Research Topics
| I V ZhdanovaSummaryAffiliation: Boston University Country: USA Publications
Research Grants
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Detail Information
Publications
Aging of intrinsic circadian rhythms and sleep in a diurnal nonhuman primate, Macaca mulattaI V Zhdanova
Laboratory of Sleep and Circadian Physiology, Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany St R 913, Boston, MA 02118 2394, USA
J Biol Rhythms 26:149-59. 2011....- Familial circadian rhythm disorder in the diurnal primate, Macaca mulattaIrina V Zhdanova
Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts, United States of America
PLoS ONE 7:e33327. 2012..The large isolated family of rhesus macaques harboring the disorder provides a powerful new tool for translational research of regulatory circuits underlying circadian disorders and their effective treatment... - Sleep and its regulation in zebrafishIrina V Zhdanova
Laboratory of Sleep and Circadian Physiology, Department of Anatomy and Neurobiology, Boston University Medical School, 715 Albany St, R 913, Boston, MA 02118 2394, USA
Rev Neurosci 22:27-36. 2011..The established sensitivity of zebrafish to many pharmacological hypnotics should also contribute to the development of new, safe and effective sleep medications... - Aging of the circadian system in zebrafish and the effects of melatonin on sleep and cognitive performanceI V Zhdanova
Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany Street, Boston, 02118 MA, USA
Brain Res Bull 75:433-41. 2008.... - Comment on 'Melatonin as a hypnotic: con'Irina V Zhdanova
Department of Anatomy and Neurobiology, School of Medicine, Boston University, Boston, MA 02118, USA
Sleep Med Rev 9:81; discussion 83-4. 2005 - Melatonin as a hypnotic: proIrina V Zhdanova
Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
Sleep Med Rev 9:51-65. 2005..1-0.3 mg, orally) and time of administration (at bedtime) is recommended, in order to avoid known and unknown side effects of melatonin treatment... - Advances in the management of insomniaIrina V Zhdanova
Boston University School of Medicine, Department of Anatomy and Neurobiology, 715 Albany Street R 913, Boston MA 02118, USA
Expert Opin Pharmacother 5:1573-9. 2004..Current studies of processes involved in normal sleep regulation and pathophysiology of insomnia should result in the development of new medications based on physiological mechanisms of sleep... - Melatonin alters behavior and cAMP levels in nucleus accumbens induced by cocaine treatmentIrina V Zhdanova
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Brain Res 956:323-31. 2002.... - Behavioral effects of melatonin treatment in non-human primatesI V Zhdanova
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Sleep Res Online 1:114-8. 1998..These data suggest that melatonin may modulate motor activity and sleep pattern in certain diurnally-active primates... - Melatonin promotes sleep-like state in zebrafishI V Zhdanova
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Brain Res 903:263-8. 2001.... - Chronic cocaine treatment induces dysregulation in the circadian pattern of rats' feeding behaviorM Giorgetti
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Brain Res 877:170-5. 2000..The results of this study demonstrate that sub-chronic cocaine administration alters the circadian pattern of rats' feeding behavior... - Endogenous melatonin levels and the fate of exogenous melatonin: age effectsI V Zhdanova
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139, USA
J Gerontol A Biol Sci Med Sci 53:B293-8. 1998.... - Effects of melatonin ingestion on cAMP and cGMP levels in human plasmaI V Zhdanova
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Endocrinol 163:457-62. 1999..These results demonstrate a stimulating effect of melatonin treatment on plasma cGMP levels in humans and suggest a correlation between the increase in circulating cGMP levels and the sleep-promoting effect of the pineal hormone... - Melatonin treatment for age-related insomniaI V Zhdanova
Department of Brain and Cognitive Sciences, Clinical Research Center, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
J Clin Endocrinol Metab 86:4727-30. 2001..Although control subjects, like insomniacs, had low melatonin levels, their sleep was unaffected by any melatonin dose... - Melatonin promotes sleep in three species of diurnal nonhuman primatesIrina V Zhdanova
Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Physiol Behav 75:523-9. 2002.... - Gender differences in zebrafish responses to cocaine withdrawalMarcos A López Patiño
Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany St R 913 Boston, MA 02118, USA
Physiol Behav 95:36-47. 2008.... - Anxiogenic effects of cocaine withdrawal in zebrafishMarcos A López-Patiño
Department of Anatomy and Neurobiology, School of Medicine, Boston University, 715 Albany Street, Boston, MA 02118, USA
Physiol Behav 93:160-71. 2008..Thus, zebrafish, a powerful model for the study of vertebrate genetics, could provide insights into the molecular mechanisms of drug withdrawal... - Melatonin: a sleep-promoting hormoneI V Zhdanova
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139, USA
Sleep 20:899-907. 1997..This review also illustrates the authors' cautious attitude toward melatonin treatment that induces supraphysiologic circulating levels of the hormone... - The circadian system is a target and modulator of prenatal cocaine effectsEva H Shang
Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts, United States of America
PLoS ONE 2:e587. 2007..We hypothesize that some of the prenatal effects of cocaine might be related to dysregulation of physiological rhythms due to alterations in the integrating circadian clock function... - Melatonin treatment attenuates symptoms of acute nicotine withdrawal in humansI V Zhdanova
Department of Brain and Cognitive Sciences, E18 439, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Pharmacol Biochem Behav 67:131-5. 2000..quot; Melatonin treatment did not significantly change the responses on the performance tests used. These data suggest that melatonin can help to counteract the acute effects of smoking cessation on mood... - Melatonin stimulates cell proliferation in zebrafish embryo and accelerates its developmentNadia Danilova
Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, Massachusetts 02139, USA
FASEB J 18:751-3. 2004..We propose that melatonin has a role in extending the safe limit of proliferation rate at night to allow more rapid development when potentially damaging ultraviolet light is absent... - Effects of low oral doses of melatonin, given 2-4 hours before habitual bedtime, on sleep in normal young humansI V Zhdanova
Clinical Research Center, Massachusetts Institute of Technology, Cambridge 02142, USA
Sleep 19:423-31. 1996.... - Differential effects of genotoxic stress on both concurrent body growth and gradual senescence in the adult zebrafishStephanie B Tsai
Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, USA
Aging Cell 6:209-24. 2007..Moreover, our present findings indicate that genotoxic DNA damage may play a role as a rate-limiting factor during the induction of senescence, but not in the inhibition of continuous, density-dependent growth in adult zebrafish... - Expression of glucose-dependent insulinotropic polypeptide in the zebrafishMichelle C Musson
Section of Gastroenterology, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts 02118, USA
Am J Physiol Regul Integr Comp Physiol 297:R1803-12. 2009..In conclusion, the results of these studies suggest that although the zebrafish appears to be a model of an early stage of evolutionary development of GIP expression, the peptide may not possess incretin properties in this species... - Stimulation of melatonin receptors decreases calcium levels in xenopus tectal cells by activating GABA(C) receptorsClaudia Prada
Neuroscience Program, State University of New York at Buffalo, Buffalo, NY 14214, USA
J Neurophysiol 94:968-78. 2005..These results imply that melatonin, acting by MT2 receptors, modulates GABA(C) receptor activity in the optic tectum and that this effect is influenced by the light-dark cycle... - Circadian rhythm sleep disorders: part II, advanced sleep phase disorder, delayed sleep phase disorder, free-running disorder, and irregular sleep-wake rhythm. An American Academy of Sleep Medicine reviewRobert L Sack
Department of Psychiatry, Oregon Health Sciences University, Portland, OR, USA
Sleep 30:1484-501. 2007..We herein report on the accumulated evidence regarding the evaluation and treatment of Advamced Sleep Phase Disorder (ASPD), Delayed Sleep Phase Disorder (DSPD), Free-Running Disorder (FRD) and Irregular Sleep-Wake Rhythm ISWR)... - Circadian rhythm sleep disorders: part I, basic principles, shift work and jet lag disorders. An American Academy of Sleep Medicine reviewRobert L Sack
Department of Psychiatry, Oregon Health Sciences University, Portland, OR, USA
Sleep 30:1460-83. 2007..We then report on the accumulated evidence regarding the evaluation and treatment of shift work disorder (SWD) and jet lag disorder (JLD)...
Research Grants
- CIRCADIAN SYSTEM AND PRENATAL COCAINE IN ZEBRAFISHIrina Zhdanova; Fiscal Year: 2009....
- Melatonin and Aging in Non-human PrimatesIrina Zhdanova; Fiscal Year: 2006..This approach will also allow determining the role of melatonin in primate sleep and whether the acute sleep-promoting and hypothermic effects of melatonin are mediated via the SCN. ..
- Melatonin, behavior and neuronal activityIrina Zhdanova; Fiscal Year: 2006..abstract_text> ..
- Cocaine-induced behaviors in larval zebrafishIrina Zhdanova; Fiscal Year: 2005..This could advance our understanding of the neuronal and intracellular targets of addictive substances and the genetic bases of vulnerability to drug addiction. ..
- CIRCADIAN SYSTEM AND PRENATAL COCAINE IN ZEBRAFISHIrina V Zhdanova; Fiscal Year: 2010....