J B Wilk

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi request reprint Segregation analysis of serum uric acid in the NHLBI Family Heart Study
    J B Wilk
    Boston University School of Medicine, MA 02118, USA
    Hum Genet 106:355-9. 2000
  2. ncbi request reprint Genetic loci influencing lung function: a genome-wide scan in the Framingham Study
    Oscar Joost
    Boston University School of Medicine, Boston, Massachusetts, USA
    Am J Respir Crit Care Med 165:795-9. 2002
  3. pmc Departure from multiplicative interaction for catechol-O-methyltransferase genotype and active/passive exposure to tobacco smoke among women with breast cancer
    Brian D Bradbury
    Department of Epidemiology, Boston University School of Public Health, 715 Albany St, T3E, Boston, MA 02118, USA
    J Carcinog 5:3. 2006
  4. pmc A case-only analysis of the interaction between N-acetyltransferase 2 haplotypes and tobacco smoke in breast cancer etiology
    Timothy L Lash
    Boston University School of Public Health, Boston, MA, USA
    Breast Cancer Res 7:R385-93. 2005
  5. pmc The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports
    L Adrienne Cupples
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S1. 2007
  6. pmc Genome-wide association of sleep and circadian phenotypes
    Daniel J Gottlieb
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S9. 2007
  7. pmc Asthma-susceptibility variants identified using probands in case-control and family-based analyses
    Blanca E Himes
    Harvard MIT Division of Health Sciences and Technology, Cambridge, MA, USA
    BMC Med Genet 11:122. 2010
  8. pmc Polymorphisms near EXOC4 and LRGUK on chromosome 7q32 are associated with Type 2 Diabetes and fasting glucose; the NHLBI Family Heart Study
    Jason M Laramie
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    BMC Med Genet 9:46. 2008
  9. pmc Genomewide association study for onset age in Parkinson disease
    Jeanne C Latourelle
    Boston University School of Medicine, Boston, MA, USA
    BMC Med Genet 10:98. 2009
  10. pmc Evidence for a gene influencing heart rate on chromosome 5p13-14 in a meta-analysis of genome-wide scans from the NHLBI Family Blood Pressure Program
    Jason M Laramie
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    BMC Med Genet 7:17. 2006

Detail Information

Publications44

  1. ncbi request reprint Segregation analysis of serum uric acid in the NHLBI Family Heart Study
    J B Wilk
    Boston University School of Medicine, MA 02118, USA
    Hum Genet 106:355-9. 2000
    ..These results support the hypothesis that uric acid is a multifactorial trait possibly influenced by more than one major gene, modifying genes, and environmental factors...
  2. ncbi request reprint Genetic loci influencing lung function: a genome-wide scan in the Framingham Study
    Oscar Joost
    Boston University School of Medicine, Boston, Massachusetts, USA
    Am J Respir Crit Care Med 165:795-9. 2002
    ..FEV1 was most influenced by the locus on chromosome 6 (logarithm of the odds favoring genetic linkage [LOD] = 2.4), whereas chromosome 21 contained markers with the strongest linkage to FVC (LOD = 2.6)...
  3. pmc Departure from multiplicative interaction for catechol-O-methyltransferase genotype and active/passive exposure to tobacco smoke among women with breast cancer
    Brian D Bradbury
    Department of Epidemiology, Boston University School of Public Health, 715 Albany St, T3E, Boston, MA 02118, USA
    J Carcinog 5:3. 2006
    ..8, 10). CONCLUSION : With greater control over potential misclassification errors and a large case-only population, we found evidence to support an interaction between COMT genotype and tobacco smoke exposure in breast cancer etiology...
  4. pmc A case-only analysis of the interaction between N-acetyltransferase 2 haplotypes and tobacco smoke in breast cancer etiology
    Timothy L Lash
    Boston University School of Public Health, Boston, MA, USA
    Breast Cancer Res 7:R385-93. 2005
    ..We hypothesized that women with breast cancer who were slow acetylators would be at increased risk of breast cancer associated with active and passive exposure to tobacco smoke...
  5. pmc The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports
    L Adrienne Cupples
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S1. 2007
    ....
  6. pmc Genome-wide association of sleep and circadian phenotypes
    Daniel J Gottlieb
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S9. 2007
    ..More than 700 participants were genotyped using the Affymetrix 100K SNP GeneChip, providing a unique opportunity to assess genetic linkage and association of these traits...
  7. pmc Asthma-susceptibility variants identified using probands in case-control and family-based analyses
    Blanca E Himes
    Harvard MIT Division of Health Sciences and Technology, Cambridge, MA, USA
    BMC Med Genet 11:122. 2010
    ..We sought to find asthma-susceptibility variants by using probands from a single population in both family-based and case-control association designs...
  8. pmc Polymorphisms near EXOC4 and LRGUK on chromosome 7q32 are associated with Type 2 Diabetes and fasting glucose; the NHLBI Family Heart Study
    Jason M Laramie
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    BMC Med Genet 9:46. 2008
    ..As part of a fine mapping study of the region, we evaluated the relationship of polymorphisms to fasting glucose levels and Type 2 diabetes...
  9. pmc Genomewide association study for onset age in Parkinson disease
    Jeanne C Latourelle
    Boston University School of Medicine, Boston, MA, USA
    BMC Med Genet 10:98. 2009
    ..There have been previous genomewide association studies (GWAS) to identify genes influencing PD susceptibility, but this is the first to identify genes contributing to the variation in onset age...
  10. pmc Evidence for a gene influencing heart rate on chromosome 5p13-14 in a meta-analysis of genome-wide scans from the NHLBI Family Blood Pressure Program
    Jason M Laramie
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    BMC Med Genet 7:17. 2006
    ..Previous family studies have shown a significant heritable component to heart rate with several groups conducting genomic linkage scans to identify quantitative trait loci...
  11. pmc The Gly2019Ser mutation in LRRK2 is not fully penetrant in familial Parkinson's disease: the GenePD study
    Jeanne C Latourelle
    Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA, USA
    BMC Med 6:32. 2008
    ..Studies of the penetrance of LRRK2 mutations have produced a wide range of estimates, possibly due to differences in study design and recruitment, including in particular differences between samples of familial PD versus sporadic PD...
  12. pmc A genome-wide association study of pulmonary function measures in the Framingham Heart Study
    Jemma B Wilk
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    PLoS Genet 5:e1000429. 2009
    ..Though it is unclear what gene or regulatory effect explains the association, the region warrants further investigation...
  13. ncbi request reprint Adrenergic receptor polymorphisms associated with resting heart rate: the HyperGEN Study
    J B Wilk
    Boston University School of Medicine, MA 02118, USA
    Ann Hum Genet 70:566-73. 2006
    ..In summary, each of the ADR gene polymorphisms was associated with heart rate in at least one stratum studied, but there was no consistent association from which one would infer a large genetic contribution to heart rate...
  14. ncbi request reprint Reporting association to hypertension. Rare genotypes with protective effects or common genotypes increasing risk
    Jemma B Wilk
    Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Am J Hypertens 19:1166. 2006
  15. ncbi request reprint Herbicide exposure modifies GSTP1 haplotype association to Parkinson onset age: the GenePD Study
    J B Wilk
    Department of Neurology, Boston University School of Medicine, 715 Albany St, E 338, Boston, MA 02118, USA
    Neurology 67:2206-10. 2006
    ..Using the GenePD Study sample of familial PD cases, we explored whether GSTP1 polymorphisms were associated with the age at onset of PD symptoms and whether that relation was modified by exposure to herbicides...
  16. pmc Framingham Heart Study genome-wide association: results for pulmonary function measures
    Jemma B Wilk
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    BMC Med Genet 8:S8. 2007
    ..We conducted genome-wide association (GWA) analyses (Affymetrix 100K SNP GeneChip) for measures of lung function in the Framingham Heart Study...
  17. pmc NYD-SP18 is associated with obesity in the NHLBI Family Heart Study
    J B Wilk
    Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA
    Int J Obes (Lond) 32:930-5. 2008
    ..The NHLBI Family Heart Study (FHS) genome-wide linkage scan identified a region of chromosome 7q with a logarithm of odds score of 4.9 for body mass index (BMI)...
  18. ncbi request reprint Evidence for a gene influencing heart rate on chromosome 4 among hypertensives
    Jemma B Wilk
    Contact address Boston University School of Medicine, 715 Albany Street, Room B 604, Boston, MA 02118, USA
    Hum Genet 111:207-13. 2002
    ....
  19. ncbi request reprint Evidence for major genes influencing pulmonary function in the NHLBI family heart study
    J B Wilk
    Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Genet Epidemiol 19:81-94. 2000
    ..These results support the hypothesis that complex relationships exist for lung function traits and that multiple genes and environmental factors influence lung function...
  20. ncbi request reprint A genome-wide scan of pulmonary function measures in the National Heart, Lung, and Blood Institute Family Heart Study
    Jemma B Wilk
    Boston University School of Medicine, B 601, 715 Albany Street, Boston, MA 02118, USA
    Am J Respir Crit Care Med 167:1528-33. 2003
    ..0. FEV1 and FVC were suggestively linked to regions on chromosome 18 with multipoint LOD scores of 2.4 for FEV1 and 1.5 for FVC at 31 cM (D18S843) and a LOD of 2.9 for FVC at 79 cM (D18S858)...
  21. ncbi request reprint Genome-wide linkage analyses for age at diagnosis of hypertension and early-onset hypertension in the HyperGEN study
    Jemma B Wilk
    Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Am J Hypertens 17:839-44. 2004
    ....
  22. ncbi request reprint Linkage and association with pulmonary function measures on chromosome 6q27 in the Framingham Heart Study
    Jemma B Wilk
    Neurology Department, Boston University School of Medicine, Boston, MA 02118, USA
    Hum Mol Genet 12:2745-51. 2003
    ..This study supports the presence of a gene influencing pulmonary function on the q-terminus of chromosome 6 in the region of 184 cM (D6S503) to 190 cM (D6S281)...
  23. ncbi request reprint Influence of marker heterozygosity and genetic heterogeneity on fine mapping
    N L Heard-Costa
    Neurology Department, Boston University School of Medicine, 715 Albany Street, Boston, MA 02145, USA
    Genet Epidemiol 21:S467-72. 2001
    ..Our studies did not reveal a large effect of unlinked families on the shape of the lod score peak...
  24. ncbi request reprint Segregation analysis of Parkinson disease revealing evidence for a major causative gene
    N E Maher
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
    Am J Med Genet 109:191-7. 2002
    ..Such gene environment interactions, involving reduced penetrance in PD, may explain the low concordance rates among monozygotic twins for this disease...
  25. ncbi request reprint BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study
    S Karamohamed
    Department of Neurology, Boston University School of Medicine, MA, USA
    Neurology 65:1823-5. 2005
    ..Homozygosity for the rare allele of the functional BDNF G196A (Val66Met) variant was associated with a 5.3-year older onset age (p = 0.0001). These findings suggest that BDNF may influence PD onset age...
  26. ncbi request reprint A haplotype at the PARK3 locus influences onset age for Parkinson's disease: the GenePD study
    S Karamohamed
    Department of Neurology, Boston University School of Medicine, MA 02118, USA
    Neurology 61:1557-61. 2003
    ..To identify a haplotype influencing onset age for Parkinson's disease (PD) in the PARK3 region on chromosome 2p13...
  27. pmc Common variants in the 5' region of the leptin gene are associated with body mass index in men from the National Heart, Lung, and Blood Institute Family Heart Study
    Y Jiang
    Department of Neurology, Evans Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Am J Hum Genet 75:220-30. 2004
    ..00005). All five of these SNPs are predicted to modify transcription-factor binding sites. This may indicate new functional variants in an extended promoter region of LEP...
  28. ncbi request reprint Family-based association tests for qualitative and quantitative traits using single-nucleotide polymorphism and microsatellite data
    J B Wilk
    Boston University Schools of Medicine and Public Health, Boston, Massachusetts, USA
    Genet Epidemiol 21:S364-9. 2001
    ..The magnitude of the associations between SNPs and the dichotomous or quantitative trait definitions were similar in the outbred and isolated populations...
  29. ncbi request reprint Absence of previously reported variants in the SCNA (G88C and G209A), NR4A2 (T291D and T245G) and the DJ-1 (T497C) genes in familial Parkinson's disease from the GenePD study
    Samer Karamohamed
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
    Mov Disord 20:1188-91. 2005
    ..None of the variants were found in the GenePD families. Our results suggest that other variants or genes account for the familial risk of PD within the GenePD study...
  30. pmc Secreted modular calcium-binding protein 2 haplotypes are associated with pulmonary function
    Jemma B Wilk
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
    Am J Respir Crit Care Med 175:554-60. 2007
    ..Previously reported linkage to FEV(1) (LOD score = 5.0) on 6q27 in the Framingham Heart Study (FHS) led us to explore a candidate gene, SMOC2, at 168.6 Mb...
  31. ncbi request reprint Heritability of longitudinal change in lung function. The Framingham study
    D J Gottlieb
    Research Service, VA Boston Healthcare System, and Department of Medicine and Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
    Am J Respir Crit Care Med 164:1655-9. 2001
    ....
  32. doi request reprint Multiple genes influence BMI on chromosome 7q31-34: the NHLBI Family Heart Study
    Jason M Laramie
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
    Obesity (Silver Spring) 17:2182-9. 2009
    ..002, and 0.03, respectively) and the case-control sample (P = 0.01, 0.0003, and 0.03, respectively), regardless of the genetic model tested. These findings suggest that several genes may be associated with BMI in the 7q31-34 region...
  33. pmc Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene
    Blanca E Himes
    Harvard MIT Division of Health Sciences and Technology, Cambridge, MA, 02138, USA
    Am J Hum Genet 84:581-93. 2009
    ..Further study of PDE4D variants might lead to improved understanding of the role of PDE4D in asthma pathophysiology and the efficacy of PDE4 inhibitor medications...
  34. pmc TSLP polymorphisms are associated with asthma in a sex-specific fashion
    G M Hunninghake
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Allergy 65:1566-75. 2010
    ..Single nucleotide polymorphisms (SNPs) in thymic stromal lymphopoietin (TSLP) have been associated with IgE (in girls) and asthma (in general). We sought to determine whether TSLP SNPs are associated with asthma in a sex-specific fashion...
  35. pmc Replication of association between ELAVL4 and Parkinson disease: the GenePD study
    Anita L Destefano
    Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, Crosstown Center, 3rd Floor, Boston, MA 02118, USA
    Hum Genet 124:95-9. 2008
    ..This replication of association with rs967582 in a third cohort further implicates ELAVL4 as a PD susceptibility gene...
  36. pmc PARK3 influences age at onset in Parkinson disease: a genome scan in the GenePD study
    Anita L Destefano
    Department of Neurology, Boston University Schools of Medicine and of Public Health, Boston, MA 02118, USA
    Am J Hum Genet 70:1089-95. 2002
    ....
  37. pmc HaploBuild: an algorithm to construct non-contiguous associated haplotypes in family based genetic studies
    Jason M Laramie
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    Bioinformatics 23:2190-2. 2007
    ..This strategy permits HaploBuild to construct more biologically relevant haplotypes that are not constrained by arbitrary length and contiguous orientation. Availability: http://snp.bumc.bu.edu...
  38. pmc Sepiapterin reductase expression is increased in Parkinson's disease brain tissue
    Jennifer E Tobin
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
    Brain Res 1139:42-7. 2007
    ..While the association of SPR to PD is not strong enough to support that this is the PARK3 gene, this study further implicates a role for SPR in idiopathic PD...
  39. ncbi request reprint Systemic inflammation and COPD: the Framingham Heart Study
    Robert E Walter
    Section of Pulmonary, Allergy, and Critical Care Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Chest 133:19-25. 2008
    ..We examined the hypothesis that systemic inflammatory biomarkers are associated with impaired lung function, particularly among those with extensive cigarette smoking...
  40. ncbi request reprint Epidemiologic study of 203 sibling pairs with Parkinson's disease: the GenePD study
    N E Maher
    Department of Neurology, Boston University School of Medicine, MA 02118, USA
    Neurology 58:79-84. 2002
    ..To examine patterns of familial aggregation and factors influencing onset age in a sample of siblings with PD...
  41. ncbi request reprint Influence of heterozygosity for parkin mutation on onset age in familial Parkinson disease: the GenePD study
    Mei Sun
    Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Arch Neurol 63:826-32. 2006
    ..The PARK2 gene at 6q26 encodes parkin, whose inactivation is implicated in an early-onset autosomal recessive form of Parkinson disease (PD)...
  42. ncbi request reprint A population association study of angiotensinogen polymorphisms and haplotypes with left ventricular phenotypes
    Laura J Rasmussen-Torvik
    Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA
    Hypertension 46:1294-9. 2005
    ..The single SNP association was driven by a large group of SNPs in high linkage disequilibrium that includes the promoter SNP rs5051...
  43. ncbi request reprint Racial differences in the association of coronary calcified plaque with left ventricular hypertrophy: the National Heart, Lung, and Blood Institute Family Heart Study and Hypertension Genetic Epidemiology Network
    Weihong Tang
    Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA
    Am J Cardiol 97:1441-8. 2006
    ....