Ting C Zhao

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc HDAC inhibition elicits myocardial protective effect through modulation of MKK3/Akt-1
    Ting C Zhao
    Cardiovascular Research Laboratory, Department of Surgery, Roger Williams Medical Center, Boston University Medical School, Providence, Rhode Island, United States of America
    PLoS ONE 8:e65474. 2013
  2. pmc Glucagon-like peptide-1 (GLP-1) and protective effects in cardiovascular disease: a new therapeutic approach for myocardial protection
    Ting C Zhao
    Cardiovascular Research Laboratory, Department of Surgery, Roger Williams Medical Center, Boston University Medical School, 50 Maude Street, Providence, RI 02908, USA
    Cardiovasc Diabetol 12:90. 2013
  3. pmc Inhibition of histone deacetylases preserves myocardial performance and prevents cardiac remodeling through stimulation of endogenous angiomyogenesis
    Ling Zhang
    Cardiovascular Laboratories, Department of Surgery, Boston University Medical School, Roger William Medical Center, 50 Maude Street, Providence, RI 02908, USA
    J Pharmacol Exp Ther 341:285-93. 2012
  4. pmc gp-91 mediates histone deacetylase inhibition-induced cardioprotection
    Ting C Zhao
    Department of Surgery, Roger William Medical Center, Boston University Medical School, Providence, RI 02908, USA
    Biochim Biophys Acta 1803:872-80. 2010
  5. pmc Inhibition of histone deacetylase-induced myocardial repair is mediated by c-kit in infarcted hearts
    Ling Zhang
    Department of Surgery, Boston University Medical School, Roger Williams Medical Center, Providence, Rhode Island 02908, USA
    J Biol Chem 287:39338-48. 2012
  6. pmc Autophagy protects against necrotic renal epithelial cell-induced death of renal interstitial fibroblasts
    Murugavel Ponnusamy
    Department of Medicine, Rhode Island Hospital, Providence, Rhode Island, USA
    Am J Physiol Renal Physiol 303:F83-91. 2012
  7. pmc Effect of disruption of Akt-1 of lin(-)c-kit(+) stem cells on myocardial performance in infarcted heart
    Andy Tseng
    Department of Pediatrics, Women and Infants Hospital, The Warren Alpert Medical School at Brown University, Providence, RI, USA
    Cardiovasc Res 87:704-12. 2010
  8. pmc HDAC inhibition promotes cardiogenesis and the survival of embryonic stem cells through proteasome-dependent pathway
    Hong P Chen
    Department of Surgery, Roger William Medical Center, Boston University Medical School, Providence, Rhode Island 02908, USA
    J Cell Biochem 112:3246-55. 2011
  9. ncbi request reprint Inhibition of histone deacetylases triggers pharmacologic preconditioning effects against myocardial ischemic injury
    Ting C Zhao
    Department of Pediatrics, Women and Infants Hospital, The Warren Alpert Brown Medical School, Brown University, Providence, RI 02905, USA
    Cardiovasc Res 76:473-81. 2007
  10. ncbi request reprint Blocking sirtuin 1 and 2 inhibits renal interstitial fibroblast activation and attenuates renal interstitial fibrosis in obstructive nephropathy
    Murugavel Ponnusamy
    Department of Medicine, Alpert Medical School of Brown University and Rhode Island Hospital, Providence, Rhode Island M P, X Z, Y Y, E T, R G, S Z First Affiliated Hospital of Harbin Medical University, Harbin, China X Z Departments of Nephrology J T, S Z and Emergency Medicine Y Y, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China and Department of Surgery, Roger William Medical Center, Boston University Medical School, Providence, Rhode Island T C Z
    J Pharmacol Exp Ther 350:243-56. 2014

Collaborators

Detail Information

Publications11

  1. pmc HDAC inhibition elicits myocardial protective effect through modulation of MKK3/Akt-1
    Ting C Zhao
    Cardiovascular Research Laboratory, Department of Surgery, Roger Williams Medical Center, Boston University Medical School, Providence, Rhode Island, United States of America
    PLoS ONE 8:e65474. 2013
    ..Taken together, these results indicate that stimulation of the MKK3 and Akt-1 pathway is a novel approach to HDAC inhibition -induced cardioprotection...
  2. pmc Glucagon-like peptide-1 (GLP-1) and protective effects in cardiovascular disease: a new therapeutic approach for myocardial protection
    Ting C Zhao
    Cardiovascular Research Laboratory, Department of Surgery, Roger Williams Medical Center, Boston University Medical School, 50 Maude Street, Providence, RI 02908, USA
    Cardiovasc Diabetol 12:90. 2013
    ....
  3. pmc Inhibition of histone deacetylases preserves myocardial performance and prevents cardiac remodeling through stimulation of endogenous angiomyogenesis
    Ling Zhang
    Cardiovascular Laboratories, Department of Surgery, Boston University Medical School, Roger William Medical Center, 50 Maude Street, Providence, RI 02908, USA
    J Pharmacol Exp Ther 341:285-93. 2012
    ..Taken together, our results indicate that HDAC inhibition preserves cardiac performance and mitigates myocardial remodeling through stimulating cardiac endogenous regeneration...
  4. pmc gp-91 mediates histone deacetylase inhibition-induced cardioprotection
    Ting C Zhao
    Department of Surgery, Roger William Medical Center, Boston University Medical School, Providence, RI 02908, USA
    Biochim Biophys Acta 1803:872-80. 2010
    ..These results suggest that a cascade consisting of gp-91 and HDAC inhibition plays an essential role in orchestrating the cardioprotective effect...
  5. pmc Inhibition of histone deacetylase-induced myocardial repair is mediated by c-kit in infarcted hearts
    Ling Zhang
    Department of Surgery, Boston University Medical School, Roger Williams Medical Center, Providence, Rhode Island 02908, USA
    J Biol Chem 287:39338-48. 2012
    ..Our results provide evidence that HDAC inhibition promotes myocardial repair and prevents cardiac remodeling, which is dependent upon c-kit signaling...
  6. pmc Autophagy protects against necrotic renal epithelial cell-induced death of renal interstitial fibroblasts
    Murugavel Ponnusamy
    Department of Medicine, Rhode Island Hospital, Providence, Rhode Island, USA
    Am J Physiol Renal Physiol 303:F83-91. 2012
    ..Furthermore, necrotic RPTC-induced autophagy and cell death in renal fibroblasts is mediated by the activation of the MEK1-ERK1/2 signaling pathway...
  7. pmc Effect of disruption of Akt-1 of lin(-)c-kit(+) stem cells on myocardial performance in infarcted heart
    Andy Tseng
    Department of Pediatrics, Women and Infants Hospital, The Warren Alpert Medical School at Brown University, Providence, RI, USA
    Cardiovasc Res 87:704-12. 2010
    ..We have demonstrated an important role of bone marrow-derived stem cells in preservation of myocardial function. We investigated whether Akt-1 of lin(-)c-kit(+) stem cells preserves ventricular function following myocardial infarction (MI)...
  8. pmc HDAC inhibition promotes cardiogenesis and the survival of embryonic stem cells through proteasome-dependent pathway
    Hong P Chen
    Department of Surgery, Roger William Medical Center, Boston University Medical School, Providence, Rhode Island 02908, USA
    J Cell Biochem 112:3246-55. 2011
    ..Taken together, our study is the first to demonstrate that HDAC inhibition through proteasome pathway forms a novel signaling to determine the cardiac lineage commitment and elicits the survival pathway...
  9. ncbi request reprint Inhibition of histone deacetylases triggers pharmacologic preconditioning effects against myocardial ischemic injury
    Ting C Zhao
    Department of Pediatrics, Women and Infants Hospital, The Warren Alpert Brown Medical School, Brown University, Providence, RI 02905, USA
    Cardiovasc Res 76:473-81. 2007
    ..However, it remains unknown whether inhibition of HDACs plays a role in myocardial ischemia and reperfusion (I/R) injury. We hypothesize that HDAC inhibition triggers preconditioning-like effects against I/R injury...
  10. ncbi request reprint Blocking sirtuin 1 and 2 inhibits renal interstitial fibroblast activation and attenuates renal interstitial fibrosis in obstructive nephropathy
    Murugavel Ponnusamy
    Department of Medicine, Alpert Medical School of Brown University and Rhode Island Hospital, Providence, Rhode Island M P, X Z, Y Y, E T, R G, S Z First Affiliated Hospital of Harbin Medical University, Harbin, China X Z Departments of Nephrology J T, S Z and Emergency Medicine Y Y, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China and Department of Surgery, Roger William Medical Center, Boston University Medical School, Providence, Rhode Island T C Z
    J Pharmacol Exp Ther 350:243-56. 2014
    ..Blocking SIRT1/2 activation may have therapeutic potential for the treatment of chronic kidney disease. ..
  11. doi request reprint Histone deacetylase 1/2 mediates proliferation of renal interstitial fibroblasts and expression of cell cycle proteins
    Maoyin Pang
    Department of Medicine, Brown University School of Medicine, Rhode Island Hospital, Providence, Rhode Island 02903, USA
    J Cell Biochem 112:2138-48. 2011
    ..Further, STAT3 mediates the proliferative action of HDACs...