J Zhang

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi Molecular characterization of the mouse Fas ligand promoter in airway epithelial cells
    J Zhang
    The Pulmonary Center and the Department of Biochemistry, Boston University School of Medicine, 80 E Concord Street, Boston, MA 02118, USA
    Biochim Biophys Acta 1490:291-301. 2000
  2. ncbi Characterization of a novel cis-element that regulates Fas ligand expression in corneal endothelial cells
    J Zhang
    The Pulmonary Center and the Department of Biochemistry, Boston, MA 02118, USA
    J Biol Chem 274:26537-42. 1999
  3. pmc Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation
    W Xia
    Department of Neurology and Program in Neuroscience, Harvard Medical School and Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 97:9299-304. 2000
  4. pmc Osterix enhances BMSC-associated osseointegration of implants
    B Xu
    Division of Oral Biology, Tufts University School of Dental Medicine, One Kneeland Street, Boston, MA 02111, USA
    J Dent Res 88:1003-7. 2009
  5. pmc Phenotypic analysis of Dlx5 overexpression in post-natal bone
    J Zhang
    Division of Oral Biology, Department of General Dentistry, Tufts University School of Dental Medicine, One Kneeland Street, Boston, MA 02111, USA
    J Dent Res 87:45-50. 2008
  6. ncbi Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi
    W Xia
    Department of Neurology, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Biochemistry 37:16465-71. 1998
  7. ncbi Molecular cloning and characterization of human trabeculin-alpha, a giant protein defining a new family of actin-binding proteins
    Y Sun
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 274:33522-30. 1999
  8. pmc Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease
    W Xia
    Department of Neurology, Harvard Medical School, Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 94:8208-13. 1997
  9. ncbi Epidermal growth factor induces Egr-1 promoter activity in hepatocytes in vitro and in vivo
    J C Tsai
    Department of Molecular Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Am J Physiol Gastrointest Liver Physiol 281:G1271-8. 2001
  10. ncbi Expression of estrogen receptors alpha and beta in human meningiomas
    R S Carroll
    Brain Tumor Center, Brigham and Women s Hospital, and Department of Surgery, Harvard Medical School, Boston, MA, USA
    J Neurooncol 42:109-16. 1999

Collaborators

Detail Information

Publications86

  1. ncbi Molecular characterization of the mouse Fas ligand promoter in airway epithelial cells
    J Zhang
    The Pulmonary Center and the Department of Biochemistry, Boston University School of Medicine, 80 E Concord Street, Boston, MA 02118, USA
    Biochim Biophys Acta 1490:291-301. 2000
    ....
  2. ncbi Characterization of a novel cis-element that regulates Fas ligand expression in corneal endothelial cells
    J Zhang
    The Pulmonary Center and the Department of Biochemistry, Boston, MA 02118, USA
    J Biol Chem 274:26537-42. 1999
    ..By UV cross-linking analysis, we found that an approximately 30-kDa corneal nuclear protein binds to the Fas ligand promoter TCCT box and, thus, likely plays an important role in Fas ligand expression in corneal endothelial cells...
  3. pmc Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation
    W Xia
    Department of Neurology and Program in Neuroscience, Harvard Medical School and Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 97:9299-304. 2000
    ..Thus, PSs are complexed with the gamma-secretase substrates C83 and C99 in the subcellular locations where Abeta is generated, indicating that PSs are directly involved in the pathogenically critical intramembranous proteolysis of APP...
  4. pmc Osterix enhances BMSC-associated osseointegration of implants
    B Xu
    Division of Oral Biology, Tufts University School of Dental Medicine, One Kneeland Street, Boston, MA 02111, USA
    J Dent Res 88:1003-7. 2009
    ..We concluded that exogenous BMSCs participate in the osseointegration after implantation, and that Osx overexpression accelerates osseointegration...
  5. pmc Phenotypic analysis of Dlx5 overexpression in post-natal bone
    J Zhang
    Division of Oral Biology, Department of General Dentistry, Tufts University School of Dental Medicine, One Kneeland Street, Boston, MA 02111, USA
    J Dent Res 87:45-50. 2008
    ..Our results suggest that Dlx5 promotes expression of early markers of osteogenic differentiation and increases mineralization post-natally...
  6. ncbi Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi
    W Xia
    Department of Neurology, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Biochemistry 37:16465-71. 1998
    ..Our results indicate PS1 and APP can interact in the ER and Golgi, where PS1 is required for proper gamma-secretase processing of APP CTFs, and that PS1 mutations augment Abeta42 levels principally in Golgi-like vesicles...
  7. ncbi Molecular cloning and characterization of human trabeculin-alpha, a giant protein defining a new family of actin-binding proteins
    Y Sun
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 274:33522-30. 1999
    ..Finally, the presence of cDNAs similar to, yet distinct from, trabeculin-alpha in both human and mouse suggests that trabeculins may form a new subfamily of giant actin-binding/cytoskeletal cross-linking proteins...
  8. pmc Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease
    W Xia
    Department of Neurology, Harvard Medical School, Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 94:8208-13. 1997
    ....
  9. ncbi Epidermal growth factor induces Egr-1 promoter activity in hepatocytes in vitro and in vivo
    J C Tsai
    Department of Molecular Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Am J Physiol Gastrointest Liver Physiol 281:G1271-8. 2001
    ..Together, these results suggest that the 1,200-bp promoter contains information for EGF response in hepatocytes both in vitro and in intact animals...
  10. ncbi Expression of estrogen receptors alpha and beta in human meningiomas
    R S Carroll
    Brain Tumor Center, Brigham and Women s Hospital, and Department of Surgery, Harvard Medical School, Boston, MA, USA
    J Neurooncol 42:109-16. 1999
    ..The involvement of ER-beta in meningioma biology should be examined further, given the differences in the ER-alpha and ER-beta gene products...
  11. ncbi Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation
    W Q Qiu
    Department of Neurology and Program in Neuroscience, Harvard Medical School and Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, Massachusetts 02115 5716, USA
    J Biol Chem 273:32730-8. 1998
    ..We conclude that a principal protease capable of down-regulating the levels of secreted Abeta extracellularly is IDE...
  12. ncbi AP-2alpha transcription factor is required for early morphogenesis of the lens vesicle
    J A West-Mays
    Department of Ophthalmology, New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts, 02111, USA
    Dev Biol 206:46-62. 1999
    ..Together these findings demonstrate a requirement for AP-2alpha in early morphogenesis of the eye...
  13. ncbi HRad17, a human homologue of the Schizosaccharomyces pombe checkpoint gene rad17, is overexpressed in colon carcinoma
    S Bao
    Dana Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 59:2023-8. 1999
    ....
  14. ncbi KDR activation in astrocytic neoplasms
    R S Carroll
    Neurosurgical Laboratories, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer 86:1335-41. 1999
    ..Stimulation of aortic endothelial cells results in receptor tyrosine phosphorylation (receptor activation). In this study the activation state of the KDR receptors was determined in low grade, anaplastic, and high grade gliomas...
  15. ncbi T cell receptor BV gene rearrangements in the spinal cords and cerebrospinal fluid of patients with amyotrophic lateral sclerosis
    M A Panzara
    Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, 02114, USA
    Neurobiol Dis 6:392-405. 1999
    ..Our results suggest that an immunological process involving the specific expansion of Vbeta2 TCR-positive T-cells may be important in the pathogenesis of ALS...
  16. pmc Enhanced osseointegration of titanium implant through the local delivery of transcription factor SATB2
    S G Yan
    Division of Oral Biology, Department of General Dentistry, Tufts University School of Dental Medicine, 1 Kneeland Street, Boston, MA 02111, USA
    Biomaterials 32:8676-83. 2011
    ..These results conclude that in vivo overexpression of SATB2 significantly accelerates osseointegration of titanium implants and SATB2 can serve as a potent molecule in promoting tissue regeneration...
  17. ncbi A pivotal role for Mcl-1 in Bortezomib-induced apoptosis
    K Podar
    Department of Medical Oncology, Jerome Lipper Multiple Myeloma Center, Harvard Medical School, Dana Farber Cancer Institute, Boston, MA 022115, USA
    Oncogene 27:721-31. 2008
    ..To prevent relapse of MM in patients treated with Bortezomib, we therefore recommend the combination of Bortezomib with agents that induce MM cell death independent of Mcl-1...
  18. doi Targeting tumor gene by shRNA-expressing Salmonella-mediated RNAi
    H Guo
    Skip Ackerman Center for Molecular Therapeutics, Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Gene Ther 18:95-105. 2011
    ....
  19. pmc Discovery of notch-sparing gamma-secretase inhibitors
    C E Augelli-Szafran
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Curr Alzheimer Res 7:207-9. 2010
    ..These compounds are of low molecular weight and are under evaluation for drug-like properties. The discovery and development of these compounds will be discussed...
  20. ncbi Endothelin-1 gene suppression by shear stress: pharmacological evaluation of the role of tyrosine kinase, intracellular calcium, cytoskeleton, and mechanosensitive channels
    A M Malek
    Department of Neurosurgery, Brigham and Women s Hospital, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Mol Cell Cardiol 31:387-99. 1999
    ....
  21. pmc Magnetic resonance imaging traits in siblings discordant for Alzheimer disease
    Karen T Cuenco
    Department of Medicine, Boston University Schools of Medicine and Public Health, Boston, MA 02118, USA
    J Neuroimaging 18:268-75. 2008
    ..We evaluated semi-quantitative MRI measures as endophenotypes for genetic studies by assessing their association with AD in families from the Multi-Institutional Research in Alzheimer Genetic Epidemiology (MIRAGE) Study...
  22. pmc Systemically transplanted bone marrow stromal cells contributing to bone tissue regeneration
    S Li
    Division of Oral Biology, Department of General Dentistry, Tufts University School of Dental Medicine, Boston, Massachusetts 02111, USA
    J Cell Physiol 215:204-9. 2008
    ..In conclusion, BMSCs can migrate to bone wound sites and participate in bone regeneration in orocraniofacial region...
  23. ncbi Silencing p21(Waf1/Cip1/Sdi1) expression increases gene transduction efficiency in primitive human hematopoietic cells
    J Zhang
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Gene Ther 12:1444-52. 2005
    ..Decreasing p21 expression transiently while increasing gene-transfer vector integration may ultimately facilitate clinical applications of gene therapy...
  24. ncbi Assessment of alterations in gene expression in recurrent malignant glioma after radiotherapy using complementary deoxyribonucleic acid microarrays
    T Joki
    Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
    Neurosurgery 48:195-201; discussion 201-2. 2001
    ..In contrast, growth factors that participate in autocrine loops demonstrate elevated levels of gene expression. These results suggest that maintenance of autocrine loops may be important in tumor regrowth after radiotherapy...
  25. ncbi Human immunodeficiency virus type 1 RNA in peripheral blood mononuclear cells of patients receiving prolonged highly active antiretroviral therapy
    J Zhang
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Infect Dis 184:1341-4. 2001
    ..Early viral spliced mRNA was detected in the PBMC of all patients who had positive results of testing for HIV-1 genomic RNA, and the level of viral genomic RNA in these patients was 34-2214 copies per 10(6) cells...
  26. ncbi A Phase I study to evaluate the pharmacokinetics of axitinib (AG-13736) in healthy Chinese volunteers
    Y Chen
    Pfizer Oncology, San Diego, CA, USA
    Int J Clin Pharmacol Ther 49:679-87. 2011
    ..To assess axitinib plasma pharmacokinetics and safety of single oral doses of axitinib under fed conditions in healthy Chinese volunteers...
  27. ncbi Induction of heparin-binding EGF-like growth factor expression during myogenesis. Activation of the gene by MyoD and localization of the transmembrane form of the protein on the myotube surface
    X Chen
    Department of Surgery, Children s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 270:18285-94. 1995
    ....
  28. ncbi Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue
    M B Podlisny
    Center for Neurologic Diseases, Harvard Medical School, Boston, Massachusetts, 02115, USA
    Neurobiol Dis 3:325-37. 1997
    ..Our results indicate that presenilins are rapidly processed to N- and C-terminal fragments in both neural and nonneural cells and that interference with this processing is not an obligatory feature of FAD-causing mutations...
  29. ncbi FADD is required for DR4- and DR5-mediated apoptosis: lack of trail-induced apoptosis in FADD-deficient mouse embryonic fibroblasts
    A A Kuang
    Department of Molecular and Cell Biology, Cancer Research Laboratory and Division of Immunology, University of California, Berkeley 94720 3200, USA
    J Biol Chem 275:25065-8. 2000
    ..We conclude that FADD is required for DR4- and DR5-mediated apoptosis...
  30. ncbi The origin of the Jingwei gene and the complex modular structure of its parental gene, yellow emperor, in Drosophila melanogaster
    W Wang
    Department of Ecology and Evolution, University of Chicago Department of Molecular and Cellular Biology, Harvard University
    Mol Biol Evol 17:1294-301. 2000
    ..The composite gene structure of ymp manifests the complexity of the gene concept, which should be considered in genomic research, e.g., gene finding...
  31. ncbi Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor beta
    K Slentz-Kesler
    Department of Genomic Sciences, Glaxo Wellcome, Inc, 5 Moore Drive, Research Triangle Park, North Carolina, 27709, USA
    Genomics 69:63-71. 2000
    ....
  32. ncbi Molecular characterization and expression of the M6 gene of grass carp hemorrhage virus (GCHV), an aquareovirus
    T Qiu
    State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan
    Arch Virol 146:1391-7. 2001
    ..The result indicates that the protein encoded by M6 may share a putative Asn-42-Pro-43 proteolytic cleavage site with mu1...
  33. ncbi Mouse phosphoglycerate mutase M and B isozymes: cDNA cloning, enzyme activity assay and mapping
    J Zhang
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, No 220 Handan Road, Shanghai 200433, P R China
    Gene 264:273-9. 2001
    ..The partial genomic sequence of Pgam2 was determined, which showed that mouse Pgam2 consisted at least three exons and two introns. In addition, a pseudogene of Pgam1, Pgam1-ps1, was identified from mouse genomic sequence...
  34. ncbi Characterization of three Toll-like genes from mosquito Aedes aegypti
    C Luna
    Yale University School of Medicine, Epidemiology and Public Health, New Haven, CT 06520, USA
    Insect Mol Biol 12:67-74. 2003
    ..2) Only one of three amino acid residues essential for DmToll function is required for AeToll1A function...
  35. ncbi Expression of cDNAs encoding mouse cardiac troponin T isoforms: characterization of a large sample of independent clones
    J P Jin
    Department of Medical Biochemistry, University of Calgary, Alberta, Canada
    Gene 168:217-21. 1996
    ..Three novel alternative splicing acceptor sites in the 5'-untranslated portion of exon 2 have been identified with different frequencies...
  36. ncbi Xenopus VegT RNA is localized to the vegetal cortex during oogenesis and encodes a novel T-box transcription factor involved in mesodermal patterning
    J Zhang
    Department of Cell Biology and Anatomy R 124, University of Miami School of Medicine, Florida 33101, USA
    Development 122:4119-29. 1996
    ..Our results suggest that VegT is a localized transcription factor, which operates sequentially in several developmental pathways during embryogenesis, including dorsoventral and posterior patterning of mesoderm...
  37. ncbi Cloning and characterization of Siglec-10, a novel sialic acid binding member of the Ig superfamily, from human dendritic cells
    N Li
    Institute of Immunology, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China
    J Biol Chem 276:28106-12. 2001
    ....
  38. ncbi Mouse protein Z-dependent protease inhibitor cDNA
    J Zhang
    Division of Hematology, Barnes Jewish Hospital at Washington University Medical Center, St Louis, MO 63110, USA
    Thromb Haemost 85:861-5. 2001
    ..By Northern analysis, mouse ZPI mRNA is 1.6 kb in size and, similar to both human and rat, it is detectable in liver, but not in heart, brain, spleen, lung, kidney, skeletal muscle or testes...
  39. ncbi Molecular cloning and characterization of a novel calcium/calmodulin-dependent protein kinase II inhibitor from human dendritic cells
    J Zhang
    Department of Clinical Laboratory, Changzheng Hospital, Shanghai 200003, People s Republic of China
    Biochem Biophys Res Commun 285:229-34. 2001
    ..These results characterize a potential cellular inhibitor protein of CaMKII that plays an important role in the regulation of cell growth...
  40. ncbi Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin
    E V Pindel
    Department of Biochemistry, Indiana University School of Medicine, Indianapolis, Indiana 46202 5122, USA
    J Biol Chem 272:14769-75. 1997
    ..hCE-2 may play an important role in the degradation of cocaine and heroin in human tissues...
  41. ncbi The promoter of the HaCaT keratinocyte differentiation-related gene keratin 4 contains a functional AP-2 binding site
    R Wanner
    Institute of Molecular Biology and Biochemistry, UKBF, FU Berlin, Berlin, Germany
    Arch Dermatol Res 289:705-8. 1997
    ..Thus, the role of AP-2 in the process of keratinocyte differentiation appears to be considerable. In addition, further regulatory elements were found to be necessary for full transcription of K4...
  42. ncbi Molecular cloning and characterization of a new fasting-inducible short-chain dehydrogenase/reductase from rat liver(1)
    J Zhang
    Department of Pediatrics, 509 Burnett Womack Building, CB 7220, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Biochim Biophys Acta 1435:184-90. 1999
    ..Additional experiments including purification of recombinant RLF98 protein are in progress to define the specific function of this protein and the role it plays during fasting-induced catabolism...
  43. ncbi Cystatin F is a glycosylated human low molecular weight cysteine proteinase inhibitor
    J Ni
    Human Genome Sciences, Inc, Rockville, Maryland 20850 3338, USA
    J Biol Chem 273:24797-804. 1998
    ....
  44. ncbi Identification of serine 643 of protein kinase C-delta as an important autophosphorylation site for its enzymatic activity
    W Li
    Laboratory of Cellular and Molecular Biology, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 272:24550-5. 1997
    ..Taken together, our results demonstrate that serine 643 of PKC-delta is a major autophosphorylation site, and phosphorylation of this site plays an important role in controlling its enzymatic activity and biological function...
  45. ncbi An embryonic alternative transcription initiation site and the 5'-upstream structure of mouse cardiac troponin T gene
    J P Jin
    Department of Medical Biochemistry, University of Calgary Faculty of Medicine, Alberta, Canada
    Biochem Biophys Res Commun 214:1168-74. 1995
    ..Genomic cloning and sequencing further revealed an 1.5-kb 5'-upstream sequence of the mouse cardiac TnT gene and relationships between the promoter regulatory elements and the alternative transcription initiation sites...
  46. pmc Pro-B-cell-specific transcription and proapoptotic function of protein kinase Ceta
    T A Morrow
    Graduate Program in Immunology, The Johns Hopkins University School of Public Health, Baltimore, Maryland 21205, USA
    Mol Cell Biol 19:5608-18. 1999
    ..These results suggest that the expression and proteolytic activation of PKCeta play an important role in the regulation of cell division and cell death during early B-cell development...
  47. pmc Molecular cloning and characterization of NF-IL3A, a transcriptional activator of the human interleukin-3 promoter
    W Zhang
    Laboratory of Molecular Aspects of Hematopoiesis, Sloan Kettering Institute, New York, New York, USA
    Mol Cell Biol 15:6055-63. 1995
    ..One or more copies of the A region also confer NF-IL3A responsiveness on a heterologous promoter in T cells. NF-IL3A appears to play an important role in the expression of IL-3 by T cells...
  48. ncbi Primary structure of the catalytic subunit of calf thymus DNA polymerase delta: sequence similarities with other DNA polymerases
    J Zhang
    Department of Biochemistry, University of Miami, Florida 33101
    Biochemistry 30:11742-50. 1991
    ..abstract truncated at 250 words)..
  49. ncbi Natural disruption of the mouse mast cell protease 7 gene in the C57BL/6 mouse
    J E Hunt
    Department of Medicine, Harvard Medical School, Boston, Masschusetts 02115
    J Biol Chem 271:2851-5. 1996
    ..Moreover, the mMCP-7 gene is the first found in any species that sequentially has undergone a splice site mutation to cause retention of an intron and then a second splice site mutation to cause activation of a cryptic splice site...
  50. pmc A uridine-rich sequence required for translation of prokaryotic mRNA
    J Zhang
    Department of Biochemistry, University of Connecticut Health Center, Farmington 06030
    Proc Natl Acad Sci U S A 89:2605-9. 1992
    ..These data demonstrate that sequences other than those previously recognized can be essential for translation initiation...
  51. ncbi Cloning, mapping, and sequencing of 3' and its flanking region of bovine alpha-s1 casein gene
    R Chen
    Institute of Biophysics, CAS, Beijing, China
    Chin J Biotechnol 8:235-45. 1992
    ..Some divergences in restriction endonucleases sites, a few deletions, and many point mutations were found in introns and exons when compared with those which were published...
  52. pmc Control of the proinflammatory state in cystic fibrosis lung epithelial cells by genes from the TNF-alphaR/NFkappaB pathway
    O Eidelman
    Department of Anatomy, Institute of Molecular Medicine F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Mol Med 7:523-34. 2001
    ....
  53. ncbi Prokaryotic expression and allergenicity assessment of hygromycin B phosphotransferase protein derived from genetically modified plants
    Y Lu
    The Supervision, Inspection and Testing Center of Genetically Modified Organisms, Ministry of Agriculture, Beijing 100083, China
    J Food Sci 72:M228-32. 2007
    ..Alignment of the amino acid sequence of HPT with those of known allergens did not produce evidence of sequence similarities between these allergens and the HPT protein. We conclude that HPT has a low probability to induce allergenicity...
  54. ncbi Immobilized MICA could expand human Vdelta1 gammadelta T cells in vitro that displayed major histocompatibility complex class I chain-related A-dependent cytotoxicity to human epithelial carcinomas
    J Qi
    Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, 5 Dong Dan San Tiao, Beijing 100005, PR China
    Scand J Immunol 58:211-20. 2003
    ....
  55. pmc Adipose pyruvate carboxylase: amino acid sequence and domain structure deduced from cDNA sequencing
    J Zhang
    Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, FL 33101
    Proc Natl Acad Sci U S A 90:1766-70. 1993
    ....
  56. ncbi [Cloning and characterization of a novel mouse short-chain dehydrogenase/reductases cDNA mHsdl2#, encoding a protein with a SDR domaid and a SCP2 domain]
    J Dai
    Mol Biol (Mosk) 39:799-805. 2005
    ..The predicted mouse HSDL2 protein, which has a peroxisomal target signal, is localized in the cytoplasm of NIH 3T3 cells...
  57. ncbi Identification of one intron loss and phylogenetic evolution of Dfak gene in the Drosophila melanogaster species group
    S Jin
    Wuhan Center for Developmental Biology, Institute of Hydrobiology, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Wuhan 430072, China
    Genetica 125:223-30. 2005
    ..melanogaster and D. simulans provides a unique diagnostic tool for taxonomic classification of the melanogaster subgroup from other group of genus Drosophila...
  58. ncbi Fermented papaya preparation attenuates beta-amyloid precursor protein: beta-amyloid-mediated copper neurotoxicity in beta-amyloid precursor protein and beta-amyloid precursor protein Swedish mutation overexpressing SH-SY5Y cells
    J Zhang
    State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Academia Sinica, Chaoyang District, Beijing, 100101, PR China
    Neuroscience 143:63-72. 2006
    ..Our results also show that FPP prevents the cell apoptosis through bax/bcl-2 sensitive pathway...
  59. ncbi Molecular characterization of MbADGF, a novel member of the adenosine deaminase-related growth factor in the cabbage armyworm, Mamestra brassicae: the functional roles in the midgut cell proliferation
    J Zhang
    Division of Biofunctional Science, Graduate School of Science and Technology, Kobe University, Nada, Kobe, Japan
    Insect Mol Biol 16:351-60. 2007
    ....
  60. ncbi Cathepsin K: isolation and characterization of the murine cDNA and genomic sequence, the homologue of the human pycnodysostosis gene
    B D Gelb
    Division of Pediatric Cardiology, Mount Sinai School of Medicine, New York, New York, 10029, USA
    Biochem Mol Med 59:200-6. 1996
    ..The availability of the mouse cathepsin K cDNA and genomic sequences will facilitate generation of a mouse model of cathepsin K deficiency by gene targeting...
  61. ncbi ESDN is a marker of vascular remodeling and regulator of cell proliferation in graft arteriosclerosis
    M M Sadeghi
    Raymond and Beverly Sackler Cardiovascular Molecular Imaging Laboratory, Yale University School of Medicine, New Haven, CT, USA
    Am J Transplant 7:2098-105. 2007
    ..We conclude that ESDN is a marker of vascular remodeling and regulator of VSMC proliferation. ESDN may serve as a therapeutic or diagnostic target for GA...
  62. ncbi Human DNA helicase IV is nucleolin, an RNA helicase modulated by phosphorylation
    N Tuteja
    International Centre for Genetic Engineering and Biotechnology, Area Science Park, Trieste, Italy
    Gene 160:143-8. 1995
    ..The Gly-rich C-terminal domain possesses a limited ATP-dependent duplex-unwinding activity which contributes to the helicase activity of HDH IV/nucleolin...
  63. ncbi Peroxisome proliferator-activated receptor gamma inhibits transforming growth factor beta-induced connective tissue growth factor expression in human aortic smooth muscle cells by interfering with Smad3
    M Fu
    Cardiovascular Research Institute, Morehouse School of Medicine, Atlanta, Georgia 30310, USA
    J Biol Chem 276:45888-94. 2001
    ..Taken together, the data suggest that PPAR gamma inhibits TGF-beta-induced CTGF expression in HASMCs by directly interfering with the Smad3 signaling pathway...
  64. ncbi Anti-inflammatory effects of prostaglandin E2 in the central nervous system in response to brain injury and circulating lipopolysaccharide
    J Zhang
    Laboratory of Molecular Endocrinology, CHUL Research Center and Department of Anatomy and Physiology, Laval University, , Canada
    J Neurochem 76:855-64. 2001
    ....
  65. ncbi Cloning, tissue expression pattern and genomic organization of latexin, a human homologue of rat carboxypeptidase A inhibitor
    Q Liu
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, PR China
    Mol Biol Rep 27:241-6. 2000
    ..9 kb according to the genomic sequence of the clone RP11-79M21 and the gap sequence cloned in this paper. LXN was assigned to 3q25-q26.2 according to the position of the marker SHGC-35682 found adjacent to LXN gene...
  66. ncbi Molecular cloning, characterization and expression of a nitric oxide synthase from porcine pulmonary artery endothelial cells
    J Zhang
    Department of Medicine, University of Florida, Gainesville, USA
    Comp Biochem Physiol B Biochem Mol Biol 116:485-91. 1997
    ..The molecular weight of porcine ecNOS mRNA was estimated to be 4.7 kb by Northern blot analysis, similar to human ecNOS mRNA. This suggests that porcine ecNOS is similar to human ecNOS in deduced amino acid sequence and structure...
  67. ncbi Characterization and expression of the mouse pregnant specific uterus protein gene and its rat homologue in the intestine and uterus
    J Zhang
    Department of Physiology, Faculty of Medicine, National University of Singapore, 10 Kent Ridge Crescent, 119260, Singapore, Singapore
    Biochim Biophys Acta 1492:526-30. 2000
    ..The pattern of expression in the mouse was similar. Expression of Psup in the mouse was localized to the epithelial cells in the intestine and pregnant uterus by in situ hybridization. The data show tissue-specific expression of Psup...
  68. pmc Resistance to DNA fragmentation and chromatin condensation in mice lacking the DNA fragmentation factor 45
    J Zhang
    Department of Cell Biology, Neurobiology, and Anatomy, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Proc Natl Acad Sci U S A 95:12480-5. 1998
    ..These results demonstrate that DFF45 is critical for the induction of DNA fragmentation and chromatin condensation in vivo, but is not required for normal immune system development...
  69. ncbi Structure and chromosomal location of the rat gene encoding the heart fatty acid-binding protein
    J Zhang
    Department of Biological Sciences, Simon Fraser University, Burnaby, Canada
    Eur J Biochem 266:347-51. 1999
    ..Using intron-specific primers flanking exon 2, unspliced primary transcript RNA of the FABP gene was detected in a preparation of total RNA isolated from rat heart, proving that the cloned gene is expressed in adult cardiac tissue...
  70. ncbi Structural analysis of the human BIN1 gene. Evidence for tissue-specific transcriptional regulation and alternate RNA splicing
    R Wechsler-Reya
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 272:31453-8. 1997
    ..This study lays the foundation for genetic and epigenetic investigations into the role of BIN1 in normal and neoplastic cell regulation...
  71. ncbi SHP-1 regulates Lck-induced phosphatidylinositol 3-kinase phosphorylation and activity
    B Cuevas
    Division of Medicine, and the Cell Growth Regulation Laboratory, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 274:27583-9. 1999
    ....
  72. ncbi Computational EST database analysis identifies a novel member of the neuropoietic cytokine family
    Y Shi
    Department of Molecular Biology, Department of Pharmacology, Department of Protein Expression, Human Genome Sciences, Inc, 9410 Key West Avenue, Rockville, Maryland 20850, USA
    Biochem Biophys Res Commun 262:132-8. 1999
    ..Furthermore, the signal transduction pathway for CLC was characterized in the neuroblastoma cell line SK-N-MC and found to involve tyrosine phosphorylation of gp130 and STAT-1...
  73. pmc A unique insert in the linker domain of Syk is necessary for its function in immunoreceptor signalling
    S Latour
    McGill Cancer Centre, McGill University, Montreal, Quebec, Canada H3G 1Y6
    EMBO J 17:2584-95. 1998
    ..Furthermore, they provided evidence that the linker region can regulate the ability of Syk to bind ITAMs, thus identifying a novel function for this domain...
  74. ncbi Identification of mouse TRAP100: a transcriptional coregulatory factor for thyroid hormone and vitamin D receptors
    J Zhang
    Department of Physiology, University of Maryland School of Medicine, Baltimore 21201, USA
    Mol Endocrinol 13:1130-40. 1999
    ..Collectively, these findings suggest that TRAP100, in concert with other TRAPs, plays an important functional role in mediating transactivation by specific NRs...
  75. ncbi Overlapping activators and repressors delimit transcriptional response to receptor tyrosine kinase signals in the Drosophila eye
    C Xu
    Department of Biological Sciences, University of Pittsburgh, Pennsylvania 15260, USA
    Cell 103:87-97. 2000
    ..We show that Sevenless activates prospero independent of the enhancer and involves targeted degradation of Tramtrack, a transcription repressor...
  76. ncbi Molecular cloning and tissue expression analysis of the beta subunit of elongation factor 1 in the mouse
    Q Liu
    State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, P R China
    Biochem Genet 38:111-7. 2000
  77. ncbi Complete sequence and organization of Periplaneta fuliginosa densovirus genome
    H Guo
    Institute of Virology, Wuhan University, Wuhan, 430072, P R China
    Acta Virol 44:315-22. 2000
    ..The ORF6 polypeptide has distinct homology to the structural polypeptides of insect parvoviruses. The organization of PfDNV genome was compared to those of other parvoviruses...
  78. ncbi Cloning and characterization of IL-1HY2, a novel interleukin-1 family member
    H Lin
    Functional Genomics Department, Hyseq Inc, Sunnyvale, California 94086, USA
    J Biol Chem 276:20597-602. 2001
    ..These data suggest that IL-1HY2 is a novel IL-1 family member and that it may participate in a network of IL-1 family members to regulate adapted and innate immune responses...
  79. ncbi Orphanin FQ: an endogenous antagonist of rat brain dopamine transporter
    Z Liu
    Shanghai Institute of Biological Sciences, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
    Neuroreport 12:699-702. 2001
    ....
  80. ncbi Complete nucleotide sequence of the S10 genome segment of grass carp reovirus (GCRV)
    T Qiu
    State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrology, Chinese Academy of Sciences, Wuhan
    Dis Aquat Organ 44:69-74. 2001
    ..It was predicted that this segment gene encodes an outer capsid protein...
  81. ncbi Identification of a novel type I cytokine receptor CRL2 preferentially expressed by human dendritic cells and activated monocytes
    W Zhang
    Institute of Immunology, Second Military Medical University, 800 Xiangyin Road, Shanghai, 200433, People s Republic of China
    Biochem Biophys Res Commun 281:878-83. 2001
    ..We also prepared a CRL2Ig fusion protein. The identification of its ligand and involvement of signal transduction will help to elucidate its potential function...
  82. pmc Epstein-Barr virus BamHi-a rightward transcript-encoded RPMS protein interacts with the CBF1-associated corepressor CIR to negatively regulate the activity of EBNA2 and NotchIC
    J Zhang
    Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland 21231, USA
    J Virol 75:2946-56. 2001
    ..We conclude that RPMS acts as a negative regulator of EBNA2 and Notch activity through its interactions with the CBF1-associated corepressor complex...
  83. ncbi Cloning of the murine Krit1 cDNA reveals novel mammalian 5' coding exons
    J Zhang
    Howard Hughes Medical Institute and The Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Genomics 70:392-5. 2000
    ..These data have immediate relevance to mutation screening efforts in cerebral cavernous malformation and may contribute to our understanding of the normal biology of KRIT1 and the pathogenesis of this disorder...
  84. pmc Single-chain antibody displayed on a recombinant measles virus confers entry through the tumor-associated carcinoembryonic antigen
    A L Hammond
    Molecular Medicine Program, Mayo Foundation, Rochester, Minnesota 55905, USA
    J Virol 75:2087-96. 2001
    ..Thus, MV not only tolerates the addition of a scAb on its H protein but also infects cells via a novel interaction between the scAb and its targeted receptor...
  85. ncbi The cloning and characterization of a murine secretory leukocyte protease inhibitor cDNA
    R J Zitnik
    Department of Internal Medicine, Yale University, New Haven, Connecticut 06520, USA
    Biochem Biophys Res Commun 232:687-97. 1997
    ..Such species-specific evolution of this protease inhibitor is notable given that species-specific structure-function differences have previously been reported for the alpha-1 antitrypsin family...
  86. pmc The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis
    S A Laporte
    Howard Hughes Medical Institute Laboratories and Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 96:3712-7. 1999
    ..These findings point to a role for AP-2 in GPCR endocytosis, and they suggest that AP-2 functions as a clathrin adaptor for the endocytosis of diverse classes of membrane receptors...