T E Van Dyke

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi request reprint Enhancing the value of scaling and root-planing: Arestin clinical trial results
    Thomas E Van Dyke
    Boston University School of Dental Medicine, Boston, MA 02118, USA
    J Int Acad Periodontol 4:72-6. 2002
  2. ncbi request reprint The clinical significance of new therapies for the management of periodontal disease
    Thomas E Van Dyke
    Boston University Goldman School of Dental Medicine, 100 E Newton Street, Boston, MA 02118, USA
    J Int Acad Periodontol 7:191-6. 2005
  3. doi request reprint Inflammation and factors that may regulate inflammatory response
    Thomas E Van Dyke
    Department of Periodontology and Oral Biology, Boston University Goldman School of Dental Medicine, 100 E Newton Street, Boston, MA 02118, USA
    J Periodontol 79:1503-7. 2008
  4. doi request reprint Inflammation and periodontal diseases: a reappraisal
    Thomas E Van Dyke
    Department of Periodontology and Oral Biology, Boston University Goldman School of Dental Medicine, 100 E Newton Street, Boston, MA 02118, USA
    J Periodontol 79:1501-2. 2008
  5. ncbi request reprint Combination oxycodone 5 mg/ibuprofen 400 mg for the treatment of postoperative pain: a double-blind, placebo- and active-controlled parallel-group study
    Thomas Van Dyke
    Goldman School of Dental Medicine, Boston University, 100 East Newton Street, Rm 107, Boston, MA 02118, USA
    Clin Ther 26:2003-14. 2004
  6. ncbi request reprint Periodontal diagnosis: evaluation of current concepts and future needs
    T E Van Dyke
    Boston University, Goldman School of Dental Medicine, Boston, MA 02118, USA
    J Int Acad Periodontol 2:71-8. 2000
  7. ncbi request reprint Resolution of inflammation: a new paradigm for the pathogenesis of periodontal diseases
    T E Van Dyke
    Department of Periodontology and Oral Biology, Boston University, Goldman School of Dental Medicine, 100 East Newton Street, Boston, MA 02118, USA
    J Dent Res 82:82-90. 2003
  8. pmc The management of inflammation in periodontal disease
    Thomas E Van Dyke
    Division of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, 100 E Newton Street, Boston, MA 02118, USA
    J Periodontol 79:1601-8. 2008
  9. pmc Risk factors for periodontitis
    Thomas E Van Dyke
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, MA 02118, USA
    J Int Acad Periodontol 7:3-7. 2005
  10. ncbi request reprint Defective calcium influx factor activity in neutrophils from patients with localized juvenile periodontitis
    K Shibata
    Department of Periodontology and Oral Biology, Boston University Goldman School of Dental Medicine, MA 02118, USA
    J Periodontol 71:797-802. 2000

Research Grants

  1. Periodontal Inflammation in Type 1 Diabetes
    Thomas Van Dyke; Fiscal Year: 2002
  2. Neutrophils and Periodontitis in Diabetes
    Thomas Van Dyke; Fiscal Year: 2009

Detail Information

Publications90

  1. ncbi request reprint Enhancing the value of scaling and root-planing: Arestin clinical trial results
    Thomas E Van Dyke
    Boston University School of Dental Medicine, Boston, MA 02118, USA
    J Int Acad Periodontol 4:72-6. 2002
    ..SRP alone was statistically significant. These data further support the adjunctive use of minocycline in a slow release vehicle for the treatment of periodontitis with SRP...
  2. ncbi request reprint The clinical significance of new therapies for the management of periodontal disease
    Thomas E Van Dyke
    Boston University Goldman School of Dental Medicine, 100 E Newton Street, Boston, MA 02118, USA
    J Int Acad Periodontol 7:191-6. 2005
    ....
  3. doi request reprint Inflammation and factors that may regulate inflammatory response
    Thomas E Van Dyke
    Department of Periodontology and Oral Biology, Boston University Goldman School of Dental Medicine, 100 E Newton Street, Boston, MA 02118, USA
    J Periodontol 79:1503-7. 2008
    ..Greater understanding of the complex pathways involved in inflammation may provide alternative therapeutic strategies to combat inflammation and chronic diseases potentially arising from it...
  4. doi request reprint Inflammation and periodontal diseases: a reappraisal
    Thomas E Van Dyke
    Department of Periodontology and Oral Biology, Boston University Goldman School of Dental Medicine, 100 E Newton Street, Boston, MA 02118, USA
    J Periodontol 79:1501-2. 2008
  5. ncbi request reprint Combination oxycodone 5 mg/ibuprofen 400 mg for the treatment of postoperative pain: a double-blind, placebo- and active-controlled parallel-group study
    Thomas Van Dyke
    Goldman School of Dental Medicine, Boston University, 100 East Newton Street, Rm 107, Boston, MA 02118, USA
    Clin Ther 26:2003-14. 2004
    ..This study compared the efficacy and safety of a single dose of oxycodone 5 mg/ibuprofen 400 mg versus its individual components and placebo in a third-molar extraction model...
  6. ncbi request reprint Periodontal diagnosis: evaluation of current concepts and future needs
    T E Van Dyke
    Boston University, Goldman School of Dental Medicine, Boston, MA 02118, USA
    J Int Acad Periodontol 2:71-8. 2000
    ..To this end, work has begun on genetic predictors of susceptibility which might be used to implement prevention programmes or alter treatment decisions...
  7. ncbi request reprint Resolution of inflammation: a new paradigm for the pathogenesis of periodontal diseases
    T E Van Dyke
    Department of Periodontology and Oral Biology, Boston University, Goldman School of Dental Medicine, 100 East Newton Street, Boston, MA 02118, USA
    J Dent Res 82:82-90. 2003
    ....
  8. pmc The management of inflammation in periodontal disease
    Thomas E Van Dyke
    Division of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, 100 E Newton Street, Boston, MA 02118, USA
    J Periodontol 79:1601-8. 2008
    ..Work in animal models of periodontitis has revealed the potential of this therapeutic approach for its prevention and treatment and forced the reconsideration of our understanding of the pathogenesis of human periodontal diseases...
  9. pmc Risk factors for periodontitis
    Thomas E Van Dyke
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, MA 02118, USA
    J Int Acad Periodontol 7:3-7. 2005
    ..In this review, we will assess the data implicating various inherited and acquired risk factors for susceptibility to periodontal diseases...
  10. ncbi request reprint Defective calcium influx factor activity in neutrophils from patients with localized juvenile periodontitis
    K Shibata
    Department of Periodontology and Oral Biology, Boston University Goldman School of Dental Medicine, MA 02118, USA
    J Periodontol 71:797-802. 2000
    ..CIF is thought to be a second messenger for the opening of membrane calcium channels when intracellular calcium stores are depleted. We examined CIF activity in neutrophils from normal subjects and LJP patients...
  11. pmc Topical H2 antagonist prevents periodontitis in a rabbit model
    H Hasturk
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, 100 East Newton Street, Suite 108, Boston, MA 02118, USA
    Infect Immun 74:2402-14. 2006
    ..gingivalis-elicited periodontal inflammation, arresting and/or preventing tissue destruction and influencing cell populations present in the inflammatory cell infiltrate...
  12. ncbi request reprint RvE1 protects from local inflammation and osteoclast- mediated bone destruction in periodontitis
    H Hasturk
    Goldman School of Dental Medicine, Department of Periodontology and Oral Biology, Boston University, Boston, Massachusetts, USA
    FASEB J 20:401-3. 2006
    ..Consistent with these potent actions, topical application of RvE1 in rabbit periodontitis conferred dramatic protection against inflammation induced tissue and bone loss associated with periodontitis...
  13. ncbi request reprint Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissue homeostasis in vivo
    Hatice Hasturk
    Goldman School of Dental Medicine, Department of Periodontology and Oral Biology, Boston University, Boston, MA 02118, USA
    J Immunol 179:7021-9. 2007
    ..This report is the first to show that resolution of inflammation by a naturally occurring endogenous lipid mediator results in complete regeneration of pathologically lost tissues, including bone...
  14. pmc PDK1 regulates chemotaxis in human neutrophils
    M Yagi
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, 100 East Newton Street, Suite 107, Boston, MA 02118, USA
    J Dent Res 88:1119-24. 2009
    ..Analysis of these data demonstrates that PDK1 is essential for the chemotactic migration of neutrophils, and in the absence of PDK1, neutrophil chemotaxis is impaired...
  15. ncbi request reprint Amplified crevicular leukocyte activity in aggressive periodontal disease
    R Buchmann
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, Boston, MA, USA
    J Dent Res 81:716-21. 2002
    ..Analysis of the data further suggests that surgical therapy is a more predictable method for removal of the pro-inflammatory etiology...
  16. ncbi request reprint [The pathogenesis of periodontal disease: a paradigm shift]
    J Ekstein
    Goldman School of Dental Medicine, Boston University, Boston, USA
    Refuat Hapeh Vehashinayim 27:35-9, 63. 2010
    ..Still, the question to be asked and investigated is whether dampening of the inflammatory response in certain individuals susceptible to periodontitis might prevent development of disease. This is a question yet to be answered...
  17. pmc An endogenous regulator of inflammation, resolvin E1, modulates osteoclast differentiation and bone resorption
    B S Herrera
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, Boston, MA 2118, USA
    Br J Pharmacol 155:1214-23. 2008
    ..It was of interest to determine whether RvE1 has direct actions on osteoclast (OC) development and bone resorption...
  18. pmc Toll-like receptors regulate B cell cytokine production in patients with diabetes
    M Jagannathan
    Department of Pathology, Boston University School of Medicine, Boston, MA, USA
    Diabetologia 53:1461-71. 2010
    ..The aim of this work was to define the function of B cells in diabetes mellitus patients through focus on B cell responses to pattern recognition receptors...
  19. ncbi request reprint Control of inflammation and periodontitis
    Thomas E Van Dyke
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, Boston, MA, USA
    Periodontol 2000 45:158-66. 2007
  20. ncbi request reprint Host-mediated resolution of inflammation in periodontal diseases
    Alpdogan Kantarci
    Department of Peridontics and Oral Biology, Boston University, Massachusetts, USA
    Periodontol 2000 40:144-63. 2006
  21. pmc Type 1 diabetes predisposes to enhanced gingival leukocyte margination and macromolecule extravasation in vivo
    C Sima
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, Boston, MA, USA
    J Periodontal Res 45:748-56. 2010
    ..However, the cellular and molecular mechanisms linking the two conditions are not clear. The impact of chronic hyperglycemia on leukocyte margination and macromolecule extravasation was determined in gingival vessels in vivo...
  22. pmc Does periodontal treatment improve glycemic control in diabetic patients? A meta-analysis of intervention studies
    S J Janket
    Department of General Dentistry, Boston University, Goldman School of Dental Medicine, 100 East Newton Street, Boston, MA 02118, USA
    J Dent Res 84:1154-9. 2005
    ..The weighted average decrease in actual HbA1c level was 0.38% for all studies, 0.66% when restricted to type 2 diabetic patients, and 0.71% if antibiotics were given to them. However, none was statistically significant...
  23. ncbi request reprint Cytoskeletal actin reorganization in neutrophils from patients with localized juvenile periodontitis
    C M Champagne
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University Medical Center, MA 02118, USA
    J Periodontol 69:209-18. 1998
    ..Hence, the chemotaxis defect in LJP PMN appears to be mediated by signaling events that carry their effect independently of an intact cytoskeleton...
  24. pmc Salivary immunoglobulins and prevalent coronary artery disease
    S Janket
    General Dentistry, Boston University School of Dental Medicine, 100 East Newton Street, Rm G 619, Boston, MA 02118, USA
    J Dent Res 89:389-94. 2010
    ..Salivary IgA warrants further studies to confirm its role in the risk assessment of CAD...
  25. ncbi request reprint Inducible nitric oxide synthase mediates bone development and P. gingivalis-induced alveolar bone loss
    R Gyurko
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, 100 East Newton Street, Room 107, Boston, MA 02118, USA
    Bone 36:472-9. 2005
    ..These data indicate that iNOS promotes bone resorption during bone development as well as after bacterial infection, and that iNOS is an important signal for normal osteoclast differentiation...
  26. ncbi request reprint Lipoxin signaling in neutrophils and their role in periodontal disease
    Alpdogan Kantarci
    Department of Periodontology and Oral Biology, Boston University Goldman School of Dental Medicine, 100 East Newton Street, G 05, Boston, MA 02118, USA
    Prostaglandins Leukot Essent Fatty Acids 73:289-99. 2005
    ....
  27. ncbi request reprint Gingipain-specific IgG in the sera of patients with periodontal disease is necessary for opsonophagocytosis of Porphyromonas gingivalis
    Frank C Gibson
    Department of Medicine, Section of Infectious Diseases, Boston University Medical School, Boston, MA, USA
    J Periodontol 76:1629-36. 2005
    ..GAgP patients develop specific antibodies to gingipains; however, the function of these antibodies in the clearance of P. gingivalis infection is poorly understood...
  28. pmc Resolution of inflammation in periodontitis
    Alpdogan Kantarci
    Department of Periodontology and Oral Biology, Boston University Goldman School of Dental Medicine, Boston, MA 02118, USA
    J Periodontol 76:2168-74. 2005
    ....
  29. ncbi request reprint The effects of xerogenic medications on oral mucosa among the Veterans Dental Study participants
    Sok Ja Janket
    Department of General Dentistry, Goldman School of Dental Medicine, Boston University, Boston, MA 02118, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103:223-30. 2007
    ..To examine the association of xerogenic medications with the oral mucosa inflammation score (OMS) in US male veterans...
  30. pmc Oral infection, hyperglycemia, and endothelial dysfunction
    Sok Ja Janket
    Department of General Dentistry, Boston University School of Dental Medicine, Boston, MA 02118, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105:173-9. 2008
    ..e., IL-6, TNF-alpha, and CRP) have been reported to be associated with periodontal disease and increased risk for CVD. We will review published evidence related to these 2 pathways and offer a consensus...
  31. pmc The use of rodent models to investigate host-bacteria interactions related to periodontal diseases
    Dana T Graves
    Department of Periodontology and Oral Biology, Boston University School of Dental Medicine, Boston, MA 02118, USA
    J Clin Periodontol 35:89-105. 2008
    ....
  32. pmc Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Rev Immunol 8:349-61. 2008
    ..These mediators have anti-inflammatory and pro-resolution properties, thereby protecting organs from collateral damage, stimulating the clearance of inflammatory debris and promoting mucosal antimicrobial defence...
  33. ncbi request reprint Neutrophil-mediated tissue injury in periodontal disease pathogenesis: findings from localized aggressive periodontitis
    Alpdogan Kantarci
    Boston University Goldman School of Dental Medicine, Department of Periodontology and Oral Biology, Boston, MA 02118, USA
    J Periodontol 74:66-75. 2003
    ..In this model, it appears that a hyperresponsiveness of the neutrophil, due to cell priming/predisposition, results in enhanced tissue damage...
  34. pmc Chronic hyperglycemia predisposes to exaggerated inflammatory response and leukocyte dysfunction in Akita mice
    Robert Gyurko
    Department of Periodontology and Oral Biology, Boston University, Boston, MA 02118, USA
    J Immunol 177:7250-6. 2006
    ..Thus, leukocyte defects in hyperglycemia may contribute to periodontal tissue damage by impairing the innate immune response to periodontal pathogens as well as by increasing free radical load in the gingival microvasculature...
  35. ncbi request reprint Localized aggressive periodontitis is linked to human chromosome 1q25
    Yefu Li
    Department of Oral and Developmental Biology, Harvard School of Dental Medicine, 180 Longwood Avenue, Boston, MA 02115, USA
    Hum Genet 114:291-7. 2004
    ..No mutation in COX2 was identified in the patients...
  36. ncbi request reprint Neutrophil-mediated host response to Porphyromonas gingivalis
    Alpdogan Kantarci
    Boston University, Goldman School of Dental Medicine, Department of Periodontology and Oral Biology, Boston, MA 02118, USA
    J Int Acad Periodontol 4:119-25. 2002
    ..It is essential to understand the mechanisms underlying the interactions between the neutrophils and the microbial virulence factors to be able to develop rational, novel treatment strategies...
  37. ncbi request reprint A molecular defect in intracellular lipid signaling in human neutrophils in localized aggressive periodontal tissue damage
    Karsten Gronert
    Department of Anesthesiology, Perioperative and Pain Medicine, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 172:1856-61. 2004
    ..Moreover, they identify a potential molecular lesion in PMN signal transduction that may account for their aberrant responses and tissue destruction in this disease...
  38. ncbi request reprint IgG antibody levels to Porphyromonas gingivalis and clinical measures in children
    Cara L Donley
    The Children s Hospital, Department of Dentistry, Boston, MA, USA
    J Periodontol 75:221-8. 2004
    ..The objective of this study was to examine the prevalence of P. gingivalis in dental plaque and of serum immunoglobulin G (IgG) antibody levels to P. gingivalis, and their relationship to periodontal clinical measures in children...
  39. ncbi request reprint Differential effects of growth factors and cytokines on the synthesis of SPARC, DNA, fibronectin and alkaline phosphatase activity in human periodontal ligament cells
    Tsuyoshi Fujita
    Department of Periodontal Medicine, Division of Frontier Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3, Kasumi, Minami Ku, Hiroshima 734 8553, Japan
    Cell Biol Int 28:281-6. 2004
    ..The differences in regulation of function of periodontal ligament cells by these peptides may be involved in the regeneration and repair of periodontal tissue...
  40. pmc Role for periodontitis in the progression of lipid deposition in an animal model
    Ashish Jain
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, 100 East Newton Street, Boston, MA 02118, USA
    Infect Immun 71:6012-8. 2003
    ..The data support the concept that infections at remote locations can modulate atherosclerotic events distantly...
  41. pmc Mice lacking inducible nitric oxide synthase demonstrate impaired killing of Porphyromonas gingivalis
    Robert Gyurko
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, Massachusetts 02118, USA
    Infect Immun 71:4917-24. 2003
    ..gingivalis. These results indicate that modulation of superoxide levels is a mechanism by which NO influences PMN function and that NO is an important element of the host defense against P. gingivalis...
  42. ncbi request reprint The oral/dental/craniofacial complex as a model for inflammatory disease
    Thomas E Van Dyke
    Department of Periodontology and Oral Biology, Boston University, Boston, Massachusetts, USA
    Compend Contin Educ Dent 23:465-8, 470, 472 passim; quiz 476. 2002
    ..In this article, the inflammatory process in periodontitis is reviewed with an emphasis on control pathways that naturally limit inflammation...
  43. pmc Epithelial and connective tissue cell CTGF/CCN2 expression in gingival fibrosis
    A Kantarci
    Department of Periodontology and Oral Biology, Boston University, Goldman School of Dental Medicine, 700 Albany Street, Boston, MA 02118, USA
    J Pathol 210:59-66. 2006
    ..These findings suggest that interactions between epithelial and connective tissues could contribute to gingival fibrosis...
  44. ncbi request reprint Periodontal disease is associated with brachial artery endothelial dysfunction and systemic inflammation
    Salomon Amar
    Department of Periodontology, Boston University School of Dental Medicine, Mass, USA
    Arterioscler Thromb Vasc Biol 23:1245-9. 2003
    ..Epidemiological studies suggest that severe periodontal disease is associated with increased cardiovascular disease risk, but the mechanisms remain unknown...
  45. ncbi request reprint Cellular and molecular susceptibility determinants for periodontitis
    Thomas E Van Dyke
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, Boston, MA, USA
    Periodontol 2000 45:10-3. 2007
  46. ncbi request reprint Association between interleukin-1 genotype and periodontal disease in a diabetic population
    Sergio Guzman
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, Boston, MA 02118, USA
    J Periodontol 74:1183-90. 2003
    ....
  47. pmc Apoptotic neutrophils and T cells sequester chemokines during immune response resolution through modulation of CCR5 expression
    Amiram Ariel
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 7:1209-16. 2006
    ..Our results suggest that CCR5+ apoptotic leukocytes act as 'terminators' of chemokine signaling during the resolution of inflammation...
  48. ncbi request reprint Lipoxins in chronic inflammation
    Alpdogan Kantarci
    Boston University Goldman School of Dental Medicine, Department of Periodontology and Oral Biology, 100 East Newton Street G 05, Boston, MA 02118, USA
    Crit Rev Oral Biol Med 14:4-12. 2003
    ..The parallels and possible associations with periodontal diseases are discussed...
  49. pmc Phosphorylation of pleckstrin increases proinflammatory cytokine secretion by mononuclear phagocytes in diabetes mellitus
    Yong Ding
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, Boston, MA 02118, USA
    J Immunol 179:647-54. 2007
    ..The phosphorylation is in part due to the activation of PKC through RAGE binding, and pleckstrin is a critical molecule for proinflammatory cytokine secretion in response to elevated AGE in diabetes...
  50. pmc Activation of RAGE induces elevated O2- generation by mononuclear phagocytes in diabetes
    Yong Ding
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, G 107, Boston, MA 02118, USA
    J Leukoc Biol 81:520-7. 2007
    ....
  51. pmc Moesin functions as a lipopolysaccharide receptor on human monocytes
    Z N Tohme
    Goldman School of Dental Medicine, Boston University, Boston, Massachusetts 02118, USA
    Infect Immun 67:3215-20. 1999
    ..Antimoesin blocked only LPS-mediated events. The data suggest that moesin functions as an independent LPS receptor on human monocytes. The role of moesin in transduction of CD14-mediated signals is discussed...
  52. ncbi request reprint Nitric oxide synthase activity in neutrophils from patients with localized aggressive periodontitis
    K Shibata
    Department of Periodontology and Oral Biology, Boston University Goldman School of Dental Medicine, MA 02118, USA
    J Periodontol 72:1052-8. 2001
    ..CONCLUSIONS: This study suggests that NOS is present in human neutrophils and may be involved in FMLP-induced chemotaxis in normal neutrophils. NOS activity is increased in LAgP and is negatively correlated to chemotaxis response...
  53. pmc Enhanced superoxide release and elevated protein kinase C activity in neutrophils from diabetic patients: association with periodontitis
    M Karima
    Goldman School of Dental Medicine, Department of Periodontology and Oral Biology, Boston University, Boston MA 02118, USA
    J Leukoc Biol 78:862-70. 2005
    ..Thus, hyperglycemia can lead to a novel form of neutrophil priming, where elevated PKC activity results in increased phosphorylation of p47-phox and O(2)(-) release...
  54. ncbi request reprint Clinical characteristics and microbiota of progressing slight chronic periodontitis in adults
    Anne C R Tanner
    Department of Molecular Genetics, Clinical Research Center, The Forsyth Institute, Boston, MA 02115, USA
    J Clin Periodontol 34:917-30. 2007
    ..This study sought clinical and microbial risk indicators for progressing slight periodontitis...
  55. ncbi request reprint PMN responses in chronic periodontal disease: evaluation by gingival crevicular fluid enzymes and elastase-alpha-1-proteinase inhibitor complex
    Rainer Buchmann
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, Boston, MA, USA rainerbuhmann yahoo de
    J Clin Periodontol 29:563-72. 2002
    ....
  56. pmc Modeling of trabecular bone and lamina dura following selective alveolar decortication in rats
    Jean David Sebaoun
    Department of Orthodontics, School of Dental Medicine, Boston University, Boston, MA, USA
    J Periodontol 79:1679-88. 2008
    ..The aim of this study was to investigate the alveolar response to corticotomy as a function of time and proximity to the surgical injury in a rat model...
  57. ncbi request reprint Resolution of crevicular fluid leukocyte activity in patients treated for aggressive periodontal disease
    Rainer Buchmann
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, MA, USA
    J Periodontol 73:995-1002. 2002
    ..The hypothesis that comprehensive periodontal treatment expedites resolution of amplified leukocyte activity and facilitates the reconstitution of periodontal health was tested...
  58. ncbi request reprint Aggressive periodontitis: 5-year follow-up of treatment
    Rainer Buchmann
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, MA, USA
    J Periodontol 73:675-83. 2002
    ..The hypothesis that in subjects with aggressive periodontitis, a long-term stability of periodontal health can be achieved following comprehensive mechanical/surgical and systemic antimicrobial therapy was tested in this prospective study...
  59. pmc Resolvin E1 receptor activation signals phosphorylation and phagocytosis
    Taisuke Ohira
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Center for Experimental Therapeutics and Reperfusion Injury, Boston, Massachusetts 02115, USA
    J Biol Chem 285:3451-61. 2010
    ..These phosphorylation-signaling pathways identified for RvE1 receptor-ligand interactions underscore the importance of endogenous pro-resolving agonists in resolving acute inflammation...
  60. pmc Diabetes-induced oxidative stress is mediated by Ca2+-independent phospholipase A2 in neutrophils
    Srinivas Ayilavarapu
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, Boston, MA 02118, USA
    J Immunol 184:1507-15. 2010
    ....
  61. ncbi request reprint Change of antibiotic susceptibility following periodontal therapy. A pilot study in aggressive periodontal disease
    Rainer Buchmann
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, Boston, MA, USA
    J Clin Periodontol 30:222-9. 2003
    ..The hypothesis was tested that bacterial susceptibilities in aggressive periodontitis change upon administration of systemic antibiotics as adjuncts to periodontal therapy...
  62. ncbi request reprint Effect of topical cimetidine rinse on gingival crevicular neutrophil leukocyte function
    Thomas E Van Dyke
    Boston University, Goldman School of Dental Medicine, Boston, MA, USA
    J Periodontol 76:998-1005. 2005
    ..Three coordinated mechanism-of-action clinical studies were conducted to examine the effects of topical cimetidine rinse on neutrophil function in the gingival crevice...
  63. ncbi request reprint Reduced inflammation and tissue damage in transgenic rabbits overexpressing 15-lipoxygenase and endogenous anti-inflammatory lipid mediators
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    J Immunol 171:6856-65. 2003
    ..Moreover, they suggest that LXs can be targets for novel approaches to diseases, e.g., periodontitis and arthritis, where inflammation and bone destruction are features...
  64. ncbi request reprint Platelet-rich plasma: growth factors and pro- and anti-inflammatory properties
    Hesham El-Sharkawy
    Department of Periodontology and Oral Biology, Boston University Goldman School of Dental Medicine, Boston, MA 02118, USA
    J Periodontol 78:661-9. 2007
    ..However, it is not clear how PRP affects the inflammatory response. The purpose of this study was to analyze the growth factors in PRP and to study the effects of PRP on monocyte cytokine release and lipoxin A(4) (LXA(4)) generation...
  65. pmc CD38 expression in neutrophils from patients with localized aggressive periodontitis
    Tsuyoshi Fujita
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, Boston, MA 02118, USA
    J Periodontol 76:1960-5. 2005
    ..In this study, we focused on the level of CD38 expression between LAgP and normal subjects and examined the involvement of CD38 in abnormal neutrophil chemotaxis of LAgP patients...
  66. ncbi request reprint Efficacy of a fluoridated hydrogen peroxide-based mouthrinse for the treatment of gingivitis: a randomized clinical trial
    Hatice Hasturk
    Boston University Goldman School of Dental Medicine, Boston, MA 02118, USA
    J Periodontol 75:57-65. 2004
    ..The first phase (28 days) included the experimental gingivitis phase; the second phase (5 months) was the oral hygiene phase, which included rinsing...
  67. ncbi request reprint Compliance as a prognostic indicator: retrospective study of 505 patients treated and maintained for 15 years
    Takanari Miyamoto
    Department of General Dentistry, Goldman School of Dental Medicine, Boston University, Boston, MA 02118, USA
    J Periodontol 77:223-32. 2006
    ..The relationship of patient compliance to overall tooth prognosis remains controversial. There are little data, often conflicting, that pertain to tooth loss as a function of patient compliance...
  68. ncbi request reprint Cardiovascular disease and periodontal diseases: commonality and causation
    Sheilesh Dave
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, Boston, Massachusetts, USA
    Compend Contin Educ Dent 25:26-37. 2004
    ..This article reviews some of the emerging concepts for the inflammatory mechanisms of periodontal diseases and atherosclerosis and examines the potential role of local inflammation in systemic inflammatory disease...
  69. pmc B cells from periodontal disease patients express surface Toll-like receptor 4
    Hyunjin Shin
    Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA
    J Leukoc Biol 85:648-55. 2009
    ..In contrast, B cell TLR4 was not activated by the prototypic TLR4 ligand Escherichia coli LPS. These findings raise the unexpected possibility that TLR4 engagement modulates B cell activation in PD patients...
  70. pmc Ceruloplasmin induces polymorphonuclear leukocyte priming in localized aggressive periodontitis
    Tomoyuki Iwata
    Department of Periodontology and Oral Biology, Boston University Goldman School of Dental Medicine, Boston, MA, USA
    J Periodontol 80:1300-6. 2009
    ..Ceruloplasmin (CP) is also induced by hypoxia and inflammation. The aim of this study was to investigate the role of CP in O(2)(-) generation in PMNs from healthy subjects and patients with LAgP...
  71. pmc Simultaneous measurements of cytoplasmic Ca2+ responses and intracellular pH in neutrophils of localized aggressive periodontitis (LAP) patients
    Jens Martin Herrmann
    Boston University, Goldman School of Dental Medicine, 100 East Newton St, Boston, MA 02118, USA
    J Leukoc Biol 78:612-9. 2005
    ....
  72. ncbi request reprint A stable aspirin-triggered lipoxin A4 analog blocks phosphorylation of leukocyte-specific protein 1 in human neutrophils
    Taisuke Ohira
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard University Medical School, Boston, MA 02115, USA
    J Immunol 173:2091-8. 2004
    ....
  73. pmc Resolvin E1 regulates adenosine diphosphate activation of human platelets
    Gabrielle Fredman
    Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Center for Experimental Therapeutics and Reperfusion Injury, Boston, Mass 02115, USA
    Arterioscler Thromb Vasc Biol 30:2005-13. 2010
    ..To investigate the ability of resolvin E1 (RvE1) to regulate adenosine diphosphate (ADP) activation of platelets via specific receptors because RvE1 reduces platelet aggregation with certain agonists, including ADP...
  74. pmc Sequential chemotactic and phagocytic activation of human polymorphonuclear neutrophils
    Jens Martin Herrmann
    Department of Biochemistry, Boston University School of Medicine, 80 East Concord Street, Boston, MA 02118, USA
    Infect Immun 75:3989-98. 2007
    ....
  75. pmc Priming of neutrophil oxidative burst in diabetes requires preassembly of the NADPH oxidase
    Kazuhiro Omori
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, 100 East Newton Street, Suite 107, Boston, MA 02118, USA
    J Leukoc Biol 84:292-301. 2008
    ..5 mM). These data suggest that HG and increased AGE prime neutrophils and increase oxidative stress inducing the translocation of p47phox to the cell membrane and preassembly with p22phox by stimulating a RAGE-ERK1/2 pathway...
  76. pmc Role for fimbriae and lysine-specific cysteine proteinase gingipain K in expression of interleukin-8 and monocyte chemoattractant protein in Porphyromonas gingivalis-infected endothelial cells
    Hamdy Nassar
    Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Infect Immun 70:268-76. 2002
    ..gingivalis wild-type strain. These results indicate that P. gingivalis can temporally modulate the chemokine response in endothelial cells through both fimbriae and gingipain-mediated mechanisms...
  77. ncbi request reprint CD38 cleavage in fMLP- and IL-8-induced chemotaxis is dependent on p38 MAP kinase but independent of p44/42 MAP kinase
    Tsuyoshi Fujita
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, 100 East Newton Street, G 107, Boston, MA 02118, USA
    Cell Signal 17:167-75. 2005
    ..Activation of the protease for cleavage appears to be a postreceptor event that is dependent on p38 MAP kinase signaling...
  78. ncbi request reprint Identification of mRNAs for the various diacylglycerol kinase isoforms in neutrophils from patients with localized aggressive periodontitis
    Kosuke Oyaizu
    Department of Periodontology and Oral Biology, Boston University Goldman School of Dental Medicine, Boston, Massachusetts 02118, USA
    J Periodontal Res 38:488-95. 2003
    ..This reduction could be related to a mutation, post-translational modification, differential expression, or lack of expression of a particular isoform(s)...
  79. ncbi request reprint Hereditary gingival fibromatosis associated with generalized aggressive periodontitis: a case report
    Piero Casavecchia
    Department of Periodontology and Oral Biology, Boston University, Goldman School of Dental Medicine, Boston, MA 02118, USA
    J Periodontol 75:770-8. 2004
    ..A syndromic association between gingival fibromatosis and a wide variety of other genetically inherited disorders has been described. However, its coexistence with aggressive periodontitis has not been reported...
  80. pmc TLR cross-talk specifically regulates cytokine production by B cells from chronic inflammatory disease patients
    Madhumita Jagannathan
    Department of Pathology, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 183:7461-70. 2009
    ..We conclude that disease-associated alteration of B cell TLR responses specifically regulates cytokine production and may influence chronic inflammation...
  81. ncbi request reprint Subantimicrobial dose doxycycline enhances the efficacy of scaling and root planing in chronic periodontitis: a multicenter trial
    Philip M Preshaw
    Department of Periodontology, Newcastle University School of Dental Sciences, Newcastle, UK
    J Periodontol 75:1068-76. 2004
    ..The aim of this study was to further assess the role of SDD as an adjunct to scaling and root planing (SRP) in the treatment of CP...
  82. pmc Diabetic periodontitis: a model for activated innate immunity and impaired resolution of inflammation
    Hamdy Nassar
    Department of Periodontology, School of Dental Medicine, Al Azhar University, Cairo, Egypt
    Periodontol 2000 43:233-44. 2007
  83. ncbi request reprint The relationship between Porphyromonas gingivalis infection and local and systemic factors in children
    Enrique Bimstein
    Department of Pediatric Dentistry, College of Dentistry, University of Florida, Gainesville, FL 32610 0426, USA
    J Periodontol 75:1371-6. 2004
    ..gingivalis (IgG-Pg), and examine their relationship to demographic, systemic, and oral variables...
  84. pmc Effect of neutrophil apoptosis on monocytic cytokine response to Porphyromonas gingivalis lipopolysaccharide
    Ezel Berker
    Department of Periodontology, Faculty of Dentistry, Hacettepe University, Ankara, Turkey
    J Periodontol 76:964-71. 2005
    ..In this study, we investigated the effect of apoptotic neutrophils on interleukin (IL)-10 and IL-1beta production from monocytes in response to Porphyromonas gingivalis lipopolysaccharide...
  85. ncbi request reprint The Periodontitis and Vascular Events (PAVE) pilot study: recruitment, retention, and community care controls
    David J Couper
    Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA
    J Periodontol 79:80-9. 2008
    ....
  86. pmc Salivary lysozyme and prevalent coronary heart disease: possible effects of oral health on endothelial dysfunction
    Sok Ja Janket
    Arterioscler Thromb Vasc Biol 26:433-4. 2006
  87. ncbi request reprint The challenge of treating periodontal patients who smoke--the efficacy of Arestin
    Richard J Oringer
    Department of Periodontics, School of Dental Medicine, Stony Brook University, Stony Brook, New York 11794 8703, USA
    J Int Acad Periodontol 4:89-94. 2002
    ..No serious adverse events were recorded in any of the studies...
  88. ncbi request reprint Bringing light to the heat: "inflammation and periodontal diseases: a reappraisal"
    Kenneth S Kornman
    Interleukin Genetics, Waltham, MA, USA
    J Periodontol 79:1313. 2008
  89. ncbi request reprint Origin and function of the cellular components in gingival crevice fluid
    Andrew J Delima
    Periodontol 2000 31:55-76. 2003
  90. ncbi request reprint The Periodontitis and Vascular Events (PAVE) pilot study: adverse events
    James D Beck
    Department of Dental Ecology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Periodontol 79:90-6. 2008
    ..This article describes the occurrence of adverse events during the pilot study...

Research Grants7

  1. Periodontal Inflammation in Type 1 Diabetes
    Thomas Van Dyke; Fiscal Year: 2002
    ....
  2. Neutrophils and Periodontitis in Diabetes
    Thomas Van Dyke; Fiscal Year: 2009
    ..These studies have the potential of leading to better methods of treating periodontal disease and perhaps other complications of diabetes. ..