Y Zhang

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi Nuclear translocation of the N-terminal prodomain of interleukin-16
    Y Zhang
    Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 276:1299-303. 2001
  2. ncbi Processing and activation of pro-interleukin-16 by caspase-3
    Y Zhang
    Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 273:1144-9. 1998
  3. pmc Subchondral bone marrow lesions are highly associated with, and predict subchondral bone attrition longitudinally: the MOST study
    F W Roemer
    Quantitative Imaging Center QIC, Department of Radiology, Boston University Medical Center, Boston, MA 02118, USA
    Osteoarthritis Cartilage 18:47-53. 2010
  4. pmc Peripatellar synovitis: comparison between non-contrast-enhanced and contrast-enhanced MRI and association with pain. The MOST study
    M D Crema
    Department of Radiology, Quantitative Imaging Center, Boston University School of Medicine, Boston, MA, USA
    Osteoarthritis Cartilage 21:413-8. 2013
  5. pmc Change in MRI-detected subchondral bone marrow lesions is associated with cartilage loss: the MOST Study. A longitudinal multicentre study of knee osteoarthritis
    F W Roemer
    Department of Radiology, Boston University Medical Center, FGH Building, 3 Floor, 820 Harrison Ave, Boston, MA 02118, USA
    Ann Rheum Dis 68:1461-5. 2009
  6. pmc A comparison of dedicated 1.0 T extremity MRI vs large-bore 1.5 T MRI for semiquantitative whole organ assessment of osteoarthritis: the MOST study
    F W Roemer
    Quantitative Imaging Center QIC, Department of Radiology, Boston University Medical Center, Boston, MA 02118, USA
    Osteoarthritis Cartilage 18:168-74. 2010
  7. pmc Change in cartilage morphometry: a sample of the progression cohort of the Osteoarthritis Initiative
    D J Hunter
    Division of Research, New England Baptist Hospital, 125 Parker Hill Ave, Boston, MA 02120, USA
    Ann Rheum Dis 68:349-56. 2009
  8. ncbi Conservation of structure and function between human and murine IL-16
    J Keane
    The Pulmonary Center, Boston University School of Medicine, MA 02118, USA
    J Immunol 160:5945-54. 1998
  9. pmc Knee alignment differences between Chinese and Caucasian subjects without osteoarthritis
    W F Harvey
    Boston University Clinical Epidemiology Research and Training Unit, Boston, MA 02118, USA
    Ann Rheum Dis 67:1524-8. 2008
  10. pmc Cartilage loss occurs in the same subregions as subchondral bone attrition: a within-knee subregion-matched approach from the Multicenter Osteoarthritis Study
    T Neogi
    Boston University School of Medicine, 650 Albany Street, Clinical Epidemiology Unit, Suite X 200, Boston, MA 02118, USA
    Arthritis Rheum 61:1539-44. 2009

Collaborators

Detail Information

Publications105 found, 100 shown here

  1. ncbi Nuclear translocation of the N-terminal prodomain of interleukin-16
    Y Zhang
    Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 276:1299-303. 2001
    ....
  2. ncbi Processing and activation of pro-interleukin-16 by caspase-3
    Y Zhang
    Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 273:1144-9. 1998
    ..Pro-IL-16 is a substrate for caspase-3, and cleavage by this enzyme releases biologically active IL-16 from its inactive precursor...
  3. pmc Subchondral bone marrow lesions are highly associated with, and predict subchondral bone attrition longitudinally: the MOST study
    F W Roemer
    Quantitative Imaging Center QIC, Department of Radiology, Boston University Medical Center, Boston, MA 02118, USA
    Osteoarthritis Cartilage 18:47-53. 2010
    ..The aim of this study was to evaluate the cross-sectional and longitudinal association of BMLs with SBA in the same subregion of the knee...
  4. pmc Peripatellar synovitis: comparison between non-contrast-enhanced and contrast-enhanced MRI and association with pain. The MOST study
    M D Crema
    Department of Radiology, Quantitative Imaging Center, Boston University School of Medicine, Boston, MA, USA
    Osteoarthritis Cartilage 21:413-8. 2013
    ....
  5. pmc Change in MRI-detected subchondral bone marrow lesions is associated with cartilage loss: the MOST Study. A longitudinal multicentre study of knee osteoarthritis
    F W Roemer
    Department of Radiology, Boston University Medical Center, FGH Building, 3 Floor, 820 Harrison Ave, Boston, MA 02118, USA
    Ann Rheum Dis 68:1461-5. 2009
    ..Additionally, to examine the association of change in BMLs from baseline to 30-month follow-up with the risk of cartilage loss in the same subregion at follow-up...
  6. pmc A comparison of dedicated 1.0 T extremity MRI vs large-bore 1.5 T MRI for semiquantitative whole organ assessment of osteoarthritis: the MOST study
    F W Roemer
    Quantitative Imaging Center QIC, Department of Radiology, Boston University Medical Center, Boston, MA 02118, USA
    Osteoarthritis Cartilage 18:168-74. 2010
    ..The aim of this study was to compare semi-quantitative (SQ) scoring on a 1.0 T system using 1.5 T MRI as the standard of reference...
  7. pmc Change in cartilage morphometry: a sample of the progression cohort of the Osteoarthritis Initiative
    D J Hunter
    Division of Research, New England Baptist Hospital, 125 Parker Hill Ave, Boston, MA 02120, USA
    Ann Rheum Dis 68:349-56. 2009
    ..Our objective was to assess the rate of natural disease progression of cartilage morphometry measures from baseline to 1 year in knees with osteoarthritis (OA) from a subset of participants from the Osteoarthritis Initiative (OAI)...
  8. ncbi Conservation of structure and function between human and murine IL-16
    J Keane
    The Pulmonary Center, Boston University School of Medicine, MA 02118, USA
    J Immunol 160:5945-54. 1998
    ..The data suggest cross-species conservation of IL-16 receptor structures as well. Inhibitory peptides may be useful in disease states where the proinflammatory functions of IL-16 are detrimental to the host...
  9. pmc Knee alignment differences between Chinese and Caucasian subjects without osteoarthritis
    W F Harvey
    Boston University Clinical Epidemiology Research and Training Unit, Boston, MA 02118, USA
    Ann Rheum Dis 67:1524-8. 2008
    ..We measured various knee alignment indices among Chinese and Caucasians and assessed whether these indices were different between the two racial groups...
  10. pmc Cartilage loss occurs in the same subregions as subchondral bone attrition: a within-knee subregion-matched approach from the Multicenter Osteoarthritis Study
    T Neogi
    Boston University School of Medicine, 650 Albany Street, Clinical Epidemiology Unit, Suite X 200, Boston, MA 02118, USA
    Arthritis Rheum 61:1539-44. 2009
    ..We therefore evaluated whether SBA was associated with cartilage loss within the same subregion of the knee...
  11. ncbi Comparison of the prevalence of knee osteoarthritis between the elderly Chinese population in Beijing and whites in the United States: The Beijing Osteoarthritis Study
    Y Zhang
    Boston University School of Medicine, Massachusetts 02118, USA
    Arthritis Rheum 44:2065-71. 2001
    ..The prevalence in men was comparable. Possible explanations for these differences range from genetic differences to heavy physical activity among Chinese...
  12. doi Retinoblastoma protein modulates gankyrin-MDM2 in regulation of p53 stability and chemosensitivity in cancer cells
    W Qiu
    Graduate Program in Molecular Medicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    Oncogene 27:4034-43. 2008
    ..These results indicate that Rb antagonizes gankyrin to inhibit MDM2-mediate p53 ubiquitination in cancer cells and suggest that the status of both p53 and Rb is important for efficacy of cancer chemotherapy...
  13. ncbi Bone mass and the risk of colon cancer among postmenopausal women: the Framingham study
    Y Zhang
    Boston University Arthritis Center, Boston University School of Medicine, MA, USA
    Am J Epidemiol 153:31-7. 2001
    ..033). No association was found between bone mass and rectal cancer. The findings suggest that women with higher bone mass, perhaps reflecting greater cumulative estrogen exposure, have a decreased risk of colon cancer...
  14. pmc The relation of femoral notch stenosis to ACL tears in persons with knee osteoarthritis
    V Stein
    Division of Research, New England Baptist Hospital, Boston, MA 02120, USA
    Osteoarthritis Cartilage 18:192-9. 2010
    ..The purpose of this study was to test if persons with knee osteoarthritis (OA) and ACL tears have smaller NWI independent of prior joint injury and osteophyte volume...
  15. ncbi Lineage-specific overexpression of the P2Y1 receptor induces platelet hyper-reactivity in transgenic mice
    B Hechler
    Department of Biochemistry, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, USA
    J Thromb Haemost 1:155-63. 2003
    ....
  16. ncbi Cell surface Trk receptors mediate NGF-induced survival while internalized receptors regulate NGF-induced differentiation
    Y Zhang
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 20:5671-8. 2000
    ..Thus, interactions between Trk receptor tyrosine kinases and intracellular signaling molecules are dictated both by phosphotyrosine motifs within the receptors and by the intracellular location of phosphorylated receptors...
  17. ncbi AIM-1 transgenic mice with a curly tail phenotype and its chromosome location
    D Chinnappan
    Department of Biochemistry, Boston University School of Medicine, Boston MA 02118, USA
    Cytogenet Genome Res 98:231A. 2002
  18. ncbi Bone mineral density and verbal memory impairment: Third National Health and Nutrition Examination Survey
    Y Zhang
    Boston University Arthritis Center, Boston University School of Medicine, Boston, MA 02115, USA
    Am J Epidemiol 154:795-802. 2001
    ..001). These results suggest that bone mineral density in the elderly is associated with verbal memory impairment. The mechanisms underlying this relation are not understood, but cumulative exposure to estrogen may play a role...
  19. pmc Premorbid knee osteoarthritis is not characterised by diffuse thinness: the Framingham Osteoarthritis Study
    D J Hunter
    Boston University School of Medicine, Boston, MA, USA
    Ann Rheum Dis 67:1545-9. 2008
    ....
  20. pmc Reproducible and inexpensive probe preparation for oligonucleotide arrays
    Y Zhang
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Nucleic Acids Res 29:E66-6. 2001
    ..Validation of this protocol is demonstrated by hybridizing PCR products with oligonucleotide-coated microspheres and PCR amplified cDNA with Affymetrix Cancer GeneChip microarrays...
  21. pmc ΔNp63α regulates Erk signaling via MKP3 to inhibit cancer metastasis
    J Bergholz
    1 Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA 2 Center of Growth, Metabolism and Aging, College of Life Sciences and State Key Laboratory of Biotherapy, Sichuan University, Chengdu, China
    Oncogene 33:212-24. 2014
    ..Taken together, these results suggest an important role for ΔNp63α in preventing cancer metastasis by inhibition of Erk2 signaling via MKP3. ..
  22. ncbi Identification of a novel substitution in the constant region of a gene coding for an amyloidogenic kappa1 light chain
    J Wally
    Section of Hematology and Oncology, Department of Medicine, Boston Medical Center and Boston University School of Medicine, Boston, MA 02118, USA
    Biochim Biophys Acta 1454:49-56. 1999
    ..Our findings indicate that further investigation is warranted into the contributions genetic polymorphisms and light chain constant regions may make to amyloidogenesis...
  23. ncbi Longitudinal analysis of the relationship between serum insulin-like growth factor-I and radiographic knee osteoarthritis
    L Fraenkel
    Arthritis Center, Boston University Medical Center, Massachusetts 02118, USA
    Osteoarthritis Cartilage 6:362-7. 1998
    ..To examine the relation between serum insulin-like growth factor I (IGF-I) levels and both incident and progressive radiographic knee osteoarthritis (OA) in the Framingham Osteoarthritis Study...
  24. pmc The association of meniscal damage with joint effusion in persons without radiographic osteoarthritis: the Framingham and MOST osteoarthritis studies
    F W Roemer
    Quantitative Imaging Center QIC, Department of Radiology, Boston University Medical Center, Boston, MA 02118, USA
    Osteoarthritis Cartilage 17:748-53. 2009
    ..To assess the cross-sectional association between meniscal status and joint effusion on magnetic resonance imaging (MRI) in knees without radiographic osteoarthritis (OA)...
  25. ncbi One-step, highly efficient site-directed mutagenesis by toxic protein selection
    W Xu
    Dana Farber Cancer Institute, Boston, MA 02115, USA
    Biotechniques 32:1266-8, 1270. 2002
    ..Based on stringent selection through the toxic CcdB protein, mutagenesis efficiency of 90%-100% was reached even after one round of transformation...
  26. ncbi Repression of AIM-1 kinase mRNA as part of a program of genes regulated by Mpl ligand
    Y Zhang
    Department of Biochemistry and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Biochem Biophys Res Commun 282:844-9. 2001
    ..These data point to the potential importance of the transcriptional regulation of the AIM-1 gene for promoting megakaryocyte polyploidization...
  27. ncbi ΔNp63α activates CD82 metastasis suppressor to inhibit cancer cell invasion
    J Wu
    Department of Biochemistry, Boston University School of Medicine, Boston, MA, 02118, USA
    Cell Death Dis 5:e1280. 2014
    ..Taken together, this study reveals that ΔNp63α upregulates CD82 to inhibit cell invasion, and suggests that GSK3β can regulate cell invasion by modulating the ΔNp63α-CD82 axis. ..
  28. ncbi Lewis blood group phenotype as an independent risk factor for coronary heart disease (the NHLBI Family Heart Study)
    R C Ellison
    Evans Department of Medicine, Boston University School of Medicine, Massachusetts 02118, USA
    Am J Cardiol 83:345-8. 1999
    ..We conclude that the Le(a-b-) phenotype is associated with an increased risk for CHD; its effect does not appear to act predominantly through conventional cardiovascular risk factors. At present, mechanisms of effect are unknown...
  29. ncbi Elongation factor Ts of Chlamydia trachomatis: structure of the gene and properties of the protein
    Y Zhang
    Maxwell Finland Laboratory for Infectious Diseases, Boston Medical Center, Boston University School of Medicine, Massachusetts 02118, USA
    Arch Biochem Biophys 344:43-52. 1997
    ..coli elongation factor Tu (EF-Tu). These data show that the second gene of the identified cluster is tsf. Unlike EF-Ts from any other species, its activity was comparable to that of E. coli EF-Ts in exchange reaction with E. coli EF-Tu...
  30. ncbi Exploring the relation of alcohol consumption to risk of breast cancer
    R C Ellison
    Section of Preventive Medicine and Epidemiology, Evans Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Am J Epidemiol 154:740-7. 2001
    ..Cohort studies with less than 10 years of follow-up gave estimates 11% higher than cohort studies with longer follow-up periods. No meaningful difference was seen by menopausal status or type of beverage consumed...
  31. ncbi Deregulated expression of c-myc in megakaryocytes of transgenic mice increases megakaryopoiesis and decreases polyploidization
    A Thompson
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02139, USA
    J Biol Chem 271:22976-82. 1996
    ..These transgenic mice represent a novel in vivo model for a Myc-induced myeloproliferative disorder which can be controlled...
  32. ncbi Disruption of IRS-2 causes type 2 diabetes in mice
    D J Withers
    Howard Hughes Medical Institute, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 391:900-4. 1998
    ..Our results indicate that dysfunction of IRS-2 may contribute to the pathophysiology of human type 2 diabetes...
  33. pmc Psychological factors and their relation to osteoarthritis pain
    B L Wise
    University School of Medicine, Boston, MA, USA
    Osteoarthritis Cartilage 18:883-7. 2010
    ..We assessed associations between mental health and osteoarthritis (OA) pain...
  34. ncbi Phenotypic and functional characteristics of macrophage-like cells differentiated in pro-inflammatory cytokine-containing cultures
    F F Hou
    Renal Division, Division of Immunology and Rheumatology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Immunol Cell Biol 78:205-13. 2000
    ..Elevated levels of IL-1beta and TNF-alpha in the inflammatory tissues may therefore not only prolong the survival of recruited monocytes, but maintain them in an inflammatory state...
  35. pmc Incident long-term warfarin use and risk of osteoporotic fractures: propensity-score matched cohort of elders with new onset atrial fibrillation
    D Misra
    Boston University School of Medicine, 650 Albany St, Suite X 200, Clinical Epidemiology Unit, Boston, MA, 02118, USA
    Osteoporos Int 25:1677-84. 2014
    ..We examined the association between long-term warfarin use and fracture risk at the hip, spine, and wrist in elders. No significant association was found between long-term warfarin use and fracture risk, despite biological plausibility...
  36. pmc Diuretic initiation and the acute risk of hip fracture
    S D Berry
    Institute for Aging Research, Hebrew SeniorLife and Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Osteoporos Int 24:689-95. 2013
    ..No statistical association was found following the initiation of a comparator medication: ACE inhibitors. Awareness of these short-term risks may reduce hip fractures...
  37. pmc Conservation of early odontogenic signaling pathways in Aves
    Y Chen
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 97:10044-9. 2000
    ....
  38. ncbi Characterization of the mouse cyclin D3 gene: exon/intron organization and promoter activity
    Z Wang
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, 02128, USA
    Genomics 35:156-63. 1996
    ..The characterization of the mouse cyclin D3 gene and insight into its promoter region will allow further studies defining the molecular events regulating the expression of this cyclin in proliferating and quiescent cells...
  39. ncbi Relation between dietary fiber consumption and fibrinogen and plasminogen activator inhibitor type 1: The National Heart, Lung, and Blood Institute Family Heart Study
    L Djousse
    Evans Department of Medicine, Boston University School of Medicine, 02118, USA
    Am J Clin Nutr 68:568-75. 1998
    ..39 for men and 0.36 for women). These data suggest that higher fiber intake is inversely associated with PAI-1, but not with fibrinogen concentration...
  40. ncbi Human keratinocytes express EMMPRIN, an extracellular matrix metalloproteinase inducer
    R DeCastro
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, Massachusetts, USA
    J Invest Dermatol 106:1260-5. 1996
    ..These results establish the presence of EMMPRIN in the normal epidermis and raise the possibility of its involvement in regulation of matrix remodeling at the epidermal-dermal interface...
  41. ncbi Differential patterns of cocaine-induced organ toxicity in murine heart versus liver
    J F Wang
    The Charles A. Dana Research Institute and Harvard-Thorndike Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Exp Biol Med (Maywood) 226:52-60. 2001
    ..The results suggest that the liver is more sensitive than the heart to cocaine toxicity, and induction of apoptosis or TNF-alpha elevation may be a common mechanism responsible for cocaines toxicity...
  42. ncbi The association between patellar alignment and patellofemoral joint osteoarthritis features--an MRI study
    L Kalichman
    Boston University Clinical Epidemiology Research and Training Unit, 715 Albany St, Boston, MA 02118, USA
    Rheumatology (Oxford) 46:1303-8. 2007
    ..The aim of our study was to evaluate the association between patellar alignment (using standard MRI images of extended knees) and MRI indices of patellofemoral (PF) osteoarthritis (OA) features...
  43. ncbi The related adhesion focal tyrosine kinase differentially phosphorylates p130Cas and the Cas-like protein, p105HEF1
    A Astier
    Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 272:19719-24. 1997
    ..These data suggest that RAFTK itself is sufficient for HEF1 phosphorylation, whereas a cooperation between RAFTK and Src kinases is required for the complete phosphorylation of p130(Cas)...
  44. ncbi Common and contrasting genomic profiles among the major human lung cancer subtypes
    G Tonon
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cold Spring Harb Symp Quant Biol 70:11-24. 2005
    ..These findings suggest that the AC and SCC subtypes may arise from a common cell of origin and they are driven to their distinct phenotypic end points by altered expression of a limited number of key genes such as p63...
  45. ncbi ARF promotes accumulation of retinoblastoma protein through inhibition of MDM2
    D L F Chang
    Graduate Program in Molecular Medicine, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Oncogene 26:4627-34. 2007
    ..Thus, this study demonstrates that ARF plays a direct role in regulation of Rb and suggests that inactivation of ARF may lead to defects in both p53 and Rb pathways in human cancer development...
  46. ncbi An intermediate conductance K+ channel in the cell membrane of mouse intestinal smooth muscle
    F Vogalis
    Brockton West Roxbury VA Medical Center and Harvard Medical School, 1400 VFW Parkway, Boston, MA 02132, USA
    Biochim Biophys Acta 1371:309-16. 1998
    ..Our results suggest that IK channels contribute significantly to the Ca2+-dependent K+ conductance in visceral smooth muscle...
  47. ncbi Nitric oxide-stimulated increase in extracellular adenosine accumulation in rat forebrain neurons in culture is associated with ATP hydrolysis and inhibition of adenosine kinase activity
    P A Rosenberg
    Department of Neurology and Program in Neuroscience, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 20:6294-301. 2000
    ..Furthermore, nitric oxide-stimulated adenosine accumulation may be important in the regulation of behavioral state...
  48. pmc Cloning and expression of a single-chain catalytic antibody that acts as a glutathione peroxidase mimic with high catalytic efficiency
    X Ren
    Key Laboratory of Supramolecular Structure and Spectroscopy, Jilin University, Changchun 130023, China
    Biochem J 359:369-74. 2001
    ....
  49. pmc Molecular cloning and characterization of chemokine-like factor 1 (CKLF1), a novel human cytokine with unique structure and potential chemotactic activity
    W Han
    Laboratory of Medical Immunology, School of Basic Medical Science, Peking University, 38 Xueyuan Road, Beijing, 100083, China
    Biochem J 357:127-35. 2001
    ..These results suggest that CKLF1 might have important roles in inflammation and in the regeneration of skeletal muscle...
  50. ncbi Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor
    H Wang
    Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    Science 293:853-7. 2001
    ..Our finding reveals Arg 3 of H4 as a novel methylation site by PRMT1 and indicates that Arg 3 methylation plays an important role in transcriptional regulation...
  51. ncbi Expression and functional characterization of Escherichia coli NusA and lambda Q as glutathione S-transferase fusion proteins
    Y Zhang
    Department of Botany Microbiology, University of Oklahoma, Norman 73019, USA
    Protein Expr Purif 6:625-31. 1995
    ....
  52. pmc Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulation
    Y Zhang
    Department of Oncology, DNAX Research Institute, Palo Alto, California 94304 1104, USA
    Mol Cell Biol 21:5190-9. 2001
    ..Our experiments demonstrate that disruption of the Mad2-Cdc20 interaction perturbs the mitotic checkpoint, leading to premature activation of the APC, sensitizing the cells to the cytotoxic effects of microtubule-inhibiting drugs...
  53. ncbi Urogenital distribution of a mouse membrane-associated prostaglandin E(2) synthase
    Y Guan
    Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
    Am J Physiol Renal Physiol 281:F1173-7. 2001
    ..In conclusion, mPGES is constitutively expressed along the urogenital tract, where it may have important roles in normal physiology and disease...
  54. ncbi siRNA targeting the leader sequence of SARS-CoV inhibits virus replication
    T Li
    Department of Biological Sciences and Biotechnology, Institute of Biomedicine, Tsinghua University, Beijing, China
    Gene Ther 12:751-61. 2005
    ..This report provides evidence that targeting Leader sequence using siRNA could be a powerful tool in inhibiting SARS-CoV replication...
  55. ncbi Secretory expression of recombinant proteins in an attenuated Vibrio anguillarum strain for potential use in vaccines
    M Shao
    State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China
    J Fish Dis 28:723-8. 2005
    ..In the case of GFP-HlyAs, nearly 70% of the total fusion protein was efficiently secreted into culture supernatant, and in the case of AngE-HlyAs, the secretion efficiency was determined to be about 300 microg L(-1) by Western blotting...
  56. ncbi FlaC, a protein of Campylobacter jejuni TGH9011 (ATCC43431) secreted through the flagellar apparatus, binds epithelial cells and influences cell invasion
    Y C Song
    Department of Medical Genetics and Microbiology, Medical Science Building, 1 King s College Circle, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Mol Microbiol 53:541-53. 2004
    ..Invasion of HEp-2 cells by flaC null mutants was reduced to a level of 14% compared with wild type, suggesting that FlaC plays an important role in cell invasion...
  57. ncbi Urinary pentosidine does not predict cartilage loss among subjects with symptomatic knee OA: the BOKS Study
    D J Hunter
    Boston University Clinical Epidemiology Research and Training Unit, Boston, MA 02118, USA
    Osteoarthritis Cartilage 15:93-7. 2007
    ..We used data from a longitudinal observation study to determine if urinary pentosidine could serve as a marker to predict cartilage loss...
  58. ncbi [Expression of pyruvate oxidase gene sopox from Streptococcus sanguis in E. coli]
    B Hou
    Department of Periodontology, School of Stomatology, WCUMS, Chengdu 610041, China
    Hua Xi Yi Ke Da Xue Xue Bao 32:15-7. 2001
    ..CONCLUSION: Sopox was successfully cloned into pBV220 and expressed in E. coli JM105...
  59. ncbi Combination therapy for treating breast cancer using antiestrogen, ERA-923, and the mammalian target of rapamycin inhibitor, temsirolimus
    T M Sadler
    Department of Oncology, Wyeth Research, 401 North Middle Town Road, Pearl River, New York, New York 10965, USA
    Endocr Relat Cancer 13:863-73. 2006
    ..Results demonstrated for the first time that the combination of temsirolimus and a pure antiestrogen has excellent anticancer activity in preclinical models and, therefore, may have clinical use in treating hormone-dependent tumors...
  60. ncbi Symmetry and clustering of symptomatic hand osteoarthritis in elderly men and women: the Framingham Study
    J Niu
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, MA 02118, USA
    Rheumatology (Oxford) 42:343-8. 2003
    ..The goal of this study was to study patterns of joint involvement in symptomatic hand OA among elderly Caucasian men and women...
  61. ncbi A novel Bacillus thuringiensis strain LLB6, isolated from bryophytes, and its new cry2Ac-type gene
    L L Zhang
    Key Laboratory of Biopesticide and Chemical Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou, Fujian, P R China
    Lett Appl Microbiol 44:301-7. 2007
    ..To isolate and characterize the novel Bacillus thuringiensis strains from bryophytes collected from Wuyi Mountain, Fujian Province of China, and identify new B. thuringiensis strains and toxins active against mosquitoes...
  62. ncbi Trapeziometacarpal subluxation predisposes to incident trapeziometacarpal osteoarthritis (OA): the Framingham Study
    D J Hunter
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, and Brigham and Women s Hospital, Boston, MA 02118, USA
    Osteoarthritis Cartilage 13:953-7. 2005
    ..However, as yet there have been no longitudinal evaluations to determine if this hypothesis is true. We examined the relation of radial subluxation to the risk of radiographic OA at trapeziometacarpal joint...
  63. ncbi [Introduction of Vitreoscilla hemoglobin gene in a recombinant E. coli for PHB production]
    H Yu
    Department of Chemical Engineering, Institute of Biochemical Engineering, Tsinghua University, Beijing 100084, China
    Wei Sheng Wu Xue Bao 41:548-52. 2001
    ..The higher amounts of VHb could be got correspond to the lower level of DO. Because of the introduction of vgb, cell growth and PHB accumulation of VG1 (pTU14) were all strongly promoted during the process of batch culture...
  64. pmc Location of the nupC gene on the physical map of Escherichia coli K-12
    Y Zhang
    Institute of Cell and Molecular Biology, University of Edinburgh, Scotland
    J Bacteriol 174:5758-9. 1992
  65. pmc Characterization of the Bacillus subtilis thiC operon involved in thiamine biosynthesis
    Y Zhang
    Department of Chemistry, Cornell University, Ithaca, New York 14853, USA
    J Bacteriol 179:3030-5. 1997
    ..Transcription of the thiC operon is not regulated by thiamine or 2-methyl-4-amino-5-hydroxymethylpyrimidine and is only slightly repressed by 4-methyl-5-(beta-hydroxyethyl)thiazole...
  66. ncbi Cloning, expression, and regulation of rabbit cyclooxygenase-2 in renal medullary interstitial cells
    Y Guan
    Division of Nephrology, Veterans Affairs Medical Center, Nashville, Tennessee, USA
    Am J Physiol 273:F18-26. 1997
    ..Phorbol ester also upregulated immunoreactive COX2. Constitutive COX2 in these tissues has important implications for side effects of COX2-selective inhibitors...
  67. pmc Immunodominant major outer membrane proteins of Ehrlichia chaffeensis are encoded by a polymorphic multigene family
    N Ohashi
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus 43210 1093, USA
    Infect Immun 66:132-9. 1998
    ..chaffeensis. These findings suggest that the 30-kDa-range proteins of E. chaffeensis represent a family of antigenically related homologous proteins encoded by a single gene family...
  68. ncbi Mutational analysis of the roles of residues in Escherichia coli elongation factor Ts in the interaction with elongation factor Tu
    Y Zhang
    Department of Chemistry, University of North Carolina, Chapel Hill, North Carolina 27599 3290, USA
    J Biol Chem 273:4556-62. 1998
    ..Mutations prepared in EF-Tu indicate that His-19 and Gln-114 but not Glu-348 in EF-Tu are moderately important for its interaction with EF-Ts...
  69. ncbi The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis
    Y Zhang
    MRC Tuberculosis and Related Infections Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK
    Nature 358:591-3. 1992
    ..Deletion of katG from the chromosome was associated with INH resistance in two patient isolates of M. tuberculosis...
  70. pmc Transcriptional analysis of essential genes of the Escherichia coli fatty acid biosynthesis gene cluster by functional replacement with the analogous Salmonella typhimurium gene cluster
    Y Zhang
    Department of Microbiology, University of Illinois, Urbana 61801, USA
    J Bacteriol 180:3295-303. 1998
    ..Insertion of the omega-Cm cassette between fabH and fabD caused greatly decreased transcription of the fabD and fabG genes and slower cellular growth, indicating that fabD has only a weak promoter(s)...
  71. ncbi The capsule biosynthetic locus of Pasteurella multocida A:1
    J Y Chung
    Department of Microbiology, Monash University, Clayton, Vic, Australia
    FEMS Microbiol Lett 166:289-96. 1998
    ..Region 3 comprises two ORFs whose postulated products show similarity to proteins that are involved in the phospholipid substitution of the polysaccharide capsule...
  72. ncbi Identification and cloning of human mitochondrial translational release factor 1 and the ribosome recycling factor
    Y Zhang
    Department of Chemistry, Campus Box 3290, University of North Carolina, Chapel Hill, NC 27599 3290, USA
    Biochim Biophys Acta 1443:245-50. 1998
    ..The complete cDNA for the human mitochondrial ribosome recycling factor has been assembled using EST clones. This factor has been expressed in Escherichia coli and purified as a His-tagged protein...
  73. ncbi Human skeletal muscle insulin receptor substrate-1. Characterization of the cDNA, gene, and chromosomal localization
    E Araki
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts
    Diabetes 42:1041-54. 1993
    ..Thus, IRS-1 is widely expressed and highly conserved across species and tissues.(ABSTRACT TRUNCATED AT 250 WORDS)..
  74. pmc Characterization of the katG gene encoding a catalase-peroxidase required for the isoniazid susceptibility of Mycobacterium tuberculosis
    B Heym
    Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, Paris, France
    J Bacteriol 175:4255-9. 1993
    ..tuberculosis, M. smegmatis, and Escherichia coli was demonstrated by Western blotting (immunoblotting). Homologous genes were detected in other mycobacteria, even those which are naturally insensitive to isoniazid...
  75. ncbi Cloning of the nupC gene of Escherichia coli encoding a nucleoside transport system, and identification of an adjacent insertion element, IS 186
    J E Craig
    Institute of Cell and Molecular Biology, University of Edinburgh, UK
    Mol Microbiol 11:1159-68. 1994
    ..This arrangement is shown to reflect the previously established gene order on the E. coli chromosome...
  76. ncbi Genetic analysis of superoxide dismutase, the 23 kilodalton antigen of Mycobacterium tuberculosis
    Y Zhang
    MRC Tuberculosis and Related Infections Unit, RPMS, Hammersmith Hospital, London, UK
    Mol Microbiol 5:381-91. 1991
    ..tuberculosis, but the structural gene is not preceded by a signal peptide sequence. Insertion of the M. tuberculosis SOD gene into a novel shuttle vector demonstrated the mycobacteria but is ineffective in Escherichia coli...
  77. ncbi cDNA sequence of a Drosophila melanogaster gene, Dfur1, encoding a protein structurally related to the subtilisin-like proprotein processing enzyme furin
    A J Roebroek
    Molecular Oncology Section, University of Leuven, Belgium
    FEBS Lett 289:133-7. 1991
    ..Furthermore, unlike human furin, Dfurin1 possessed an extended amino-terminal region in which a potential transmembrane anchor was present...
  78. pmc NusA changes the conformation of Escherichia coli RNA polymerase at the binding site for the 3' end of the nascent RNA
    Y Zhang
    Department of Botany Microbiology, University of Oklahoma, Norman 73019
    J Bacteriol 176:1787-9. 1994
    ..A change in the binding site for the 3' end of the RNA occurred, and NusA increased interactions of the RNA with the beta subunit of the polymerase. NusA was not contacted by the 3' end of the RNA...
  79. ncbi Localization of human immunodeficiency virus Rev in transfected and virus-infected cells
    L Luznik
    Department of Medicine, UCSD School of Medicine, La Jolla, California 92093 0665, USA
    AIDS Res Hum Retroviruses 11:795-804. 1995
    ..Our observations are consistent with the proposed dual role of Rev in mRNA transport and splicing...
  80. ncbi Subunits coupling H+ transport and ATP synthesis in the Escherichia coli ATP synthase. Cys-Cys cross-linking of F1 subunit epsilon to the polar loop of F0 subunit c
    Y Zhang
    Department of Biomolecular Chemistry, University of Wisconsin Medical School, Madison 53706, USA
    J Biol Chem 270:24609-14. 1995
    ....
  81. ncbi The human glioma pathogenesis-related protein is structurally related to plant pathogenesis-related proteins and its gene is expressed specifically in brain tumors
    E V Murphy
    Department of Neurologic Surgery, University of California, San Francisco 94143, USA
    Gene 159:131-5. 1995
    ..We speculate that there may be functional similarities between the human and plant proteins as well...
  82. pmc Effect of an ntrBC mutation on the posttranslational regulation of nitrogenase activity in Rhodospirillum rubrum
    Y Zhang
    Department of Biochemistry, University of Wisconsin Madison 53706, USA
    J Bacteriol 177:5322-6. 1995
    ..rubrum. The expression of glutamine synthetase, as well as its posttranslational regulation, was also altered in this ntrBC mutant...
  83. ncbi Strain variation in the katG region of Mycobacterium tuberculosis
    Y Zhang
    MRC Tuberculosis and Related Infections Unit, Hammersmith Hospital, London, UK
    Mol Microbiol 14:301-8. 1994
    ..These results indicate that the katG region of the M. tuberculosis genome is highly variable and unstable. The presence of repetitive sequences may contribute to instability in this region of the genome...
  84. ncbi Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
    H P Harding
    Skirball Institute of Biomolecular Medicine, Department of Medicine, NYU School of Medicine, New York 10016, USA
    Nature 397:271-4. 1999
    ..These properties implicate PERK in a signalling pathway that attenuates protein translation in response to ER stress...
  85. ncbi Caspase-mediated cleavage of p21Waf1/Cip1 converts cancer cells from growth arrest to undergoing apoptosis
    Y Zhang
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan
    Oncogene 18:1131-8. 1999
    ..Thus, caspase-3-mediated cleavage and inactivation of p21 protein may convert cancer cells from growth arrest to undergoing apoptosis, leading to the acceleration of chemotherapy-induced apoptotic process in cancer cells...
  86. pmc Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1
    Y Zhang
    Departments of Neurology, Neuroscience, and Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287 0005, USA
    Proc Natl Acad Sci U S A 97:13354-9. 2000
    ..The loss of Parkin's ubiquitin-protein ligase function in familial-linked mutations suggests that this may be the cause of familial autosomal recessive Parkinson's disease...
  87. pmc The MinE ring required for proper placement of the division site is a mobile structure that changes its cellular location during the Escherichia coli division cycle
    X Fu
    Department of Microbiology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Proc Natl Acad Sci U S A 98:980-5. 2001
    ....
  88. ncbi Chromosomal localization, expression pattern, and promoter analysis of the mouse gene encoding adipocyte-specific secretory protein Acrp30
    K Das
    Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York, 10461, USA
    Biochem Biophys Res Commun 280:1120-9. 2001
    ..Finally, we have characterized the mouse Acrp30 promoter in tissue culture cells. We propose that Acrp30 promoter has the potential to drive strong adipocyte specific heterologous gene expression in transgenic mice...
  89. ncbi Caenorhabditis elegans auxilin: a J-domain protein essential for clathrin-mediated endocytosis in vivo
    T Greener
    Laboratory of Cell Biology, NHLBI, NIH, Bethesda, MD 20892 0301, USA
    Nat Cell Biol 3:215-9. 2001
    ..We conclude that auxilin is required for in vivo clathrin-mediated endocytosis and development in C. elegans...
  90. ncbi Constitutive alpha-secretase cleavage of the beta-amyloid precursor protein in the furin-deficient LoVo cell line: involvement of the pro-hormone convertase 7 and the disintegrin metalloprotease ADAM10
    E Lopez-Perez
    IPMC du CNRS, UMR6097, Valbonne, France
    J Neurochem 76:1532-9. 2001
    ..Transfection analysis allowed us to further establish that the pro-hormone convertase 7 and ADAM10 but not ADAM17 (TACE, tumour necrosis factor alpha-converting enzyme) likely contribute to constitutive sAPPalpha secretion by LoVo cells...
  91. ncbi The carcinoembryonic antigen (CEA) gene family in non-human primates
    G Q Zhou
    Department of Immunology, , SE-901 85, , Sweden
    Gene 264:105-12. 2001
    ..Presence of GPI-linked CEA subgroup members in African green monkey was suggested by sequencing. Both monkey species would thus seem suitable for functional studies of selected CEA subgroup members...
  92. ncbi A MAGE-3 peptide recognized on HLA-B35 and HLA-A1 by cytolytic T lymphocytes
    E S Schultz
    Ludwig Institute for Cancer Research, Brussels, Belgium
    Tissue Antigens 57:103-9. 2001
    ..These results infer that the current clinical use of peptide EVDPIGHLY can now be extended to HLA-B*3501 patients...
  93. ncbi Role of furin in delivery of a CTL epitope of an anthrax toxin-fusion protein
    Y Zhang
    Department of Microbiology, Kurume University School of Medicine, Fukuoka, Japan
    Microbiol Immunol 45:119-25. 2001
    ..The results suggest that furin plays a critical role in delivery of the CTL epitope of LFn fusion protein...
  94. ncbi Evidence that dim1 associates with proteins involved in pre-mRNA splicing, and delineation of residues essential for dim1 interactions with hnRNP F and Npw38/PQBP-1
    Y Zhang
    Division of Basic Science, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Gene 257:33-43. 2000
    ..These results parallel the arrest phenotypes associated with global disruption of zygotic gene expression, suggesting that Dim1 proteins maintain an essential function in gene expression in higher eukaryotes...
  95. pmc The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1
    M Furukawa
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7295, USA
    Mol Cell Biol 20:8185-97. 2000
    ..This pathway may be commonly utilized for the assembly of other cullin ligases...
  96. ncbi Characterization of a human 20alpha-hydroxysteroid dehydrogenase
    Y Zhang
    Oncology and Molecular Endocrinology Research Center, CHUQ PCHUL and Laval University, Quebec, Quebec G1V 4G2, Canada
    J Mol Endocrinol 25:221-8. 2000
    ..The present study clearly indicates that the genuine human 20alpha-HSD belongs to the aldoketo reductase family, like the 20alpha-HSDs from other species...
  97. ncbi Axin forms a complex with MEKK1 and activates c-Jun NH(2)-terminal kinase/stress-activated protein kinase through domains distinct from Wnt signaling
    Y Zhang
    Regulatory Biology Laboratory, Institute of Molecular and Cell Biology, National University of Singapore, 30 Medical Drive, Singapore 117609, Republic of Singapore
    J Biol Chem 274:35247-54. 1999
    ..Our results suggest that Axin, in addition to its function in the Wnt pathway, may play a dual role in cells through its activation of JNK/stress-activated protein kinase signaling cascade...
  98. pmc Membrane redistribution of the Escherichia coli MinD protein induced by MinE
    S L Rowland
    Department of Microbiology, University of Connecticut Health Center, Farmington, Connecticut 06032, USA
    J Bacteriol 182:613-9. 2000
    ..Studies with the isolated N-terminal and C-terminal MinE domains indicated different roles for the two MinE domains in the redistribution of membrane-associated MinD...
  99. pmc Mutagenesis and functional characterization of the glnB, glnA, and nifA genes from the photosynthetic bacterium Rhodospirillum rubrum
    Y Zhang
    Departments of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Bacteriol 182:983-92. 2000
    ....
  100. pmc The human RAD18 gene product interacts with HHR6A and HHR6B
    H Xin
    306 Health Sciences Research Building, Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536, USA
    Nucleic Acids Res 28:2847-54. 2000
    ..Consistent with its role as a fundamental lesion bypass protein, the RAD18 gene is ubiquitously expressed in various human tissues...
  101. ncbi Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them
    Y Zhang
    Department of Pharmacology and the Institute for Cell and Developmental Biology, SUNY at Stony Brook, Stony Brook, New York 11794 8651, USA
    J Biol Chem 275:35224-32. 2000
    ..These results suggest that PEA-15 may stabilize PLD or act as a PLD chaperone. The common involvement of PEA-15 and PLD in apoptosis, ERK activation, and glucose transport additionally suggests functional significance...