Vanessa Xanthakis

Summary

Affiliation: Boston University
Country: USA

Publications

  1. doi request reprint Relations between subclinical disease markers and type 2 diabetes, metabolic syndrome, and incident cardiovascular disease: the Jackson Heart Study
    Vanessa Xanthakis
    Framingham Heart Study, Framingham, MA Department of Biostatistics, Boston University School of Public Health, Boston, MA Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, MA
    Diabetes Care 38:1082-8. 2015
  2. doi request reprint Ideal cardiovascular health: associations with biomarkers and subclinical disease and impact on incidence of cardiovascular disease in the Framingham Offspring Study
    Vanessa Xanthakis
    From the Framingham Heart Study, Framingham, MA V X, J M M, R S V Department of Biostatistics, Boston University School of Public Health, Boston, MA V X, D M E Section of Preventive Medicine and Epidemiology V X, R S V and Section of General Internal Medicine, Department of Medicine J M M, Boston University School of Medicine, Boston, MA Department of Radiology, Tufts University Medical Center, Boston, MA J F P Division of Molecular and Translational Cardiology, Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany K C W Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston J L J Cardiology Division, Vanderbilt University Medical Center, Nashville, TN T J W and Royal North Shore Hospital University of Sydney, Sydney, Australia G T
    Circulation 130:1676-83. 2014
  3. pmc Aldosterone and the risk of hypertension
    Vanessa Xanthakis
    Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, 801 Massachusetts Avenue, Suite 470, Boston, MA 02118, USA
    Curr Hypertens Rep 15:102-7. 2013
  4. pmc Cardiometabolic correlates and heritability of fetuin-A, retinol-binding protein 4, and fatty-acid binding protein 4 in the Framingham Heart Study
    Bernhard M Kaess
    National Heart, Blood, and Lung Institute s Framingham Heart Study, Framingham, MA 01702, USA
    J Clin Endocrinol Metab 97:E1943-7. 2012
  5. pmc Aortic root remodeling over the adult life course: longitudinal data from the Framingham Heart Study
    Carolyn S P Lam
    Framingham Heart Study, Framingham, MA 01702 5803, USA
    Circulation 122:884-90. 2010
  6. pmc Correlates of echocardiographic indices of cardiac remodeling over the adult life course: longitudinal observations from the Framingham Heart Study
    Susan Cheng
    The Framingham Heart Study, Framingham, MA 01702 5803, USA
    Circulation 122:570-8. 2010
  7. pmc Circulating insulin-like growth factor-1 and its binding protein-3: metabolic and genetic correlates in the community
    Carolyn S P Lam
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mount Wayte Avenue, Framingham, MA 01702, USA
    Arterioscler Thromb Vasc Biol 30:1479-84. 2010
  8. pmc Blood pressure tracking over the adult life course: patterns and correlates in the Framingham heart study
    Susan Cheng
    Framingham Heart Study, Framingham, MA, USA
    Hypertension 60:1393-9. 2012
  9. pmc Circulating vascular growth factors and central hemodynamic load in the community
    Justin P Zachariah
    Framingham Heart Study, 73 Mount Wayte Ave, Framingham, MA 01702 5803, USA
    Hypertension 59:773-9. 2012
  10. pmc Association of novel biomarkers of cardiovascular stress with left ventricular hypertrophy and dysfunction: implications for screening
    Vanessa Xanthakis
    Framingham Heart Study, Framingham, MA
    J Am Heart Assoc 2:e000399. 2013

Detail Information

Publications23

  1. doi request reprint Relations between subclinical disease markers and type 2 diabetes, metabolic syndrome, and incident cardiovascular disease: the Jackson Heart Study
    Vanessa Xanthakis
    Framingham Heart Study, Framingham, MA Department of Biostatistics, Boston University School of Public Health, Boston, MA Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, MA
    Diabetes Care 38:1082-8. 2015
    ..S. are at higher risk of CVD compared with non-Hispanic whites; however, data on the prevalence of subclinical disease measures in AAs and their association to CVD remain unclear and may explain the higher CVD risk in this group...
  2. doi request reprint Ideal cardiovascular health: associations with biomarkers and subclinical disease and impact on incidence of cardiovascular disease in the Framingham Offspring Study
    Vanessa Xanthakis
    From the Framingham Heart Study, Framingham, MA V X, J M M, R S V Department of Biostatistics, Boston University School of Public Health, Boston, MA V X, D M E Section of Preventive Medicine and Epidemiology V X, R S V and Section of General Internal Medicine, Department of Medicine J M M, Boston University School of Medicine, Boston, MA Department of Radiology, Tufts University Medical Center, Boston, MA J F P Division of Molecular and Translational Cardiology, Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany K C W Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston J L J Cardiology Division, Vanderbilt University Medical Center, Nashville, TN T J W and Royal North Shore Hospital University of Sydney, Sydney, Australia G T
    Circulation 130:1676-83. 2014
    ..The American Heart Association Cardiovascular Health score (CVH score) is inversely associated with cardiovascular disease (CVD) incidence, but the mechanisms underlying this association warrant exploration...
  3. pmc Aldosterone and the risk of hypertension
    Vanessa Xanthakis
    Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, 801 Massachusetts Avenue, Suite 470, Boston, MA 02118, USA
    Curr Hypertens Rep 15:102-7. 2013
    ..The combination of the aforementioned observations underscores the importance of the mineralocorticoid pathway in the pathogenesis of hypertension...
  4. pmc Cardiometabolic correlates and heritability of fetuin-A, retinol-binding protein 4, and fatty-acid binding protein 4 in the Framingham Heart Study
    Bernhard M Kaess
    National Heart, Blood, and Lung Institute s Framingham Heart Study, Framingham, MA 01702, USA
    J Clin Endocrinol Metab 97:E1943-7. 2012
    ..Fetuin-A, retinol-binding protein 4 (RBP4), and fatty-acid binding protein 4 (FABP4) are novel biomarkers that may link adiposity to insulin resistance and the metabolic syndrome (MetSyn)...
  5. pmc Aortic root remodeling over the adult life course: longitudinal data from the Framingham Heart Study
    Carolyn S P Lam
    Framingham Heart Study, Framingham, MA 01702 5803, USA
    Circulation 122:884-90. 2010
    ..Aortic root remodeling in adulthood is known to be associated with cardiovascular outcomes. However, there is a lack of longitudinal data defining the clinical correlates of aortic root remodeling over the adult life course...
  6. pmc Correlates of echocardiographic indices of cardiac remodeling over the adult life course: longitudinal observations from the Framingham Heart Study
    Susan Cheng
    The Framingham Heart Study, Framingham, MA 01702 5803, USA
    Circulation 122:570-8. 2010
    ..The heart progressively remodels over the life course, yet longitudinal data characterizing such remodeling in the community are limited...
  7. pmc Circulating insulin-like growth factor-1 and its binding protein-3: metabolic and genetic correlates in the community
    Carolyn S P Lam
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mount Wayte Avenue, Framingham, MA 01702, USA
    Arterioscler Thromb Vasc Biol 30:1479-84. 2010
    ..The metabolic and genetic correlates of circulating insulin-like growth factor-1 (IGF-1) and its main circulating carrier, IGF-1-binding-protein-3 (IGFBP-3), are unclear...
  8. pmc Blood pressure tracking over the adult life course: patterns and correlates in the Framingham heart study
    Susan Cheng
    Framingham Heart Study, Framingham, MA, USA
    Hypertension 60:1393-9. 2012
    ..We also observed a differential impact of select vascular risk factors on the individual components of BP, underscoring distinct regulation of these measures over the life course...
  9. pmc Circulating vascular growth factors and central hemodynamic load in the community
    Justin P Zachariah
    Framingham Heart Study, 73 Mount Wayte Ave, Framingham, MA 01702 5803, USA
    Hypertension 59:773-9. 2012
    ....
  10. pmc Association of novel biomarkers of cardiovascular stress with left ventricular hypertrophy and dysfunction: implications for screening
    Vanessa Xanthakis
    Framingham Heart Study, Framingham, MA
    J Am Heart Assoc 2:e000399. 2013
    ..It is unknown whether newer biomarkers are associated with LVH and LVSD and can serve as screening tools...
  11. pmc Clinical and genetic correlates of circulating angiopoietin-2 and soluble Tie-2 in the community
    Wolfgang Lieb
    Framingham Heart Study, Framingham, MA 01702 5803, USA
    Circ Cardiovasc Genet 3:300-6. 2010
    ..The clinical and genetic correlates of circulating angiopoietin-2 (Ang-2) and its soluble receptor/regulator Tie-2 (sTie-2) have not been determined in a community-based sample...
  12. pmc Longitudinal tracking of left atrial diameter over the adult life course: Clinical correlates in the community
    David D McManus
    Framingham Heart Study, MA 01702 5803, USA
    Circulation 121:667-74. 2010
    ..Increased left atrial diameter (LAD) is associated with elevated risk of atrial fibrillation (AF) and cardiovascular disease. Information is limited regarding the short- or long-term correlates of LAD...
  13. pmc Association of exhaled carbon monoxide with subclinical cardiovascular disease and their conjoint impact on the incidence of cardiovascular outcomes
    Susan Cheng
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA Division of Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Eur Heart J 35:2980-7. 2014
    ....
  14. pmc Prognostic utility of novel biomarkers of cardiovascular stress: the Framingham Heart Study
    Thomas J Wang
    Cardiology Division, GRB 800, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    Circulation 126:1596-604. 2012
    ..Biomarkers for predicting cardiovascular events in community-based populations have not consistently added information to standard risk factors. A limitation of many previously studied biomarkers is their lack of cardiovascular specificity...
  15. pmc Longitudinal tracking of left ventricular mass over the adult life course: clinical correlates of short- and long-term change in the framingham offspring study
    Wolfgang Lieb
    Framingham Heart Study, 73 Mount Wayte Ave, Framingham, MA 01702 5803, USA
    Circulation 119:3085-92. 2009
    ..Information is limited on the longitudinal tracking of left ventricular (LV) mass over the adult life course and the determinants of such change...
  16. pmc Plasma asymmetric dimethylarginine, L-arginine and left ventricular structure and function in a community-based sample
    Wolfgang Lieb
    Framingham Heart Study, Boston University School of Medicine, Framingham, MA 01702 5803, USA
    Atherosclerosis 204:282-7. 2009
    ..It is unclear if circulating ADMA and L-arginine levels are related to cardiac structure and function in the general population...
  17. pmc Association of sex steroids, gonadotrophins, and their trajectories with clinical cardiovascular disease and all-cause mortality in elderly men from the Framingham Heart Study
    Robin Haring
    Preventive Medicine and Epidemiology Section, School of Medicine, Boston University, Boston, MA, USA
    Clin Endocrinol (Oxf) 78:629-34. 2013
    ..The impact of longitudinal trajectory patterns from serial sex steroid and gonadotrophin measurements on the observed associations is unknown to date...
  18. pmc Assessing the incremental predictive performance of novel biomarkers over standard predictors
    Vanessa Xanthakis
    Framingham Heart Study, Framingham, MA, U S A Department of Biostatistics, Boston University School of Public Health, Boston, MA, U S A Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, MA, U S A
    Stat Med 33:2577-84. 2014
    ..We recommend that authors report the effect of a new biomarker after controlling for standard predictors modeled as individual variables...
  19. doi request reprint Cardiovascular Health Status and Incidence of Heart Failure in the Framingham Offspring Study
    Matthew Nayor
    From the Framingham Heart Study, MA M N, R S V, V X Division of Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA M N Departments of Biostatistics D M E, V X, Epidemiology R S V, V X, and Sections of Preventive Medicine and Epidemiology and Cardiology, Department of Medicine R S V, V X, Boston University School of Public Health, MA
    Circ Heart Fail 9:e002416. 2016
    ..The American Heart Association Cardiovascular Health (CVH) score is inversely associated with cardiovascular disease, but its relations to cardiac remodeling traits and heart failure (HF) incidence have not been examined...
  20. pmc Multilevel modeling versus cross-sectional analysis for assessing the longitudinal tracking of cardiovascular risk factors over time
    Vanessa Xanthakis
    Framingham Heart Study, Framingham, MA, U S A Department of Biostatistics, Boston University School of Public Health, Boston, MA, U S A Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, MA, U S A
    Stat Med 32:5028-38. 2013
    ..We illustrate these steps using echocardiographic data from the Framingham Heart Study with SAS PROC MIXED...
  21. pmc Identification of cis- and trans-acting genetic variants explaining up to half the variation in circulating vascular endothelial growth factor levels
    Stephanie Debette
    Department of Neurology, Boston University School of Medicine, B602, 72 East Concord St, Boston, MA 02118, USA
    Circ Res 109:554-63. 2011
    ..Vascular endothelial growth factor (VEGF) affects angiogenesis, atherosclerosis, and cancer. Although the heritability of circulating VEGF levels is high, little is known about its genetic underpinnings...
  22. pmc Association of the endogenous nitric oxide synthase inhibitor ADMA with carotid artery intimal media thickness in the Framingham Heart Study offspring cohort
    Renke Maas
    Department of Neurology, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA
    Stroke 40:2715-9. 2009
    ..We hypothesized that plasma ADMA concentrations are positively related to common carotid artery intimal-media thickness (CCA-IMT) and to internal carotid (ICA)/bulb IMT...