PHILIP A contact WOLF

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Contributions of the Framingham Heart Study to stroke and dementia epidemiologic research at 60 years
    Philip A Wolf
    Department of Neurology, Medicine, and Public Health, Boston University School of Medicine, Boston, MA 02118, USA
    Arch Neurol 69:567-71. 2012
  2. pmc Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study
    Christopher J O'Donnell
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S4. 2007
  3. pmc The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports
    L Adrienne Cupples
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S1. 2007
  4. pmc Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes
    Martin G Larson
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S5. 2007
  5. pmc Genome-wide association with select biomarker traits in the Framingham Heart Study
    Emelia J Benjamin
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S11. 2007
  6. pmc Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study
    Sudha Seshadri
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S15. 2007
  7. ncbi request reprint Impact of atrial fibrillation on mortality, stroke, and medical costs
    P A Wolf
    Department of Neurology, Boston University, Mass, USA
    Arch Intern Med 158:229-34. 1998
  8. ncbi request reprint Relation of obesity to cognitive function: importance of central obesity and synergistic influence of concomitant hypertension. The Framingham Heart Study
    Philip A Wolf
    Boston University School of Medicine, Boston, MA 02118 2526, USA
    Curr Alzheimer Res 4:111-6. 2007
  9. ncbi request reprint Anticardiolipin antibodies and risk of ischemic stroke and transient ischemic attack: the Framingham cohort and offspring study
    Vallabh Janardhan
    Department of Neurology, Boston University, Boston, Mass, USA
    Stroke 35:736-41. 2004
  10. ncbi request reprint Obesity, diabetes and cognitive deficit: The Framingham Heart Study
    Merrill F Elias
    Boston University, Department of Mathematics and Statistics, Statistics and Consulting Unit, 111 Cummington Street, Boston, MA 02215, USA
    Neurobiol Aging 26:11-6. 2005

Detail Information

Publications89

  1. pmc Contributions of the Framingham Heart Study to stroke and dementia epidemiologic research at 60 years
    Philip A Wolf
    Department of Neurology, Medicine, and Public Health, Boston University School of Medicine, Boston, MA 02118, USA
    Arch Neurol 69:567-71. 2012
    ..Identification of persons at heightened risk for stroke, mild cognitive impairment, Alzheimer disease, and cognitive decline years prior to disease onset may facilitate delay in disease onset and prevention...
  2. pmc Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study
    Christopher J O'Donnell
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S4. 2007
    ..We conducted a genome-wide association study (GWAS) for SCA measurements in the community-based Framingham Heart Study...
  3. pmc The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports
    L Adrienne Cupples
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S1. 2007
    ....
  4. pmc Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes
    Martin G Larson
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S5. 2007
    ..Prior investigations have reported several single gene variants associated with CHD, stroke, HF, and AF. We report a community-based genome-wide association study of major CVD outcomes...
  5. pmc Genome-wide association with select biomarker traits in the Framingham Heart Study
    Emelia J Benjamin
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S11. 2007
    ..Genome-wide association studies (GWAS) provide mechanisms to investigate the genetic contributions to biomarker variability unconstrained by current knowledge of physiological relations...
  6. pmc Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study
    Sudha Seshadri
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S15. 2007
    ..We conducted a genome-wide association (GWA) and linkage analysis exploring the genetic basis of these endophenotypes in a community-based sample...
  7. ncbi request reprint Impact of atrial fibrillation on mortality, stroke, and medical costs
    P A Wolf
    Department of Neurology, Boston University, Mass, USA
    Arch Intern Med 158:229-34. 1998
    ..The impact of atrial fibrillation (AF) on mortality, stroke, and medical costs is unknown...
  8. ncbi request reprint Relation of obesity to cognitive function: importance of central obesity and synergistic influence of concomitant hypertension. The Framingham Heart Study
    Philip A Wolf
    Boston University School of Medicine, Boston, MA 02118 2526, USA
    Curr Alzheimer Res 4:111-6. 2007
    ..We hypothesized that mid-life obesity may modulate the impact of conventional cardiovascular risk factors (CVRF) on cognitive impairment. We tested this hypothesis in the community-based Framingham Offspring Study sample...
  9. ncbi request reprint Anticardiolipin antibodies and risk of ischemic stroke and transient ischemic attack: the Framingham cohort and offspring study
    Vallabh Janardhan
    Department of Neurology, Boston University, Boston, Mass, USA
    Stroke 35:736-41. 2004
    ..Prior cohort studies included only selected subjects, mostly men. We related serum concentrations of aCLs to incident first ischemic stroke/TIA among men and women in the Framingham Heart Study cohort and offspring...
  10. ncbi request reprint Obesity, diabetes and cognitive deficit: The Framingham Heart Study
    Merrill F Elias
    Boston University, Department of Mathematics and Statistics, Statistics and Consulting Unit, 111 Cummington Street, Boston, MA 02215, USA
    Neurobiol Aging 26:11-6. 2005
    ..To determine the independent effects of obesity on cognitive performance and to examine interactions between obesity and non-insulin dependent diabetes mellitus (NIDDM)...
  11. ncbi request reprint Framingham stroke risk profile and lowered cognitive performance
    Merrill F Elias
    Statistics and Consulting Unit, Department of Mathematics and Statistics, Boston University, Boston, MA 02215, USA
    Stroke 35:404-9. 2004
    ....
  12. ncbi request reprint Depressive symptoms and risk of stroke: the Framingham Study
    Kimberly J Salaycik
    Department of Neurology, Framingham Heart Study, Boston University School of Medicine, 715 Albany St, B 608B, Boston, MA 02118 2526, USA
    Stroke 38:16-21. 2007
    ..This study sought to examine whether depressive symptoms are associated with an increased risk of cerebrovascular events in a community-based sample...
  13. pmc Apolipoprotein e, alcohol consumption, and risk of ischemic stroke: the Framingham Heart Study revisited
    Luc Djousse
    Division of Aging, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
    J Stroke Cerebrovasc Dis 18:384-8. 2009
    ..We sought to examine whether epsilon(4) allele of the apoE gene influences the association between alcohol consumption and ischemic stroke or high-density lipoprotein (HDL) cholesterol...
  14. ncbi request reprint The lifetime risk of stroke: estimates from the Framingham Study
    Sudha Seshadri
    Department of Neurology, School of Medicine, Boston University, Boston, MA 02118 2526, USA
    Stroke 37:345-50. 2006
    ..The lifetime risk (LTR) of stroke has not been reported for the United States population; such data would assist public education and health planning...
  15. ncbi request reprint Plasma homocysteine as a risk factor for dementia and Alzheimer's disease
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, MA 02118 2526, USA
    N Engl J Med 346:476-83. 2002
    ..Studies of newly diagnosed dementia are required in order to establish whether the elevated homocysteine levels precede the onset of dementia or result from dementia-related nutritional and vitamin deficiencies...
  16. pmc Carotid artery atherosclerosis, MRI indices of brain ischemia, aging, and cognitive impairment: the Framingham study
    Jose R Romero
    Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA
    Stroke 40:1590-6. 2009
    ..The relation of carotid atherosclerosis to cognitive impairment and MRI indices of ischemia and aging in midlife is less clear...
  17. doi request reprint General cardiovascular risk profile for use in primary care: the Framingham Heart Study
    RALPH B D'AGOSTINO
    Boston University, Department of Mathematics and Statistics, 111 Cummington St, Boston, MA 02215, USA
    Circulation 117:743-53. 2008
    ..The present report presents a single multivariable risk function that predicts risk of developing all CVD and of its constituents...
  18. ncbi request reprint Serum cholesterol and cognitive performance in the Framingham Heart Study
    Penelope K Elias
    Statistics and Consulting Unit, Department of Mathematics and Statistics, Boston University, 111 Cummington St, Boston, Massachusetts 02215, USA
    Psychosom Med 67:24-30. 2005
    ....
  19. pmc Gender differences in stroke incidence and poststroke disability in the Framingham heart study
    Rodica E Petrea
    Department of Neurology, Boston University School of Medicine, Boston, MA 02118 2526, USA
    Stroke 40:1032-7. 2009
    ..Stroke is emerging as a major public health problem for women, as it is for men. Controversy persists regarding gender differences in stroke incidence, severity, and poststroke disability...
  20. pmc Association of pericardial fat, intrathoracic fat, and visceral abdominal fat with cardiovascular disease burden: the Framingham Heart Study
    Amir A Mahabadi
    Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 165 Charles River Plaza, Boston, MA 02114, USA
    Eur Heart J 30:850-6. 2009
    ..The aim of this study was to assess whether pericardial fat, intrathoracic fat, and visceral abdominal adipose tissue (VAT) are associated with the prevalence of cardiovascular disease (CVD)...
  21. ncbi request reprint Plasma total cholesterol level as a risk factor for Alzheimer disease: the Framingham Study
    Zaldy Sy Tan
    Division on Aging, Harvard Medical School, Boston, MA, USA
    Arch Intern Med 163:1053-7. 2003
    ..We examined the impact of baseline and lifetime plasma total cholesterol levels averaged across many years on the risk for AD in a large, population-based cohort...
  22. ncbi request reprint Metabolic syndrome compared with type 2 diabetes mellitus as a risk factor for stroke: the Framingham Offspring Study
    Robert M Najarian
    Department of Neurology, Boston University School of Medicine, MA 02118 2526, USA
    Arch Intern Med 166:106-11. 2006
    ..Metabolic syndrome (MetS) has been recognized as a prediabetic constellation of symptoms and an independent risk factor for cardiovascular disease...
  23. ncbi request reprint Genome-wide scan for white matter hyperintensity: the Framingham Heart Study
    Anita L Destefano
    Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    Stroke 37:77-81. 2006
    ..We performed a genome-wide linkage analysis to identify chromosomal regions that may harbor genes influencing WMH in a family-based sample of the Framingham Heart Study...
  24. ncbi request reprint Visual association pathology in preclinical Alzheimer disease
    Ann C McKee
    Department of Neurology and Pathology, Boston University School of Medicine, Bedford Veterans Administration Medical Center, MA 01730, USA
    J Neuropathol Exp Neurol 65:621-30. 2006
    ..Dense AD pathology in area 19 is present in some cognitively intact subjects with preclinical AD. The unique metabolic, connectional, and vascular features of this region may confer enhanced vulnerability to neurodegeneration...
  25. ncbi request reprint Peripheral and cerebral atherothrombosis and cardiovascular events in different vascular territories: insights from the Framingham Study
    William B Kannel
    Framingham Heart Study, 73 Mt Wayte Avenue, Framingham, MA 01702 5827, USA
    Curr Atheroscler Rep 8:317-23. 2006
    ....
  26. ncbi request reprint The Third Generation Cohort of the National Heart, Lung, and Blood Institute's Framingham Heart Study: design, recruitment, and initial examination
    Greta Lee Splansky
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Boston University School of Medicine, Framingham, MA 01702 5827, USA
    Am J Epidemiol 165:1328-35. 2007
    ....
  27. ncbi request reprint Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study
    Ernst J Schaefer
    Lipid Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tuffs University, Boston, MA 02111, USA
    Arch Neurol 63:1545-50. 2006
    ..Docosahexaenoic acid (DHA) is an abundant fatty acid in the brain. In the diet, DHA is found mostly in fatty fish. The content of DHA has been shown to be decreased in the brain and plasma of patients with dementia...
  28. pmc Prevalence and correlates of silent cerebral infarcts in the Framingham offspring study
    Rohit R Das
    Department of Neurology, Boston University, Boston, MA 02118, USA
    Stroke 39:2929-35. 2008
    ..8% and 17.7% depending on age, ethnicity, presence of comorbidities, and imaging techniques. We document the prevalence and risk factors associated with SCI at midlife in the community-based Framingham sample...
  29. pmc Association of plasma total homocysteine levels with subclinical brain injury: cerebral volumes, white matter hyperintensity, and silent brain infarcts at volumetric magnetic resonance imaging in the Framingham Offspring Study
    Sudha Seshadri
    Department of Neurology, School of Medicine, Boston University, Boston, Massachusetts 02118 2526, USA
    Arch Neurol 65:642-9. 2008
    ..Elevated plasma total homocysteine (tHcy) levels have been associated with increased risk of dementia and stroke, but it is uncertain whether the mediating mechanisms are predominantly cellular, vascular, or both...
  30. ncbi request reprint Trends in incidence, lifetime risk, severity, and 30-day mortality of stroke over the past 50 years
    Raphael Carandang
    Department of Neurology, School of Medicine, Boston University, Boston, Mass 02118 2526, USA
    JAMA 296:2939-46. 2006
    ..Prior estimates of long-term trends in the incidence and severity of stroke have varied; trends in lifetime risk have not been reported...
  31. ncbi request reprint Lifetime risk of stroke and dementia: current concepts, and estimates from the Framingham Study
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118 2526, USA
    Lancet Neurol 6:1106-14. 2007
    ..Thus, the lifetime burden attributable to common neurological disease is immense...
  32. ncbi request reprint Characteristics of Framingham offspring participants with long-lived parents
    Dellara F Terry
    Boston University School of Medicine, Geriatrics Section, Boston Medical Center, 88 E Newton St, Robinson 2, Boston, MA 02118, USA
    Arch Intern Med 167:438-44. 2007
    ..Prior research has suggested that delay or avoidance of cardiovascular disease and cardiovascular disease risk factors plays an important role in longevity...
  33. pmc Thyroid function and the risk of Alzheimer disease: the Framingham Study
    Zaldy S Tan
    Department of Medicine, Gerontology Division, Beth Israel Deaconess Medical Center, 110 Francis St, LMOB 1A, Boston, MA 02215, USA
    Arch Intern Med 168:1514-20. 2008
    ..Clinical hypothyroidism and hyperthyroidism are recognized causes of reversible dementia, but previous studies relating thyrotropin levels to cognitive performance in clinically euthyroid persons have yielded inconsistent results...
  34. ncbi request reprint Cardiovascular risk factors predictive for survival and morbidity-free survival in the oldest-old Framingham Heart Study participants
    Dellara F Terry
    Department of Geriatrics, Boston Medical Center, School of Medicine, Boston University, Boston, Massachusetts 02118, USA
    J Am Geriatr Soc 53:1944-50. 2005
    ..To examine whether midlife cardiovascular risk factors predict survival and survival free of major comorbidities to the age of 85...
  35. ncbi request reprint Alcohol consumption and risk of ischemic stroke: The Framingham Study
    Luc Djousse
    Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, MA 02118, USA
    Stroke 33:907-12. 2002
    ..Stroke is a major cause of death in the United States. The association between alcohol consumption and ischemic stroke (IS) remains controversial...
  36. pmc Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment-Part 2
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, MA, USA
    Alzheimers Dement 7:35-52. 2011
    ..Improved accuracy in the clinical diagnosis of AD is anticipated with the addition of molecular and structural biomarkers in the next generation of epidemiological studies...
  37. pmc Cardiac index is associated with brain aging: the Framingham Heart Study
    Angela L Jefferson
    Department of Neurology, Alzheimer s Disease Center, Boston University School of Medicine, 72 E Concord St, B 7800, Boston, MA 02118, USA
    Circulation 122:690-7. 2010
    ..We hypothesized that cardiac function, as measured by cardiac index, would be associated with preclinical brain magnetic resonance imaging (MRI) and neuropsychological markers of ischemia and Alzheimer disease in the community...
  38. pmc Genome-wide analysis of genetic loci associated with Alzheimer disease
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
    JAMA 303:1832-40. 2010
    ..Genome-wide association studies (GWAS) have recently identified CLU, PICALM, and CR1 as novel genes for late-onset Alzheimer disease (AD)...
  39. ncbi request reprint Managing and analysing data from a large-scale study on Framingham Offspring relating brain structure to cognitive function
    Joseph M Massaro
    Department of Biostatistics, Boston University School of Public Health, 715 Albany Street T3E, Boston, MA 02118, USA
    Stat Med 23:351-67. 2004
    ..We are currently performing analyses of data collected through 2002, and we discuss the statistical issues arising relating brain structure parameters to cognitive function...
  40. ncbi request reprint Dietary patterns, smoking, and subclinical heart disease in women: opportunities for primary prevention from the Framingham Nutrition Studies
    Barbara E Millen
    Department of Social and Behavioral Sciences at Boston University School of Public Health, MA 02118, USA
    J Am Diet Assoc 104:208-14. 2004
    ..To investigate the relationship between a heart-healthy dietary pattern and subclinical heart disease in women, and to identify potential opportunities for primary prevention...
  41. pmc Parental occurrence of stroke and risk of stroke in their children: the Framingham study
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, 72 E Concord St, B602, Boston, MA 02118, USA
    Circulation 121:1304-12. 2010
    ..Data relating parental history of stroke to stroke risk in offspring remain surprisingly inconsistent, largely because of heterogeneity of study design and the absence of verified, as opposed to historical, data on parental stroke status...
  42. ncbi request reprint Absence of association between polymorphisms in the hemostatic factor pathway genes and carotid intimal medial thickness: the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
    Stroke 35:e65-7. 2004
    ..We sought to test whether carotid IMT is associated with polymorphisms in several well-characterized genes in the hemostatic factor pathways...
  43. ncbi request reprint Long-term alcohol consumption and the risk of atrial fibrillation in the Framingham Study
    Luc Djousse
    Section of Preventive Medicine and Epidemiology, Evans Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Am J Cardiol 93:710-3. 2004
    ..In conclusion, our data indicate little association between long-term moderate alcohol consumption and the risk of AF, but a significantly increased risk of AF among subjects consuming >36 g/day (approximatively >3 drinks/day)...
  44. pmc Association of MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality: the Framingham Offspring Study
    Stephanie Debette
    Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA
    Stroke 41:600-6. 2010
    ..We simultaneously assessed the relation of white matter hyperintensities and BI with incident stroke, mild cognitive impairment, dementia, and mortality in a middle-aged community-based cohort...
  45. pmc Genome-wide association studies of MRI-defined brain infarcts: meta-analysis from the CHARGE Consortium
    Stephanie Debette
    Department of Neurology, Boston University School of Medicine, Boston, Mass, USA
    Stroke 41:210-7. 2010
    ..We performed meta-analysis of genome-wide association studies of white participants in 6 studies comprising the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium...
  46. pmc Bivariate heritability of total and regional brain volumes: the Framingham Study
    Anita L Destefano
    Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Avenue, Boston, MA 02118, USA
    Alzheimer Dis Assoc Disord 23:218-23. 2009
    ..These data extend current knowledge by showing that these 2 different types of magnetic resonance imaging measures do not share underlying genetic or environmental influences...
  47. ncbi request reprint Genetic variation in white matter hyperintensity volume in the Framingham Study
    Larry D Atwood
    Department of Neurology, Boston University School of Medicine, 715 Albany Street, B 609, Boston, Mass 02118, USA
    Stroke 35:1609-13. 2004
    ..73). We investigated heritability of WMH in a family-based sample of the Framingham Heart Study for sex differences and the impact of age...
  48. ncbi request reprint New norms for a new generation: cognitive performance in the framingham offspring cohort
    Rhoda Au
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118 2526, USA
    Exp Aging Res 30:333-58. 2004
    ..These findings suggest that continued surveillance of each generation is necessary to document the impact that unique social and economic variables have on cognitive function. Here, the authors provide updated normative data...
  49. pmc Association of the endogenous nitric oxide synthase inhibitor ADMA with carotid artery intimal media thickness in the Framingham Heart Study offspring cohort
    Renke Maas
    Department of Neurology, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA
    Stroke 40:2715-9. 2009
    ..We hypothesized that plasma ADMA concentrations are positively related to common carotid artery intimal-media thickness (CCA-IMT) and to internal carotid (ICA)/bulb IMT...
  50. pmc Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry
    Emelia J Benjamin
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Nat Genet 41:879-81. 2009
    ..19; P = 2.3 x 10(-7)). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 x 10(-11); combined RR = 1.25; combined P = 1.8 x 10(-15))...
  51. pmc Visceral fat is associated with lower brain volume in healthy middle-aged adults
    Stephanie Debette
    Department of Neurology, Boston University School of Medicine, MA, USA
    Ann Neurol 68:136-44. 2010
    ....
  52. pmc Profiles by sex of brain MRI and cognitive function in the framingham offspring study
    Mark Albert
    Department of Neurology, Boston University School of Medicine, Boston, MA 02118 2526, USA
    Alzheimer Dis Assoc Disord 24:190-3. 2010
    ..To examine whether there are sex-specific associations between brain magnetic resonance imaging (MRI) measures and neuropsychologic (NP) test performance...
  53. pmc Genetics of the Framingham Heart Study population
    Diddahally R Govindaraju
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Adv Genet 62:33-65. 2008
    ..Finally, the use of this unique sample to study genotype and environment interactions is described...
  54. pmc Obstructive sleep apnea-hypopnea and incident stroke: the sleep heart health study
    Susan Redline
    Brigham and Women s Hospital, 221 Longwood Ave, Boston, MA 02115M, USA
    Am J Respir Crit Care Med 182:269-77. 2010
    ....
  55. pmc White matter hyperintensity and cognitive functioning in the racial and ethnic minority cohort of the Framingham Heart Study
    Karina Stavitsky
    Department of Psychology, Boston University, Boston, MA 02118, USA
    Neuroepidemiology 35:117-22. 2010
    ..This study investigated the association of WMH and cognition in an ethnic and racial minority cohort (Omni) of the Framingham Heart Study and compared these results to the Caucasian (Offspring) cohort...
  56. pmc Association of carotid artery atherosclerosis with circulating biomarkers of extracellular matrix remodeling: the Framingham Offspring Study
    Jose R Romero
    Department of Neurology, School of Medicine, Boston University, Boston, Massachusetts 02118 2526, USA
    J Stroke Cerebrovasc Dis 17:412-7. 2008
    ..We sought to relate circulating biomarkers of extracellular matrix turnover to site-specific measures of carotid artery atherosclerosis on duplex ultrasound...
  57. ncbi request reprint Variants at the APOA5 locus, association with carotid atherosclerosis, and modification by obesity: the Framingham Study
    Roberto Elosua
    US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Lipid Res 47:990-6. 2006
    ..APOA5 variants were associated with CCA IMT, particularly in obese participants. The mechanism of these associations and the effect modification by obesity are independent of fasting triglyceride levels...
  58. ncbi request reprint Homocysteine and cognitive performance in the Framingham offspring study: age is important
    Merrill F Elias
    The Statistics and Consulting Unit, Department of Mathematics and Statistics, Boston University, Boston, MA, USA
    Am J Epidemiol 162:644-53. 2005
    ..Early preventive interventions may be important, because the inverse association between tHcy and cognitive performance is observed beyond middle age...
  59. pmc Relations of biomarkers of distinct pathophysiological pathways and atrial fibrillation incidence in the community
    Renate B Schnabel
    National Heart, Lung, and Blood Institute s and Boston University s Framingham Study, Framingham, Mass, USA
    Circulation 121:200-7. 2010
    ..Biomarkers of multiple pathophysiological pathways have been related to incident atrial fibrillation (AF), but their predictive ability remains controversial...
  60. ncbi request reprint Left ventricular mass, blood pressure, and lowered cognitive performance in the Framingham offspring
    Merrill F Elias
    Statistics and Consulting Unit, Department of Mathematics and Statistics, Boston University, Mass, USA
    Hypertension 49:439-45. 2007
    ....
  61. pmc Association of plasma ADMA levels with MRI markers of vascular brain injury: Framingham offspring study
    Aleksandra Pikula
    Boston University School of Medicine, Boston, MA, USA
    Stroke 40:2959-64. 2009
    ..The relation of plasma ADMA to subclinical vascular brain injury has not been previously studied in a middle-aged, community-based sample...
  62. ncbi request reprint Dementia after stroke: the Framingham Study
    Cristina S Ivan
    Department of Neurology, Boston University School of Medicine, Boston, Mass 02118 2526, USA
    Stroke 35:1264-8. 2004
    ..Previous case-control studies were hospital-based. We used a nested case-control design to prospectively evaluate these risk factors in the community-based Framingham Study cohort...
  63. ncbi request reprint Bone mineral density and the risk of Alzheimer disease
    Zaldy Sy Tan
    Division on Aging, Harvard Medical School, Beth Israel Deaconess Medical Center, 110 Francis Street, Boston, MA 02215, USA
    Arch Neurol 62:107-11. 2005
    ..Bone mineral density (BMD) is a potential surrogate marker for cumulative estrogen exposure and has been associated with cognitive performance and risk of cognitive deterioration...
  64. ncbi request reprint Homocysteine and the brain: vascular risk factor or neurotoxin?
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    Lancet Neurol 2:11. 2003
  65. pmc Free testosterone levels are associated with mobility limitation and physical performance in community-dwelling men: the Framingham Offspring Study
    Joanne B Krasnoff
    Boston University School of Medicine, Section of Endocrinology, Diabetes, and Nutrition, 670 Albany Street, Second Floor, Boston, Massachusetts 02118 2393, USA
    J Clin Endocrinol Metab 95:2790-9. 2010
    ..Mobility limitation is associated with increased morbidity and mortality. The relationship between circulating testosterone and mobility limitation and physical performance is incompletely understood...
  66. ncbi request reprint Association of white matter hyperintensity volume with decreased cognitive functioning: the Framingham Heart Study
    Rhoda Au
    Department of Neurology, Boston University School of Medicine, Boston, Mass 02118 2526, USA
    Arch Neurol 63:246-50. 2006
    ..To examine the relationship between white matter hyperintensity (WMH) volume on magnetic resonance images and cognitive tests in a large, population-based sample...
  67. ncbi request reprint Plasma natriuretic peptide levels and the risk of cardiovascular events and death
    Thomas J Wang
    Framingham Heart Study, Framingham, MA 01702 5827, USA
    N Engl J Med 350:655-63. 2004
    ..The prognostic significance of plasma natriuretic peptide levels in apparently asymptomatic persons has not been established...
  68. ncbi request reprint Carotid intima-media thickness is associated with premature parental coronary heart disease: the Framingham Heart Study
    Thomas J Wang
    Framingham Heart Study, Framingham, Mass 01702 5827, USA
    Circulation 108:572-6. 2003
    ..We hypothesized that an important mediator of the familial predisposition to CHD is subclinical atherosclerosis, which is detectable by noninvasive imaging...
  69. ncbi request reprint A risk score for predicting stroke or death in individuals with new-onset atrial fibrillation in the community: the Framingham Heart Study
    Thomas J Wang
    Framingham Heart Study, Framingham, MA 01702 5827, USA
    JAMA 290:1049-56. 2003
    ....
  70. ncbi request reprint Prevalence and prognostic impact of subclinical cardiovascular disease in individuals with the metabolic syndrome and diabetes
    Erik Ingelsson
    National Heart, Lung, and Blood Institute s Framingham Study, Framingham, Massachusetts 01702 5803, USA
    Diabetes 56:1718-26. 2007
    ..93 [1.15-3.24]). In our community-based sample, individuals with MetS have a high prevalence of subclinical atherosclerosis that likely contributes to the increased risk of overt CVD associated with the condition...
  71. ncbi request reprint Temporal relations of atrial fibrillation and congestive heart failure and their joint influence on mortality: the Framingham Heart Study
    Thomas J Wang
    Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, Mass 01702 5827, USA
    Circulation 107:2920-5. 2003
    ..Atrial fibrillation (AF) and congestive heart failure (CHF) frequently occur together, but there is limited information regarding their temporal relations and the combined influence of these conditions on mortality...
  72. ncbi request reprint Doppler transmitral flow indexes and risk of atrial fibrillation (the Framingham Heart Study)
    Ramachandran S Vasan
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts 01702 5827, USA
    Am J Cardiol 91:1079-83. 2003
    ..Thus, in our elderly community-based sample, increased VTI E/A and a low atrial filling fraction were markers of increased risk of AF, suggesting that altered atrial filling may antedate AF...
  73. ncbi request reprint Genetic and environmental contributions to atherosclerosis phenotypes in men and women: heritability of carotid intima-media thickness in the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Mass 01702, USA
    Stroke 34:397-401. 2003
    ..There is controversy regarding the proportion of variability in IMT explained by genetic factors. Thus, it is uncertain whether carotid IMT is a heritable trait that can be used in genetic studies...
  74. ncbi request reprint Association of C-reactive protein with carotid atherosclerosis in men and women: the Framingham Heart Study
    Thomas J Wang
    Framingham Heart Study, Framingham, Mass 01702 5827, USA
    Arterioscler Thromb Vasc Biol 22:1662-7. 2002
    ..The objective of this study was to examine the relationship between C-reactive protein (CRP) and carotid atherosclerosis...
  75. ncbi request reprint Primary prevention drug therapy: can it meet patients' requirements for reduced risk?
    Hilary A Llewellyn-Thomas
    Center for the Evaluative Clinical Sciences, Department of Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire 03755 3863, USA
    Med Decis Making 22:326-39. 2002
    ....
  76. ncbi request reprint Cerebral microbleeds: prevalence and associations with cardiovascular risk factors in the Framingham Study
    Tom Jeerakathil
    Department of Neurology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton
    Stroke 35:1831-5. 2004
    ..We examined these relationships in the Framingham Study (FHS)...
  77. ncbi request reprint Lifetime risk for development of atrial fibrillation: the Framingham Heart Study
    Donald M Lloyd-Jones
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University Feinberg School of Medicine, 680 N Lake Shore Drive, Suite 1102, Chicago, IL, 60611, USA
    Circulation 110:1042-6. 2004
    ..Atrial fibrillation (AF) is the most common cardiac dysrhythmia and a source of considerable morbidity and mortality, but lifetime risk for AF has not been estimated...
  78. ncbi request reprint Assessment by cardiovascular magnetic resonance, electron beam computed tomography, and carotid ultrasonography of the distribution of subclinical atherosclerosis across Framingham risk strata
    Sekar Kathiresan
    Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Cardiol 99:310-4. 2007
    ..In conclusion, in a community-based sample, correlations among subclinical atherosclerosis test results are low, and a substantial proportion has high levels of subclinical atherosclerosis detected on >or=2 imaging tests...
  79. doi request reprint Prediction of intermittent claudication, ischemic stroke, and other cardiovascular disease by detection of abdominal aortic calcific deposits by plain lumbar radiographs
    Yamini S Levitzky
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Cardiol 101:326-31. 2008
    ..AAC appears to be useful for risk stratification in patients at intermediate CHD risk...
  80. doi request reprint Walking speed and risk of incident ischemic stroke among postmenopausal women
    Aileen P McGinn
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue Belfer 1006A, Bronx, NY 10461, USA
    Stroke 39:1233-9. 2008
    ..However, few studies have investigated the association of walking speed with risk of incident ischemic stroke...
  81. pmc Leukocyte telomere length and carotid artery intimal medial thickness: the Framingham Heart Study
    Christopher J O'Donnell
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mount Wayte Avenue 2, Framingham, MA 01702 5827, USA
    Arterioscler Thromb Vasc Biol 28:1165-71. 2008
    ..The purpose of this study was to examine the link between LTL and the predisposition to atherosclerosis, as determined by carotid artery intimal medial thickness (IMT) in participants of the Framingham Offspring Study...
  82. ncbi request reprint Diabetes mellitus and risk of developing Alzheimer disease: results from the Framingham Study
    Abimbola Akomolafe
    Department of Medicine, Morehouse School of Medicine, Atlanta, GA, USA
    Arch Neurol 63:1551-5. 2006
    ..Diabetes mellitus (DM) could increase the risk of Alzheimer disease (AD) through several biologically plausible pathways, but the relationship between DM and the development of AD remains uncertain...
  83. ncbi request reprint Longitudinal genetic analysis of executive function in elderly men
    Christina N Lessov-Schlaggar
    Center for Health Sciences, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
    Neurobiol Aging 28:1759-68. 2007
    ..These results suggest that common genetic factors underlie longitudinal EF task performance. Genetic influences on EF decline, however, appear to be evident at longer time intervals between assessments...
  84. pmc Association of alcohol consumption with brain volume in the Framingham study
    Carol Ann Paul
    Neuroscience Program, Wellesley College, 106 Central St, Wellesley, MA 02418, USA
    Arch Neurol 65:1363-7. 2008
    ..There is evidence that drinking large amounts of alcohol is related to brain atrophy. It is uncertain what the effects of low to moderate consumption might be...
  85. ncbi request reprint Prediction of lifetime risk for cardiovascular disease by risk factor burden at 50 years of age
    Donald M Lloyd-Jones
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Circulation 113:791-8. 2006
    ..Lifetime risk for atherosclerotic cardiovascular disease (CVD) has not previously been estimated, and the effect of risk factor burden on lifetime risk is unknown...
  86. ncbi request reprint Measures of brain morphology and infarction in the framingham heart study: establishing what is normal
    Charles DeCarli
    Department of Neurology and Center for Neuroscience, 4860 Y Street, Suite 3700, Sacramento, CA 95817, USA
    Neurobiol Aging 26:491-510. 2005
    ....
  87. ncbi request reprint Obesity and the risk of new-onset atrial fibrillation
    Thomas J Wang
    Framingham Heart Study, Framingham, Mass 01702 5827, USA
    JAMA 292:2471-7. 2004
    ..Obesity is associated with atrial enlargement and ventricular diastolic dysfunction, both known predictors of atrial fibrillation (AF). However, it is unclear whether obesity is a risk factor for AF...
  88. ncbi request reprint Warfarin and aspirin use and the predictors of major bleeding complications in atrial fibrillation (the Framingham Heart Study)
    Colleen Sam
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Cardiol 94:947-51. 2004
    ..61), but participants using warfarin were younger. A total of 65 participants (17%) had major bleeding complications <or=5 years after initial AF. Age was not a significant predictor of bleeding...
  89. ncbi request reprint Risk of hospitalized stroke in men enrolled in the Honolulu Heart Program and the Framingham Study: A comparison of incidence and risk factor effects
    Beatriz L Rodriguez
    Division of Clinical Epidemiology, John A Burns School of Medicine, University of Hawaii at Manoa, USA
    Stroke 33:230-6. 2002
    ..Our purpose was to compare the 20-year incidence of hospitalized stroke between Japanese-American men in the Honolulu Heart Program and white men in the Framingham Study...

Research Grants60

  1. EPIDEMIOLOGY OF DEMENTIA IN THE FRAMINGHAM STUDY
    PHILIP A contact WOLF; Fiscal Year: 2010
    ..The purpose of this risk score is to accurately identify high-risk persons for enrollment in preventive and treatment trials. ..
  2. EPIDEMIOLOGY OF DEMENTIA IN THE FRAMINGHAM STUDY
    Philip Wolf; Fiscal Year: 2004
    ..We will also be in a unique position to relate precursors of, and prior cardiovascular disease to dementia including vascular dementia and to determine the contribution of vascular factors to the dementia of AD. ..
  3. PRECURSORS OF STROKE INCIDENCE AND PROGNOSIS
    Philip Wolf; Fiscal Year: 2003
    ..Until now only educated guesses among possible candidate genes for stroke risk were possible, these studies prioritize the recognized candidates and to identify new loci. ..
  4. MRI, GENETIC AND COGNITIVE PRECURSORS OF AD AND DEMENTIA
    Philip Wolf; Fiscal Year: 2003
    ..We will perform genetic linkage analyses for MRI and cognitive performance measures in order to identify regions of the genome containing genes predisposing to AD and dementia. ..
  5. MRI, Genetics & Cognitive Precursors of AD & Dementia
    Philip Wolf; Fiscal Year: 2009
    ..Since control of CVRF clearly prevents clinical stroke, it is hoped that data from this study will encourage control of CVRF and reduce the likelihood of cognitive decline and dementia. ..
  6. PRECURSORS OF STROKE INCIDENCE AND PROGNOSIS
    Philip A Wolf; Fiscal Year: 2010
    ..Understanding these interactions will advance our ability to formulate strategies to prevent stroke and minimize disability resulting from stroke. ..
  7. MRI, Cognitive, Genetic & Biomarker Precursors of AD & Dementia in Young Adults
    Philip A Wolf; Fiscal Year: 2010
    ..We will relate these data to previously measured risk factors and biomarkers already available on these subjects to determine a "pre-MCI" continuum of structural and functional indices of AD and dementia. ..
  8. PRECURSORS OF STROKE INCIDENCE AND PROGNOSIS
    Philip Wolf; Fiscal Year: 2009
    ..Understanding these interactions will advance our ability to formulate strategies to prevent stroke and minimize disability resulting from stroke. ..
  9. EPIDEMIOLOGY OF DEMENTIA IN THE FRAMINGHAM STUDY
    Philip Wolf; Fiscal Year: 2009
    ..And if so, do these risk factors promote AD via a nonvascular mechanism or "add" to brain injury thereby leading to earlier age of onset and/or accelerated. ..
  10. MRI, Cognitive, Genetic & Biomarker Precursors of AD & Dementia in Young Adults
    Philip Wolf; Fiscal Year: 2009
    ..We will relate these data to previously measured risk factors and biomarkers already available on these subjects to determine a "pre-MCI" continuum of structural and functional indices of AD and dementia. ..
  11. PRECURSORS OF STROKE INCIDENCE AND PROGNOSIS
    Philip Wolf; Fiscal Year: 2007
    ..Clinical and subclinical stroke in the Offspring will be related to documented stroke in parents and siblings to assess the impact of stroke risk factors depending on family history of stroke. ..
  12. MRI, Genetics & Cognitive Precursors of AD & Dementia
    Philip Wolf; Fiscal Year: 2007
    ..Since control of CVRF clearly prevents clinical stroke, it is hoped that data from this study will encourage control of CVRF and reduce the likelihood of cognitive decline and dementia. ..
  13. EPIDEMIOLOGY OF DEMENTIA IN THE FRAMINGHAM STUDY
    Philip Wolf; Fiscal Year: 2007
    ..And if so, do these risk factors promote AD via a nonvascular mechanism or "add" to brain injury thereby leading to earlier age of onset and/or accelerated. ..
  14. EPIDEMIOLOGY OF DEMENTIA IN THE FRAMINGHAM COHORT
    Philip Wolf; Fiscal Year: 1993
    ....
  15. PRECURSORS OF STROKE INCIDENCE AND PROGNOSIS
    Philip Wolf; Fiscal Year: 1993
    ..Lastly, examination of noninvasive carotid and cardiac functional measures will be related to subsequent occurrence, type and severity of stroke...
  16. PRECURSORS OF STROKE INCIDENCE AND PROGNOSIS
    Philip Wolf; Fiscal Year: 1991
    ..The decline in mortality rates from stroke has accelerated in recent years. Secular trends in incidence by stroke type will require more cases occurring over time and should be available as a by product of this proposal...