Abdulamaged M Traish

Summary

Affiliation: Boston University
Country: USA

Publications

  1. doi request reprint 5α-reductases in human physiology: an unfolding story
    Abdulmaged M Traish
    Department of Urology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Endocr Pract 18:965-75. 2012
  2. pmc Are the adverse effects of glitazones linked to induced testosterone deficiency?
    M Carruthers
    Centre for Men s Health, 20 20 Harley Street, London, UK
    Cardiovasc Diabetol 7:30. 2008
  3. pmc Streptozotocin-induced diabetes in the rat is associated with changes in vaginal hemodynamics, morphology and biochemical markers
    Noel N Kim
    Institute for Sexual Medicine, Department of Urology, Boston University School of Medicine, Boston, USA
    BMC Physiol 6:4. 2006
  4. pmc Immunodetection of nmt55/p54nrb isoforms in human breast cancer
    M Pavao
    Department of Biochemistry, Boston University School of Medicine, Center for Advanced Biomedical Research, 700 Albany Street, W607, Boston, MA 02118, USA
    BMC Cancer 1:15. 2001
  5. doi request reprint Androgens play a pivotal role in maintaining penile tissue architecture and erection: a review
    Abdulmaged M Traish
    Department of Biochemistry, Institute for Sexual Medicine, Boston University School of Medicine, Center for Advanced Biomedical Research, 700 Albany St, W607, Boston, MA 02118, USA
    J Androl 30:363-9. 2009
  6. ncbi request reprint Effects of medical or surgical castration on erectile function in an animal model
    Abdulmaged M Traish
    Department of Urology, Boston University School of Medicine, Massachusetts 02118, USA
    J Androl 24:381-7. 2003
  7. ncbi request reprint The brain, the penis and steroid hormones: clinical correlates with endothelial dysfunction
    Abdulmaged M Traish
    Department of Biochemistry and Urology, Boston University School of Medicine, Center for Advanced Biomedical Research, 700 Albany Street, Boston, MA 02118, USA
    Curr Pharm Des 14:3723-36. 2008
  8. ncbi request reprint The physiological role of androgens in penile erection: regulation of corpus cavernosum structure and function
    Abdulmaged Traish
    Boston University School of Medicine, Department of Urology, Boston, MA 02118, USA
    J Sex Med 2:759-70. 2005
  9. doi request reprint Testosterone therapy in women with gynecological and sexual disorders: a triumph of clinical endocrinology from 1938 to 2008
    Abdulmaged M Traish
    Boston University School of Medicine, Department of Biochemistry, Boston, MA, USA
    J Sex Med 6:334-51. 2009
  10. ncbi request reprint Biochemical and physiological mechanisms of female genital sexual arousal
    Abdulmaged M Traish
    Arch Sex Behav 31:393-400. 2002

Research Grants

  1. FEMALE SEXUAL AROUSAL: CLITORAL AND VAGINAL PHYSIOLOGY
    Abdulmaged Traish; Fiscal Year: 2003

Collaborators

Detail Information

Publications74

  1. doi request reprint 5α-reductases in human physiology: an unfolding story
    Abdulmaged M Traish
    Department of Urology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Endocr Pract 18:965-75. 2012
    ..5α-reductases are a family of isozymes expressed in a wide host of tissues including the central nervous system (CNS) and play a pivotal role in male sexual differentiation, development and physiology...
  2. pmc Are the adverse effects of glitazones linked to induced testosterone deficiency?
    M Carruthers
    Centre for Men s Health, 20 20 Harley Street, London, UK
    Cardiovasc Diabetol 7:30. 2008
    ..These led to consideration of an evidence-based hypothesis which would explain these diverse effects, and further suggested novel approaches by which this hypothesis could be tested...
  3. pmc Streptozotocin-induced diabetes in the rat is associated with changes in vaginal hemodynamics, morphology and biochemical markers
    Noel N Kim
    Institute for Sexual Medicine, Department of Urology, Boston University School of Medicine, Boston, USA
    BMC Physiol 6:4. 2006
    ..We further related these changes with estrogen receptor alpha (ERalpha) and androgen receptor (AR) expression...
  4. pmc Immunodetection of nmt55/p54nrb isoforms in human breast cancer
    M Pavao
    Department of Biochemistry, Boston University School of Medicine, Center for Advanced Biomedical Research, 700 Albany Street, W607, Boston, MA 02118, USA
    BMC Cancer 1:15. 2001
    ..The objective of this study was to determine if this reduced expression in human breast tumors was attributed to the regulation of mRNA transcription or the presence of altered forms of this protein...
  5. doi request reprint Androgens play a pivotal role in maintaining penile tissue architecture and erection: a review
    Abdulmaged M Traish
    Department of Biochemistry, Institute for Sexual Medicine, Boston University School of Medicine, Center for Advanced Biomedical Research, 700 Albany St, W607, Boston, MA 02118, USA
    J Androl 30:363-9. 2009
    ..This knowledge has a profound impact on the potential use of androgens in the clinical setting to treat patients with erectile dysfunction...
  6. ncbi request reprint Effects of medical or surgical castration on erectile function in an animal model
    Abdulmaged M Traish
    Department of Urology, Boston University School of Medicine, Massachusetts 02118, USA
    J Androl 24:381-7. 2003
    ..We conclude that androgen deprivation produces structural alterations in the corpus cavernosum leading to corporal veno-occlusive dysfunction...
  7. ncbi request reprint The brain, the penis and steroid hormones: clinical correlates with endothelial dysfunction
    Abdulmaged M Traish
    Department of Biochemistry and Urology, Boston University School of Medicine, Center for Advanced Biomedical Research, 700 Albany Street, Boston, MA 02118, USA
    Curr Pharm Des 14:3723-36. 2008
    ....
  8. ncbi request reprint The physiological role of androgens in penile erection: regulation of corpus cavernosum structure and function
    Abdulmaged Traish
    Boston University School of Medicine, Department of Urology, Boston, MA 02118, USA
    J Sex Med 2:759-70. 2005
    ....
  9. doi request reprint Testosterone therapy in women with gynecological and sexual disorders: a triumph of clinical endocrinology from 1938 to 2008
    Abdulmaged M Traish
    Boston University School of Medicine, Department of Biochemistry, Boston, MA, USA
    J Sex Med 6:334-51. 2009
    ....
  10. ncbi request reprint Biochemical and physiological mechanisms of female genital sexual arousal
    Abdulmaged M Traish
    Arch Sex Behav 31:393-400. 2002
    ..A comprehensive and integral understanding of female sexual function requires detailed investigation of the vascular, neurological (central and peripheral), and structural components of this complex physiological process...
  11. doi request reprint The dark side of testosterone deficiency: II. Type 2 diabetes and insulin resistance
    Abdulamaged M Traish
    Department of Biochemistry and Urology, Boston University School of Medicine, Boston, MA 02118, USA
    J Androl 30:23-32. 2009
    ....
  12. doi request reprint The dark side of testosterone deficiency: I. Metabolic syndrome and erectile dysfunction
    Abdulmaged M Traish
    Department of Biochemistry and Urology, Boston University School of Medicine, Boston, MA 02118, USA
    J Androl 30:10-22. 2009
    ..Specifically, we will focus on exploring the relationships between hypogonadism, obesity, MetS, and ED...
  13. ncbi request reprint Is vardenafil "noninferior" or superior to sildenafil in the management of erectile dysfunction? Revisiting the biochemical, physiological, and clinical evidence
    Abdulmaged Traish
    Boston University Laboratory for Sexual Medicine Research, Boston, MA 02118, USA
    J Sex Med 5:1762-8; discussion 1768-9. 2008
  14. ncbi request reprint Sex steroid hormones differentially regulate nitric oxide synthase and arginase activities in the proximal and distal rabbit vagina
    A M Traish
    Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA
    Int J Impot Res 15:397-404. 2003
    ..We suggest that changes in vaginal blood flow and compliance may depend on the endocrine status and the levels of circulating androgens and estrogens...
  15. ncbi request reprint Binding characteristics of [3H]delta(5)-androstene-3beta,17beta-diol to a nuclear protein in the rabbit vagina
    Abdulmaged M Traish
    Department of Biochemistry, Boston University School of Medicine, 700 Albany Street, Room W607, Boston, MA 02118, USA
    Steroids 69:71-8. 2004
    ..These data suggest that rabbit vaginal tissue expresses a novel binding protein which specifically binds delta(5)-androstene-3beta,17beta-diol and is distinct from the androgen and estrogen receptors...
  16. ncbi request reprint Are the Endocrine Society's Clinical Practice Guidelines on Androgen Therapy in Women misguided? A commentary
    Abdulmaged Traish
    Laboratory for Sexual Medicine Research, Boston University, Boston, MA 02118, USA
    J Sex Med 4:1223-34; discussion 1234-5. 2007
    ....
  17. ncbi request reprint Weapons of penile smooth muscle destruction: androgen deficiency promotes accumulation of adipocytes in the corpus cavernosum
    A M Traish
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Aging Male 8:141-6. 2005
    ..Androgen deficiency promotes differentiation into adipogenic lineage, and accumulation of adipocytes in the corpus cavernosum may contribute to erectile dysfunction...
  18. ncbi request reprint Are androgens critical for penile erections in humans? Examining the clinical and preclinical evidence
    Abdulmaged M Traish
    Department of Biochemistry and Urology, Institute for Sexual Medicine, Center for Advanced Biomedical Research, Boston University School of Medicine, Boston, MA, USA
    J Sex Med 3:382-404; discussion 404-7. 2006
    ..Nevertheless, based on the preclinical and clinical data available in the literature, to date, we infer that androgens play a critical role in maintaining erectile physiology in humans...
  19. ncbi request reprint Adipocyte accumulation in penile corpus cavernosum of the orchiectomized rabbit: a potential mechanism for veno-occlusive dysfunction in androgen deficiency
    Abdulmaged M Traish
    Department of Biochemistry, Institute for Sexual Medicine, Boston University School of Medicine, 700 Albany St, Room W607, Boston, MA 02118, USA
    J Androl 26:242-8. 2005
    ..We hypothesize that androgen deprivation promotes differentiation of progenitor stroma cells into an adipogenic lineage producing fat-containing cells, thus altering erectile function...
  20. ncbi request reprint Role of androgens in female genital sexual arousal: receptor expression, structure, and function
    Abdulmaged M Traish
    Department of Biochemistry, Boston University School of Medicine, Massachusetts, Boston 02118, USA
    Fertil Steril 77:S11-8. 2002
    ..In this article, we review the mechanisms of androgen action and discuss new data on the effects of androgens in vaginal and clitoral tissues...
  21. doi request reprint Mechanisms of obesity and related pathologies: androgen deficiency and endothelial dysfunction may be the link between obesity and erectile dysfunction
    Abdulmaged M Traish
    Department of Biochemistry and Urology, Boston University School of Medicine, MA 02118, USA
    FEBS J 276:5755-67. 2009
    ..Thus, clinical screening for the risk of erectile dysfunction in obese patients should include the assessment of waist circumference, testosterone levels, body mass index and physical inactivity...
  22. ncbi request reprint Androgens in female genital sexual arousal function: a biochemical perspective
    Abdulmaged M Traish
    Departments of Biochemistry and Urology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Sex Marital Ther 28:233-44. 2002
    ..Androgens modulate the growth and function of female genital sexual organs included the labia, vagina, and clitoris. This article discusses the potential role for androgens in facilitating female genital sexual arousal...
  23. ncbi request reprint Cyclic AMP regulates mRNA expression of alpha-1d and alpha-2a adrenergic receptors in cultured human corpus cavernosum smooth muscle cells
    A Traish
    Department of Urology, Boston University School of Medicine, MA 02118, USA
    Int J Impot Res 12:S41-47. 2000
    ..These observations further support the concept that erectile function is a balance between contractile and relaxatory processes, which in turn regulate structure and function of the corpora cavernosa...
  24. doi request reprint Dehydroepiandrosterone (DHEA)--a precursor steroid or an active hormone in human physiology
    Abdulmaged M Traish
    Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA
    J Sex Med 8:2960-82; quiz 2983. 2011
    ..In the central nervous system, DHEA is considered a neurosteroid with a wide range of functions...
  25. doi request reprint Testosterone and cardiovascular disease: an old idea with modern clinical implications
    Abdulmaged M Traish
    Department of Biochemistry and Urology, Boston University School of Medicine, Laboratories for Sexual Medicine, Institute for Sexual Medicine, Center for Advanced Biomedical Research, 700 Albany Street, W607, Boston, MA 02118, United States
    Atherosclerosis 214:244-8. 2011
    ..Emerging evidence indicates that androgens may provide a protective effect against the development and/or progression of atherosclerosis in men...
  26. doi request reprint Safety of physiological testosterone therapy in women: lessons from female-to-male transsexuals (FMT) treated with pharmacological testosterone therapy
    Abdulmaged M Traish
    Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA
    J Sex Med 7:3758-64. 2010
    ..This unsubstantiated fear has hampered progress in treating women with sexual dysfunction using T therapy in physiological doses to achieve circulating levels in the normal range...
  27. ncbi request reprint Effects of castration and androgen replacement on erectile function in a rabbit model
    A M Traish
    Department of Urology, Boston University School of Medicine, Massachusetts 02118, USA
    Endocrinology 140:1861-8. 1999
    ..The results of this study demonstrate that androgen deprivation alters the functional responses and structure of erectile tissue...
  28. ncbi request reprint Development of human and rabbit vaginal smooth muscle cell cultures: effects of vasoactive agents on intracellular levels of cyclic nucleotides
    A Traish
    Department of Urology, Center for Advanced Biomedical Research, Boston University School of Medicine, Massachusetts 02118, USA
    Mol Cell Biol Res Commun 2:131-7. 1999
    ....
  29. doi request reprint The dark side of testosterone deficiency: III. Cardiovascular disease
    Abdulmaged M Traish
    Department of Biochemistry and Urology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Androl 30:477-94. 2009
    ..It should be emphasized, however, that androgen replacement therapy should be done with very thorough and careful monitoring for prostate diseases...
  30. ncbi request reprint Role of alpha adrenergic receptors in erectile function
    A Traish
    Department of Urology, Boston University School of Medicine, MA 02118, USA
    Int J Impot Res 12:S48-63. 2000
    ....
  31. doi request reprint Androgen deficiency and atherosclerosis: The lipid link
    Abdulmaged M Traish
    Department of Biochemistry and Urology, Boston University School of Medicine, Boston, MA 02118, USA
    Vascul Pharmacol 51:303-13. 2009
    ....
  32. pmc Epidermal growth factor receptor expression escapes androgen regulation in prostate cancer: a potential molecular switch for tumour growth
    A M Traish
    Department of Biochemistry and Urology, Boston University School of Medicine, Boston, MA 02118, USA
    Br J Cancer 101:1949-56. 2009
    ..We advance the hypothesis that a molecular switch, responsible for downregulating EGFR expression by androgens in the normal prostate, is either lost or modified in PCa...
  33. doi request reprint Biochemical factors modulating female genital sexual arousal physiology
    Abdulmaged M Traish
    Boston University School of Medicine, Department of Biochemistry, Boston, MA 02118, USA
    J Sex Med 7:2925-46. 2010
    ..These hemodynamic events are mediated by a host of neurotransmitters and vasoactive agents...
  34. ncbi request reprint Intracavernosal sildenafil facilitates penile erection independent of the nitric oxide pathway
    I W McAuley
    Department of Urology, Boston University School of Medicine, Massachusetts 02118, USA
    J Androl 22:623-8. 2001
    ....
  35. ncbi request reprint The evolving role of testosterone in the treatment of erectile dysfunction
    R Shabsigh
    Department of Urology, Columbia University, New York, NY 10032, USA
    Int J Clin Pract 60:1087-92. 2006
    ..Screening for hypogonadism may be useful in men with ED who fail prior PDE5 inhibitors, especially in populations at risk for hypogonadism such as type 2 diabetes and the metabolic syndrome...
  36. ncbi request reprint Loss of expression of a 55 kDa nuclear protein (nmt55) in estrogen receptor-negative human breast cancer
    A M Traish
    Department of Biochemistry, Boston University School of Medicine, MA 02118, USA
    Diagn Mol Pathol 6:209-21. 1997
    ....
  37. ncbi request reprint Inhibition of cyclic GMP hydrolysis in human corpus cavernosum smooth muscle cells by vardenafil, a novel, selective phosphodiesterase type 5 inhibitor
    N N Kim
    Department of Urology, Boston University School of Medicine, Massachusetts 02118, USA
    Life Sci 69:2249-56. 2001
    ..The more pronounced increase of cGMP in the presence of NO in intact cells suggests that vardenafil will be effective at lower doses than sildenafil under clinical conditions...
  38. ncbi request reprint Effects of ovariectomy and steroid hormones on vaginal smooth muscle contractility
    N N Kim
    Department of Urology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Int J Impot Res 16:43-50. 2004
    ..These observations suggest that steroid hormones may be important regulators of vaginal tissue structure and contractility...
  39. ncbi request reprint Alpha-adrenergic receptor blockade by phentolamine increases the efficacy of vasodilators in penile corpus cavernosum
    N N Kim
    Department of Urology, Boston University School of Medicine, Massachusetts 02118, USA
    Int J Impot Res 12:S26-36. 2000
    ..These findings suggest that antagonism of alpha-adrenergic signaling enables other independent relaxatory pathways to predominate within penile trabecular smooth muscle...
  40. ncbi request reprint Development and characterization of monoclonal antibodies to a specific domain of human estrogen receptor
    A M Traish
    Department of Biochemistry, Boston University School of Medicine, MA 02118
    Steroids 55:196-208. 1990
    ..These results demonstrate the development of site-specific MoAbs to the native form of the hER using synthetic peptides as immunogens...
  41. ncbi request reprint Roles of IKK kinases and protein kinase CK2 in activation of nuclear factor-kappaB in breast cancer
    R Romieu-Mourez
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118-2394, USA
    Cancer Res 61:3810-8. 2001
    ....
  42. ncbi request reprint Estrogen receptor antibodies: specificity and utility in detection, localization and analyses of estrogen receptor alpha and beta
    M Pavao
    Department of Biochemistry, Center for Advanced Biomedical Research, Boston University School of Medicine, 700 Albany Street, Boston, MA 02118, USA
    Steroids 66:1-16. 2001
    ..The advent of new antibodies remains a powerful tool for assessment of ER expression and post-translational modification and receptor function in many experimental systems...
  43. ncbi request reprint Hemodynamic evaluation of the female sexual arousal response in an animal model
    K Min
    Department of Urology, Boston University School of Medicine, 700 Albany Street, W607, Boston, MA 02118, USA
    J Sex Marital Ther 27:557-65. 2001
    ....
  44. ncbi request reprint Monoclonal and polyclonal antibodies to human progesterone receptor peptide-(533-547) recognize a specific site in unactivated (8S) and activated (4S) progesterone receptor and distinguish between intact and proteolyzed receptors
    A M Traish
    Department of Biochemistry, Boston University School of Medicine, Massachusetts 02118
    Endocrinology 127:1167-75. 1990
    ....
  45. ncbi request reprint Binding of site-directed monoclonal antibodies to an epitope located in the A/B region (amino acids 140-154) of human estrogen receptor-induced conformational changes in an epitope in the DNA-binding domain
    A M Traish
    Department of Biochemistry, Boston University School of Medicine, MA 02118, USA
    Steroids 61:549-56. 1996
    ..These data further suggest that the DNA-binding region is sensitive to conformational changes induced in the native protein...
  46. ncbi request reprint Monoclonal antibodies to human endothelin-1: characterization and utilization in radioimmunoassay and immunocytochemistry
    A M Traish
    Department of Biochemistry, Boston University, School of Medicine, MA 02118
    Hybridoma 11:147-63. 1992
    ....
  47. ncbi request reprint Endothelin: localization, synthesis, activity, and receptor types in human penile corpus cavernosum
    I Saenz de Tejada
    Department of Urology, Boston University Medical Center, Massachusetts 02118
    Am J Physiol 261:H1078-85. 1991
    ....
  48. pmc Binding of type II nuclear receptors and estrogen receptor to full and half-site estrogen response elements in vitro
    C M Klinge
    Department of Biochemistry, The University of Louisville School of Medicine, Louisville, KY 40292, USA
    Nucleic Acids Res 25:1903-12. 1997
    ....
  49. ncbi request reprint Expression of functional prostaglandin D (DP) receptors in human corpus cavernosum smooth muscle
    R B Moreland
    Department of Urology, Boston University School of Medicine, Boston, Massachusetts, USA
    Int J Impot Res 14:446-52. 2002
    ..These data are consistent with the expression of functional DP receptors in human corpus cavernosum. This suggests the presence of an intact prostanoid autocrine system that may play a role in regulating penile erectile function...
  50. ncbi request reprint Selective P2Y2 receptor agonists stimulate vaginal moisture in ovariectomized rabbits
    Kweonsik Min
    Department of Urology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Fertil Steril 79:393-8. 2003
    ..To determine the expression of P2Y(2) receptors in vaginal and cervical tissues and the effects of P2Y(2) receptor agonists INS45973 and INS365 on vaginal moisture...
  51. ncbi request reprint Effects of ovariectomy and estrogen replacement on basal and pelvic nerve stimulated vaginal lubrication in an animal model
    Kweonsik Min
    Department of Urology, Inje University School of Medicine, Pusan, South Korea
    J Sex Marital Ther 29:77-84. 2003
    ..Estrogen replacement normalized lubrication values and tissue wet weight to control levels. In conclusion, vaginal tissue integrity and lubrication are diminished by ovariectomy and are normalized by estrogen replacement...
  52. ncbi request reprint Differential effects of estradiol, progesterone, and testosterone on vaginal structural integrity
    Monica A Pessina
    Department of Anatomy and Neurobiology, Institute for Sexual Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Endocrinology 147:61-9. 2006
    ..Present observations also suggest that combined replacement regimens may be required for an optimal physiological response...
  53. ncbi request reprint Biochemical and functional characterization of alpha-adrenergic receptors in the rabbit vagina
    Noel N Kim
    Department of Urology, School of Medicine, Boston University, 700 Albany St W607, Boston, MA 02118, USA
    Life Sci 71:2909-20. 2002
    ..Thus, vaginal tissue expresses functional alpha-1 and alpha-2 AR, which modulate vaginal smooth muscle contractility and genital engorgement...
  54. ncbi request reprint Modulation of rat vaginal blood flow and estrogen receptor by estradiol
    Soo Woong Kim
    Department of Urology, Seoul National University College of Medicine, Seoul, Korea
    J Urol 172:1538-43. 2004
    ..The effects of subphysiological and physiological levels of estradiol on vaginal blood flow and estrogen receptor were investigated...
  55. ncbi request reprint Efficacy of vardenafil and sildenafil in facilitating penile erection in an animal model
    Seong Choi
    Department of Urology, Boston University School of Medicine, Massachusetts 02118, USA
    J Androl 23:332-7. 2002
    ..On the basis of the biochemical data and physiological responses from this study, further clinical evaluation of vardenafil as treatment for erectile dysfunction is warranted...
  56. ncbi request reprint Laser oximetry: A novel noninvasive method to determine changes in penile hemodynamics in an anesthetized rabbit model
    Seong Choi
    Department of Urology, Kosin University School of Medicine, Pusan, South Korea
    J Androl 23:278-83. 2002
    ..Its sensitivity in detecting small changes in oxyhemoglobin concentration and its noninvasive nature make it advantageous over invasive methods such as ICP monitoring and laser Doppler flowmetry...
  57. ncbi request reprint Pilot study of the endothelin-A receptor selective antagonist BMS-193884 for the treatment of erectile dysfunction
    Noel N Kim
    Department of Urology, Boston University School of Medicine, Massachusetts 02118, USA
    J Androl 23:76-83. 2002
    ..The disparity between the laboratory and clinical studies suggests that there may be differences between species with regard to the role of endothelin in erectile function...
  58. ncbi request reprint Cocaine and ephedrine-induced priapism: case reports and investigation of potential adrenergic mechanisms
    Ricardo Munarriz
    Department of Urology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Urology 62:187-92. 2003
    ..However, the effects of cocaine and ephedrine on adrenergic regulation of cavernosal tissue and the potential role of sympathetic dysregulation in the development of priapism have not been studied...
  59. ncbi request reprint Human arginase II: crystal structure and physiological role in male and female sexual arousal
    Evis Cama
    Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6323, USA
    Biochemistry 42:8445-51. 2003
    ..Therefore, arginase II is a potential target for the treatment of male and female sexual arousal disorders...
  60. ncbi request reprint Physiology of female sexual function: animal models
    Annamaria Giraldi
    Rigshospitalet, Copenhagen, Denmark
    J Sex Med 1:237-53. 2004
    ..Data concerning the physiology of desire, arousal, and orgasm in women are limited because of ethical constraints. Aim. To gain knowledge of physiology of female sexual function through animal models...
  61. ncbi request reprint Dose-response relationship between testosterone and erectile function: evidence for the existence of a critical threshold
    Abdullah Armagan
    Department of Urology, Suleyman Demirel University Faculty of Medicine, Isparta, Turkey
    J Androl 27:517-26. 2006
    ..However, different androgen-dependent tissues may exhibit varying sensitivities to circulating testosterone with regard to growth and function...
  62. ncbi request reprint Role of arginase in the male and female sexual arousal response
    Noel N Kim
    Department of Urology and Institute for Sexual Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    J Nutr 134:2873S-2879S; discussion 2895S. 2004
    ....
  63. ncbi request reprint Differential regulation of the expression of estrogen, progesterone, and androgen receptors by sex steroid hormones in the vagina: immunohistochemical studies
    Monica A Pessina
    Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
    J Sex Med 3:804-14. 2006
    ..The goal of this study was to assess changes in steroid hormone receptor expression and distribution in response to sex steroid hormone deprivation and administration...
  64. pmc Testosterone and erectile function: from basic research to a new clinical paradigm for managing men with androgen insufficiency and erectile dysfunction
    Abdulmaged M Traish
    Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA
    Eur Urol 52:54-70. 2007
    ....
  65. ncbi request reprint Testosterone increases blood flow and expression of androgen and estrogen receptors in the rat vagina
    Abdulmaged M Traish
    Departments of Biochemistry, and Urology, Boston University School of Medicine, Boston, MA, USA
    J Sex Med 4:609-19. 2007
    ..The mechanisms by which testosterone modulates female genital sexual arousal responses are poorly understood...
  66. ncbi request reprint An in vivo rat model to investigate female vaginal arousal response
    Soo Woong Kim
    Department of Urology, Seoul National University College of Medicine, Seoul, Korea
    J Urol 171:1357-61. 2004
    ..We established a rat model to investigate the female vaginal arousal response and the role of the nitric oxide (NO) pathway on vaginal blood flow in vivo...
  67. ncbi request reprint Reperfusion of ischemic corporal tissue: physiologic and biochemical changes in an animal model of ischemic priapism
    Ricardo Munarriz
    Department of Urology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Urology 62:760-4. 2003
    ..Data are limited concerning reperfusion injury of ischemic erectile tissue associated with reactive oxygen species (ROS) and the potential role of ROS scavengers in the clinical therapy of ischemic priapism...
  68. ncbi request reprint Pharmacological and functional characterization of novel EP and DP receptor agonists: DP1 receptor mediates penile erection in multiple species
    Nadia Brugger
    EMD Serono Research Institute Medicinal Chemistry, Rockland, MA, USA
    J Sex Med 5:344-56. 2008
    ..Despite the widespread use of prostaglandin E(1) as an efficacious treatment for male erectile dysfunction for more than two decades, research on prostanoid function in penile physiology has been limited...
  69. ncbi request reprint Identification of G2/M targets for the MAP kinase pathway by functional proteomics
    Elisabeth C Roberts
    Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder 80309 0215, USA
    Proteomics 6:4541-53. 2006
    ....
  70. ncbi request reprint The multifunctional nuclear protein p54nrb is multiphosphorylated in mitosis and interacts with the mitotic regulator Pin1
    Ariane Proteau
    CREFSIP and Département de médecine, Laval University, Pavillon C E Marchand, Room 4263 Laval University, Que, Canada, G1K 7P4
    J Mol Biol 346:1163-72. 2005
    ..Our results also showed that Pin1 binding was favored when at least two of the three threonine residues were phosphorylated, suggesting a regulation mechanism based on multisite phosphorylation...
  71. pmc Extracellular signal-regulated kinase 7, a regulator of hormone-dependent estrogen receptor destruction
    Lorin M Henrich
    Department of Microbiology and Center for Cell Signaling, University of Virginia, Charlottesville, Virginia 22908, USA
    Mol Cell Biol 23:5979-88. 2003
    ..ERK7 targets the ER alpha ligand-binding domain for destruction by enhancing its ubiquitination. Thus, ERK7 is a novel regulator of estrogen responsiveness through its control of ER alpha turnover...
  72. doi request reprint Testosterone therapy and breast cancer?
    Andre T Guay
    Fertil Steril 90:468; author reply 468-9. 2008
  73. ncbi request reprint Clinical biologic pathophysiologies of women's sexual dysfunction
    Rossella Nappi
    University of Pavia, Italy
    J Sex Med 2:4-25. 2005
    ..Data concerning the biologic pathophysiology of desire, arousal, and orgasm in women are limited...

Research Grants4

  1. FEMALE SEXUAL AROUSAL: CLITORAL AND VAGINAL PHYSIOLOGY
    Abdulmaged Traish; Fiscal Year: 2003
    ....