Yinzhi Zhao

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi request reprint Inhibition of the expression of lysyl oxidase and its substrates in cadmium-resistant rat fetal lung fibroblasts
    Yinzhi Zhao
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Toxicol Sci 90:478-89. 2006
  2. pmc The critical role of the cellular thiol homeostasis in cadmium perturbation of the lung extracellular matrix
    Yinzhi Zhao
    Department of Biochemistry, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA
    Toxicology 267:60-9. 2010
  3. pmc Microtubules as a critical target for arsenic toxicity in lung cells in vitro and in vivo
    Yinzhi Zhao
    Department of Biochemistry, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA
    Int J Environ Res Public Health 9:474-95. 2012
  4. ncbi request reprint Perturbation of copper (Cu) homeostasis and expression of Cu-binding proteins in cadmium-resistant lung fibroblasts
    Denise K Chou
    Department of Biochemistry, Boston University School of Medicine, MA 02118, USA
    Toxicol Sci 99:267-76. 2007
  5. pmc Transcriptional and posttranscriptional inhibition of lysyl oxidase expression by cigarette smoke condensate in cultured rat fetal lung fibroblasts
    Song Gao
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Toxicol Sci 87:197-203. 2005
  6. ncbi request reprint Downregulation of lysyl oxidase and upregulation of cellular thiols in rat fetal lung fibroblasts treated with cigarette smoke condensate
    Li Jun Chen
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Toxicol Sci 83:372-9. 2005
  7. ncbi request reprint Cloning and characterization of the rat lysyl oxidase gene promoter: identification of core promoter elements and functional nuclear factor I-binding sites
    Song Gao
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 282:25322-37. 2007
  8. pmc Lysyl oxidase, a critical intra- and extra-cellular target in the lung for cigarette smoke pathogenesis
    Wande Li
    Department of Biochemistry, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA
    Int J Environ Res Public Health 8:161-84. 2011
  9. pmc Hypoxia-response element (HRE)-directed transcriptional regulation of the rat lysyl oxidase gene in response to cobalt and cadmium
    Song Gao
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Toxicol Sci 132:379-89. 2013
  10. ncbi request reprint Nickel (Ni2+) enhancement of microtubule assembly in vitro is dependent on GTP function
    Wande Li
    Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA
    Toxicol Appl Pharmacol 193:202-8. 2003

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Inhibition of the expression of lysyl oxidase and its substrates in cadmium-resistant rat fetal lung fibroblasts
    Yinzhi Zhao
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Toxicol Sci 90:478-89. 2006
    ....
  2. pmc The critical role of the cellular thiol homeostasis in cadmium perturbation of the lung extracellular matrix
    Yinzhi Zhao
    Department of Biochemistry, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA
    Toxicology 267:60-9. 2010
    ..Thus, Cd upregulation of cellular thiols may be a critical cellular event facilitating downregulation of LO, a potential mechanism for Cd-induced emphysema...
  3. pmc Microtubules as a critical target for arsenic toxicity in lung cells in vitro and in vivo
    Yinzhi Zhao
    Department of Biochemistry, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA
    Int J Environ Res Public Health 9:474-95. 2012
    ..Thus, tubulin sulfhydryls and MAPs are major molecular targets for As³⁺ damage to the lung triggering MT disassembly cascades...
  4. ncbi request reprint Perturbation of copper (Cu) homeostasis and expression of Cu-binding proteins in cadmium-resistant lung fibroblasts
    Denise K Chou
    Department of Biochemistry, Boston University School of Medicine, MA 02118, USA
    Toxicol Sci 99:267-76. 2007
    ..These results suggest that downregulation of LO is linked with upregulation of other Cu-binding proteins and with alteration in Cu homeostasis in the CdR phenotype...
  5. pmc Transcriptional and posttranscriptional inhibition of lysyl oxidase expression by cigarette smoke condensate in cultured rat fetal lung fibroblasts
    Song Gao
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Toxicol Sci 87:197-203. 2005
    ..Thus, transcriptional perturbation of LO and its substrates may be a critical mechanism for ECM damage in CS-induced emphysema...
  6. ncbi request reprint Downregulation of lysyl oxidase and upregulation of cellular thiols in rat fetal lung fibroblasts treated with cigarette smoke condensate
    Li Jun Chen
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Toxicol Sci 83:372-9. 2005
    ..These results suggest that upregulation by CSC of cellular thiols may play an important role in the downregulation of LO and subsequently destabilization of the lung ECM in CS-induced emphysema...
  7. ncbi request reprint Cloning and characterization of the rat lysyl oxidase gene promoter: identification of core promoter elements and functional nuclear factor I-binding sites
    Song Gao
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 282:25322-37. 2007
    ..In conclusion, the isolated rat LO gene promoter contains functionally independent initiator and downstream core promoter elements, and the conserved NFI-binding sites play a critical role in the LO gene activation...
  8. pmc Lysyl oxidase, a critical intra- and extra-cellular target in the lung for cigarette smoke pathogenesis
    Wande Li
    Department of Biochemistry, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA
    Int J Environ Res Public Health 8:161-84. 2011
    ..In view of multiple biological functions and regulation characteristics of the LO gene, molecular mechanisms for CS damage to lung LO and its role in emphysema and cancer pathogenesis are discussed in this review...
  9. pmc Hypoxia-response element (HRE)-directed transcriptional regulation of the rat lysyl oxidase gene in response to cobalt and cadmium
    Song Gao
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Toxicol Sci 132:379-89. 2013
    ..Thus, modulation of the HRE activity by Co and Cd plays a critical role in LO gene transactivation...
  10. ncbi request reprint Nickel (Ni2+) enhancement of microtubule assembly in vitro is dependent on GTP function
    Wande Li
    Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA
    Toxicol Appl Pharmacol 193:202-8. 2003
    ..These results point to an important role of GTP/Ni2+ interaction in modulating the Ni2+ enhancement of MT assembly in vitro...
  11. ncbi request reprint Lysyl oxidase oxidizes basic fibroblast growth factor and inactivates its mitogenic potential
    Wande Li
    Department of Biochemistry, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts 02118, USA
    J Cell Biochem 88:152-64. 2003
    ..The present results illustrate a mechanism by which LO can depress normal and transformed cell growth...