Karen Symes

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Sweet cues: How heparan sulfate modification of fibronectin enables growth factor guided migration of embryonic cells
    Karen Symes
    Department of Biochemistry, Boston University School of Medicine Boston, MA, USA
    Cell Adh Migr 4:507-10. 2010
  2. pmc PDGF-A interactions with fibronectin reveal a critical role for heparan sulfate in directed cell migration during Xenopus gastrulation
    Erin M Smith
    Department of Biochemistry, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 106:21683-8. 2009
  3. ncbi request reprint A role for CK2alpha/beta in Xenopus early embryonic development
    Isabel Dominguez
    Hematology Oncology Section, Department of Medicine, Boston University Medical School, Boston, MA, USA
    Mol Cell Biochem 274:125-31. 2005
  4. ncbi request reprint Protein kinase CK2 is required for dorsal axis formation in Xenopus embryos
    Isabel Dominguez
    Section of Hematology Oncology Department of Medicine, Boston University School of Medicine, Boston MA 02118, USA
    Dev Biol 274:110-24. 2004
  5. pmc Distinct effectors of platelet-derived growth factor receptor-alpha signaling are required for cell survival during embryogenesis
    Melanie Van Stry
    Department of Biochemistry, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 102:8233-8. 2005
  6. pmc Apoptosis regulates notochord development in Xenopus
    Marina A Malikova
    Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA
    Dev Biol 311:434-48. 2007
  7. pmc Migrating anterior mesoderm cells and intercalating trunk mesoderm cells have distinct responses to Rho and Rac during Xenopus gastrulation
    Ruiyi Ren
    Department of Biochemistry, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Dev Dyn 235:1090-9. 2006
  8. ncbi request reprint Distinct functions of Rho and Rac are required for convergent extension during Xenopus gastrulation
    Emilios Tahinci
    Department of Biochemistry, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Dev Biol 259:318-35. 2003
  9. ncbi request reprint Guidance of mesoderm cell migration in the Xenopus gastrula requires PDGF signaling
    Martina Nagel
    Department of Zoology, University of Toronto, 25 Harbord Street, Toronto, Ontario M5S 3G5, Canada
    Development 131:2727-36. 2004
  10. ncbi request reprint The mitochondrial-apoptotic pathway is triggered in Xenopus mesoderm cells deprived of PDGF receptor signaling during gastrulation
    Melanie Van Stry
    Boston University School of Medicine, Boston, MA 02118, USA
    Dev Biol 268:232-42. 2004

Research Grants

Collaborators

  • David C Seldin
  • Isabel Dominguez
  • Paris Ataliotis
  • Melanie Van Stry
  • Emilios Tahinci
  • Martina Nagel
  • Erin M Smith
  • Marina A Malikova
  • Ruiyi Ren
  • Maria Mitsi
  • Matthew A Nugent
  • Rudi Winklbauer
  • Stuart L Schreiber
  • Andrius Kazlauskas
  • Rudolf Winklbauer
  • Kelly A McLaughlin

Detail Information

Publications10

  1. pmc Sweet cues: How heparan sulfate modification of fibronectin enables growth factor guided migration of embryonic cells
    Karen Symes
    Department of Biochemistry, Boston University School of Medicine Boston, MA, USA
    Cell Adh Migr 4:507-10. 2010
    ..A model based on this observation is discussed here as well as the possibility that other growth factors/morphogens utilize similar mechanisms involving fibronectin or additional ECM proteins...
  2. pmc PDGF-A interactions with fibronectin reveal a critical role for heparan sulfate in directed cell migration during Xenopus gastrulation
    Erin M Smith
    Department of Biochemistry, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 106:21683-8. 2009
    ..4). We further demonstrate that endogenous HSPG's are required for the PDGF-AA-guided mesendoderm movement, suggesting an in vivo role for HSPGs in mediating the interaction between PDGF-AA and fibronectin...
  3. ncbi request reprint A role for CK2alpha/beta in Xenopus early embryonic development
    Isabel Dominguez
    Hematology Oncology Section, Department of Medicine, Boston University Medical School, Boston, MA, USA
    Mol Cell Biochem 274:125-31. 2005
    ..Our results demonstrate that CK2 is required for dorsal axis formation and is for normal upregulation of Wnt signaling genes and targets. Thus, CK2 is a regulator of endogenous axis formation in vertebrates...
  4. ncbi request reprint Protein kinase CK2 is required for dorsal axis formation in Xenopus embryos
    Isabel Dominguez
    Section of Hematology Oncology Department of Medicine, Boston University School of Medicine, Boston MA 02118, USA
    Dev Biol 274:110-24. 2004
    ..Taken together, these studies demonstrate that CK2 is a bona fide member of the Wnt pathway and has a critical role in the establishment of the dorsal embryonic axis...
  5. pmc Distinct effectors of platelet-derived growth factor receptor-alpha signaling are required for cell survival during embryogenesis
    Melanie Van Stry
    Department of Biochemistry, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 102:8233-8. 2005
    ..Furthermore, we demonstrate that small molecule inducers of dimerization provide a powerful system to manipulate receptor function in developing embryos...
  6. pmc Apoptosis regulates notochord development in Xenopus
    Marina A Malikova
    Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA
    Dev Biol 311:434-48. 2007
    ..These data indicate that apoptosis is required for normal notochord development during the formation of the anterior-posterior axis, and its role in this process is discussed...
  7. pmc Migrating anterior mesoderm cells and intercalating trunk mesoderm cells have distinct responses to Rho and Rac during Xenopus gastrulation
    Ruiyi Ren
    Department of Biochemistry, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Dev Dyn 235:1090-9. 2006
    ..Rho alone, however, regulates the retraction of the lagging edge of the cell. We propose that within the gastrulating Xenopus embryo, two types of mesoderm cells that undergo different motilities have distinct responses to Rho GTPases...
  8. ncbi request reprint Distinct functions of Rho and Rac are required for convergent extension during Xenopus gastrulation
    Emilios Tahinci
    Department of Biochemistry, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Dev Biol 259:318-35. 2003
    ..We propose that Rho and Rac operate in distinct signaling pathways that are integrated to control cell motility during convergent extension...
  9. ncbi request reprint Guidance of mesoderm cell migration in the Xenopus gastrula requires PDGF signaling
    Martina Nagel
    Department of Zoology, University of Toronto, 25 Harbord Street, Toronto, Ontario M5S 3G5, Canada
    Development 131:2727-36. 2004
    ..This is consistent with an instructive role for PDGFA in the guidance of mesoderm migration...
  10. ncbi request reprint The mitochondrial-apoptotic pathway is triggered in Xenopus mesoderm cells deprived of PDGF receptor signaling during gastrulation
    Melanie Van Stry
    Boston University School of Medicine, Boston, MA 02118, USA
    Dev Biol 268:232-42. 2004
    ..Based on these data, we propose that PDGFR signaling is necessary for survival of prospective head mesoderm cells, and also plays an essential role in the control of their cell movement during gastrulation...

Research Grants5

  1. CELL MOVEMENT DURING XENOPUS DEVELOPMENT--METASTASIS
    Karen Symes; Fiscal Year: 2004
    ..The cells response to constitutively active or dominant versions of these proteins will be analyzed by time-lapse micrography and confocal microscopy. ..