Research Topics
Species | M M WerlerSummaryAffiliation: Boston University Country: USA Publications
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Publications
Alcohol consumption and time to recognition of pregnancyErika M Edwards
Data Coordinating Center, Boston University School of Public Health, 715 Albany St, 580, Boston, MA 02118, USA
Matern Child Health J 10:467-72. 2006..This study evaluates whether women who consume alcohol are at an increased risk of recognizing pregnancy later than women who do not, adjusting for confounding factors that have been associated with alcohol consumption during pregnancy...- Effect of high parity on occurrence of anemia in pregnancy: a cohort studyYahya M Al-Farsi
Department of Family Medicine and Public Health, College of Medicine and Health Sciences, Sultan Qaboos University, Oman
BMC Pregnancy Childbirth 11:7. 2011..The authors' aim in conducting this study was to overcome this methodological concern... - Achieving a public health recommendation for preventing neural tube defects with folic acidM M Werler
Slone Epidemiology Unit, Boston University School of Public Health, Boston, Mass, USA
Am J Public Health 89:1637-40. 1999..This study examined 3 approaches to achieving the public health recommendation that all women of child-bearing age ingest 0.40 mg of folic acid per day to reduce the occurrence of neural tube defects (NTDs)... - Teratogen update: pseudoephedrineMartha M Werler
Slone Epidemiology Center, Boston University, Boston, Massachusetts 02115, USA
Birth Defects Res A Clin Mol Teratol 76:445-52. 2006..In addition, the majority of decongestant use is in oral form and the question of whether intranasal formulations carry risk has not been adequately addressed... - Hemifacial microsomia: from gestation to childhoodMartha M Werler
Slone Epidemiology Center, Boston University, Boston, Massachusetts 02215, USA
J Craniofac Surg 20:664-9. 2009..When data on the full study sample are available, further analyses will determine whether the preliminary findings remain and if they vary by HFM phenotype, parenting style, or indicators of social risk... - Gulf War veterans and hemifacial microsomiaMartha M Werler
Slone Epidemiology Center, Boston University, Boston, Massachusetts 02215, USA
Birth Defects Res A Clin Mol Teratol 73:50-2. 2005..We used data collected from a case-control study of HFM to estimate risk in relation to parental military service and, in particular, Gulf War service... - Demographic and reproductive factors associated with hemifacial microsomiaMartha M Werler
Slone Epidemiology Center, Boston University, 1010 Commonwealth Avenue, Boston, MA 02215, USA
Cleft Palate Craniofac J 41:494-50. 2004..To identify demographic and reproductive risk factors for hemifacial microsomia in offspring... - Vasoactive exposures, vascular events, and hemifacial microsomiaMartha M Werler
Slone Epidemiology Center, Boston University, Boston, Massachusetts 02215, USA
Birth Defects Res A Clin Mol Teratol 70:389-95. 2004..We collected data in a case-control study to identify whether vasoactive exposures or vascular events during early pregnancy affect the risk of HFM... - Findings on potential teratogens from a case-control study in Western AustraliaMartha M Werler
Telethon Institute for Child Health Research, Subiaco, Western Australia, Australia
Aust N Z J Obstet Gynaecol 43:443-7. 2003..To examine, in Western Australian women, pregnancy use of drugs that have been found to be associated with birth defect risks in other studies... - Association of vasoconstrictive exposures with risks of gastroschisis and small intestinal atresiaMartha M Werler
Slone Epidemiology Center, Boston University, 1010 Commonwealth Avenue, Boston, MA 02215, USA
Epidemiology 14:349-54. 2003..The present study examined risks of gastroschisis and small intestinal atresia associated with combined exposure to vasoconstrictive drugs and cigarette smoking... - Maternal medication use and risks of gastroschisis and small intestinal atresiaMartha M Werler
Slone Epidemiology Unit, Boston University School of Public Health, Boston, MA, USA
Am J Epidemiol 155:26-31. 2002..Although pseudoephedrine has previously been shown to increase gastroschisis risk, findings of this study raise questions about interactions between medications and possible confounding by underlying illness... - Epidemiologic analysis of maternal factors and amniotic band defectsMartha M Werler
Slone Epidemiology Center, Boston University School of Public Health, Boston, Massachusetts 02215, USA
Birth Defects Res A Clin Mol Teratol 67:68-72. 2003..Little is known about risk factors for either ARS or BWC, except that maternal age has been shown to affect risk inversely... - Folic acid antagonists during pregnancy and the risk of birth defectsS Hernandez-Diaz
Slone Epidemiology Unit, Boston University School of Public Health, Brookline, Mass 02446, USA
N Engl J Med 343:1608-14. 2000..We evaluated whether the folic acid component of multivitamins is responsible for the reduction in risk by examining the associations between maternal use of folic acid antagonists and these congenital malformations... - Use of a job-exposure matrix to assess occupational exposures in relation to birth defectsC Louik
Slone Epidemiology Unit, School of Public Health, Boston University School of Medicine, Brookline, Mass, USA
J Occup Environ Med 42:693-703. 2000..Application of the NIOSH JEM to the birth defects study database (and probably other databases as well) does not provide a useful means of assessing occupational exposures... - Is there epidemiologic evidence to support vascular disruption as a pathogenesis of gastroschisis?Martha M Werler
Slone Epidemiology Center at Boston University, Boston, Massachusetts 02215, USA
Am J Med Genet A 149:1399-406. 2009..However, the observation that increased ORs for some vasoactive exposures were confined to older women raises the question of whether inherent maternal factors might influence risk... - Neural tube defects in relation to use of folic acid antagonists during pregnancyS Hernandez-Diaz
Slone Epidemiology Unit, Boston University School of Public Health, Brookline, MA 02446, USA
Am J Epidemiol 153:961-8. 2001..These findings suggest that a number of FAAs may increase NTD risk, and they provide estimates of risk for selected drugs... - Fruit and vegetable intake and risk of upper respiratory tract infection in pregnant womenLin Li
Department of Epidemiology, School of Public Health, Boston University, Boston, MA, USA
Public Health Nutr 13:276-82. 2010..The present study evaluated the association between fruit and vegetable intake and the incidence of upper respiratory tract infection (URTI) during pregnancy... - First-trimester use of selective serotonin-reuptake inhibitors and the risk of birth defectsCarol Louik
Slone Epidemiology Center at Boston University, Boston, MA 02215, USA
N Engl J Med 356:2675-83. 2007..The risk of birth defects after antenatal exposure to selective serotonin-reuptake inhibitors (SSRIs) remains controversial... - Socioeconomic status as a modifier of the relationship between antibiotic use during pregnancy and birthweightJessica W Nelson
Department of Environmental Health, Boston University School of Public Health, Boston, MA 02118, USA
Birth 35:196-203. 2008.... - Gestational hypertension in pregnancies supported by infertility treatments: role of infertility, treatments, and multiple gestationsSonia Hernandez-Diaz
Slone Epidemiology Center at Boston University, Boston, Massachusetts 02215, USA
Fertil Steril 88:438-45. 2007..To investigate the association between infertility treatments and gestational hypertension and preeclampsia... - Selective serotonin reuptake inhibitor use and risk of gestational hypertensionSengwee Toh
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Am J Psychiatry 166:320-8. 2009..The purpose of this study was to assess the effects of treatment with selective serotonin reuptake inhibitors (SSRIs) on the risks of gestational hypertension and preeclampsia... - Maternal dietary glycemic intake and the risk of neural tube defectsMahsa M Yazdy
Slone Epidemiology Center, Boston University, Boston, MA02215, USA
Am J Epidemiol 171:407-14. 2010..0); for high DGL, it was 1.8 (95% confidence interval: 0.8, 4.0). Diets with proportionally high DGI or DGL may put the developing fetus at risk of an NTD, adding further evidence that hyperglycemia lies within the pathogenic pathway... - Maternal vasoactive exposures, amniotic bands, and terminal transverse limb defectsMartha M Werler
Slone Epidemiology Center at Boston University, Boston, Massachusetts 02215, USA mwerler slone bu edu
Birth Defects Res A Clin Mol Teratol 85:52-7. 2009..If amniotic bands are secondary to vascular disruption, then a shared pathogenesis for each case group might be exhibited by similar risk factors... - Asthma in pregnancy and its pharmacologic treatmentCarol Louik
Slone Epidemiology Center at Boston University, Boston, Massachusetts 02215, USA
Ann Allergy Asthma Immunol 105:110-7. 2010..Asthma is among the most common serious medical problems in pregnancy, and its prevalence may be increasing. Management is problematic because asthma may harm the fetus, yet little is known about fetal risks of asthma medications... - Decongestant use during pregnancy and its association with preterm deliveryRohini K Hernandez
Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts 02118, USA
Birth Defects Res A Clin Mol Teratol 88:715-21. 2010..Despite the frequent intake of decongestants during pregnancy, only one study to date has evaluated the association of decongestants with preterm delivery, and it identified a reduced risk. We examined this association in more detail... - Hypothesis: could Epstein-Barr virus play a role in the development of gastroschisis?Martha M Werler
Slone Epidemiology Center at Boston University, Boston, Massachusetts 02215, USA
Birth Defects Res A Clin Mol Teratol 88:71-5. 2010..There is both anecdotal and published evidence showing that gastroschisis sometimes (but not always) occurs in clusters, raising the possibility that an infectious agent might be involved in its pathogenesis... - Methylenetetrahydrofolate reductase polymorphisms and the risk of gestational hypertensionSonia Hernandez-Diaz
Slone Epidemiology Center, Boston University School of Public Health, Boston, MA, USA
Epidemiology 16:628-34. 2005..It is also unknown whether the fetal genotype is relevant, or whether folic acid supplementation modifies this association... - Nausea and vomiting in pregnancy: maternal characteristics and risk factorsCarol Louik
Slone Epidemiology Centre, Boston University, MA 02115, USA
Paediatr Perinat Epidemiol 20:270-8. 2006..Together with selected demographic characteristics that differentiate early- vs. late-onset NVP, these findings warrant further investigation... - Erythromycin use during pregnancy in relation to pyloric stenosisCarol Louik
Slone Epidemiology Unit, Boston University School of Medicine, Brookline, MA 02446, USA
Am J Obstet Gynecol 186:288-90. 2002.... - Risk of gestational hypertension in relation to folic acid supplementation during pregnancySonia Hernandez-Diaz
Slone Epidemiology Center, Boston University School of Public Health, MA 02215, USA
Am J Epidemiol 156:806-12. 2002..55 (95% confidence interval: 0.39, 0.79). This finding suggests that folic acid-containing multivitamins may reduce the risk of gestational hypertension... - Case-crossover and case-time-control designs in birth defects epidemiologySonia Hernandez-Diaz
Slone Epidemiology Center, Boston University School of Public Health, 1010 Commonwealth Avenue, Boston, MA 02215, USA
Am J Epidemiol 158:385-91. 2003..9 (95% CI: 1.2, 7.2), but it requires controls. In the presence of gestational time trends of exposure, the new designs do not offer clear advantages over the case-control design... - Trends and predictors of folic acid awareness and periconceptional use in pregnant womenLolkje T W de Jong-van den Berg
Slone Epidemiology Center, Boston University School of Public Health, Boston, Mass, USA
Am J Obstet Gynecol 192:121-8. 2005..The purpose of this study was to describe recent trends in folic acid awareness and use in the periconceptional period among pregnant women in relation to maternal sociodemographic and other relevant factors... - Use of over-the-counter medications during pregnancyMartha M Werler
Slone Epidemiology Center at Boston University, Boston, MA, USA
Am J Obstet Gynecol 193:771-7. 2005..We describe the patterns of over-the-counter medication use among pregnant women... - Causal knowledge as a prerequisite for confounding evaluation: an application to birth defects epidemiologyMiguel A Hernán
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Am J Epidemiol 155:176-84. 2002..65 (95% confidence interval: 0.46, 0.94) should be used because the adjusted odds ratio is invalid. Causal diagrams are used to encode qualitative a priori subject matter knowledge... - Antidepressant use during pregnancy and the risk of preterm delivery and fetal growth restrictionSengwee Toh
Department of Population Medicine, Harvard Medical School Harvard Pilgrim Health Care Institute, 133 Brookline Ave 6th Floor, Boston, MA 02215, USA
J Clin Psychopharmacol 29:555-60. 2009..The associations between prenatal exposure to antidepressants and preterm delivery and fetal growth restriction are controversial and poorly understood. We studied the relation between antidepressant use and these outcomes... - Periconceptional multivitamin use and infant birth weight disparitiesHeather H Burris
Department of Neonatology, Beth Israel Deaconess Medical Center, Harvard University, 330 Brookline Ave, Boston, MA 02215, USA
Ann Epidemiol 20:233-40. 2010..Our objective was to determine whether maternal periconceptional multivitamin (MVI) use is associated with this disparity... - Can folic acid protect against congenital heart defects in Down syndrome?Willemijn M Meijer
Slone Epidemiology Center, Boston University, Boston, Massachusetts 02215-1201, USA
Birth Defects Res A Clin Mol Teratol 76:714-7. 2006..95, 95% CI: 0.61-1.47) nor separately for conotruncal defects, VSDs, ASDs, or ECDs. CONCLUSIONS: Our study does not show a protective effect of FA on heart anomalies among infants with DS... - Sensitivity and specificity of computerized algorithms to classify gestational periods in the absence of information on date of conceptionSengwee Toh
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Am J Epidemiol 167:633-40. 2008..However, the sensitivity of this algorithm is lower for preterm deliveries, suggesting limited validity to assess drug safety for pregnancy outcomes associated with prematurity... - Pre-pregnant body mass index, weight gain and the risk of delivering large babies among non-diabetic mothersC Kabali
Boston University School of Public Health, Boston, Massachusetts, USA
Int J Gynaecol Obstet 97:100-4. 2007..However, previous studies have focused on the separate effects of these two indices of weight in diabetic women... - Folic acid-containing supplement consumption during pregnancy and risk for oral clefts: a meta-analysisRachel L Badovinac
Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA
Birth Defects Res A Clin Mol Teratol 79:8-15. 2007..We undertook this meta-analysis to test the hypothesis that nonsyndromic oral cleft birth prevalences are different for those whose mothers took folic acid-containing supplements and for those whose mothers did not... - Gender differences in the professional and private lives of plastic surgeonsTerri J Halperin
Department of Plastic Surgery, Children s Hospital, Harvard Medical School and Slone Epidemiology Center, Boston University, Boston, MA, USA
Ann Plast Surg 64:775-9. 2010..Nevertheless, female plastic surgeons appear to have similar career satisfaction and are no more likely to retire earlier or more frequently than male plastic surgeons... - Risk factors for persistent pulmonary hypertension of the newbornSonia Hernandez diaz
Slone Epidemiology Center at Boston University, 1010 Commonwealth Ave, Boston, MA 02215, USA
Pediatrics 120:e272-82. 2007..We performed a case-control study to determine possible antenatal and perinatal predictors of persistent pulmonary hypertension of the newborn... - Low maternal alcohol consumption during pregnancy and oral clefts in offspring: the Slone Birth Defects StudyKatie A Meyer
Department of Applied Medical Sciences, School of Applied Science, Engineering, and Technology, University of Southern Maine, Portland, Maine, USA
Birth Defects Res A Clin Mol Teratol 67:509-14. 2003..These findings did not change when we considered possible modifying effects of vitamin supplement use. CONCLUSIONS: Our findings do not support an association between oral clefts and a low level of alcohol consumption... - Maternal use of acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs), and muscular ventricular septal defectsMario A Cleves
Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Arkansas Center for Birth Defects Research and Prevention, 11219 Financial Centre Parkway, Little Rock, AR 72211, USA
Birth Defects Res A Clin Mol Teratol 70:107-13. 2004..CONCLUSIONS: Significant associations were not detected between the occurrence of mVSDs and maternal use of NSAIDs or acetaminophen adjusting for maternal fever, nor were they detected between maternal fever and mVSDs... - Maternal obesity, gestational diabetes, and central nervous system birth defectsJames L Anderson
The University of Texas, Houston Health Science Center, School of Public Health, Houston, Texas, USA
Epidemiology 16:87-92. 2005..Our objective was to evaluate whether gestational diabetes influenced the association of prepregnancy maternal obesity and risks for CNS birth defects... - Fat intake and the risk of gastroschisisAnna Maria Siega-Riz
Department of Nutrition, School of Public Health, University of North Carolina, Chapel Hill, 27516, USA
Birth Defects Res A Clin Mol Teratol 76:241-5. 2006..The objective of this study was to examine the association between dietary fats and gastroschisis and whether maternal age modified this association... - Selective serotonin-reuptake inhibitors and risk of persistent pulmonary hypertension of the newbornChristina D Chambers
Department of Pediatrics, University of California, San Diego, La Jolla, CA 92103, USA
N Engl J Med 354:579-87. 2006..We performed a case-control study to assess whether PPHN is associated with exposure to SSRIs during late pregnancy... - Maternal exposure to statins and risk for birth defects: a case-series approachEmily E Petersen
National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Am J Med Genet A 146:2701-5. 2008 - Antifungal drugs and the risk of selected birth defectsTonia C Carter
Department of Epidemiology, School of Public Health, State University of New York at Albany, Albany, USA
Am J Obstet Gynecol 198:191.e1-7. 2008..This study examined whether first-trimester antifungal drug use was associated with the risk of selected birth defects... - Association between prepregnancy maternal body mass index and the risk of having an infant with a congenital diaphragmatic herniaD Kim Waller
School of Public Health, University of Texas Houston Health Science Center, Houston, Texas 77225, USA
Birth Defects Res A Clin Mol Teratol 67:73-6. 2003..The objective of the current study was to examine the association between maternal body mass index and the risk of a CDH-affected offspring based on a larger number of cases of CDH... - Maternal corticosteroid use and orofacial cleftsSuzan L Carmichael
March of Dimes Foundation California Department of Health Services, California Birth Defects Monitoring Program, Berkeley, CA, USA
Am J Obstet Gynecol 197:585.e1-7; discussion 683-4, e1-7. 2007..The purpose of this study was to examine whether maternal corticosteroid use during pregnancy is associated with delivering an infant with an orofacial cleft... - Maternal hypertension, antihypertensive medication use, and the risk of severe hypospadiasAlissa R Caton
Department of Epidemiology and Biostatistics, School of Public Health, University at Albany, Rensselaer, New York, USA
Birth Defects Res A Clin Mol Teratol 82:34-40. 2008..The objective of this study was to investigate the relationship between high blood pressure, antihypertensive medication use, and severe hypospadias...
Research Grants
- BURPPE:BU Reproductive, Perinatal, and Pediatric Epidemiology Training ProgramMartha Werler; Fiscal Year: 2007....
- Dietary Glycemic Load, Obesity, and Birth Defect RisksMartha Werler; Fiscal Year: 2007....