Donald Thea

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Pregnancy loss and role of infant HIV status on perinatal mortality among HIV-infected women
    Hae Young Kim
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    BMC Pediatr 12:138. 2012
  2. pmc HIV prevention is not enough: child survival in the context of prevention of mother to child HIV transmission
    Louise Kuhn
    Gertrude H, Sergievsky Center, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    J Int AIDS Soc 12:36. 2009
  3. pmc Validation of the UCLA Child Post traumatic stress disorder-reaction index in Zambia
    Laura K Murray
    Johns Hopkins University Bloomberg School of Public Health, Dept, of International Health, Baltimore, MD, USA
    Int J Ment Health Syst 5:24. 2011
  4. pmc Reuse of single-dose nevirapine in subsequent pregnancies for the prevention of mother-to-child HIV transmission in Lusaka, Zambia: a cohort study
    Jan Walter
    Childrens Hospital Los Angeles, University of Southern California, Los Angeles, CA, USA
    BMC Infect Dis 8:172. 2008
  5. ncbi request reprint Issues in the design of a clinical trial with a behavioral intervention--the Zambia exclusive breast-feeding study
    Donald M Thea
    Center for International Health and Development, Boston University School of Public Health, 710 Albany Street, 715, Boston, MA 02118, USA
    Control Clin Trials 25:353-65. 2004
  6. doi request reprint Neonatal mortality--4 million reasons for progress
    Donald Thea
    Boston University School of Public Health, Boston, MA 02118, USA
    Lancet 371:1893-5. 2008
  7. pmc Post-weaning breast milk HIV-1 viral load, blood prolactin levels and breast milk volume
    Donald M Thea
    Center for International Health and Development at the Boston University School of Public Health, Boston, Massachusetts, USA
    AIDS 20:1539-47. 2006
  8. pmc Temporal and lateral dynamics of HIV shedding and elevated sodium in breast milk among HIV-positive mothers during the first 4 months of breast-feeding
    Katherine Semrau
    Center for International Health and Development at the Boston University School of Public Health, Boston, Massachusetts, USA
    J Acquir Immune Defic Syndr 47:320-8. 2008
  9. pmc Women in couples antenatal HIV counseling and testing are not more likely to report adverse social events
    Katherine Semrau
    Center for International Health and Development at the Boston University School of Public Health, Boston, Massachusetts 02118, USA
    AIDS 19:603-9. 2005
  10. ncbi request reprint Two-dose versus monthly intermittent preventive treatment of malaria with sulfadoxine-pyrimethamine in HIV-seropositive pregnant Zambian women
    Davidson H Hamer
    Center for International Health and Development, Boston University School of Public Health, Boston, MA 02118, USA
    J Infect Dis 196:1585-94. 2007

Collaborators

Detail Information

Publications43

  1. pmc Pregnancy loss and role of infant HIV status on perinatal mortality among HIV-infected women
    Hae Young Kim
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    BMC Pediatr 12:138. 2012
    ..Here we examine risk factors for these adverse pregnancy outcomes in a cohort of HIV-infected women in Zambia considering the impact of infant HIV status...
  2. pmc HIV prevention is not enough: child survival in the context of prevention of mother to child HIV transmission
    Louise Kuhn
    Gertrude H, Sergievsky Center, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    J Int AIDS Soc 12:36. 2009
    ..This will lead to reduced HIV transmission and will protect the health of women without compromising the health and well-being of infants and young children...
  3. pmc Validation of the UCLA Child Post traumatic stress disorder-reaction index in Zambia
    Laura K Murray
    Johns Hopkins University Bloomberg School of Public Health, Dept, of International Health, Baltimore, MD, USA
    Int J Ment Health Syst 5:24. 2011
    ..abstract:..
  4. pmc Reuse of single-dose nevirapine in subsequent pregnancies for the prevention of mother-to-child HIV transmission in Lusaka, Zambia: a cohort study
    Jan Walter
    Childrens Hospital Los Angeles, University of Southern California, Los Angeles, CA, USA
    BMC Infect Dis 8:172. 2008
    ..The effects of these mutations on the efficacy of SDNVP use in a subsequent pregnancy are not well understood...
  5. ncbi request reprint Issues in the design of a clinical trial with a behavioral intervention--the Zambia exclusive breast-feeding study
    Donald M Thea
    Center for International Health and Development, Boston University School of Public Health, 710 Albany Street, 715, Boston, MA 02118, USA
    Control Clin Trials 25:353-65. 2004
    ....
  6. doi request reprint Neonatal mortality--4 million reasons for progress
    Donald Thea
    Boston University School of Public Health, Boston, MA 02118, USA
    Lancet 371:1893-5. 2008
  7. pmc Post-weaning breast milk HIV-1 viral load, blood prolactin levels and breast milk volume
    Donald M Thea
    Center for International Health and Development at the Boston University School of Public Health, Boston, Massachusetts, USA
    AIDS 20:1539-47. 2006
    ..The effect of abrupt weaning, advocated as a safe transition from exclusive breastfeeding in HIV-exposed children, on the quantity of HIV viral load in breast milk (BMVL) is not known...
  8. pmc Temporal and lateral dynamics of HIV shedding and elevated sodium in breast milk among HIV-positive mothers during the first 4 months of breast-feeding
    Katherine Semrau
    Center for International Health and Development at the Boston University School of Public Health, Boston, Massachusetts, USA
    J Acquir Immune Defic Syndr 47:320-8. 2008
    ..To better understand the dynamics of breast milk HIV shedding and its relation to postnatal HIV transmission, we investigated the temporal and lateral relations of breast milk viral shedding and sodium concentrations in HIV-positive women...
  9. pmc Women in couples antenatal HIV counseling and testing are not more likely to report adverse social events
    Katherine Semrau
    Center for International Health and Development at the Boston University School of Public Health, Boston, Massachusetts 02118, USA
    AIDS 19:603-9. 2005
    ..Couple counseling has been promoted as a strategy to improve uptake of interventions to prevent mother-to-child HIV transmission (pMTCT) and to minimize adverse social outcomes associated with disclosure of HIV status...
  10. ncbi request reprint Two-dose versus monthly intermittent preventive treatment of malaria with sulfadoxine-pyrimethamine in HIV-seropositive pregnant Zambian women
    Davidson H Hamer
    Center for International Health and Development, Boston University School of Public Health, Boston, MA 02118, USA
    J Infect Dis 196:1585-94. 2007
    ..However, the optimal dosing regimen in settings in which human immunodeficiency virus (HIV) is highly prevalent among pregnant women remains controversial...
  11. pmc Reduced mortality associated with breast-feeding-acquired HIV infection and breast-feeding among HIV-infected children in Zambia
    Matthew P Fox
    Center for International Health and Development, Boston University, Boston, MA 02118, USA
    J Acquir Immune Defic Syndr 48:90-6. 2008
    ..This study assessed whether children infected postpartum have longer survival from time of infection versus those infected during gestation or delivery...
  12. pmc Impact of chloroquine on viral load in breast milk
    Katherine Semrau
    Center for International Health and Development, Boston University School of Public Health, Boston, MA 02118, USA
    Trop Med Int Health 11:800-3. 2006
    ..Further research is needed to determine the potential role of chloroquine in prevention of HIV transmission through breastfeeding...
  13. pmc Role of breastfeeding cessation in mediating the relationship between maternal HIV disease stage and increased child mortality among HIV-exposed uninfected children
    Matthew P Fox
    Center for International Health and Development, Boston University, Boston, MA 02118, USA
    Int J Epidemiol 38:569-76. 2009
    ..Maternal CD4 count predicts child mortality in HIV-uninfected children born to HIV-infected women...
  14. pmc Community case management of fever due to malaria and pneumonia in children under five in Zambia: a cluster randomized controlled trial
    Kojo Yeboah-Antwi
    Center for Global Health and Development, Boston University School of Public Health, Boston, Massachusetts, United States of America
    PLoS Med 7:e1000340. 2010
    ..This study was designed to assess the effectiveness and feasibility of using CHWs to manage nonsevere pneumonia and uncomplicated malaria with the aid of rapid diagnostic tests (RDTs)...
  15. ncbi request reprint No room for complacency about adherence to antiretroviral therapy in sub-Saharan Africa
    Christopher J Gill
    Center for International Health and Development, Department of International Health, Boston University School of Public Health, MA 02118, USA
    AIDS 19:1243-9. 2005
    ....
  16. pmc Barriers to acceptance and adherence of antiretroviral therapy in urban Zambian women: a qualitative study
    Laura K Murray
    Boston University School of Public Health, Center for International Health and Development, Boston, MA, USA
    AIDS Care 21:78-86. 2009
    ..Qualitative studies are critical to better understand why ART eligible individuals are choosing not to initiate or continue treatment to achieve needed adherence levels...
  17. pmc Violence and abuse among HIV-infected women and their children in Zambia: a qualitative study
    Laura K Murray
    Boston University School of Public Health, Center for International Health and Development, Applied Mental Health Research Group, Boston, Massachusetts 02118, USA
    J Nerv Ment Dis 194:610-5. 2006
    ..This study shows the local perspective of the overlap between violence and HIV. Results are discussed in relation to the need for violence and abuse to be addressed as HIV services are implemented in sub-Saharan Africa...
  18. pmc Analyzing media coverage of the global fund diseases compared with lower funded diseases (childhood pneumonia, diarrhea and measles)
    David L Hudacek
    Center for Global Health and Development, Boston University, Boston, Massachusetts, United States of America
    PLoS ONE 6:e20438. 2011
    ..This study investigates the potential relationship between media agenda setting and funding levels in the context of the actual burden of disease...
  19. ncbi request reprint The cost of HIV/AIDS to businesses in southern Africa
    Sydney Rosen
    Center for International Health and Development, Boston University School of Public Health, Boston, Massachusetts 02118, USA
    AIDS 18:317-24. 2004
    ..Information on the potential costs of HIV/AIDS to the private sector is needed if companies are to be given a financial incentive to invest in prevention and treatment interventions...
  20. pmc High uptake of exclusive breastfeeding and reduced early post-natal HIV transmission
    Louise Kuhn
    Gertrude H Sergievsky Center, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, United States of America
    PLoS ONE 2:e1363. 2007
    ..We conducted a prospective, observational study in Lusaka, Zambia, to test the hypothesis that EBF is associated with a lower risk of postnatal HIV transmission than non-EBF...
  21. pmc Effects of early, abrupt weaning on HIV-free survival of children in Zambia
    Louise Kuhn
    Gertrude H Sergievsky Center and the Department of Epidemiology, Mailman School of Public Health, Columbia University, New York 10032, USA
    N Engl J Med 359:130-41. 2008
    ..We conducted a randomized trial to evaluate whether abrupt weaning at 4 months as compared with the standard practice has a net benefit for HIV-free survival of children...
  22. pmc Bystander effects: children who escape infection but not harm
    Louise Kuhn
    Gertrude H Sergievsky Center, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    J Acquir Immune Defic Syndr 46:517-8. 2007
  23. ncbi request reprint Veterinary field test as screening tool for mastitis and HIV-1 viral load in breastmilk from HIV-infected Zambian women
    Stephanie M Dorosko
    Breastfeed Med 2:172-5. 2007
    ....
  24. pmc Low and undetectable breast milk interleukin-7 concentrations are associated with reduced risk of postnatal HIV transmission
    Jan Walter
    Gertrude H Sergievsky Center and Department of Epidemiology, Mailman School of Public Health, Columbia University New York, NY, USA
    J Acquir Immune Defic Syndr 46:200-7. 2007
    ..To investigate if breast milk interleukin [IL]-7 concentrations are associated with postnatal HIV transmission...
  25. ncbi request reprint Maternal adherence to the zidovudine regimen for HIV-exposed infants to prevent HIV infection: a preliminary study
    Penelope A Demas
    AIDS Research Program, Department of Epidemiology and Social Medicine, Montefiore Medical Center, Bronx, New York 10467, USA
    Pediatrics 110:e35. 2002
    ....
  26. pmc Alpha-defensins in the prevention of HIV transmission among breastfed infants
    Louise Kuhn
    Gertrude H Sergievsky Center and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    J Acquir Immune Defic Syndr 39:138-42. 2005
    ..3, 95% confidence interval: 0.09-0.93). Our data suggest that there may be a role for alpha-defensins in prevention of HIV transmission to breastfed infants...
  27. pmc Prolonged breast-feeding and mortality up to two years post-partum among HIV-positive women in Zambia
    Louise Kuhn
    Gertrude H Sergievsky Center, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    AIDS 19:1677-81. 2005
    ..A previously reported association between prolonged lactation and maternal mortality has generated concern that breast-feeding may be detrimental for HIV-positive women...
  28. pmc Treatment of paediatric malaria during a period of drug transition to artemether-lumefantrine in Zambia: cross sectional study
    Dejan Zurovac
    Malaria Public Health and Epidemiology Group, Centre for Geographic Medicine, KEMRI Wellcome Trust Collaborative Programme, PO Box 43640, 00100 GPO, Nairobi, Kenya
    BMJ 331:734. 2005
    ..To evaluate treatment practices for uncomplicated malaria after the policy change from chloroquine to sulfadoxine-pyrimethamine and to artemether-lumefantrine in Zambia...
  29. pmc Does severity of HIV disease in HIV-infected mothers affect mortality and morbidity among their uninfected infants?
    Louise Kuhn
    Gertrude H Sergievsky Center, Mailman School of Public Health, Columbia University, New York, NY, USA
    Clin Infect Dis 41:1654-61. 2005
    ..We investigated the hypothesis that the severity of HIV disease and immune dysfunction among mothers is associated with increased morbidity and mortality among their uninfected infants...
  30. pmc Predictors of nonadherence to single-dose nevirapine therapy for the prevention of mother-to-child HIV transmission
    Sandra Albrecht
    Gertrude H Sergievsky Center, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    J Acquir Immune Defic Syndr 41:114-8. 2006
    ..Adequate adherence is required for prevention of mother-to-child transmission of HIV (pMTCT) programs to be effective. We investigated predictors and extent of nonadherence to single-dose nevirapine...
  31. ncbi request reprint Adherence to zidovudine for the prevention of perinatal transmission in HIV-infected pregnant women: the impact of social network factors, side effects, and perceived treatment efficacy
    Penelope A Demas
    AIDS Research Program, Montefiore Medical Center, 111 East 210 Street, Bronx, NY 10467, USA
    Women Health 42:99-115. 2005
    ..These social network factors may enable HIV-infected pregnant women to cope more effectively with the multiple stressors they face and facilitate prenatal care...
  32. pmc Nevirapine resistance viral mutations after repeat use of nevirapine for prevention of perinatal HIV transmission
    Louise Kuhn
    J Acquir Immune Defic Syndr 42:260-2. 2006
  33. pmc Reduction in preterm delivery and neonatal mortality after the introduction of antenatal cotrimoxazole prophylaxis among HIV-infected women with low CD4 cell counts
    Jan Walter
    Gertrude H Sergievsky Center and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    J Infect Dis 194:1510-8. 2006
    ..We investigated whether antenatal cotrimoxazole prophylaxis begun during pregnancy for HIV-infected pregnant women with low CD4 cell counts would affect birth outcomes...
  34. pmc Human immunodeficiency virus-specific CD8(+) T cells in human breast milk
    Steffanie Sabbaj
    Departments of Medicine, University of Alabama at Birmingham, 35294 2170, USA
    J Virol 76:7365-73. 2002
    ..Their presence suggests a role in limiting transmission and provides a rationale for vaccine strategies to enhance these responses...
  35. ncbi request reprint Re: HIV-1 disease progression in breast-feeding and formula-feeding mothers: a prospective 2-year comparison of T cell subsets, HIV-1 RNA levels, and mortality
    Louise Kuhn
    J Infect Dis 195:1728-9; author reply 1729-30. 2007
  36. pmc Failure of standard antimicrobial therapy in children aged 3-59 months with mild or asymptomatic HIV infection and severe pneumonia
    Prakash Jeena
    Department of Paediatrics and Child Health, King Edward Hospital, University of KwaZulu Natal, Durban, South Africa
    Bull World Health Organ 84:269-75. 2006
    ....
  37. ncbi request reprint AIDS is your business
    Sydney Rosen
    Boston University School of Public Health s Center for International Health, USA
    Harv Bus Rev 81:80-7, 125. 2003
    ..The annual reduction in the AIDS "tax" would have been as much as 40.4%. The authors' conclusion? Fighting AIDS not only helps those infected; it also makes good business sense...
  38. ncbi request reprint Questions regarding the effectiveness of trimethoprim-sulfamethoxazole (cotrimoxazole) prophylaxis in African children
    Christopher J Gill
    Clin Infect Dis 37:863-4; author reply 864. 2003
  39. ncbi request reprint Oral amoxicillin versus injectable penicillin for severe pneumonia in children aged 3 to 59 months: a randomised multicentre equivalency study
    Emmanuel Addo-Yobo
    Lancet 364:1141-8. 2004
    ..We aimed to determine whether oral amoxicillin and parenteral penicillin were equivalent in the treatment of severe pneumonia in children aged 3-59 months...
  40. ncbi request reprint Brief hospitalization and pulse oximetry for predicting amoxicillin treatment failure in children with severe pneumonia
    Linda Y Fu
    Department of General and Community Pediatrics, George Washington University, Children s National Medical Center, 111 Michigan Ave, NW, Washington, DC 20010, USA
    Pediatrics 118:e1822-30. 2006
    ....
  41. pmc The mucosae-associated epithelial chemokine (MEC/CCL28) modulates immunity in HIV infection
    Eleonora Castelletti
    Department of Preclinical Sciences, Laboratorio Interdisciplinare Technologie Avanzate Vialba, University of Milano, Milano, Italy
    PLoS ONE 2:e969. 2007
    ..The CCL28 circuit was analyzed in HIV-infected and-exposed individuals and in HIV-unexposed controls; the effect of CCL28 administration on gastrointestinal MLP IgA-ASC was verified in a mouse model...
  42. doi request reprint Ambulatory short-course high-dose oral amoxicillin for treatment of severe pneumonia in children: a randomised equivalency trial
    Tabish Hazir
    Children s Hospital, Pakistan Institute of Medical Sciences, Islamabad, Pakistan
    Lancet 371:49-56. 2008
    ..Our aim was to determine whether home treatment with high-dose oral amoxicillin and inpatient treatment with parenteral ampicillin were equivalent for the treatment of severe pneumonia in children...
  43. ncbi request reprint WHO guidelines for treatment of severe pneumonia
    Shamim Qazi
    Lancet 370:385; author reply 385-6. 2007

Research Grants7

  1. REDUCE POSTNATAL TRANSMISSION OF HIV THROUGH BREASTMILK
    Donald Thea; Fiscal Year: 2004
    ..abstract_text> ..
  2. Short Exclusive Breastfeeding to Reduce Postnatal Transmission of HIV
    Donald Thea; Fiscal Year: 2006
    ..The question of the relative risks and benefits of early cessation of breastfeeding remains crucially relevant in an era where antiretroviral drug treatment is poised to become more widely available. ..