Ramachandran S Vasan

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Metabolic syndrome and inflammatory biomarkers: a community-based cross-sectional study at the Framingham Heart Study
    Dhayana Dallmeier
    National Heart, Lung, and Blood Institute s and Boston University s Framingham Heart Study, Framingham, USA
    Diabetol Metab Syndr 4:28. 2012
  2. pmc Correlation of renin angiotensin and aldosterone system activity with subcutaneous and visceral adiposity: the framingham heart study
    Conall M O'Seaghdha
    National Heart, Lung and Blood Institute s Framingham Heart Study, 73 Mt, Wayte Avenue Suite 2, Framingham, MA, USA
    BMC Endocr Disord 12:3. 2012
  3. pmc Circulating vascular growth factors and central hemodynamic load in the community
    Justin P Zachariah
    Framingham Heart Study, 73 Mount Wayte Ave, Framingham, MA 01702 5803, USA
    Hypertension 59:773-9. 2012
  4. pmc Nicotinic acetylcholine receptor subunit variants are associated with blood pressure; findings in the Old Order Amish and replication in the Framingham Heart Study
    Patrick F McArdle
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    BMC Med Genet 9:67. 2008
  5. pmc The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports
    L Adrienne Cupples
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S1. 2007
  6. pmc Genome-wide association with select biomarker traits in the Framingham Heart Study
    Emelia J Benjamin
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S11. 2007
  7. pmc Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project
    Caroline S Fox
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S18. 2007
  8. pmc Phenotype-genotype association grid: a convenient method for summarizing multiple association analyses
    Daniel Levy
    National Heart, Lung, and Blood Institute, Bethesda, MD, USA
    BMC Genet 7:30. 2006
  9. ncbi request reprint Clinical utility of different lipid measures for prediction of coronary heart disease in men and women
    Erik Ingelsson
    Framingham Heart Study, 73 Mount Wayte Ave, Suite 2, Framingham, MA 01702 5803
    JAMA 298:776-85. 2007
  10. ncbi request reprint Relative importance of borderline and elevated levels of coronary heart disease risk factors
    Ramachandran S Vasan
    Framingham Heart Study, Framingham, Massachusetts 01702 5803, USA
    Ann Intern Med 142:393-402. 2005

Research Grants

  1. Ventricular Matrix Remodeling: Correlates and Prognosis
    Vasan Ramachandran; Fiscal Year: 2001
  2. Ventricular Vascular Coupling: Correlates and Prognosis
    Vasan Ramachandran; Fiscal Year: 2009
  3. Biomarkers of Metabolic and Vascular Risk in Obesity
    Vasan Ramachandran; Fiscal Year: 2009
  4. Biomarkers of Ventricular and Vascular Remodeling
    Vasan Ramachandran; Fiscal Year: 2009
  5. Genome-wide Association Study of Cardiac Structure and Function
    Vasan Ramachandran; Fiscal Year: 2009
  6. Biomarkers of Metabolic and Vascular Risk in Obesity
    VASAN S RAMACHANDRAN; Fiscal Year: 2010
  7. Biomarkers of Ventricular and Vascular Remodeling
    Vasan Ramachandran; Fiscal Year: 2007
  8. Ventricular Vascular Coupling: Correlates and Prognosis
    Vasan Ramachandran; Fiscal Year: 2007
  9. Genetics of Oxidative Stress in Ventricular Remodeling
    Vasan Ramachandran; Fiscal Year: 2002
  10. Ventricular Matrix Remodeling: Correlates and Prognosis
    Vasan Ramachandran; Fiscal Year: 2002

Detail Information

Publications129 found, 100 shown here

  1. pmc Metabolic syndrome and inflammatory biomarkers: a community-based cross-sectional study at the Framingham Heart Study
    Dhayana Dallmeier
    National Heart, Lung, and Blood Institute s and Boston University s Framingham Heart Study, Framingham, USA
    Diabetol Metab Syndr 4:28. 2012
    ..abstract:..
  2. pmc Correlation of renin angiotensin and aldosterone system activity with subcutaneous and visceral adiposity: the framingham heart study
    Conall M O'Seaghdha
    National Heart, Lung and Blood Institute s Framingham Heart Study, 73 Mt, Wayte Avenue Suite 2, Framingham, MA, USA
    BMC Endocr Disord 12:3. 2012
    ..abstract:..
  3. pmc Circulating vascular growth factors and central hemodynamic load in the community
    Justin P Zachariah
    Framingham Heart Study, 73 Mount Wayte Ave, Framingham, MA 01702 5803, USA
    Hypertension 59:773-9. 2012
    ....
  4. pmc Nicotinic acetylcholine receptor subunit variants are associated with blood pressure; findings in the Old Order Amish and replication in the Framingham Heart Study
    Patrick F McArdle
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    BMC Med Genet 9:67. 2008
    ..We assessed the role of genetic variation in three subunits of the neuromuscular nicotinic acetylcholine receptor positioned on chromosome 2q, a region showing replicated evidence of linkage to blood pressure...
  5. pmc The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports
    L Adrienne Cupples
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S1. 2007
    ....
  6. pmc Genome-wide association with select biomarker traits in the Framingham Heart Study
    Emelia J Benjamin
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S11. 2007
    ..Genome-wide association studies (GWAS) provide mechanisms to investigate the genetic contributions to biomarker variability unconstrained by current knowledge of physiological relations...
  7. pmc Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project
    Caroline S Fox
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S18. 2007
    ..We tested for association between SNPs on the Affymetrix 100K SNP GeneChip and measures of adiposity in the Framingham Heart Study...
  8. pmc Phenotype-genotype association grid: a convenient method for summarizing multiple association analyses
    Daniel Levy
    National Heart, Lung, and Blood Institute, Bethesda, MD, USA
    BMC Genet 7:30. 2006
    ..Hundreds of statistical tests may be performed for a single SNP, thereby complicating interpretation of results and inhibiting identification of patterns of association...
  9. ncbi request reprint Clinical utility of different lipid measures for prediction of coronary heart disease in men and women
    Erik Ingelsson
    Framingham Heart Study, 73 Mount Wayte Ave, Suite 2, Framingham, MA 01702 5803
    JAMA 298:776-85. 2007
    ..Evidence is conflicting regarding the performance of apolipoproteins vs traditional lipids for predicting coronary heart disease (CHD) risk...
  10. ncbi request reprint Relative importance of borderline and elevated levels of coronary heart disease risk factors
    Ramachandran S Vasan
    Framingham Heart Study, Framingham, Massachusetts 01702 5803, USA
    Ann Intern Med 142:393-402. 2005
    ..Clinical trials indicate that a sizable proportion of adults have multiple borderline coronary risk factors and may benefit from treatment...
  11. ncbi request reprint Estimated risks for developing obesity in the Framingham Heart Study
    Ramachandran S Vasan
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham 01702 5803, USA
    Ann Intern Med 143:473-80. 2005
    ..The short- and long-term risks for developing overweight or obesity are unknown...
  12. pmc Association of leukocyte telomere length with circulating biomarkers of the renin-angiotensin-aldosterone system: the Framingham Heart Study
    Ramachandran S Vasan
    Framingham Heart Study of the National Heart, Lung, and Blood Institute, Framingham, MA 01702 5827, USA
    Circulation 117:1138-44. 2008
    ..Activation of the renin-angiotensin-aldosterone system is associated with increased oxidative stress and inflammation. Therefore, LTL may be related to circulating biomarkers of the renin-angiotensin-aldosterone system...
  13. pmc Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study
    Ramachandran S Vasan
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S2. 2007
    ..We conducted a genome-wide association study (GWAS) in the community-based Framingham Heart Study...
  14. ncbi request reprint Relations of serum uric acid to longitudinal blood pressure tracking and hypertension incidence
    Johan Sundstrom
    The Framingham Heart Study, Framingham, Mass 01702 5803, USA
    Hypertension 45:28-33. 2005
    ..02) and diastolic pressure 4 years later (P=0.04). In summary, serum UA level was an independent predictor of hypertension incidence and longitudinal BP progression at short-term follow-up in our community-based sample...
  15. pmc Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data
    Ramachandran S Vasan
    Framingham Heart Study, 73 Mt Wayte Ave, Ste 2, Framingham, MA 01702 5827, USA
    JAMA 302:168-78. 2009
    ..Echocardiographic measures of left ventricular (LV) structure and function are heritable phenotypes of cardiovascular disease...
  16. pmc Association of circulating cholesteryl ester transfer protein activity with incidence of cardiovascular disease in the community
    Ramachandran S Vasan
    Framingham Heart Study, 73 Mount Wayte Ave, Framingham, MA 01702 5803, USA
    Circulation 120:2414-20. 2009
    ..Data relating circulating CETP concentrations to CVD incidence in the community are conflicting...
  17. ncbi request reprint Biomarkers of cardiovascular disease: molecular basis and practical considerations
    Ramachandran S Vasan
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Department of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, MA, USA
    Circulation 113:2335-62. 2006
  18. ncbi request reprint Serum aldosterone and the incidence of hypertension in nonhypertensive persons
    Ramachandran S Vasan
    National Heart, Lung, and Blood Institute Framingham Heart Study, Framingham, Mass 01702 5827, USA
    N Engl J Med 351:33-41. 2004
    ..Primary hyperaldosteronism is a well-recognized cause of secondary hypertension. It is unknown whether serum aldosterone levels within the physiologic range influence the risk of hypertension...
  19. pmc Association of leukocyte telomere length with echocardiographic left ventricular mass: the Framingham heart study
    Ramachandran S Vasan
    Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, MA 01702 5827, USA
    Circulation 120:1195-202. 2009
    ..Left ventricular (LV) mass is a biomarker of long-standing exposure to cardiovascular disease risk factors. We hypothesized that LTL is related inversely to LV mass...
  20. pmc Overweight, obesity, and the development of stage 3 CKD: the Framingham Heart Study
    Meredith C Foster
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA, USA
    Am J Kidney Dis 52:39-48. 2008
    ..Prior research yielded conflicting results about the magnitude of the association between body mass index (BMI) and chronic kidney disease (CKD)...
  21. ncbi request reprint Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level
    Sekar Kathiresan
    Framingham Heart Study, Framingham, MA 01702 5827, USA
    Circulation 113:1415-23. 2006
    ..Serum C-reactive protein (CRP) level is a heritable complex trait that predicts incident cardiovascular disease. We investigated the clinical and genetic sources of interindividual variability in serum CRP...
  22. pmc Cross-sectional relations of multiple biomarkers representing distinct biological pathways to plasma markers of collagen metabolism in the community
    Jacob Joseph
    Cardiology Section 111, VA Boston Healthcare System, Boston, Massachusetts, USA
    J Hypertens 27:1317-24. 2009
    ..Hence, we related a panel of biomarkers representing these pathways to plasma markers of collagen metabolism in a large community-based sample...
  23. ncbi request reprint Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
    Circulation 116:39-48. 2007
    ..The incremental utility of measuring both visceral and subcutaneous abdominal adipose tissue (SAT) in association with metabolic risk factors and underlying heritability has not been well described in a population-based setting...
  24. pmc Adiposity, cardiometabolic risk, and vitamin D status: the Framingham Heart Study
    Susan Cheng
    Framingham Heart Study, Framingham, Massachusetts, USA
    Diabetes 59:242-8. 2010
    ..Few studies relating vitamin D deficiency to obesity have included direct measures of adiposity. Furthermore, the degree to which vitamin D is associated with metabolic traits after adjusting for adiposity measures is unclear...
  25. pmc Multimarker approach to evaluate correlates of vascular stiffness: the Framingham Heart Study
    Wolfgang Lieb
    Framingham Heart Study, Framingham, MA, USA
    Circulation 119:37-43. 2009
    ..Knowledge about the pathophysiological processes that determine arterial stiffness may help guide therapeutic approaches...
  26. pmc Associations of long-term and early adult atherosclerosis risk factors with aortic and mitral valve calcium
    George Thanassoulis
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    J Am Coll Cardiol 55:2491-8. 2010
    ..To determine the association of long-term exposure to atherosclerosis risk factors with valvular calcification...
  27. pmc Relations of biomarkers representing distinct biological pathways to left ventricular geometry
    Raghava S Velagaleti
    Framingham Heart Study, 73 Mount Wayte Ave, Framingham, MA 01702 5803, USA
    Circulation 118:2252-8, 5p following 2258. 2008
    ..Several biological pathways are activated concomitantly during left ventricular (LV) remodeling. However, the relative contribution of circulating biomarkers representing these distinct pathways to LV geometry is unclear...
  28. pmc Aortic root remodeling over the adult life course: longitudinal data from the Framingham Heart Study
    Carolyn S P Lam
    Framingham Heart Study, Framingham, MA 01702 5803, USA
    Circulation 122:884-90. 2010
    ..Aortic root remodeling in adulthood is known to be associated with cardiovascular outcomes. However, there is a lack of longitudinal data defining the clinical correlates of aortic root remodeling over the adult life course...
  29. pmc Altered blood pressure progression in the community and its relation to clinical events
    Erik Ingelsson
    Framingham Heart Study, 73 Mount Wayte Ave, Ste 2, Framingham, MA 01702 5803, USA
    Arch Intern Med 168:1450-7. 2008
    ..Long-term blood pressure (BP) progression and its importance as a predictor of clinical outcome have not been well characterized across different periods...
  30. ncbi request reprint Association of parental heart failure with risk of heart failure in offspring
    Douglas S Lee
    Framingham Heart Study of the National Heart, Lung, and Blood Institute, Framingham, Mass, USA
    N Engl J Med 355:138-47. 2006
    ..The association between heart failure in parents and the prevalence of left ventricular systolic dysfunction and the risk of heart failure in their offspring has not been investigated in a community-based setting...
  31. pmc Age trends in estradiol and estrone levels measured using liquid chromatography tandem mass spectrometry in community-dwelling men of the Framingham Heart Study
    Guneet Kaur Jasuja
    Department of Mathematics, Boston University, Massachusetts, Boston, MA 02118, USA
    J Gerontol A Biol Sci Med Sci 68:733-40. 2013
    ....
  32. pmc Association of parental hypertension with concentrations of select biomarkers in nonhypertensive offspring
    Wolfgang Lieb
    Framingham Heart Study, 73 Mount Wayte Ave, Framingham, MA 01702 5803, USA
    Hypertension 52:381-6. 2008
    ..In conclusion, serum C-reactive protein concentrations are higher in nonhypertensive offspring of parents with hypertension. These data suggest that inflammation may partly mediate the familial influences on hypertension risk...
  33. pmc Association of parental obesity with concentrations of select systemic biomarkers in nonobese offspring: the Framingham Heart Study
    Wolfgang Lieb
    Framingham Heart Study, Framingham, Massachusetts, USA
    Diabetes 58:134-7. 2009
    ..Parental obesity is a risk factor for offspring obesity. It is unclear whether parental obesity also confers risk for obesity-associated conditions (e.g., a proinflammatory or prothrombotic state) in the absence of offspring obesity...
  34. pmc Multimarker approach for the prediction of heart failure incidence in the community
    Raghava S Velagaleti
    Framingham Heart Study, 73 Mount Wayte Ave, Framingham, MA 01702 5803, USA
    Circulation 122:1700-6. 2010
    ..There are no data, however, on the incremental utility of a parsimonious set of biomarkers (reflecting pathways implicated in HF) for predicting HF risk in the community...
  35. pmc Relations of serum phosphorus levels to echocardiographic left ventricular mass and incidence of heart failure in the community
    Ravi Dhingra
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mount Wayte Avenue, Suite 2, Framingham, MA, USA
    Eur J Heart Fail 12:812-8. 2010
    ..To evaluate the association of serum phosphorus with cardiac structure/function and incident heart failure...
  36. ncbi request reprint Characteristics of Framingham offspring participants with long-lived parents
    Dellara F Terry
    Boston University School of Medicine, Geriatrics Section, Boston Medical Center, 88 E Newton St, Robinson 2, Boston, MA 02118, USA
    Arch Intern Med 167:438-44. 2007
    ..Prior research has suggested that delay or avoidance of cardiovascular disease and cardiovascular disease risk factors plays an important role in longevity...
  37. pmc Galectin 3 and incident atrial fibrillation in the community
    Jennifer E Ho
    Boston University and the National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA Section of Cardiovascular Medicine, Department of Medicine, Boston University, Boston, MA Electronic address
    Am Heart J 167:729-734.e1. 2014
    ..The same mechanisms that lead to cardiac fibrosis in heart failure may influence development of atrial fibrosis and atrial fibrillation (AF). We examined the association of Gal-3 and incident AF in the community...
  38. pmc Risk assessment for incident heart failure in individuals with atrial fibrillation
    Renate B Schnabel
    NHLBI s and Boston University s Framingham Heart Study, Framingham, MA, USA
    Eur J Heart Fail 15:843-9. 2013
    ..Risk factors that predict HF in individuals with AF in the community are not well established...
  39. ncbi request reprint Temporal relations of atrial fibrillation and congestive heart failure and their joint influence on mortality: the Framingham Heart Study
    Thomas J Wang
    Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, Mass 01702 5827, USA
    Circulation 107:2920-5. 2003
    ..Atrial fibrillation (AF) and congestive heart failure (CHF) frequently occur together, but there is limited information regarding their temporal relations and the combined influence of these conditions on mortality...
  40. pmc Aminotransferase levels are associated with cardiometabolic risk above and beyond visceral fat and insulin resistance: the Framingham Heart Study
    Stacy A Porter
    Center for Population Studies, National Heart, Lung, and Blood Institute, Framingham, MA, USA
    Arterioscler Thromb Vasc Biol 33:139-46. 2013
    ..We sought to characterize associations between aminotransferase levels and cardiometabolic risk after accounting for visceral adipose tissue and insulin resistance...
  41. pmc Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes
    Martin G Larson
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S5. 2007
    ..Prior investigations have reported several single gene variants associated with CHD, stroke, HF, and AF. We report a community-based genome-wide association study of major CVD outcomes...
  42. ncbi request reprint Multimarker approach to evaluate the incidence of the metabolic syndrome and longitudinal changes in metabolic risk factors: the Framingham Offspring Study
    Erik Ingelsson
    Framingham Heart Study, Boston University School of Medicine, Framingham, MA 01702 5803, USA
    Circulation 116:984-92. 2007
    ..We evaluated the relative contributions of circulating biomarkers representing distinct biological pathways to the incidence of MetS and to longitudinal changes of its constituent risk factors...
  43. pmc A multi-marker approach to predict incident CKD and microalbuminuria
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mount Wayte Avenue, Suite 2, Framingham, MA 01702, USA
    J Am Soc Nephrol 21:2143-9. 2010
    ..In conclusion, circulating homocysteine, aldosterone, and BNP provide incremental information regarding risk for incident CKD and MA beyond traditional risk factors...
  44. ncbi request reprint Mitral annular calcification is a predictor for incident atrial fibrillation
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, MA 01702 5827, USA
    Atherosclerosis 173:291-4. 2004
    ..Mitral annular calcification (MAC) has been associated with adverse cardiovascular disease outcomes and stroke in longitudinal and community-based cohorts. Prospective data are limited on its association with atrial fibrillation (AF)...
  45. pmc Multiple inflammatory biomarkers in relation to cardiovascular events and mortality in the community
    Renate B Schnabel
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA, USA
    Arterioscler Thromb Vasc Biol 33:1728-33. 2013
    ..Evidence suggests that chronic low-grade inflammation and oxidative stress are related to cardiovascular disease (CVD) and mortality...
  46. pmc Pericardial fat is associated with prevalent atrial fibrillation: the Framingham Heart Study
    George Thanassoulis
    Framingham Heart Study, Boston University and the National Institutes of Health National Heart, Lung, and Blood Institute, 73 Mt Wayte Ave No 2, Framingham, MA 01702, USA
    Circ Arrhythm Electrophysiol 3:345-50. 2010
    ..We tested the hypothesis that pericardial fat, a unique fat deposit in close anatomic proximity to cardiac structures and autonomic fibers, is associated with prevalent AF...
  47. pmc Relations of exercise blood pressure response to cardiovascular risk factors and vascular function in the Framingham Heart Study
    George Thanassoulis
    National Institutes of Health National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702, USA
    Circulation 125:2836-43. 2012
    ..Although impaired vascular function is hypothesized to influence the BP response during exercise, limited data exist on the association of vascular function with exercise BP in the community...
  48. pmc Circulating angiogenic cell populations, vascular function, and arterial stiffness
    Susan Cheng
    Framingham Heart Study, Framingham, MA 02118, United States
    Atherosclerosis 220:145-50. 2012
    ..We examined the extent to which lower quantities of these circulating angiogenic cell phenotypes may be related to impaired vascular function and greater arterial stiffness...
  49. ncbi request reprint Natural history of asymptomatic left ventricular systolic dysfunction in the community
    Thomas J Wang
    Framingham Heart Study, Framingham, MA 01702 5827, USA
    Circulation 108:977-82. 2003
    ..We sought to characterize the natural history of ALVD, by studying unselected individuals with this condition in the community...
  50. ncbi request reprint Plasma natriuretic peptide levels and the risk of cardiovascular events and death
    Thomas J Wang
    Framingham Heart Study, Framingham, MA 01702 5827, USA
    N Engl J Med 350:655-63. 2004
    ..The prognostic significance of plasma natriuretic peptide levels in apparently asymptomatic persons has not been established...
  51. pmc Plasma asymmetric dimethylarginine, L-arginine and left ventricular structure and function in a community-based sample
    Wolfgang Lieb
    Framingham Heart Study, Boston University School of Medicine, Framingham, MA 01702 5803, USA
    Atherosclerosis 204:282-7. 2009
    ..It is unclear if circulating ADMA and L-arginine levels are related to cardiac structure and function in the general population...
  52. ncbi request reprint A risk score for predicting near-term incidence of hypertension: the Framingham Heart Study
    Nisha I Parikh
    Framingham Heart Study, Framingham, Massachusetts 01702 5803, USA
    Ann Intern Med 148:102-10. 2008
    ..Risk stratification may facilitate cost-effective approaches to management...
  53. ncbi request reprint Association of estrogen receptor beta gene polymorphisms with left ventricular mass and wall thickness in women
    Inga Peter
    Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Am J Hypertens 18:1388-95. 2005
    ..Given sex-based differences in cardiac structure and remodeling, we hypothesized that variation in estrogen pathway genes might be associated with alteration of LV structure...
  54. pmc Biomarkers of the osteoprotegerin pathway: clinical correlates, subclinical disease, incident cardiovascular disease, and mortality
    Wolfgang Lieb
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
    Arterioscler Thromb Vasc Biol 30:1849-54. 2010
    ..Experimental evidence identified the osteoprotegerin (OPG)/receptor activator of nuclear factor-kappaB (RANK)/RANK ligand (RANKL) pathway as a candidate system modulating vascular remodeling and cardiovascular disease (CVD)...
  55. pmc Association of visceral and subcutaneous adiposity with kidney function
    Jill A Young
    Tufts New England Medical Center, Boston, Massachusetts, USA
    Clin J Am Soc Nephrol 3:1786-91. 2008
    ..Visceral (VAT) and subcutaneous adipose tissue (SAT) may confer differential metabolic risk profiles. The relations of VAT and SAT were analyzed with CKD as estimated by creatinine- and cystatin-based estimating equations...
  56. pmc Cardiac dysfunction and noncardiac dysfunction as precursors of heart failure with reduced and preserved ejection fraction in the community
    Carolyn S P Lam
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702 5803, USA
    Circulation 124:24-30. 2011
    ..We hypothesized that subclinical cardiac and noncardiac organ dysfunction would accelerate the manifestation of HF...
  57. ncbi request reprint Soft drink consumption and risk of developing cardiometabolic risk factors and the metabolic syndrome in middle-aged adults in the community
    Ravi Dhingra
    Framingham Heart Study, 73 Mount Wayte Ave, Suite 2, Framingham, MA 01702 5803, USA
    Circulation 116:480-8. 2007
    ..Consumption of soft drinks has been linked to obesity in children and adolescents, but it is unclear whether it increases metabolic risk in middle-aged individuals...
  58. pmc Segment-specific association between plasma homocysteine level and carotid artery intima-media thickness in the Framingham Offspring Study
    Marion Dietrich
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    J Stroke Cerebrovasc Dis 20:155-61. 2011
    ..For CCA-IMT, no significant trends were observed in any of the analyses. The segment-specific association between elevated tHcy level and ICA/bulb-IMT suggests an association between tHcy and plaque formation...
  59. pmc Association of sex hormones, aging, and atrial fibrillation in men: the Framingham Heart Study
    Jared W Magnani
    National Heart, Lung, and Blood Institute s and Boston University s Framingham Heart Study, Boston, MA
    Circ Arrhythm Electrophysiol 7:307-12. 2014
    ..Endogenous sex hormones have been related to cardiovascular outcomes and mortality. We hypothesized that sex hormones are related to atrial fibrillation (AF) in a community-based cohort of middle-aged to older men...
  60. ncbi request reprint Relations of inflammation and novel risk factors to valvular calcification
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Cardiol 97:1502-5. 2006
    ..In conclusion, inflammatory markers were elevated in patients with valvular calcium. Our findings suggest that much of the observed association between systemic inflammatory markers and valvular calcium may be due to shared risk factors...
  61. pmc Multiple biomarkers and risk of clinical and subclinical vascular brain injury: the Framingham Offspring Study
    Aleksandra Pikula
    Boston University Schools of Medicine and Public Health, MA, USA
    Circulation 125:2100-7. 2012
    ....
  62. pmc Higher aldosterone and lower N-terminal proatrial natriuretic peptide as biomarkers of salt sensitivity in the community
    Wolfgang Lieb
    Framingham Heart Study, Framingham, MA, USA
    Eur J Cardiovasc Prev Rehabil 18:664-73. 2011
    ..Recent experimental studies have highlighted the potential role of the natriuretic peptides and aldosterone in mediating salt sensitivity...
  63. pmc Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness
    Daniel Levy
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S3. 2007
    ..Increased arterial stiffness is a key factor in the pathogenesis of systolic hypertension and cardiovascular disease. Substantial heritability of blood-pressure (BP) and arterial-stiffness suggests important genetic contributions...
  64. pmc Long-term trends in myocardial infarction incidence and case fatality in the National Heart, Lung, and Blood Institute's Framingham Heart study
    Nisha I Parikh
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702 5803, USA
    Circulation 119:1203-10. 2009
    ..We hypothesized that this paradox is due partly to the advent of increasingly sensitive biomarkers for AMI diagnosis...
  65. ncbi request reprint Brachial artery vasodilator function and systemic inflammation in the Framingham Offspring Study
    Joseph A Vita
    Evans Memorial Department of Medicine, Boston University School of Medicine, Boston, Mass, USA
    Circulation 110:3604-9. 2004
    ..The precise relations among risk factors, inflammation, and nitric oxide bioavailability remain uncertain...
  66. ncbi request reprint Multiple biomarkers for the prediction of first major cardiovascular events and death
    Thomas J Wang
    Framingham Heart Study, Framingham, MA, USA
    N Engl J Med 355:2631-9. 2006
    ..Few investigations have evaluated the incremental usefulness of multiple biomarkers from distinct biologic pathways for predicting the risk of cardiovascular events...
  67. pmc Association of carotid artery atherosclerosis with circulating biomarkers of extracellular matrix remodeling: the Framingham Offspring Study
    Jose R Romero
    Department of Neurology, School of Medicine, Boston University, Boston, Massachusetts 02118 2526, USA
    J Stroke Cerebrovasc Dis 17:412-7. 2008
    ..We sought to relate circulating biomarkers of extracellular matrix turnover to site-specific measures of carotid artery atherosclerosis on duplex ultrasound...
  68. pmc Relation of multiple inflammatory biomarkers to incident atrial fibrillation
    Renate B Schnabel
    National Heart Lung Blood Institute Framingham Study, Framingham, MA, USA
    Am J Cardiol 104:92-6. 2009
    ..18, 95% confidence interval 0.98 to 1.43, p = 0.09). In conclusion, circulating osteoprotegerin concentration was significantly associated with incident AF in our community-based sample, possibly mediated by interim cardiovascular events...
  69. pmc Carotid artery atherosclerosis, MRI indices of brain ischemia, aging, and cognitive impairment: the Framingham study
    Jose R Romero
    Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA
    Stroke 40:1590-6. 2009
    ..The relation of carotid atherosclerosis to cognitive impairment and MRI indices of ischemia and aging in midlife is less clear...
  70. pmc Clinical and genetic factors associated with lipoprotein-associated phospholipase A2 in the Framingham Heart Study
    Renate Schnabel
    The NHLBI s Framingham Heart Study, Framingham, MA 01702 5827, USA
    Atherosclerosis 204:601-7. 2009
    ..Higher circulating Lp-PLA(2) predicts cardiovascular disease risk, but sources of inter-individual variability are incompletely understood...
  71. pmc Brachial artery diameter, blood flow and flow-mediated dilation in sleep-disordered breathing
    Hassan A Chami
    Department of Medicine, Boston University School of Medicine, The Pulmonary Center, VA Boston Healthcare System, Boston, MA 02118, USA
    Vasc Med 14:351-60. 2009
    ..This study does not support a link between SDB and endothelial dysfunction as measured by brachial artery flow-mediated dilation...
  72. ncbi request reprint Prevalence and prognostic impact of subclinical cardiovascular disease in individuals with the metabolic syndrome and diabetes
    Erik Ingelsson
    National Heart, Lung, and Blood Institute s Framingham Study, Framingham, Massachusetts 01702 5803, USA
    Diabetes 56:1718-26. 2007
    ..93 [1.15-3.24]). In our community-based sample, individuals with MetS have a high prevalence of subclinical atherosclerosis that likely contributes to the increased risk of overt CVD associated with the condition...
  73. pmc Relations of inflammatory biomarkers and common genetic variants with arterial stiffness and wave reflection
    Renate Schnabel
    National Heart Lung and Blood Institute Framingham Study, Framingham, Mass, USA
    Hypertension 51:1651-7. 2008
    ..Additional studies are needed to determine whether variation in inflammatory marker genes is associated with tonometry measures...
  74. pmc Relations of biomarkers of extracellular matrix remodeling to incident cardiovascular events and mortality
    Raghava S Velagaleti
    Framingham Heart Study, 73 Mount Wayte Ave, Framingham, MA 01702 58, USA
    Arterioscler Thromb Vasc Biol 30:2283-8. 2010
    ..To evaluate if biomarkers reflecting left ventricular/vascular extracellular matrix remodeling are associated with cardiovascular disease (CVD) and death in the community...
  75. pmc Metabolic syndrome, insulin resistance, and brachial artery vasodilator function in Framingham Offspring participants without clinical evidence of cardiovascular disease
    Naomi M Hamburg
    Evans Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    Am J Cardiol 101:82-8. 2008
    ..In conclusion, our observations are consistent with the hypothesis that MS and insulin resistance impair vascular function predominantly through the influence of the component metabolic abnormalities that comprise MS...
  76. pmc Pericardial fat volume correlates with inflammatory markers: the Framingham Heart Study
    Thomas M Tadros
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Boston, Massachusetts, USA
    Obesity (Silver Spring) 18:1039-45. 2010
    ..Multiple markers of inflammation and oxidative stress correlated with pericardial and intrathoracic fat volumes, extending the known association between regional adiposity and inflammation and oxidative stress...
  77. ncbi request reprint Cross-sectional association of kidney function with valvular and annular calcification: the Framingham heart study
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, 73 Mount Wayte Avenue, Framingham, MA 01702, USA
    J Am Soc Nephrol 17:521-7. 2006
    ..Further research is warranted to understand whether traditional and novel vascular risk factor burden, as well as metabolic derangements found in early kidney disease, can account for the CKD-MAC association...
  78. pmc Relation of QRS width in healthy persons to risk of future permanent pacemaker implantation
    Susan Cheng
    Framingham Heart Study, Massachusetts, USA
    Am J Cardiol 106:668-72. 2010
    ..In conclusion, subjects with prolonged QRS durations, even without bundle branch block, are at increased risk for future pacemaker implantation. Such individuals may warrant monitoring for progressive conduction disease...
  79. ncbi request reprint Heritability and correlates of intercellular adhesion molecule-1 in the Framingham Offspring Study
    John F Keaney
    Evans Memorial Department of Medicine, Boston University School of Medicine, Massachusetts 02118, USA
    J Am Coll Cardiol 44:168-73. 2004
    ..We sought to determine the clinical factors and heritability associated with inflammation measured as circulating levels of soluble-intercellular adhesion molecule-1 (sICAM-1) in a community-based cohort...
  80. pmc Cardiac natriuretic peptides, obesity, and insulin resistance: evidence from two community-based studies
    Abigail May Khan
    Cardiology Division, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 96:3242-9. 2011
    ..It has been suggested that obesity promotes a relative natriuretic peptide deficiency, but this has been a variable finding in prior studies and the cause is unknown...
  81. pmc Prevalence, distribution, and risk factor correlates of high pericardial and intrathoracic fat depots in the Framingham heart study
    George Thanassoulis
    National Institutes of Health National Heart, Lung, and Blood Institute, Framingham Heart Study, Framingham, MA, Boston, USA
    Circ Cardiovasc Imaging 3:559-66. 2010
    ..We sought to determine the prevalence, distribution, and risk factor correlates of high pericardial and intrathoracic fat deposits...
  82. ncbi request reprint Risk factors for heart failure
    Satish Kenchaiah
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702, USA
    Med Clin North Am 88:1145-72. 2004
    ....
  83. ncbi request reprint Common genetic variation at the endothelial nitric oxide synthase locus and relations to brachial artery vasodilator function in the community
    Sekar Kathiresan
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA, USA
    Circulation 112:1419-27. 2005
    ..Sequence variants at the endothelial nitric oxide synthase (NOS3) locus have been associated with endothelial function measures, but replication has been limited...
  84. ncbi request reprint Assessment of cardiovascular risk and choice of antihypertensive therapy
    William B Kannel
    Boston University School of Medicine, 73 Mt Wayte Avenue, Suite 2, Framingham, MA 01702, USA
    Curr Hypertens Rep 6:346-51. 2004
    ..They require weight control and exercise, as well as specific choices of antihypertensive agents...
  85. ncbi request reprint Plasma natriuretic peptides for community screening for left ventricular hypertrophy and systolic dysfunction: the Framingham heart study
    Ramachandran S Vasan
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, MA 01702, USA
    JAMA 288:1252-9. 2002
    ..Prior studies were limited by small sample sizes and selection bias and none compared the diagnostic performance of these peptides in men and women...
  86. ncbi request reprint Impact of obesity on the risk of heart failure and survival after the onset of heart failure
    Satish Kenchaiah
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702, USA
    Med Clin North Am 88:1273-94. 2004
    ....
  87. ncbi request reprint Obstructive sleep apnea and plasma natriuretic peptide levels in a community-based sample
    Anjali A Patwardhan
    Boston University School of Medicine, Boston, MA, USA
    Sleep 29:1301-6. 2006
    ..We examined the association of OSAH with natriuretic peptides in a community-based sample...
  88. ncbi request reprint Association of oxidative stress, insulin resistance, and diabetes risk phenotypes: the Framingham Offspring Study
    James B Meigs
    General Medicine Division and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Diabetes Care 30:2529-35. 2007
    ..Systemic oxidative stress causes insulin resistance in rodents. We tested the hypothesis that oxidative stress and insulin resistance are associated in humans...
  89. ncbi request reprint Cross-sectional correlates of serum heat shock protein 70 in the community
    Ravi Dhingra
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Hypertens 19:227-31; discussion 232-3. 2006
    ..It is unclear whether circulating heat shock protein 70 (HSP70) levels are related to CVD risk factors, echocardiographic indexes of left ventricular (LV) remodeling, and prevalent CVD in the population...
  90. pmc Aortic root diameter and longitudinal blood pressure tracking
    Erik Ingelsson
    Framingham Heart Study, Boston University School of Medicine, Framingham, Massachusetts 01702 5803, USA
    Hypertension 52:473-7. 2008
    ..Our prospective study does not support the notion that a smaller AoR predisposes to hypertension...
  91. pmc Cross-sectional relations of lipid concentrations to left ventricular structural attributes
    Raghava S Velagaleti
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    Am J Cardiol 105:1297-9. 2010
    ..In conclusion, these data do not support an independent association between lipid concentrations and left ventricular structure...
  92. ncbi request reprint Lifetime risk for developing congestive heart failure: the Framingham Heart Study
    Donald M Lloyd-Jones
    National Heart, Lung, and Blood Institute s Framingham Heart Study, National Institutes of Health, Framingham, MA 01702, USA
    Circulation 106:3068-72. 2002
    ..Congestive heart failure (CHF) is an increasing public health problem...
  93. ncbi request reprint Usefulness of exercise testing in the prediction of coronary disease risk among asymptomatic persons as a function of the Framingham risk score
    Gary J Balady
    NHLBI s Framingham Heart Study, Framingham, Mass, USA
    Circulation 110:1920-5. 2004
    ..The purpose of this study is to determine the usefulness of exercise treadmill testing (ETT) among asymptomatic persons in predicting coronary heart disease (CHD) events over and above the Framingham CHD risk score...
  94. ncbi request reprint Increasing cardiovascular disease burden due to diabetes mellitus: the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, MA 01702 5827, USA
    Circulation 115:1544-50. 2007
    ..We tested the hypothesis that the relative burden of CVD attributable to diabetes mellitus (DM) has increased over the past 5 decades...
  95. ncbi request reprint Cross-sectional relations of multiple biomarkers from distinct biological pathways to brachial artery endothelial function
    Sekar Kathiresan
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702 5827, USA
    Circulation 113:938-45. 2006
    ..We evaluated the relative contributions of distinct biological pathways to interindividual variation in endothelial function by relating prototype biomarkers (representing these pathways) to brachial artery vasodilator function...
  96. ncbi request reprint Variation in estrogen-related genes and cross-sectional and longitudinal blood pressure in the Framingham Heart Study
    Inga Peter
    Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Massachusetts Institute of Technology, Cambridge, MA, USA
    J Hypertens 23:2193-200. 2005
    ..To examine the association between variation in estrogen-related genes and cross-sectional and longitudinal blood pressure in men and women...
  97. pmc Correlates of echocardiographic indices of cardiac remodeling over the adult life course: longitudinal observations from the Framingham Heart Study
    Susan Cheng
    The Framingham Heart Study, Framingham, MA 01702 5803, USA
    Circulation 122:570-8. 2010
    ..The heart progressively remodels over the life course, yet longitudinal data characterizing such remodeling in the community are limited...
  98. pmc Vitamin K and vitamin D status: associations with inflammatory markers in the Framingham Offspring Study
    M Kyla Shea
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Epidemiol 167:313-20. 2008
    ..The observation that high vitamin K status was associated with lower concentrations of inflammatory markers suggests that a possible protective role for vitamin K in inflammation merits further investigation...
  99. ncbi request reprint Increasing trends in incidence of overweight and obesity over 5 decades
    Nisha I Parikh
    Framingham Heart Study, Framingham, Mass 01702 5803, USA
    Am J Med 120:242-50. 2007
    ..We evaluated trends in the incidence of overweight and obesity over the past 50 years...
  100. ncbi request reprint Maternal influence on blood pressure suggests involvement of mitochondrial DNA in the pathogenesis of hypertension: the Framingham Heart Study
    Qiong Yang
    Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA
    J Hypertens 25:2067-73. 2007
    ..To investigate the contribution of the mitochondrial genome to hypertension and quantitative blood pressure (BP) phenotypes in the Framingham Heart Study cohort, a randomly ascertained, community-based sample...
  101. pmc Plasma leptin levels and incidence of heart failure, cardiovascular disease, and total mortality in elderly individuals
    Wolfgang Lieb
    Framingham Heart Study, Framingham, Massachusetts, USA
    Diabetes Care 32:612-6. 2009
    ..We tested the hypothesis that leptin levels are associated with greater risk of CHF, CVD, and mortality in elderly individuals...

Research Grants24

  1. Ventricular Matrix Remodeling: Correlates and Prognosis
    Vasan Ramachandran; Fiscal Year: 2001
    ..The proposed translational research will likely yield seminal information that could directly improve our efforts to prevent CHF through the biochemical assessment of cardiac ECM remodeling. ..
  2. Ventricular Vascular Coupling: Correlates and Prognosis
    Vasan Ramachandran; Fiscal Year: 2009
    ..LV and vascular stiffness measures at prior examinations facilitate the evaluation of longitudinal changes and associated risk. ..
  3. Biomarkers of Metabolic and Vascular Risk in Obesity
    Vasan Ramachandran; Fiscal Year: 2009
    ....
  4. Biomarkers of Ventricular and Vascular Remodeling
    Vasan Ramachandran; Fiscal Year: 2009
    ..Our proposal will advance understanding of the role of vascular growth factors in initiating and promoting vascular stiffness, LV dysfunction and HTN. ..
  5. Genome-wide Association Study of Cardiac Structure and Function
    Vasan Ramachandran; Fiscal Year: 2009
    ..These analyses will likely identify genetic risk factors for cardiac alterations that in turn predispose individuals to heart failure. ..
  6. Biomarkers of Metabolic and Vascular Risk in Obesity
    VASAN S RAMACHANDRAN; Fiscal Year: 2010
    ....
  7. Biomarkers of Ventricular and Vascular Remodeling
    Vasan Ramachandran; Fiscal Year: 2007
    ..Our proposal will advance understanding of the role of vascular growth factors in initiating and promoting vascular stiffness, LV dysfunction and HTN. ..
  8. Ventricular Vascular Coupling: Correlates and Prognosis
    Vasan Ramachandran; Fiscal Year: 2007
    ..LV and vascular stiffness measures at prior examinations facilitate the evaluation of longitudinal changes and associated risk. ..
  9. Genetics of Oxidative Stress in Ventricular Remodeling
    Vasan Ramachandran; Fiscal Year: 2002
    ....
  10. Ventricular Matrix Remodeling: Correlates and Prognosis
    Vasan Ramachandran; Fiscal Year: 2002
    ..The proposed translational research will likely yield seminal information that could directly improve our efforts to prevent CHF through the biochemical assessment of cardiac ECM remodeling. ..
  11. Genetics of Oxidative Stress in Ventricular Remodeling
    Vasan Ramachandran; Fiscal Year: 2003
    ....
  12. Ventricular Matrix Remodeling: Correlates and Prognosis
    Vasan Ramachandran; Fiscal Year: 2003
    ..The proposed translational research will likely yield seminal information that could directly improve our efforts to prevent CHF through the biochemical assessment of cardiac ECM remodeling. ..
  13. Ventricular Matrix Remodeling: Correlates and Prognosis
    Vasan Ramachandran; Fiscal Year: 2004
    ..The proposed translational research will likely yield seminal information that could directly improve our efforts to prevent CHF through the biochemical assessment of cardiac ECM remodeling. ..
  14. Ventricular Vascular Coupling: Correlates and Prognosis
    Vasan Ramachandran; Fiscal Year: 2005
    ..LV and vascular stiffness measures at prior examinations facilitate the evaluation of longitudinal changes and associated risk. ..
  15. Biomarkers of Ventricular and Vascular Remodeling
    Vasan Ramachandran; Fiscal Year: 2005
    ..Our proposal will advance understanding of the role of vascular growth factors in initiating and promoting vascular stiffness, LV dysfunction and HTN. ..
  16. Ventricular Vascular Coupling: Correlates and Prognosis
    Vasan Ramachandran; Fiscal Year: 2006
    ..LV and vascular stiffness measures at prior examinations facilitate the evaluation of longitudinal changes and associated risk. ..
  17. Biomarkers of Ventricular and Vascular Remodeling
    Vasan Ramachandran; Fiscal Year: 2006
    ..Our proposal will advance understanding of the role of vascular growth factors in initiating and promoting vascular stiffness, LV dysfunction and HTN. ..
  18. Aldosterone in Vascular Remodeling and Dysfunction
    Vasan Ramachandran; Fiscal Year: 2007
    ..Activities for career development of the candidate are also planned in the areas of proteomics and genetic epidemiology. ..
  19. Genome-wide Association Study of Cardiac Structure and Function
    VASAN S RAMACHANDRAN; Fiscal Year: 2010
    ..These analyses will likely identify genetic risk factors for cardiac alterations that in turn predispose individuals to heart failure. ..