Zou

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi Peroxynitrite and protein tyrosine nitration of prostacyclin synthase
    Ming Hui Zou
    BSEB 325, Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Science Center, 941 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
    Prostaglandins Other Lipid Mediat 82:119-27. 2007
  2. pmc Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite
    Ming Hui Zou
    Vascular Biology Unit, Whitaker Cardiovascular Institute, Department of Medicine, Boston University School of Medicine, 650 Albany Street, Boston, MA 02118, USA
    J Clin Invest 109:817-26. 2002
  3. ncbi Modulation by peroxynitrite of Akt- and AMP-activated kinase-dependent Ser1179 phosphorylation of endothelial nitric oxide synthase
    Ming Hui Zou
    Vascular Biology Unit, Whitaker Cardiovascular Institute, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 277:32552-7. 2002
  4. pmc AMPKalpha2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo: role of 26S proteasomes
    Shuangxi Wang
    Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA
    Circ Res 106:1117-28. 2010
  5. pmc Activation of NAD(P)H oxidases by thromboxane A2 receptor uncouples endothelial nitric oxide synthase
    Miao Zhang
    Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA
    Arterioscler Thromb Vasc Biol 31:125-32. 2011
  6. ncbi Proteasome-dependent degradation of guanosine 5'-triphosphate cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes mellitus
    Jian Xu
    Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Circulation 116:944-53. 2007
  7. pmc Reactive nitrogen species is required for the activation of the AMP-activated protein kinase by statin in vivo
    Hyoung Chul Choi
    Sections of Endocrinology and Nephrology, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Biol Chem 283:20186-97. 2008
  8. pmc Acute inhibition of guanosine triphosphate cyclohydrolase 1 uncouples endothelial nitric oxide synthase and elevates blood pressure
    Shuangxi Wang
    Department of Medicine, Division of Endocrinology and Diabetes, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Hypertension 52:484-90. 2008
  9. pmc Thromboxane receptor activates the AMP-activated protein kinase in vascular smooth muscle cells via hydrogen peroxide
    Miao Zhang
    Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Science Center, 941 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
    Circ Res 102:328-37. 2008
  10. pmc Phosphorylation of LKB1 at serine 428 by protein kinase C-zeta is required for metformin-enhanced activation of the AMP-activated protein kinase in endothelial cells
    Zhonglin Xie
    Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Circulation 117:952-62. 2008

Collaborators

Detail Information

Publications54

  1. ncbi Peroxynitrite and protein tyrosine nitration of prostacyclin synthase
    Ming Hui Zou
    BSEB 325, Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Science Center, 941 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
    Prostaglandins Other Lipid Mediat 82:119-27. 2007
    ....
  2. pmc Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite
    Ming Hui Zou
    Vascular Biology Unit, Whitaker Cardiovascular Institute, Department of Medicine, Boston University School of Medicine, 650 Albany Street, Boston, MA 02118, USA
    J Clin Invest 109:817-26. 2002
    ..in diabetes, contributing further to endothelial cell oxidant stress. Regulation of the zinc-thiolate center of NOS by ONOO(-) provides a novel mechanism for modulation of the enzyme function in disease...
  3. ncbi Modulation by peroxynitrite of Akt- and AMP-activated kinase-dependent Ser1179 phosphorylation of endothelial nitric oxide synthase
    Ming Hui Zou
    Vascular Biology Unit, Whitaker Cardiovascular Institute, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 277:32552-7. 2002
    ..We conclude that ONOO(-) inhibits Akt and increases AMPK-dependent Ser(1179) phosphorylation of eNOS resulting in enhanced O(2)() release...
  4. pmc AMPKalpha2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo: role of 26S proteasomes
    Shuangxi Wang
    Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA
    Circ Res 106:1117-28. 2010
    ..Recent studies suggest that AMPK activation improves endothelial function by counteracting oxidative stress in endothelial cells. How AMPK suppresses oxidative stress remains to be established...
  5. pmc Activation of NAD(P)H oxidases by thromboxane A2 receptor uncouples endothelial nitric oxide synthase
    Miao Zhang
    Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA
    Arterioscler Thromb Vasc Biol 31:125-32. 2011
    ..How TPr stimulation causes vascular injury remains poorly defined. This study was conducted to investigate the mechanism by which TPr stimulation leads to vascular injury...
  6. ncbi Proteasome-dependent degradation of guanosine 5'-triphosphate cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes mellitus
    Jian Xu
    Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Circulation 116:944-53. 2007
    ....
  7. pmc Reactive nitrogen species is required for the activation of the AMP-activated protein kinase by statin in vivo
    Hyoung Chul Choi
    Sections of Endocrinology and Nephrology, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Biol Chem 283:20186-97. 2008
    ..Taken together, our data suggest that AMPK activation by statin is peroxynitrite-mediated but PKC-zeta-dependent...
  8. pmc Acute inhibition of guanosine triphosphate cyclohydrolase 1 uncouples endothelial nitric oxide synthase and elevates blood pressure
    Shuangxi Wang
    Department of Medicine, Division of Endocrinology and Diabetes, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Hypertension 52:484-90. 2008
    ..In conclusion, GTPCH1 via BH4 maintains normal BP and endothelial function in vivo by preserving NO synthesis by eNOS...
  9. pmc Thromboxane receptor activates the AMP-activated protein kinase in vascular smooth muscle cells via hydrogen peroxide
    Miao Zhang
    Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Science Center, 941 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
    Circ Res 102:328-37. 2008
    ..We conclude that TPr stimulation triggers reactive oxygen species-mediated LKB1-dependent AMPK activation, which in return inhibits cellular protein synthesis in VSMCs...
  10. pmc Phosphorylation of LKB1 at serine 428 by protein kinase C-zeta is required for metformin-enhanced activation of the AMP-activated protein kinase in endothelial cells
    Zhonglin Xie
    Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Circulation 117:952-62. 2008
    ..The objective of the present study was to determine how metformin activates AMPK in endothelial cells...
  11. ncbi Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregulating phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in an LKB1-dependent manner
    Ping Song
    Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA
    Circulation 116:1585-95. 2007
    ..Oxidative stress plays a causal role in vascular injury in diabetes mellitus, but the mechanisms and targets remain poorly understood...
  12. pmc Aberrant endoplasmic reticulum stress in vascular smooth muscle increases vascular contractility and blood pressure in mice deficient of AMP-activated protein kinase-α2 in vivo
    Bin Liang
    Section of Molecular Medicine, Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA
    Arterioscler Thromb Vasc Biol 33:595-604. 2013
    ..The aim of this study was to investigate whether aberrant ER stress causes abnormal vasoconstriction and consequent high blood pressure in mice...
  13. pmc Activation of protease calpain by oxidized and glycated LDL increases the degradation of endothelial nitric oxide synthase
    Yunzhou Dong
    Harold Hamm Oklahoma Diabetes Center, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Cell Mol Med 13:2899-910. 2009
    ..HOG-LDL may impair endothelial function by inducing calpain-mediated eNOS degradation in a ROS- and Ca(2+)-dependent manner...
  14. ncbi Endothelial nitric oxide synthase-dependent tyrosine nitration of prostacyclin synthase in diabetes in vivo
    Hong Nie
    BSEB 325, Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA
    Diabetes 55:3133-41. 2006
    ..We conclude that diabetes increases PGIS nitration in vivo, likely via dysfunctional eNOS...
  15. ncbi Activation of protein kinase C zeta by peroxynitrite regulates LKB1-dependent AMP-activated protein kinase in cultured endothelial cells
    Zhonglin Xie
    Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 281:6366-75. 2006
    ..Taken together, we conclude that PKCzeta can regulate AMPK activity by increasing the Ser428 phosphorylation of LKB1, resulting in association of LKB1 with AMPK and consequent AMPK Thr172 phosphorylation by LKB1...
  16. pmc Inhibition of AMP-activated protein kinase accentuates lipopolysaccharide-induced lung endothelial barrier dysfunction and lung injury in vivo
    Junjie Xing
    Section of Molecular Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Am J Pathol 182:1021-30. 2013
    ..We conclude that AMPK activity supports normal endothelial barrier function and that LPS exposure inhibits AMPK, thereby contributing to endothelial barrier dysfunction and lung injury...
  17. pmc Identification of nitric oxide as an endogenous activator of the AMP-activated protein kinase in vascular endothelial cells
    Junhua Zhang
    Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 283:27452-61. 2008
    ..Taken together, we conclude that NO might act as an endogenous AMPK activator...
  18. pmc Protein kinase Czeta-dependent LKB1 serine 428 phosphorylation increases LKB1 nucleus export and apoptosis in endothelial cells
    Ping Song
    Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA
    J Biol Chem 283:12446-55. 2008
    ..Finally, ONOO(-) enhanced PKCzeta nuclear import and LKB1 nuclear export. We conclude that PKCzeta mediates LKB1-dependent Akt inhibition in response to ONOO(-), resulting in endothelial apoptosis...
  19. pmc Phosphorylation of serine 399 in LKB1 protein short form by protein kinase Cζ is required for its nucleocytoplasmic transport and consequent AMP-activated protein kinase (AMPK) activation
    Huaiping Zhu
    Section of Molecular Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73013, USA
    J Biol Chem 288:16495-505. 2013
    ..We conclude that, similar to Ser-428/431 (in LKB1(L)), Ser-399 (in LKB1(S)) is a PKCζ-dependent phosphorylation site essential for nucleocytoplasmic export of LKB1(S) and consequent AMPK activation...
  20. ncbi Activation of protein phosphatase 2A by palmitate inhibits AMP-activated protein kinase
    Yong Wu
    Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 282:9777-88. 2007
    ..Taken together, we conclude that palmitate inhibits the phosphorylation of both AMPK and endothelial nitric-oxide synthase in endothelial cells via ceramide-dependent PP2A activation...
  21. ncbi Uncoupling of endothelial nitric oxidase synthase by hypochlorous acid: role of NAD(P)H oxidase-derived superoxide and peroxynitrite
    Jian Xu
    Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, 941 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
    Arterioscler Thromb Vasc Biol 26:2688-95. 2006
    ....
  22. ncbi High glucose via peroxynitrite causes tyrosine nitration and inactivation of prostacyclin synthase that is associated with thromboxane/prostaglandin H(2) receptor-mediated apoptosis and adhesion molecule expression in cultured human aortic endothelial cel
    Ming Hui Zou
    Vascular Biology Unit, Whitaker Cardiovascular Institute, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Diabetes 51:198-203. 2002
    ....
  23. pmc AMPKα2 deletion exacerbates neointima formation by upregulating Skp2 in vascular smooth muscle cells
    Ping Song
    Section of Molecular Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, 73104, USA
    Circ Res 109:1230-9. 2011
    ..Whether AMPKα alters vascular neointima formation induced by vascular injury is unknown...
  24. pmc Impaired expression of uncoupling protein 2 causes defective postischemic angiogenesis in mice deficient in AMP-activated protein kinase α subunits
    Ming jiang Xu
    Section of Molecular Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, 73104, USA
    Arterioscler Thromb Vasc Biol 31:1757-65. 2011
    ..The aim of the present study was to determine whether mitochondrial uncoupling protein (UCP) 2 is required for AMPK-dependent angiogenesis in ischemia in vivo...
  25. pmc Upregulation of mitochondrial uncoupling protein-2 by the AMP-activated protein kinase in endothelial cells attenuates oxidative stress in diabetes
    Zhonglin Xie
    Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Diabetes 57:3222-30. 2008
    ..The present study was conducted to determine how AMPK activation suppressed tyrosine nitration of prostacyclin synthase in diabetes...
  26. pmc In vivo activation of AMP-activated protein kinase attenuates diabetes-enhanced degradation of GTP cyclohydrolase I
    Shuangxi Wang
    Division of Endocrinology and Diabetes, Department of Medicine, Herald Hamm Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Diabetes 58:1893-901. 2009
    ..The aim of this study was to test whether AMPK suppresses the degradation of GTP-cyclohydrolase (GTPCH I), a key event in vascular endothelial dysfunction in diabetes...
  27. pmc Activation of AMP-activated protein kinase alpha1 alleviates endothelial cell apoptosis by increasing the expression of anti-apoptotic proteins Bcl-2 and survivin
    Chao Liu
    Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 285:15346-55. 2010
    ..Overall, our results suggest that AMPKalpha1, but not AMPKalpha2 activation, promotes cell survival by increasing NF-kappaB-mediated expression of anti-apoptotic proteins (Bcl-2 and Survivin) and intracellular ATP contents...
  28. ncbi Estradiol-mediated endothelial nitric oxide synthase association with heat shock protein 90 requires adenosine monophosphate-dependent protein kinase
    Eberhard Schulz
    Evans Memorial Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Mass 02118, USA
    Circulation 111:3473-80. 2005
    ..We therefore investigated whether AMPK is activated by estradiol in endothelial cells and plays a role in estradiol-induced eNOS activation...
  29. pmc Tyrosine nitration of prostacyclin synthase is associated with enhanced retinal cell apoptosis in diabetes
    Ming Hui Zou
    Section of Molecular Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Am J Pathol 179:2835-44. 2011
    ..In conclusion, oxidized LDL-mediated PGIS nitration and associated thromboxane receptor stimulation might be important in the initiation and progression of diabetic retinopathy...
  30. pmc Activation of AMP-activated protein kinase α2 by nicotine instigates formation of abdominal aortic aneurysms in mice in vivo
    Shuangxi Wang
    Department of Medicine, Division of Molecular Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Nat Med 18:902-10. 2012
    ..We conclude that smoking (through nicotine) instigates AAA through AMPK-α2–mediated AP-2α–dependent MMP2 expression in VSMCs...
  31. pmc Identification of the serine 307 of LKB1 as a novel phosphorylation site essential for its nucleocytoplasmic transport and endothelial cell angiogenesis
    Zhonglin Xie
    Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Mol Cell Biol 29:3582-96. 2009
    ....
  32. pmc Thromboxane A2 receptor activates a Rho-associated kinase/LKB1/PTEN pathway to attenuate endothelium insulin signaling
    Ping Song
    Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 284:17120-8. 2009
    ..Importantly, administration of TP antagonist blocked these changes. We conclude that TP stimulation impairs insulin signaling in vascular endothelial cells by selectively activating the Rho/Rho-associated kinase/LKB1/PTEN pathway...
  33. pmc Inhibition of the AMP-activated protein kinase-α2 accentuates agonist-induced vascular smooth muscle contraction and high blood pressure in mice
    Shuangxi Wang
    Division of Molecular Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, BSEB 325, 941 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
    Hypertension 57:1010-7. 2011
    ....
  34. ncbi Quantitative assessment of tyrosine nitration of manganese superoxide dismutase in angiotensin II-infused rat kidney
    Wei Guo
    Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University Medical Center, Boston, MA 02118, USA
    Am J Physiol Heart Circ Physiol 285:H1396-403. 2003
    ..Angiotensin II-induced hypertension is accompanied by increased tyrosine nitration of MnSOD, which, because it inactivates the enzyme, may contribute to increased oxidant stress in the kidney...
  35. pmc Dissociation of Bcl-2-Beclin1 complex by activated AMPK enhances cardiac autophagy and protects against cardiomyocyte apoptosis in diabetes
    Chaoyong He
    Section of Molecular Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Diabetes 62:1270-81. 2013
    ..We concluded that dissociation of Bcl-2 from Beclin1 may be an important mechanism for preventing diabetic cardiomyopathy via AMPK activation that restores autophagy and protects against cardiac apoptosis...
  36. pmc Regulation of NAD(P)H oxidases by AMPK in cardiovascular systems
    Ping Song
    Section of Molecular Medicine, Department of Medicine, and Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Free Radic Biol Med 52:1607-19. 2012
    ..In this review, we summarize our current understanding of how AMPK functions as a physiological repressor of NAD(P)H oxidase...
  37. pmc AMP-activated protein kinase activation as a strategy for protecting vascular endothelial function
    Ming Hui Zou
    Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Clin Exp Pharmacol Physiol 35:535-45. 2008
    ..We further hypothesize that AMPK is a dual sensor for energy and redox status within a cell and AMPK may be a therapeutic target for protecting vascular endothelial function...
  38. pmc Liver kinase b1 is required for white adipose tissue growth and differentiation
    Wencheng Zhang
    Section of Molecule Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Diabetes 62:2347-58. 2013
    ..Taken together, these data indicate that LKB1 controls IRS1-dependent adipogenesis via AMPK in WAT. ..
  39. ncbi Vascular inflammation is a missing link for diabetes-enhanced atherosclerotic cardiovascular diseases
    Najeeb A Shirwany
    Section of Molecular Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Front Biosci (Landmark Ed) 17:1140-64. 2012
    ..This review aims to present the empirical underpinning of the hypothesis that inflammatory change in the vasculature might be the integrated mechanism that connects a diabetic phenotype with its attendant vascular complications...
  40. pmc AMP-activated protein kinase modulates cardiac autophagy in diabetic cardiomyopathy
    Zhonglin Xie
    Section of Molecular Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Autophagy 7:1254-5. 2011
    ..We conclude that AMPK activation protects cardiac structure and function by increasing cardiac autophagy in the diabetic heart...
  41. pmc Tyrosine nitration of PA700 activates the 26S proteasome to induce endothelial dysfunction in mice with angiotensin II-induced hypertension
    Jian Xu
    Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, 941 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
    Hypertension 54:625-32. 2009
    ..We conclude that Ang II increases tyrosine nitration of PA700 resulting in accelerated GTP cyclohydrolase I degradation, BH4 deficiency, and consequent endothelial dysfunction in hypertension...
  42. pmc Regulation of interplay between autophagy and apoptosis in the diabetic heart: new role of AMPK
    Ming Hui Zou
    Section of Molecular Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Autophagy 9:624-5. 2013
    ....
  43. pmc Arterial stiffness: a brief review
    Najeeb A Shirwany
    Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, 73104, USA
    Acta Pharmacol Sin 31:1267-76. 2010
    ..A critical discussion of new techniques for assessing vascular stiffness is also presented...
  44. ncbi AMPK: A cellular metabolic and redox sensor. A minireview
    Najeeb A Shirwany
    Section of Molecular Medicine, Department of Medicine, University of Oklahoma Health Science Center, 941 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
    Front Biosci (Landmark Ed) 19:447-74. 2014
    ..By inhibiting the formation of reactive oxygen species in the endothelium, AMPK can optimize the redox balance in the vasculature. Here, we review the role of AMPK in the cell. ..
  45. pmc Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation
    Xueliang Du
    Diabetes Research Center, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Clin Invest 116:1071-80. 2006
    ..These studies identify what we believe to be a novel mechanism contributing to the accelerated atherogenesis and increased cardiovascular disease risk occurring in people with insulin resistance...
  46. ncbi Endothelial cell activation by endotoxin involves superoxide/NO-mediated nitration of prostacyclin synthase and thromboxane receptor stimulation
    Markus Bachschmid
    Faculty of Biology, University of Konstanz, 78457 Konstanz, Germany
    FASEB J 17:914-6. 2003
    ..PGE2 together with a lack of NO and PGI2 is known to promote the adhesion of white blood cells and their immigration to the inflammatory locus...
  47. ncbi Activation of 5'-AMP-activated kinase is mediated through c-Src and phosphoinositide 3-kinase activity during hypoxia-reoxygenation of bovine aortic endothelial cells. Role of peroxynitrite
    Ming Hui Zou
    Vascular Research Laboratory, Department of Surgery, Graduate School of Medicine, The University of Tennessee, Knoxville, Tennessee 37920, USA
    J Biol Chem 278:34003-10. 2003
    ....
  48. pmc Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus
    Philip Wenzel
    Second Medical Clinic, Department of Cardiology and Angiology, Johannes Gutenberg University, Langenbeckstrasse 1, 55131 Mainz, Germany
    Atherosclerosis 198:65-76. 2008
    ....
  49. ncbi Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species
    Ming Hui Zou
    Vascular Research Laboratory, Graduate School of Medicine, University of Tennessee, Knoxville 37920, USA
    J Biol Chem 279:43940-51. 2004
    ....
  50. ncbi Peroxynitrite and vascular endothelial dysfunction in diabetes mellitus
    Ming Hui Zou
    Vascular Research Laboratory, Graduate School of Medicine, University of Tennessee, Knoxville, TN 37920, USA
    Endothelium 11:89-97. 2004
    ..The authors' studies indicate that in diabetes the synthetic enzymes of the two major endogenous vasodilators undergo oxidative inactivation by different mechanisms, which are, however, tightly interdependent...
  51. ncbi Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase
    Bradley J Davis
    Vascular Research Laboratory, Department of Surgery, Graduate School of Medicine, University of Tennessee, Knoxville, USA
    Diabetes 55:496-505. 2006
    ..Taken together, our results indicate that metformin might improve vascular endothelial functions in diabetes by increasing AMPK-dependent, hsp90-mediated eNOS activation...
  52. ncbi Nicotine-induced activation of AMP-activated protein kinase inhibits fatty acid synthase in 3T3L1 adipocytes: a role for oxidant stress
    Zhibo An
    Vascular Biology Laboratory, Department of Surgery, Graduate School of Medicine, University of Tennessee, Knoxville, TN 37922, USA
    J Biol Chem 282:26793-801. 2007
    ..Taken together, our results strongly suggest that nicotine, via ONOO(-) activates AMPK, resulting in enhanced threonine phosphorylation and consequent inhibition of FAS...
  53. ncbi CD40 ligand-dependent tyrosine nitration of prostacyclin synthase in vivo
    Bradley Davis
    Vascular Research Laboratory, Graduate School of Medicine, University of Tennessee, Knoxville, Tennessee, USA
    Circulation 112:2184-92. 2005
    ....
  54. ncbi Role for peroxynitrite in the inhibition of prostacyclin synthase in nitrate tolerance
    Ulrich Hink
    University Hospital Eppendorf, Division of Cardiology, Hamburg, Germany
    J Am Coll Cardiol 42:1826-34. 2003
    ..We tested whether in vivo nitroglycerin (NTG) treatment causes tyrosine nitration of prostacyclin synthase (PGI(2)-S), one of the nitration targets of peroxynitrite, and whether this may contribute to nitrate tolerance...