Joseph Vita

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study
    Ramachandran S Vasan
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S2. 2007
  2. pmc Genome-wide association with select biomarker traits in the Framingham Heart Study
    Emelia J Benjamin
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S11. 2007
  3. ncbi request reprint Tea consumption and cardiovascular disease: effects on endothelial function
    Joseph A Vita
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA
    J Nutr 133:3293S-3297S. 2003
  4. ncbi request reprint Effect of atorvastatin on endothelium-dependent vasodilation in patients with coronary artery disease
    Joseph A Vita
    Evans Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Massachusetts, USA
    Am J Cardiol 91:857-60. 2003
  5. pmc Flow-induced arterial remodeling relates to endothelial function in the human forearm
    Joseph A Vita
    Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    Circulation 117:3126-33. 2008
  6. ncbi request reprint Low plasma ascorbic acid independently predicts the presence of an unstable coronary syndrome
    J A Vita
    Evans Memorial Department of Medicine and Whitaker Cardiovascular Institute, Boston University Medical Center, Massachusetts 02118, USA
    J Am Coll Cardiol 31:980-6. 1998
  7. pmc Endothelial function and clinical outcome
    J A Vita
    Boston Medical Center, Boston, MA 02118, USA
    Heart 91:1278-9. 2005
  8. ncbi request reprint Polyphenols and cardiovascular disease: effects on endothelial and platelet function
    Joseph A Vita
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA
    Am J Clin Nutr 81:292S-297S. 2005
  9. ncbi request reprint Brachial artery vasodilator function and systemic inflammation in the Framingham Offspring Study
    Joseph A Vita
    Evans Memorial Department of Medicine, Boston University School of Medicine, Boston, Mass, USA
    Circulation 110:3604-9. 2004
  10. ncbi request reprint Does endothelial dysfunction contribute to the clinical status of patients with peripheral arterial disease?
    Joseph A Vita
    Evans Department of Medicine and Whitake Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, USA
    Can J Cardiol 26:45A-50A. 2010

Detail Information

Publications81

  1. pmc Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study
    Ramachandran S Vasan
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S2. 2007
    ..We conducted a genome-wide association study (GWAS) in the community-based Framingham Heart Study...
  2. pmc Genome-wide association with select biomarker traits in the Framingham Heart Study
    Emelia J Benjamin
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S11. 2007
    ..Genome-wide association studies (GWAS) provide mechanisms to investigate the genetic contributions to biomarker variability unconstrained by current knowledge of physiological relations...
  3. ncbi request reprint Tea consumption and cardiovascular disease: effects on endothelial function
    Joseph A Vita
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA
    J Nutr 133:3293S-3297S. 2003
    ..This article reviews the evidence that human tea consumption has a beneficial effect on the vascular endothelium and the clinical implications of these findings...
  4. ncbi request reprint Effect of atorvastatin on endothelium-dependent vasodilation in patients with coronary artery disease
    Joseph A Vita
    Evans Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Massachusetts, USA
    Am J Cardiol 91:857-60. 2003
  5. pmc Flow-induced arterial remodeling relates to endothelial function in the human forearm
    Joseph A Vita
    Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    Circulation 117:3126-33. 2008
    ..Experimental studies suggest that remodeling represents a response to local changes in endothelial shear stress and is nitric oxide-dependent...
  6. ncbi request reprint Low plasma ascorbic acid independently predicts the presence of an unstable coronary syndrome
    J A Vita
    Evans Memorial Department of Medicine and Whitaker Cardiovascular Institute, Boston University Medical Center, Massachusetts 02118, USA
    J Am Coll Cardiol 31:980-6. 1998
    ..This study sought to investigate the relations between plasma antioxidant status, extent of atherosclerosis and activity of coronary artery disease...
  7. pmc Endothelial function and clinical outcome
    J A Vita
    Boston Medical Center, Boston, MA 02118, USA
    Heart 91:1278-9. 2005
  8. ncbi request reprint Polyphenols and cardiovascular disease: effects on endothelial and platelet function
    Joseph A Vita
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA
    Am J Clin Nutr 81:292S-297S. 2005
    ..For these reasons, the observed effects of flavonoids on endothelial and platelet function might explain, in part, the observed beneficial effects of flavonoids on cardiovascular disease risk...
  9. ncbi request reprint Brachial artery vasodilator function and systemic inflammation in the Framingham Offspring Study
    Joseph A Vita
    Evans Memorial Department of Medicine, Boston University School of Medicine, Boston, Mass, USA
    Circulation 110:3604-9. 2004
    ..The precise relations among risk factors, inflammation, and nitric oxide bioavailability remain uncertain...
  10. ncbi request reprint Does endothelial dysfunction contribute to the clinical status of patients with peripheral arterial disease?
    Joseph A Vita
    Evans Department of Medicine and Whitake Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, USA
    Can J Cardiol 26:45A-50A. 2010
    ....
  11. ncbi request reprint Effect of cholesterol-lowering therapy on coronary endothelial vasomotor function in patients with coronary artery disease
    J A Vita
    Boston University School of Medicine, Boston, MA, USA
    Circulation 102:846-51. 2000
    ..Improved endothelial function may contribute to the beneficial effects of cholesterol-lowering therapy...
  12. pmc Serum myeloperoxidase levels independently predict endothelial dysfunction in humans
    Joseph A Vita
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Mass, USA
    Circulation 110:1134-9. 2004
    ..We therefore hypothesized that circulating levels of myeloperoxidase would predict risk of endothelial dysfunction in human subjects...
  13. ncbi request reprint Periodontal disease is associated with brachial artery endothelial dysfunction and systemic inflammation
    Salomon Amar
    Department of Periodontology, Boston University School of Dental Medicine, Mass, USA
    Arterioscler Thromb Vasc Biol 23:1245-9. 2003
    ..Epidemiological studies suggest that severe periodontal disease is associated with increased cardiovascular disease risk, but the mechanisms remain unknown...
  14. ncbi request reprint Common genetic variation at the endothelial nitric oxide synthase locus and relations to brachial artery vasodilator function in the community
    Sekar Kathiresan
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA, USA
    Circulation 112:1419-27. 2005
    ..Sequence variants at the endothelial nitric oxide synthase (NOS3) locus have been associated with endothelial function measures, but replication has been limited...
  15. pmc Long-term successful weight loss improves vascular endothelial function in severely obese individuals
    Sherman J Bigornia
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, USA
    Obesity (Silver Spring) 18:754-9. 2010
    ..The results also demonstrate that metabolic changes in association with weight loss are stronger determinants of vascular phenotype than degree of weight reduction...
  16. pmc Predictive value of reactive hyperemia for cardiovascular events in patients with peripheral arterial disease undergoing vascular surgery
    Alex L Huang
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Mass, USA
    Arterioscler Thromb Vasc Biol 27:2113-9. 2007
    ..The predictive value of reactive hyperemia for cardiovascular events in patients with atherosclerosis and the relative importance of reactive hyperemia compared with other measures of vascular function have not been previously studied...
  17. pmc Effect of combined treatment with alpha-Lipoic acid and acetyl-L-carnitine on vascular function and blood pressure in patients with coronary artery disease
    Craig J McMackin
    Evans Department of Medicine and Whitaker Cardovascular Institute, Boston University School of Medicine, Boston, MA, USA
    J Clin Hypertens (Greenwich) 9:249-55. 2007
    ..Further studies are needed to confirm these findings and determine the clinical utility of alpha-lipoic acid/acetyl-L-carnitine as antihypertensive therapy...
  18. pmc Relations of inflammatory biomarkers and common genetic variants with arterial stiffness and wave reflection
    Renate Schnabel
    National Heart Lung and Blood Institute Framingham Study, Framingham, Mass, USA
    Hypertension 51:1651-7. 2008
    ..Additional studies are needed to determine whether variation in inflammatory marker genes is associated with tonometry measures...
  19. pmc The brachial artery remodels to maintain local shear stress despite the presence of cardiovascular risk factors
    William B Chung
    Evans Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Arterioscler Thromb Vasc Biol 29:606-12. 2009
    ..Recent studies have shown that the brachial artery and other peripheral arteries are enlarged in patients with risk factors and cardiovascular disease, and we tested the hypothesis that this finding represents maladaptive remodeling...
  20. pmc Acute EGCG supplementation reverses endothelial dysfunction in patients with coronary artery disease
    Michael E Widlansky
    Evans Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA
    J Am Coll Nutr 26:95-102. 2007
    ..Recent studies with flavonoid-containing beverages suggest that the benefits of these nutrients may relate, in part, to improved endothelial function...
  21. pmc Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers
    Naomi M Hamburg
    Section of Cardiology, Boston Medical Center, 88 East Newton Street, Boston, MA 02118, USA
    Arterioscler Thromb Vasc Biol 27:2650-6. 2007
    ..Sedentary lifestyle increases the risk of cardiovascular disease and diabetes. Vascular dysfunction contributes to atherogenesis and has been linked to insulin resistance...
  22. ncbi request reprint Predictive value of noninvasively determined endothelial dysfunction for long-term cardiovascular events in patients with peripheral vascular disease
    Noyan Gokce
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, USA
    J Am Coll Cardiol 41:1769-75. 2003
    ..The goal of this study was to prospectively examine the long-term predictive value of brachial-artery endothelial dysfunction for future cardiovascular events...
  23. ncbi request reprint Short- and long-term COX-2 inhibition reverses endothelial dysfunction in patients with hypertension
    Michael E Widlansky
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Mass, USA
    Hypertension 42:310-5. 2003
    ....
  24. pmc Metabolic syndrome, insulin resistance, and brachial artery vasodilator function in Framingham Offspring participants without clinical evidence of cardiovascular disease
    Naomi M Hamburg
    Evans Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    Am J Cardiol 101:82-8. 2008
    ..In conclusion, our observations are consistent with the hypothesis that MS and insulin resistance impair vascular function predominantly through the influence of the component metabolic abnormalities that comprise MS...
  25. pmc Endothelial dysfunction in diabetes mellitus: molecular mechanisms and clinical implications
    Corey E Tabit
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA
    Rev Endocr Metab Disord 11:61-74. 2010
    ..We then discuss the implications of these studies for current management and for new approaches for the prevention and treatment of cardiovascular disease in patients with diabetes mellitus...
  26. pmc Visceral and subcutaneous adiposity and brachial artery vasodilator function
    Nisha I Parikh
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Obesity (Silver Spring) 17:2054-9. 2009
    ..265), above and beyond traditional risk factors. VAT, but not SAT was associated with FMD% after adjusting for clinical covariates. Nevertheless, the differential association with VAT as compared to SAT was minimal...
  27. ncbi request reprint Effect of medical and surgical weight loss on endothelial vasomotor function in obese patients
    Noyan Gokce
    Evans Department of Medicine, Cardiology and Endocrinology Sections, Boston University School of Medicine, Boston, MA, USA
    Am J Cardiol 95:266-8. 2005
    ..These data demonstrate that weight loss in markedly obese patients improves endothelial function and glycemic control that may represent important mechanisms of the cardiovascular benefit associated with weight reduction...
  28. pmc Relation of season and temperature to endothelium-dependent flow-mediated vasodilation in subjects without clinical evidence of cardiovascular disease (from the Framingham Heart Study)
    Michael E Widlansky
    Cardiology Department, Boston University School of Medicine, Boston, Massachusetts, USA
    Am J Cardiol 100:518-23. 2007
    ..Endothelial dysfunction may be 1 of the mechanisms influencing seasonal variation in cardiovascular events...
  29. ncbi request reprint Genome scan of systemic biomarkers of vascular inflammation in the Framingham Heart Study: evidence for susceptibility loci on 1q
    Josee Dupuis
    Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA
    Atherosclerosis 182:307-14. 2005
    ..09) less than 5cM from the interleukin-10 (IL10) gene. Multiple genes on chromosome 1 may influence inflammatory biomarker levels and may have a potential role in development of CVD...
  30. pmc Brachial artery diameter, blood flow and flow-mediated dilation in sleep-disordered breathing
    Hassan A Chami
    Department of Medicine, Boston University School of Medicine, The Pulmonary Center, VA Boston Healthcare System, Boston, MA 02118, USA
    Vasc Med 14:351-60. 2009
    ..This study does not support a link between SDB and endothelial dysfunction as measured by brachial artery flow-mediated dilation...
  31. ncbi request reprint The relationship between aldosterone, oxidative stress, and inflammation in chronic, stable human heart failure
    Eugene Kotlyar
    Cardiovascular Section, Evans Department of Medicine, Boston University, 88 E Newton Street D 8, Boston, MA, USA
    J Card Fail 12:122-7. 2006
    ..It is unknown if these findings are relevant to heart failure patients who may have much lower aldosterone levels...
  32. ncbi request reprint Heritability and correlates of intercellular adhesion molecule-1 in the Framingham Offspring Study
    John F Keaney
    Evans Memorial Department of Medicine, Boston University School of Medicine, Massachusetts 02118, USA
    J Am Coll Cardiol 44:168-73. 2004
    ..We sought to determine the clinical factors and heritability associated with inflammation measured as circulating levels of soluble-intercellular adhesion molecule-1 (sICAM-1) in a community-based cohort...
  33. ncbi request reprint Effects of black race on forearm resistance vessel function
    David F Kahn
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Mass, USA
    Hypertension 40:195-201. 2002
    ..Further studies will be required to elucidate the mechanisms and determine whether these insights will lead to more appropriately tailored management of hypertension and its complications...
  34. ncbi request reprint Vascular oxidative stress and antioxidant protection in atherosclerosis: what do the clinical trials say?
    John F Keaney
    Evans Memorial Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, Room W507, Boston, MA 02118, USA
    J Cardiopulm Rehabil 22:225-33. 2002
  35. ncbi request reprint Clinical correlates and heritability of flow-mediated dilation in the community: the Framingham Heart Study
    Emelia J Benjamin
    Evans Department of Medicine, Boston University School of Medicine, Framingham Study, Boston, Mass 01702 5827, USA
    Circulation 109:613-9. 2004
    ..Studies in selected samples have linked impaired endothelial function with cardiovascular disease and its risk factors. The clinical correlates and heritability of endothelial function in the community have not been described...
  36. ncbi request reprint Sickle cell anemia is associated with reduced nitric oxide bioactivity in peripheral conduit and resistance vessels
    Robert T Eberhardt
    Evans Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118 2393, USA
    Am J Hematol 74:104-11. 2003
    ..Resistance vessels have preserved response to exogenous NO donors but have diminished contribution of NO to endothelium-dependent vasodilation. Conduit vessels demonstrate impaired vasodilation to endogenous and exogenous NO...
  37. ncbi request reprint Acute effects of vasoactive drug treatment on brachial artery reactivity
    Noyan Gokce
    Evans Department of Medicine, Cardiology Section and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, USA
    J Am Coll Cardiol 40:761-5. 2002
    ..The goal of this study was to investigate whether concomitant therapy with vasoactive medications alters the results of noninvasive assessment of endothelial function...
  38. ncbi request reprint Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham Study
    John F Keaney
    Evans Memorial Department of Medicine, Boston University School of Medicine, Whitaker Cardiovascular Institute, 715 Albany St, Rm W507, Boston, MA 02118, USA
    Arterioscler Thromb Vasc Biol 23:434-9. 2003
    ..Thus, it has been difficult to evaluate the relative contribution of each cardiovascular risk factor to systemic oxidative stress and to determine whether such risk factors act independently and are applicable to the general population...
  39. pmc Cross-sectional relations of digital vascular function to cardiovascular risk factors in the Framingham Heart Study
    Naomi M Hamburg
    Cardiology Section, Whitaker Cardiovascular Institute, School of Medicine, Boston University, Boston, Mass 01702, USA
    Circulation 117:2467-74. 2008
    ..Baseline digital pulse amplitude reflects local peripheral arterial tone. The relation of digital pulse amplitude and digital hyperemic response to cardiovascular risk factors in the community is unknown...
  40. ncbi request reprint Associations of plasma natriuretic peptide, adrenomedullin, and homocysteine levels with alterations in arterial stiffness: the Framingham Heart Study
    Daniel Levy
    NHLBI Framingham Heart Study, Framingham, Mass, USA
    Circulation 115:3079-85. 2007
    ..Little is known about the relations of natriuretic peptides and homocysteine to arterial wall stiffness in the community...
  41. pmc Effects of flavonoid-containing beverages and EGCG on endothelial function
    Sherene M Shenouda
    Boston University School of Medicine, 88 East Newton Street, C 818, Boston, MA 02118, USA
    J Am Coll Nutr 26:366S-372S. 2007
    ....
  42. pmc Multimarker approach to evaluate correlates of vascular stiffness: the Framingham Heart Study
    Wolfgang Lieb
    Framingham Heart Study, Framingham, MA, USA
    Circulation 119:37-43. 2009
    ..Knowledge about the pathophysiological processes that determine arterial stiffness may help guide therapeutic approaches...
  43. ncbi request reprint Nitric oxide and vascular reactivity in African American patients with hypertension
    Joseph A Vita
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Card Fail 9:S199-204; discussion S205-9. 2003
  44. ncbi request reprint Endoscopic versus conventional radial artery harvest for coronary artery bypass grafting: functional and histologic assessment of the conduit
    Oz M Shapira
    Department of Cardiothoracic Surgery, Boston Medical Center, Boston, Mass 02118, USA
    J Thorac Cardiovasc Surg 131:388-94. 2006
    ..The radial artery's propensity for vasospasm and vulnerability to surgical trauma are well known. A less invasive endoscopic method to harvest the radial artery was recently introduced, but its effect on radial artery integrity is unknown...
  45. pmc Effects of systemic inflammation on endothelium-dependent vasodilation
    Alex L Huang
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Trends Cardiovasc Med 16:15-20. 2006
    ..This article will review the experimental and clinical studies that support the relevance of inflammation to nitric oxide bioactivity in human atherosclerosis...
  46. pmc Arterial stiffness in mild-to-moderate CKD
    Ashish Upadhyay
    Renal Section, Boston Medical Center and Boston University School of Medicine, Boston, Massachusetts, USA
    J Am Soc Nephrol 20:2044-53. 2009
    ..Baseline arterial measures did not associate with incident CKD or incident microalbuminuria. In summary, arterial stiffness correlates with albuminuria but not with mild-to-moderate CKD...
  47. pmc Grapes and cardiovascular disease
    Mustali M Dohadwala
    Evans Department of Medicine and the Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    J Nutr 139:1788S-93S. 2009
    ..The available data, however, strongly support the recommendation that a diet rich in fruits and vegetables, including grapes, can decrease the risk for cardiovascular disease...
  48. pmc The effect of L-arginine and creatine on vascular function and homocysteine metabolism
    Eiman Jahangir
    Boston University School of Medicine, Boston, MA 02118, USA
    Vasc Med 14:239-48. 2009
    ..The unexpected increase in homocysteine levels following creatine supplementation could have adverse effects and merits further study, since creatine is a commonly used dietary supplement...
  49. ncbi request reprint Activation of endothelial nitric-oxide synthase by the p38 MAPK in response to black tea polyphenols
    Elad Anter
    Evans Memorial Department of Medicine, The Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachussetts 02118, USA
    J Biol Chem 279:46637-43. 2004
    ..Taken together, these data identify the p38 MAPK as an upstream component of Akt-mediated eNOS activation...
  50. ncbi request reprint The clinical implications of endothelial dysfunction
    Michael E Widlansky
    Evans Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    J Am Coll Cardiol 42:1149-60. 2003
    ..This article will review this growing literature in an effort to evaluate the current clinical utility of endothelial dysfunction...
  51. ncbi request reprint Risk stratification for postoperative cardiovascular events via noninvasive assessment of endothelial function: a prospective study
    Noyan Gokce
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Circulation 105:1567-72. 2002
    ..However, the predictive value of brachial artery endothelial dysfunction for future cardiovascular events is unknown...
  52. ncbi request reprint Effects of black tea consumption on plasma catechins and markers of oxidative stress and inflammation in patients with coronary artery disease
    Michael E Widlansky
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA
    Free Radic Biol Med 38:499-506. 2005
    ..Chronic dietary flavonoid status appears to relate to endothelial function, possibly suggesting that other flavonoids or polyphenolic components of tea favorably influence vascular health and risk for cardiovascular disease...
  53. ncbi request reprint Effect of exercise on upper and lower extremity endothelial function in patients with coronary artery disease
    Noyan Gokce
    Evans Department of Medicine, Cardiology Section, and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, USA
    Am J Cardiol 90:124-7. 2002
    ..These findings suggest that exercise improves endothelial function in peripheral conduit arteries of patients with CAD and that the beneficial effect may be more marked in the vascular beds of the exercised limbs...
  54. pmc Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype
    Koji Ohashi
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 285:6153-60. 2010
    ....
  55. ncbi request reprint Effect of short-term antibiotic treatment on Chlamydia pneumoniae and peripheral endothelial function
    Jeffrey T Kuvin
    Division of Cardiology, Department of Medicine, Tufts New England Medical Center, Boston, Massachusetts, USA
    Am J Cardiol 91:732-5. 2003
  56. ncbi request reprint Testing endothelial vasomotor function: nitric oxide, a multipotent molecule
    Peter Ganz
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Boston, Mass 02115, USA
    Circulation 108:2049-53. 2003
  57. pmc Altered mitochondrial membrane potential, mass, and morphology in the mononuclear cells of humans with type 2 diabetes
    Michael E Widlansky
    Department of Medicine, Division of Cardiovascular Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Transl Res 156:15-25. 2010
    ..Furthermore, potentially clinically relevant perturbations in mitochondrial homeostasis in T2DM human mononuclear cells can be detected...
  58. pmc Effects of Concord grape juice on ambulatory blood pressure in prehypertension and stage 1 hypertension
    Mustali M Dohadwala
    Evans Department of Medicine and the Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Am J Clin Nutr 92:1052-9. 2010
    ..Consumption of flavonoid-containing foods may be useful for the management of hypertension...
  59. pmc Differential effects of natriuretic peptides on arterial and venous coronary artery bypass conduits
    Hao G Nguyen
    Department of Cardiothoracic Surgery, Boston Medical Center, Boston, Massachusetts, USA
    Ann Thorac Surg 87:748-56. 2009
    ..Natriuretic peptides play a major role in vascular homeostasis. We hypothesized that natriuretic peptides might have different effects on arterial and venous conduits...
  60. ncbi request reprint Nitric oxide-dependent vasodilation in human subjects
    Joseph A Vita
    Section of Cardiology, Boston Medical Center, Boston, Massachusetts 02118, USA
    Methods Enzymol 359:186-200. 2002
  61. ncbi request reprint Coronary endothelial dysfunction is not rapidly reversible with ascorbic acid
    Michael E Widlansky
    Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA
    Free Radic Biol Med 36:123-30. 2004
    ....
  62. pmc Endothelial function in HIV-infected persons
    Anthony Solages
    Division of Infectious Diseases, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    Clin Infect Dis 42:1325-32. 2006
    ..Impaired endothelium-dependent vasodilation is a putative surrogate marker of coronary atherosclerotic disease...
  63. pmc Altered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitus
    Sherene M Shenouda
    Boston University School of Medicine, 88 East Newton Street, Boston, MA 02118, USA
    Circulation 124:444-53. 2011
    ..We investigated the contribution of altered dynamics to endothelial dysfunction in diabetes mellitus...
  64. ncbi request reprint Heritability and a genome-wide linkage scan for arterial stiffness, wave reflection, and mean arterial pressure: the Framingham Heart Study
    Gary F Mitchell
    Cardiovascular Engineering, Inc, Holliston, Mass 01746, USA
    Circulation 112:194-9. 2005
    ..However, few prior community-based studies have evaluated the genetics of arterial stiffness and separate mean and pulsatile components of blood pressure...
  65. ncbi request reprint Shouldering the risk factor burden: infection, atherosclerosis, and the vascular endothelium
    Joseph A Vita
    Circulation 106:164-6. 2002
  66. ncbi request reprint The value of inflammation for predicting unstable angina
    John F Keaney
    N Engl J Med 347:55-7. 2002
  67. ncbi request reprint Dietary lipids and vascular function: UK Food Standards Agency workshop report
    Peter Sanderson
    Nutrition Division, Food Standards Agency, London, UK
    Br J Nutr 91:491-500. 2004
    ....
  68. ncbi request reprint Haptoglobin phenotype and prevalent coronary heart disease in the Framingham offspring cohort
    Andrew P Levy
    Technion Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Atherosclerosis 172:361-5. 2004
    ....
  69. ncbi request reprint Changes in arterial stiffness and wave reflection with advancing age in healthy men and women: the Framingham Heart Study
    Gary F Mitchell
    Cardiovascular Engineering, Inc, 327 Fiske St, Holliston, MA 01746, USA
    Hypertension 43:1239-45. 2004
    ..This phenomenon may facilitate forward transmission of potentially deleterious pressure pulsations into the periphery...
  70. ncbi request reprint Cross-sectional relations of peripheral microvascular function, cardiovascular disease risk factors, and aortic stiffness: the Framingham Heart Study
    Gary F Mitchell
    Cardiovascular Engineering, Inc, Waltham, MA 02453, USA
    Circulation 112:3722-8. 2005
    ..Aortic stiffness and small-artery structure and function share various risk factors; however, relations between these 2 measures of vascular function are complex and incompletely understood...
  71. ncbi request reprint Local shear stress and brachial artery flow-mediated dilation: the Framingham Heart Study
    Gary F Mitchell
    Cardiovascular Engineering, Inc, 327 Fiske St, Holliston, MA 01746, USA
    Hypertension 44:134-9. 2004
    ..The associations between many risk factors and brachial artery flow-mediated dilation may be attributable to reduced stimulus for dilation rather than impaired local conduit artery response during hyperemia...
  72. ncbi request reprint Effects of phenolics on vascular endothelial function
    Stephen J Duffy
    Heart Centre, The Alfred Hospital and Baker Heart Research Institute, Melbourne, Victoria, Australia
    Curr Opin Lipidol 14:21-7. 2003
    ..Epidemiological studies have demonstrated a strong link between phenolic intake and reduced cardiovascular risk, but the mechanism of benefit has not been determined...
  73. ncbi request reprint Cross-sectional correlates of increased aortic stiffness in the community: the Framingham Heart Study
    Gary F Mitchell
    Cardiovascular Engineering, Inc, 51 Sawyer Rd, Suite 100, Waltham, MA 02453, USA
    Circulation 115:2628-36. 2007
    ..Increased aortic stiffness is associated with numerous common diseases of aging, including heart disease, stroke, and renal disease. However, the prevalence and correlates of abnormally high aortic stiffness are incompletely understood...
  74. ncbi request reprint Vascular stiffness and genetic variation at the endothelial nitric oxide synthase locus: the Framingham Heart study
    Gary F Mitchell
    Cardiovascular Engineering, Inc, Waltham, MA 02453, USA
    Hypertension 49:1285-90. 2007
    ..The present study was suggestive of modest relations between common genetic variants at the NOS3 locus and arterial stiffness...
  75. pmc Shear-stress-mediated arterial remodeling in atherosclerosis: too much of a good thing?
    Annemarie E Silver
    Circulation 113:2787-9. 2006
  76. ncbi request reprint Association of nitrotyrosine levels with cardiovascular disease and modulation by statin therapy
    Mehdi H Shishehbor
    Department of Cell Biology, and the Center for Cardiovascular Diagnostics and Prevention, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    JAMA 289:1675-80. 2003
    ..Nitrotyrosine, a specific marker for protein modification by nitric oxide-derived oxidants, is enriched in human atherosclerotic lesions and low-density lipoprotein (LDL) recovered from human atheroma...
  77. ncbi request reprint Endothelial function: a barometer for cardiovascular risk?
    Joseph A Vita
    Circulation 106:640-2. 2002
  78. ncbi request reprint Cross-sectional relations of multiple biomarkers from distinct biological pathways to brachial artery endothelial function
    Sekar Kathiresan
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702 5827, USA
    Circulation 113:938-45. 2006
    ..We evaluated the relative contributions of distinct biological pathways to interindividual variation in endothelial function by relating prototype biomarkers (representing these pathways) to brachial artery vasodilator function...
  79. ncbi request reprint Effects of shear stress and flow pulsatility on endothelial function: insights gleaned from external counterpulsation therapy
    Joseph A Vita
    J Am Coll Cardiol 42:2096-8. 2003
  80. pmc Low-renin hypertension with relative aldosterone excess is associated with impaired NO-mediated vasodilation
    Stephen J Duffy
    The Heart Centre, Alfred Hospital and Baker Heart Research Institute, Melbourne, Victoria, Australia
    Hypertension 46:707-13. 2005
    ..This impairment could contribute to adverse outcomes in patients with low-renin hypertension and relative aldosterone excess...
  81. pmc Relations of measures of endothelial function and kidney disease: the Framingham Heart Study
    Meredith C Foster
    The National Heart, Lung, and Blood Institute Framingham Heart Study, Framingham, MA 01702, USA
    Am J Kidney Dis 52:859-67. 2008
    ..Endothelial dysfunction is prevalent in individuals with end-stage renal disease. Whether endothelial dysfunction is present in patients with moderate chronic kidney disease (CKD) is uncertain...

Research Grants11

  1. Clinical Utility of Endothelial Function in PAD
    Joseph Vita; Fiscal Year: 2007
    ..This work will provide novel information about the pathogenesis and management of PAD. ..
  2. Determinants of Shear Stress-Mediated Arterial Remodeling
    Joseph Vita; Fiscal Year: 2007
    ....
  3. Boston University Medical Center Leadership Program in Vascular Medicine
    Joseph Vita; Fiscal Year: 2007
    ..End of Abstract) ..
  4. Determinants of Shear Stress-Mediated Arterial Remodeling
    Joseph Vita; Fiscal Year: 2009
    ....