Sam Thiagalingam

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi Loss of heterozygosity as a predictor to map tumor suppressor genes in cancer: molecular basis of its occurrence
    Sam Thiagalingam
    Genetics and Molecular Medicine Programs and Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    Curr Opin Oncol 14:65-72. 2002
  2. ncbi Histone deacetylases: unique players in shaping the epigenetic histone code
    Sam Thiagalingam
    Genetics and Molecular Medicine Programs and Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Ann N Y Acad Sci 983:84-100. 2003
  3. ncbi A cascade of modules of a network defines cancer progression
    Sam Thiagalingam
    Department of Medicine Genetics Program and Cancer Research Center, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Cancer Res 66:7379-85. 2006
  4. ncbi Differential DNA hypermethylation of critical genes mediates the stage-specific tobacco smoke-induced neoplastic progression of lung cancer
    Andrea L Russo
    Department of Medicine (Genetics Program and Cancer Research Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Clin Cancer Res 11:2466-70. 2005
  5. ncbi hBub1 negatively regulates p53 mediated early cell death upon mitotic checkpoint activation
    Fangming Gao
    Department of Medicine, Genetics Program and Cancer Research Center, Boston University School of Medicine, Boston, MA, USA
    Cancer Biol Ther 8:548-56. 2009
  6. ncbi Smad signaling is required to maintain epigenetic silencing during breast cancer progression
    Panagiotis Papageorgis
    Departments of Medicine Genetics and Molecular Medicine Programs and Cancer Research Center, Genetics and Genomics, Boston University School of Medicine, Boston, Massachusetts, USA
    Cancer Res 70:968-78. 2010
  7. ncbi Epigenetic dysregulation of HTR2A in the brain of patients with schizophrenia and bipolar disorder
    Hamid Mostafavi Abdolmaleky
    Department of Medicine, Biomedical Genetics, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA
    Schizophr Res 129:183-90. 2011
  8. ncbi Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder
    Hamid Mostafavi Abdolmaleky
    Department of Psychiatry at Massachusetts Mental Health Center and Harvard Institute of Psychiatric Epidemiology and Genetics, Harvard Medical School, Boston, MA, USA
    Hum Mol Genet 15:3132-45. 2006
  9. ncbi Epigenetic alterations of the dopaminergic system in major psychiatric disorders
    Hamid Mostafavi Abdolmaleky
    Laboratory of Nutrition and Metabolism at BIDMC, Harvard Medical School, Boston, Massachusetts, USA
    Methods Mol Biol 448:187-212. 2008
  10. ncbi Epigenetic and pharmacoepigenomic studies of major psychoses and potentials for therapeutics
    Hamid Mostafavi Abdolmaleky
    Laboratory of Nutrition and Metabolism at BIDMC, Harvard Medical School, Boston, MA, USA
    Pharmacogenomics 9:1809-23. 2008

Research Grants

  1. Genetic Determinants of Epithelial DNA Damage in Smokers
    Sam Thiagalingam; Fiscal Year: 2004
  2. The role of hBUB1-p53 pathway in genomic stability.
    Sam Thiagalingam; Fiscal Year: 2007

Collaborators

Detail Information

Publications18

  1. ncbi Loss of heterozygosity as a predictor to map tumor suppressor genes in cancer: molecular basis of its occurrence
    Sam Thiagalingam
    Genetics and Molecular Medicine Programs and Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    Curr Opin Oncol 14:65-72. 2002
    ..The molecular defects for the occurrence of loss of heterozygosity are derived from disabled caretaker genes, which protect the integrity of DNA, or chromosome segregator genes, which mediate faithful chromosome disjunction...
  2. ncbi Histone deacetylases: unique players in shaping the epigenetic histone code
    Sam Thiagalingam
    Genetics and Molecular Medicine Programs and Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Ann N Y Acad Sci 983:84-100. 2003
    ....
  3. ncbi A cascade of modules of a network defines cancer progression
    Sam Thiagalingam
    Department of Medicine Genetics Program and Cancer Research Center, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Cancer Res 66:7379-85. 2006
    ..The formulation of MMMN cancer progression models for specific cancers is likely to provide the blueprints for the markers and targets to aid diagnosis, prevention, and therapy of this deadly disease...
  4. ncbi Differential DNA hypermethylation of critical genes mediates the stage-specific tobacco smoke-induced neoplastic progression of lung cancer
    Andrea L Russo
    Department of Medicine (Genetics Program and Cancer Research Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Clin Cancer Res 11:2466-70. 2005
    ..We also provide preliminary evidence that peripheral lymphocytes could potentially be used as a surrogate for bronchial epithelial cells to detect altered DNA methylation in smokers...
  5. ncbi hBub1 negatively regulates p53 mediated early cell death upon mitotic checkpoint activation
    Fangming Gao
    Department of Medicine, Genetics Program and Cancer Research Center, Boston University School of Medicine, Boston, MA, USA
    Cancer Biol Ther 8:548-56. 2009
    ..On the translational medicine front, it is tempting to speculate that by disabling hBub1 in p53 proficient cancer cells, apoptosis may be induced as a therapeutic approach to eradicate the tumor cells...
  6. ncbi Smad signaling is required to maintain epigenetic silencing during breast cancer progression
    Panagiotis Papageorgis
    Departments of Medicine Genetics and Molecular Medicine Programs and Cancer Research Center, Genetics and Genomics, Boston University School of Medicine, Boston, Massachusetts, USA
    Cancer Res 70:968-78. 2010
    ..Together, our findings reveal a hyperactive TGFbeta-TGFbetaR-Smad2 signaling axis needed to maintain epigenetic silencing of critical EMT genes and breast cancer progression...
  7. ncbi Epigenetic dysregulation of HTR2A in the brain of patients with schizophrenia and bipolar disorder
    Hamid Mostafavi Abdolmaleky
    Department of Medicine, Biomedical Genetics, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA
    Schizophr Res 129:183-90. 2011
    ..We hypothesized that epigenetic dysregulation of HTR2A may be involved in psycho-pathogenesis and analyzed promoter DNA methylome and expression of HTR2A in SCZ, BD and control subjects...
  8. ncbi Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder
    Hamid Mostafavi Abdolmaleky
    Department of Psychiatry at Massachusetts Mental Health Center and Harvard Institute of Psychiatric Epidemiology and Genetics, Harvard Medical School, Boston, MA, USA
    Hum Mol Genet 15:3132-45. 2006
    ....
  9. ncbi Epigenetic alterations of the dopaminergic system in major psychiatric disorders
    Hamid Mostafavi Abdolmaleky
    Laboratory of Nutrition and Metabolism at BIDMC, Harvard Medical School, Boston, Massachusetts, USA
    Methods Mol Biol 448:187-212. 2008
    ....
  10. ncbi Epigenetic and pharmacoepigenomic studies of major psychoses and potentials for therapeutics
    Hamid Mostafavi Abdolmaleky
    Laboratory of Nutrition and Metabolism at BIDMC, Harvard Medical School, Boston, MA, USA
    Pharmacogenomics 9:1809-23. 2008
    ..In fact, some therapeutics now in use target epigenetic programming. In the near future, epigenetic interventions should help stabilize affected individuals and lead to prevention strategies...
  11. ncbi Smad4 inactivation promotes malignancy and drug resistance of colon cancer
    Panagiotis Papageorgis
    Department of Medicine, Genetics and Genomics Graduate Program, Boston University School of Medicine, Boston, Massachusetts, USA
    Cancer Res 71:998-1008. 2011
    ..These findings are also consistent with targeting TGFβ-induced auxiliary pathways, such as MEK-ERK, and p38-MAPK and the glycolytic cascade, in SMAD4-deficient tumors as attractive strategies for therapeutic intervention...
  12. ncbi hBub1 deficiency triggers a novel p53 mediated early apoptotic checkpoint pathway in mitotic spindle damaged cells
    Fangming Gao
    Department of Medicine, Genetics Program and Cancer Research Center, Boston University School of Medicine, Boston, MA, USA
    Cancer Biol Ther 8:627-35. 2009
    ..On the other hand, as expected, concomitant loss of both hBub1 and p53 resulted in disabling of the p53 mediated cell death pathway leading to the accumulation of cells with aneuploidy/polyploidy...
  13. ncbi Aberrant activation of gamma-catenin promotes genomic instability and oncogenic effects during tumor progression
    Hongjie Pan
    Department of Medicine Genetics Program and Cancer Research Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Cancer Biol Ther 6:1638-43. 2007
    ..In conclusion, our studies provide a molecular basis for the promotion of genomic instability and the oncogenic effects due to overexpression of gamma-catenin in human cancer...
  14. ncbi Genetics and epigenetics in major psychiatric disorders: dilemmas, achievements, applications, and future scope
    Hamid M Abdolmaleky
    Department of Psychiatry, Harvard Medical School at Massachusetts Mental Health Center, Boston, Massachusetts, USA
    Am J Pharmacogenomics 5:149-60. 2005
    ....
  15. ncbi Loss of heterozygosity patterns provide fingerprints for genetic heterogeneity in multistep cancer progression of tobacco smoke-induced non-small cell lung cancer
    Hongjie Pan
    Department of Medicine (Genetics Program and Cancer Research Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Cancer Res 65:1664-9. 2005
    ..The gatekeeper module consists of multiple alternate target genes, which is inclusive of but not limited to genes localized to chromosomal loci 8p, 9p, 11q, and 13q...
  16. ncbi Integrin signaling in mammary epithelial cells and breast cancer
    Arthur W Lambert
    Molecular Medicine Program, Biomedical Genetics Section, Department of Medicine, Boston University School of Medicine, 72 East Concord Street, L320, Boston, MA 02118, USA
    ISRN Oncol 2012:493283. 2012
    ..This paper highlights recent studies which examine the role of integrin signaling in mammary epithelial cells and their malignant counterparts...
  17. ncbi Elucidation of epigenetic inactivation of SMAD8 in cancer using targeted expressed gene display
    Kuang-hung Cheng
    Department of Medicine (Genetics Program, Pulmonary Center and Cancer Research Center, Boston University School of Medicine, Boston, MA 02118, USA
    Cancer Res 64:1639-46. 2004
    ....
  18. ncbi Hypermethylation of the reelin (RELN) promoter in the brain of schizophrenic patients: a preliminary report
    Hamid Mostafavi Abdolmaleky
    Department of Psychiatry, Harvard Medical School at Massachusetts Mental Health Center, Boston, Massachusetts, USA
    Am J Med Genet B Neuropsychiatr Genet 134:60-6. 2005
    ..Further studies with a larger sample set would be required to validate these preliminary observations...

Research Grants9

  1. Genetic Determinants of Epithelial DNA Damage in Smokers
    Sam Thiagalingam; Fiscal Year: 2004
    ..In the long-term, these target genes may serve as nodal points for therapeutic intervention, diagnosis, prognosis and management of the disease. ..
  2. The role of hBUB1-p53 pathway in genomic stability.
    Sam Thiagalingam; Fiscal Year: 2007
    ..These analyses could lead to the molecular understanding of the hBUB1-p53 pathway in maintaining genomic stability and thus help to design novel diagnostic and therapeutic strategies in all cancers. ..