Helen Tager-Flusberg

..The implications for genetic and neurobiological studies of these subgroups are discussed, with special reference to evidence relating these cognitive phenotypes to volumetric studies of brain size and organization in autism...

..The findings from this study also have important implications for considering the difficulties that adolescents with WS and other disorders will have in everyday social situations, especially among peers...

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..For expressive language, the most significant predictors were non-verbal cognitive ability, gestures and imitation. These findings have important implications for intervention programs targeting this population...

..Future research will lead to a greater understanding of the genetic and neurocognitive mechanisms that underlie these fundamental changes in the developmental patterns of individuals with ASD...

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..These findings contradict earlier reports in the literature that people with Williams syndrome process faces abnormally...

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..The article concludes with a discussion of how the social phenotypes of both syndromes may be characterized by impaired connectivity between the amygdala and other critical regions in the 'social brain'...

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..These findings suggest ALI and SLI subjects show abnormalities in neurodevelopment of fronto-corticocerebellar circuits that manage motor control and the processing of language, cognition, working memory, and attention...

..Furthermore, combining BOLD fMRI-based GCM and DTPM analysis could provide a novel means to study effective and structural connectivity not only in the auditory cortex, but also in other cortical regions...

..Fifteen percent of the autism and SLI parents showed severe deficits. Our results suggest that impaired communication is part of the broader autism phenotype and a broader SLI phenotype, especially among male family members...

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..Error analysis indicated the same general pattern of performance across versions and subtests of the DANVA2 for all groups. These findings suggest that emotion recognition is not spared in Williams syndrome...

..This pattern of findings suggest that executive dysfunction in autism is not directly related to language impairment per se but rather involves an executive failure to use of language for self-regulation...

..The findings are discussed in terms of possible autistic impairments in episodic memory as well as working memory...

..Given that ALI relatives performed better than SLI relatives across the language measures, the hypothesis that ALI and SLI families share similar genetic loading for language is not strongly supported...

..The current study suggests Broca's area is a region of abnormal neurodevelopment in ASD, which may be linked with semantic and related language deficits frequently observed in ASD...

..Longitudinal, representative studies are needed to elucidate the developmental and etiological significance of the observed sex differences...

..These results suggest differences in semantic organization, approaches to the semantic task, or efficiency in semantic processing in ASD adolescents relative to typically developing adolescents...

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..Language laterality therefore may provide a novel way of subdividing samples, resulting in more homogenous groups for research into genetic and neurocognitive foundations of developmental disorders...

..A theoretical discussion is given in terms of how perceptual grouping may interact with category learning...

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..The infant ASD endophenotype, though elusive, may be better defined through expanding the age of study and addressing change over time in response to varied stimuli...

..In boys with autism, language and social/face processing-related regions displayed abnormal asymmetry. These structural abnormalities may relate to language and social disturbances observed in autism...

..The aim of our study was to test whether adolescents with high-functioning autism are able to integrate AV information of meaningful, phrase-length language in a task of onset asynchrony detection...

..Sleep abnormalities were more common in children (groups combined) diagnosed with major depression...

..Different themes were emphasized in the interviews from the two groups. These themes reflected the distinct phenotypes associated with these disorders, the participants life experiences, and their overall attitudes toward their syndrome...

..g., moral judgment) mental state understanding. Both group and individual data indicated significant developmental improvement in theory of mind ability, which was primarily related to the children's language abilities...

..Findings point to the early onset of an extreme sensory profile in ASD. Occupational therapists need to assess multiple domains of sensory behaviors to accurately identify the needs of toddlers with ASD...

..These findings have important implications for clinicians and researchers who depend on these types of language measures for diagnostic purposes, assessment, and investigations of language impairments in autism...

..To test the hypothesis that children born preterm are more likely to screen positive on the M-CHAT for an autism spectrum disorder...

..These discoveries establish the importance of Ca(V)1.2 in human physiology and development and implicate Ca(2+) signaling in autism...

..This program of research demonstrates that neurocognitive architecture follows the same principles in typical and atypical development...

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..2013 Wiley Periodicals, Inc. Dev Disabil Res Rev 2011;17:151-159...

..To examine prefrontal and occipital asymmetry (brain torque) in boys with autism spectrum disorder (ASD) and controls. A secondary aim was to study age-related changes in gray and white matter volume...

..ASD participants were significantly less accurate than their TD peers for trials involving low-intensity emotions and within-valence face contrasts...

..The fMRI and DTI results indicate that functional and structural properties within early stages of the auditory processing stream are preserved across multiple mammalian species at distinct evolutionary levels...

..Most intraclass correlations between siblings were adequate for use in genetic studies. CONCLUSION: The ADI-R contains correlated clusters of variables that are valid, genetically relevant, and that can be used in a variety of studies...

..This research program will not only advance our understanding of WS;it has the potential to influence developing theoretical models in the growing field of social cognitive neuroscience. ..

..These projects will be coordinated by a clinical and administrative core. ..

..In turn, children identified as showing significant risk signs at much younger ages will be able to take advantage of early interventions that may prevent the onset of symptoms or reduce the severity of the disorder. ..

..In turn, children identified as showing significant risk signs at much younger ages will be able to take advantage of early interventions that may prevent the onset of symptoms or reduce the severity of the disorder. ..

..This research program will not only advance our understanding of WS; it has the potential to influence developing theoretical models in the growing field of social cognitive neuroscience. ..

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..This research program will not only advance our understanding of WS; it has the potential to influence developing theoretical models in the growing field of social cognitive neuroscience. ..

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..Together, this program of research on WMS will provide a unique contribution to theoretical and empirical work in the newly emerging field of social cognitive neuroscience. ..

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