I V Zhdanova

Summary

Affiliation: Boston University
Country: USA

Publications

  1. doi request reprint Aging of intrinsic circadian rhythms and sleep in a diurnal nonhuman primate, Macaca mulatta
    I V Zhdanova
    Laboratory of Sleep and Circadian Physiology, Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany St R 913, Boston, MA 02118 2394, USA
    J Biol Rhythms 26:149-59. 2011
  2. pmc Familial circadian rhythm disorder in the diurnal primate, Macaca mulatta
    Irina V Zhdanova
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS ONE 7:e33327. 2012
  3. doi request reprint Sleep and its regulation in zebrafish
    Irina V Zhdanova
    Laboratory of Sleep and Circadian Physiology, Department of Anatomy and Neurobiology, Boston University Medical School, 715 Albany St, R 913, Boston, MA 02118 2394, USA
    Rev Neurosci 22:27-36. 2011
  4. pmc Aging of the circadian system in zebrafish and the effects of melatonin on sleep and cognitive performance
    I V Zhdanova
    Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany Street, Boston, 02118 MA, USA
    Brain Res Bull 75:433-41. 2008
  5. ncbi request reprint Comment on 'Melatonin as a hypnotic: con'
    Irina V Zhdanova
    Department of Anatomy and Neurobiology, School of Medicine, Boston University, Boston, MA 02118, USA
    Sleep Med Rev 9:81; discussion 83-4. 2005
  6. ncbi request reprint Melatonin as a hypnotic: pro
    Irina V Zhdanova
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
    Sleep Med Rev 9:51-65. 2005
  7. ncbi request reprint Advances in the management of insomnia
    Irina V Zhdanova
    Boston University School of Medicine, Department of Anatomy and Neurobiology, 715 Albany Street R 913, Boston MA 02118, USA
    Expert Opin Pharmacother 5:1573-9. 2004
  8. ncbi request reprint Melatonin alters behavior and cAMP levels in nucleus accumbens induced by cocaine treatment
    Irina V Zhdanova
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Brain Res 956:323-31. 2002
  9. ncbi request reprint Behavioral effects of melatonin treatment in non-human primates
    I V Zhdanova
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Sleep Res Online 1:114-8. 1998
  10. ncbi request reprint Melatonin promotes sleep-like state in zebrafish
    I V Zhdanova
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Brain Res 903:263-8. 2001

Research Grants

  1. CIRCADIAN SYSTEM AND PRENATAL COCAINE IN ZEBRAFISH
    Irina Zhdanova; Fiscal Year: 2009
  2. Melatonin and Aging in Non-human Primates
    Irina Zhdanova; Fiscal Year: 2006
  3. Melatonin, behavior and neuronal activity
    Irina Zhdanova; Fiscal Year: 2006
  4. Cocaine-induced behaviors in larval zebrafish
    Irina Zhdanova; Fiscal Year: 2005
  5. CIRCADIAN SYSTEM AND PRENATAL COCAINE IN ZEBRAFISH
    Irina V Zhdanova; Fiscal Year: 2010

Collaborators

Detail Information

Publications27

  1. doi request reprint Aging of intrinsic circadian rhythms and sleep in a diurnal nonhuman primate, Macaca mulatta
    I V Zhdanova
    Laboratory of Sleep and Circadian Physiology, Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany St R 913, Boston, MA 02118 2394, USA
    J Biol Rhythms 26:149-59. 2011
    ....
  2. pmc Familial circadian rhythm disorder in the diurnal primate, Macaca mulatta
    Irina V Zhdanova
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS ONE 7:e33327. 2012
    ..The large isolated family of rhesus macaques harboring the disorder provides a powerful new tool for translational research of regulatory circuits underlying circadian disorders and their effective treatment...
  3. doi request reprint Sleep and its regulation in zebrafish
    Irina V Zhdanova
    Laboratory of Sleep and Circadian Physiology, Department of Anatomy and Neurobiology, Boston University Medical School, 715 Albany St, R 913, Boston, MA 02118 2394, USA
    Rev Neurosci 22:27-36. 2011
    ..The established sensitivity of zebrafish to many pharmacological hypnotics should also contribute to the development of new, safe and effective sleep medications...
  4. pmc Aging of the circadian system in zebrafish and the effects of melatonin on sleep and cognitive performance
    I V Zhdanova
    Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany Street, Boston, 02118 MA, USA
    Brain Res Bull 75:433-41. 2008
    ....
  5. ncbi request reprint Comment on 'Melatonin as a hypnotic: con'
    Irina V Zhdanova
    Department of Anatomy and Neurobiology, School of Medicine, Boston University, Boston, MA 02118, USA
    Sleep Med Rev 9:81; discussion 83-4. 2005
  6. ncbi request reprint Melatonin as a hypnotic: pro
    Irina V Zhdanova
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
    Sleep Med Rev 9:51-65. 2005
    ..1-0.3 mg, orally) and time of administration (at bedtime) is recommended, in order to avoid known and unknown side effects of melatonin treatment...
  7. ncbi request reprint Advances in the management of insomnia
    Irina V Zhdanova
    Boston University School of Medicine, Department of Anatomy and Neurobiology, 715 Albany Street R 913, Boston MA 02118, USA
    Expert Opin Pharmacother 5:1573-9. 2004
    ..Current studies of processes involved in normal sleep regulation and pathophysiology of insomnia should result in the development of new medications based on physiological mechanisms of sleep...
  8. ncbi request reprint Melatonin alters behavior and cAMP levels in nucleus accumbens induced by cocaine treatment
    Irina V Zhdanova
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Brain Res 956:323-31. 2002
    ....
  9. ncbi request reprint Behavioral effects of melatonin treatment in non-human primates
    I V Zhdanova
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Sleep Res Online 1:114-8. 1998
    ..These data suggest that melatonin may modulate motor activity and sleep pattern in certain diurnally-active primates...
  10. ncbi request reprint Melatonin promotes sleep-like state in zebrafish
    I V Zhdanova
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Brain Res 903:263-8. 2001
    ....
  11. ncbi request reprint Chronic cocaine treatment induces dysregulation in the circadian pattern of rats' feeding behavior
    M Giorgetti
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Brain Res 877:170-5. 2000
    ..The results of this study demonstrate that sub-chronic cocaine administration alters the circadian pattern of rats' feeding behavior...
  12. ncbi request reprint Endogenous melatonin levels and the fate of exogenous melatonin: age effects
    I V Zhdanova
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Gerontol A Biol Sci Med Sci 53:B293-8. 1998
    ....
  13. ncbi request reprint Effects of melatonin ingestion on cAMP and cGMP levels in human plasma
    I V Zhdanova
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Endocrinol 163:457-62. 1999
    ..These results demonstrate a stimulating effect of melatonin treatment on plasma cGMP levels in humans and suggest a correlation between the increase in circulating cGMP levels and the sleep-promoting effect of the pineal hormone...
  14. ncbi request reprint Melatonin treatment for age-related insomnia
    I V Zhdanova
    Department of Brain and Cognitive Sciences, Clinical Research Center, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    J Clin Endocrinol Metab 86:4727-30. 2001
    ..Although control subjects, like insomniacs, had low melatonin levels, their sleep was unaffected by any melatonin dose...
  15. ncbi request reprint Melatonin promotes sleep in three species of diurnal nonhuman primates
    Irina V Zhdanova
    Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Physiol Behav 75:523-9. 2002
    ....
  16. doi request reprint Gender differences in zebrafish responses to cocaine withdrawal
    Marcos A López Patiño
    Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany St R 913 Boston, MA 02118, USA
    Physiol Behav 95:36-47. 2008
    ....
  17. ncbi request reprint Anxiogenic effects of cocaine withdrawal in zebrafish
    Marcos A López-Patiño
    Department of Anatomy and Neurobiology, School of Medicine, Boston University, 715 Albany Street, Boston, MA 02118, USA
    Physiol Behav 93:160-71. 2008
    ..Thus, zebrafish, a powerful model for the study of vertebrate genetics, could provide insights into the molecular mechanisms of drug withdrawal...
  18. ncbi request reprint Melatonin: a sleep-promoting hormone
    I V Zhdanova
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139, USA
    Sleep 20:899-907. 1997
    ..This review also illustrates the authors' cautious attitude toward melatonin treatment that induces supraphysiologic circulating levels of the hormone...
  19. pmc The circadian system is a target and modulator of prenatal cocaine effects
    Eva H Shang
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS ONE 2:e587. 2007
    ..We hypothesize that some of the prenatal effects of cocaine might be related to dysregulation of physiological rhythms due to alterations in the integrating circadian clock function...
  20. ncbi request reprint Melatonin treatment attenuates symptoms of acute nicotine withdrawal in humans
    I V Zhdanova
    Department of Brain and Cognitive Sciences, E18 439, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Pharmacol Biochem Behav 67:131-5. 2000
    ..quot; Melatonin treatment did not significantly change the responses on the performance tests used. These data suggest that melatonin can help to counteract the acute effects of smoking cessation on mood...
  21. ncbi request reprint Melatonin stimulates cell proliferation in zebrafish embryo and accelerates its development
    Nadia Danilova
    Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, Massachusetts 02139, USA
    FASEB J 18:751-3. 2004
    ..We propose that melatonin has a role in extending the safe limit of proliferation rate at night to allow more rapid development when potentially damaging ultraviolet light is absent...
  22. ncbi request reprint Effects of low oral doses of melatonin, given 2-4 hours before habitual bedtime, on sleep in normal young humans
    I V Zhdanova
    Clinical Research Center, Massachusetts Institute of Technology, Cambridge 02142, USA
    Sleep 19:423-31. 1996
    ....
  23. ncbi request reprint Differential effects of genotoxic stress on both concurrent body growth and gradual senescence in the adult zebrafish
    Stephanie B Tsai
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, USA
    Aging Cell 6:209-24. 2007
    ..Moreover, our present findings indicate that genotoxic DNA damage may play a role as a rate-limiting factor during the induction of senescence, but not in the inhibition of continuous, density-dependent growth in adult zebrafish...
  24. pmc Expression of glucose-dependent insulinotropic polypeptide in the zebrafish
    Michelle C Musson
    Section of Gastroenterology, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts 02118, USA
    Am J Physiol Regul Integr Comp Physiol 297:R1803-12. 2009
    ..In conclusion, the results of these studies suggest that although the zebrafish appears to be a model of an early stage of evolutionary development of GIP expression, the peptide may not possess incretin properties in this species...
  25. ncbi request reprint Stimulation of melatonin receptors decreases calcium levels in xenopus tectal cells by activating GABA(C) receptors
    Claudia Prada
    Neuroscience Program, State University of New York at Buffalo, Buffalo, NY 14214, USA
    J Neurophysiol 94:968-78. 2005
    ..These results imply that melatonin, acting by MT2 receptors, modulates GABA(C) receptor activity in the optic tectum and that this effect is influenced by the light-dark cycle...
  26. pmc Circadian rhythm sleep disorders: part II, advanced sleep phase disorder, delayed sleep phase disorder, free-running disorder, and irregular sleep-wake rhythm. An American Academy of Sleep Medicine review
    Robert L Sack
    Department of Psychiatry, Oregon Health Sciences University, Portland, OR, USA
    Sleep 30:1484-501. 2007
    ..We herein report on the accumulated evidence regarding the evaluation and treatment of Advamced Sleep Phase Disorder (ASPD), Delayed Sleep Phase Disorder (DSPD), Free-Running Disorder (FRD) and Irregular Sleep-Wake Rhythm ISWR)...
  27. pmc Circadian rhythm sleep disorders: part I, basic principles, shift work and jet lag disorders. An American Academy of Sleep Medicine review
    Robert L Sack
    Department of Psychiatry, Oregon Health Sciences University, Portland, OR, USA
    Sleep 30:1460-83. 2007
    ..We then report on the accumulated evidence regarding the evaluation and treatment of shift work disorder (SWD) and jet lag disorder (JLD)...

Research Grants14

  1. CIRCADIAN SYSTEM AND PRENATAL COCAINE IN ZEBRAFISH
    Irina Zhdanova; Fiscal Year: 2009
    ....
  2. Melatonin and Aging in Non-human Primates
    Irina Zhdanova; Fiscal Year: 2006
    ..This approach will also allow determining the role of melatonin in primate sleep and whether the acute sleep-promoting and hypothermic effects of melatonin are mediated via the SCN. ..
  3. Melatonin, behavior and neuronal activity
    Irina Zhdanova; Fiscal Year: 2006
    ..abstract_text> ..
  4. Cocaine-induced behaviors in larval zebrafish
    Irina Zhdanova; Fiscal Year: 2005
    ..This could advance our understanding of the neuronal and intracellular targets of addictive substances and the genetic bases of vulnerability to drug addiction. ..
  5. CIRCADIAN SYSTEM AND PRENATAL COCAINE IN ZEBRAFISH
    Irina V Zhdanova; Fiscal Year: 2010
    ....