Bela Suki

Summary

Affiliation: Boston University
Country: USA

Publications

  1. ncbi request reprint Contributions of the active and passive components of the cytoskeletal prestress to stiffening of airway smooth muscle cells
    Noah Rosenblatt
    Department of Biomedical Engineering, Boston University, 44 Cummington St, Boston, MA 02215, USA
    Ann Biomed Eng 35:224-34. 2007
  2. pmc Combined effects of ventilation mode and positive end-expiratory pressure on mechanics, gas exchange and the epithelium in mice with acute lung injury
    Apiradee Thammanomai
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America
    PLoS ONE 8:e53934. 2013
  3. pmc A mechanical design principle for tissue structure and function in the airway tree
    Adam S LaPrad
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts, USA
    PLoS Comput Biol 9:e1003083. 2013
  4. pmc Linking microscopic spatial patterns of tissue destruction in emphysema to macroscopic decline in stiffness using a 3D computational model
    Harikrishnan Parameswaran
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts, USA
    PLoS Comput Biol 7:e1001125. 2011
  5. pmc The major transitions of life from a network perspective
    Bela Suki
    Department of Biomedical Engineering, Boston University Boston, MA, USA
    Front Physiol 3:94. 2012
  6. ncbi request reprint Complexity and emergent phenomena
    Bela Suki
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts, USA
    Compr Physiol 1:995-1029. 2011
  7. pmc Lung parenchymal mechanics
    Bela Suki
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts, USA
    Compr Physiol 1:1317-51. 2011
  8. pmc Acute mechanical forces cause deterioration in lung structure and function in elastase-induced emphysema
    M V Szabari
    Dept of Biomedical Engineering, Boston Univ, Boston, MA 02215, USA
    Am J Physiol Lung Cell Mol Physiol 303:L567-74. 2012
  9. ncbi request reprint Biomechanics of the lung parenchyma: critical roles of collagen and mechanical forces
    Bela Suki
    Department of Biomedical Engineering, Boston University, 44 Cummington St, Boston, MA 02215, USA
    J Appl Physiol (1985) 98:1892-9. 2005
  10. pmc Extracellular matrix mechanics in lung parenchymal diseases
    Bela Suki
    Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA 02215, USA
    Respir Physiol Neurobiol 163:33-43. 2008

Collaborators

Detail Information

Publications62

  1. ncbi request reprint Contributions of the active and passive components of the cytoskeletal prestress to stiffening of airway smooth muscle cells
    Noah Rosenblatt
    Department of Biomedical Engineering, Boston University, 44 Cummington St, Boston, MA 02215, USA
    Ann Biomed Eng 35:224-34. 2007
    ....
  2. pmc Combined effects of ventilation mode and positive end-expiratory pressure on mechanics, gas exchange and the epithelium in mice with acute lung injury
    Apiradee Thammanomai
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America
    PLoS ONE 8:e53934. 2013
    ..For long-term outcome, selection of optimal PEEP and ventilation mode may be based on balancing lung physiology with epithelial injury...
  3. pmc A mechanical design principle for tissue structure and function in the airway tree
    Adam S LaPrad
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts, USA
    PLoS Comput Biol 9:e1003083. 2013
    ....
  4. pmc Linking microscopic spatial patterns of tissue destruction in emphysema to macroscopic decline in stiffness using a 3D computational model
    Harikrishnan Parameswaran
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts, USA
    PLoS Comput Biol 7:e1001125. 2011
    ..We conclude that microscopic structural changes in emphysema and the associated decline in tissue stiffness are linked by the spatial pattern of the destruction process...
  5. pmc The major transitions of life from a network perspective
    Bela Suki
    Department of Biomedical Engineering, Boston University Boston, MA, USA
    Front Physiol 3:94. 2012
    ..Finally, I discuss the implications of network associated phase transitions to issues that bear relevance to the history, the immediate present and perhaps the future, of life...
  6. ncbi request reprint Complexity and emergent phenomena
    Bela Suki
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts, USA
    Compr Physiol 1:995-1029. 2011
    ..Finally, the potential role of the science of complexity in the future of physiology, biology, and medicine is discussed...
  7. pmc Lung parenchymal mechanics
    Bela Suki
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts, USA
    Compr Physiol 1:1317-51. 2011
    ..An integrated view of lung mechanics is presented and the utility of parenchymal mechanics at the bedside as well as its possible future role in lung physiology and medicine are discussed...
  8. pmc Acute mechanical forces cause deterioration in lung structure and function in elastase-induced emphysema
    M V Szabari
    Dept of Biomedical Engineering, Boston Univ, Boston, MA 02215, USA
    Am J Physiol Lung Cell Mol Physiol 303:L567-74. 2012
    ..Thus, the acute application of DIs in mice with emphysema may serve as a useful model of AECOPD...
  9. ncbi request reprint Biomechanics of the lung parenchyma: critical roles of collagen and mechanical forces
    Bela Suki
    Department of Biomedical Engineering, Boston University, 44 Cummington St, Boston, MA 02215, USA
    J Appl Physiol (1985) 98:1892-9. 2005
    ....
  10. pmc Extracellular matrix mechanics in lung parenchymal diseases
    Bela Suki
    Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA 02215, USA
    Respir Physiol Neurobiol 163:33-43. 2008
    ..Finally, we speculate about the possibility of using targeted tissue engineering to optimize treatment of these two major lung diseases...
  11. ncbi request reprint Size distribution of recruited alveolar volumes in airway reopening
    B Suki
    Department of Biomedical Engineering, Department of Physics, Boston University, Boston, Massachusetts 02215, USA
    J Appl Physiol (1985) 89:2030-40. 2000
    ..This distribution was in good agreement with model simulations in which airways open in cascade or avalanches. Implications for mechanical ventilation may be found in these results...
  12. ncbi request reprint On the progressive nature of emphysema: roles of proteases, inflammation, and mechanical forces
    Bela Suki
    Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA 02215, USA
    Am J Respir Crit Care Med 168:516-21. 2003
  13. ncbi request reprint Temporal dynamics of recurrent airway symptoms and cellular random walk
    Bela Suki
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA
    J Appl Physiol (1985) 95:2122-7. 2003
    ..These findings may provide new insight into the mechanisms of otherwise unexplained symptom episodes...
  14. ncbi request reprint Fluctuations and power laws in pulmonary physiology
    Bela Suki
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA
    Am J Respir Crit Care Med 166:133-7. 2002
  15. ncbi request reprint Tissue heterogeneity in the mouse lung: effects of elastase treatment
    Satoru Ito
    Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
    J Appl Physiol 97:204-12. 2004
    ..The heterogeneity of alveolar size (diameters and area) was also larger in emphysema, suggesting that the model-based tissue elastance heterogeneity may reflect the underlying heterogeneity of the alveolar structure...
  16. doi request reprint Mechanical failure, stress redistribution, elastase activity and binding site availability on elastin during the progression of emphysema
    Bela Suki
    Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA 02215, USA
    Pulm Pharmacol Ther 25:268-75. 2012
    ..Such approaches will have the potential to contribute to resolving many of the outstanding issues which in turn may lead to the amelioration or perhaps the treatment of emphysema in the future...
  17. ncbi request reprint Effects of reduced tidal volume ventilation on pulmonary function in mice before and after acute lung injury
    Apiradee Thammanomai
    Dept of Biomedical Engineering, Boston Univ, Boston, MA 02215, USA
    J Appl Physiol 103:1551-9. 2007
    ..These results highlight the importance of delivering appropriate Vt to both the normal and injured lungs. By leaving the Vt uncompensated, it can significantly alter physiological and biological responses in mice...
  18. ncbi request reprint Mechanics, nonlinearity, and failure strength of lung tissue in a mouse model of emphysema: possible role of collagen remodeling
    Satoru Ito
    Dept of Biomedical Engineering, Boston Univ, 44 Cummington St, Boston MA 02215, USA
    J Appl Physiol 98:503-11. 2005
    ..002). These findings suggest that, after elastolytic injury, abnormal collagen remodeling may play a significant role in all aspects of lung functional changes and mechanical forces, leading to progressive emphysema...
  19. ncbi request reprint Lung and alveolar wall elastic and hysteretic behavior in rats: effects of in vivo elastase treatment
    Kelly K Brewer
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA
    J Appl Physiol 95:1926-36. 2003
    ..We conclude that the decreased Ptp dependence of elastance and the constant hysteresivity in the treated lungs are related to microstructural remodeling and network phenomena at the level of the alveolar walls...
  20. pmc Three-dimensional measurement of alveolar airspace volumes in normal and emphysematous lungs using micro-CT
    Harikrishnan Parameswaran
    Department of Biomedical Engineering, Boston University, 44 Cummington St, Boston, MA 02215, USA
    J Appl Physiol (1985) 107:583-92. 2009
    ..We conclude that quantifying heterogeneity in structure can provide new insight into the pathogenesis or progression of emphysema that is enhanced by improved sensitivity using 3D measurements...
  21. ncbi request reprint Fluid transport in branched structures with temporary closures: a model for quasistatic lung inflation
    Arnab Majumdar
    Center for Polymer Studies and Department of Physics, Boston University, Boston, Massachusetts 02215, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 67:031912. 2003
    ..Our general results are applicable to any physical system involving transport in bifurcating structures with removable closures...
  22. pmc Early emphysema in the tight skin and pallid mice: roles of microfibril-associated glycoproteins, collagen, and mechanical forces
    Satoru Ito
    Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
    Am J Respir Cell Mol Biol 34:688-94. 2006
    ..Our findings suggest the possibility that MAGP-2-related abnormal collagen assembly, combined with mechanical forces, is involved in the progression of emphysema in the Tsk mice...
  23. pmc Mechanical forces regulate elastase activity and binding site availability in lung elastin
    Rajiv Jesudason
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts, USA
    Biophys J 99:3076-83. 2010
    ..Our findings may also have broader implications because in vivo, enzyme activity in nearly all cellular and extracellular processes takes place in the presence of mechanical forces...
  24. pmc Structure-function relations in an elastase-induced mouse model of emphysema
    Hiroshi Hamakawa
    Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
    Am J Respir Cell Mol Biol 45:517-24. 2011
    ..We conclude that, in a mouse model of emphysema, progressive decline in lung function is sensitive to the development of airspace heterogeneity governed by local, mechanical, force-induced failure of remodeled collagen...
  25. ncbi request reprint Comparison of variable and conventional ventilation in a sheep saline lavage lung injury model
    Carissa L Bellardine
    Department of Biomedical Engineering, Boston University, Boston, MA, USA
    Crit Care Med 34:439-45. 2006
    ..We aimed at testing VV in a large animal lung injury model and exploring the mechanism of improvement in gas exchange seen with VV...
  26. pmc Mechanical and failure properties of extracellular matrix sheets as a function of structural protein composition
    Lauren D Black
    Department of Biomedical Engineering, Boston University
    Biophys J 94:1916-29. 2008
    ....
  27. ncbi request reprint Assessing the functional mechanical properties of bioengineered organs with emphasis on the lung
    Bela Suki
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts
    J Cell Physiol 229:1134-40. 2014
    ..Advantages, drawbacks, and possible pitfalls as well as interpretation of the data are given throughout. Finally, specific techniques to assess the functionality of the ECM of bioartificial lungs are separately discussed...
  28. ncbi request reprint Design of a new variable-ventilation method optimized for lung recruitment in mice
    Apiradee Thammanomai
    Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
    J Appl Physiol (1985) 104:1329-40. 2008
    ..In addition, variable stretch patterns delivered to the lung by VV can reduce the progression of lung injury due to ventilation in injured mice...
  29. pmc A zipper network model of the failure mechanics of extracellular matrices
    Michael C Ritter
    Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 106:1081-6. 2009
    ..This study reveals a role for PGs in the failure properties of engineered and native ECM with implications for the design of engineered tissues...
  30. pmc Dynamics of enzymatic digestion of elastic fibers and networks under tension
    Ascanio D Araujo
    Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 108:9414-9. 2011
    ..Our findings can help better understand remodeling processes during development or in disease in which enzyme concentrations and/or mechanical forces become abnormal...
  31. ncbi request reprint Relationship between dynamic respiratory mechanics and disease heterogeneity in sheep lavage injury
    Carissa L Bellardine Black
    Department of Biomedical Engineering, Boston University, Boston, MA, USA
    Crit Care Med 35:870-8. 2007
    ....
  32. ncbi request reprint Viscoelastic and dynamic nonlinear properties of airway smooth muscle tissue: roles of mechanical force and the cytoskeleton
    Satoru Ito
    Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA 02215, USA
    Am J Physiol Lung Cell Mol Physiol 290:L1227-37. 2006
    ....
  33. ncbi request reprint Variable ventilation induces endogenous surfactant release in normal guinea pigs
    Stephen P Arold
    Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
    Am J Physiol Lung Cell Mol Physiol 285:L370-5. 2003
    ..These data demonstrate that random variations in Vt promote endogenous release of biochemically intact surfactant, which improves alveolar stability, apparently reducing lung injury...
  34. ncbi request reprint Variable tidal volume ventilation improves lung mechanics and gas exchange in a rodent model of acute lung injury
    Stephen P Arold
    Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA 02215, USA
    Am J Respir Crit Care Med 165:366-71. 2002
    ..05) compared with conventional ventilation. These data indicate that variable ventilation is effective in improving lung function and gas exchange during acute lung injury...
  35. ncbi request reprint Dynamics of prestressed semiflexible polymer chains as a model of cell rheology
    Noah Rosenblatt
    Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA 02215, USA
    Phys Rev Lett 97:168101. 2006
    ..These results indicate that the main aspects of cell rheology are consistent with the dynamics of single polymer chains under tension...
  36. pmc Jamming dynamics of stretch-induced surfactant release by alveolar type II cells
    Arnab Majumdar
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA
    J Appl Physiol (1985) 112:824-31. 2012
    ..Our results thus highlight the importance of a jamming dynamics in stretch-induced cellular secretory processes...
  37. ncbi request reprint Relating airway diameter distributions to regular branching asymmetry in the lung
    Arnab Majumdar
    Center for Polymer Studies and Department of Physics, Boston University, Massachusetts 02215, USA
    Phys Rev Lett 95:168101. 2005
    ..Our findings suggest that the observed diameter heterogeneity is consistent with an underlying regular branching asymmetry...
  38. ncbi request reprint Perimeter growth of a branched structure: application to crackle sounds in the lung
    Adriano M Alencar
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 68:011909. 2003
    ..We generalize the binary structure of the lung to a Cayley tree with a coordination number Z between 2 and 4. For Z=4, beta remains close to 2, while for a chain, Z=2 and beta=1, exactly. We also find a mean field solution of the model...
  39. pmc Rheological behavior of living cells is timescale-dependent
    Dimitrije Stamenovic
    Department of Biomedical Engineering, Boston University, and Department of Pathology, Children s Hospital, Boston, Massachusetts, USA
    Biophys J 93:L39-41. 2007
    ....
  40. ncbi request reprint Quantitative characterization of airspace enlargement in emphysema
    Harikrishnan Parameswaran
    Department of Biomedical Engineering, Boston University, 44 Cummington St, Boston, Massachusetts 02215, USA
    J Appl Physiol 100:186-93. 2006
    ..Finally, we introduced new indexes based on the moments of diameter that we found to be more reliable than L(m) to characterize airspace enlargement in the presence of heterogeneities...
  41. ncbi request reprint Power-law creep behavior of a semiflexible chain
    Arnab Majumdar
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 78:041922. 2008
    ..These results indicate that the essential features of cellular rheology can be explained by the viscoelastic behaviors of individual semiflexible polymers of the cytoskeleton...
  42. ncbi request reprint Physiology: Dynamic instabilities in the inflating lung
    Adriano M Alencar
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA
    Nature 417:809-11. 2002
    ..Our analysis of this apparent thermodynamic paradox provides a better understanding of aeration in the deep regions of the lung, which may find application in medical conditions in which gas exchange is impaired...
  43. pmc Emphysema and mechanical stress-induced lung remodeling
    Bela Suki
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts
    Physiology (Bethesda) 28:404-13. 2013
    ..We present possible new directions and an integrated multiscale view that may prove useful in finding solutions for this disease...
  44. doi request reprint Micropatterned cell sheets with defined cell and extracellular matrix orientation exhibit anisotropic mechanical properties
    Brett C Isenberg
    Department of Biomedical Engineering, Boston University, College of Engineering, Boston, Massachusetts 02215, USA
    J Biomech 45:756-61. 2012
    ....
  45. pmc Emergent structure-function relations in emphysema and asthma
    Tilo Winkler
    Massachusetts General Hospital and Harvard Medical School, Department of Anesthesia, Critical Care and Pain Medicine, Boston, Massachusetts, USA
    Crit Rev Biomed Eng 39:263-80. 2011
    ..Multiscale, computational, network models will play a major role in this endeavor...
  46. ncbi request reprint Effects of heterogeneities on the partitioning of airway and tissue properties in normal mice
    Satoru Ito
    Dept of Biomedical Engineering, Boston University, Boston, MA 02215, USA
    J Appl Physiol 102:859-69. 2007
    ..Contribution of the chest wall and heterogeneity to the mechanical properties should be carefully considered in physiological studies in which partitioning of airway and tissue properties are attempted...
  47. pmc Variable stretch pattern enhances surfactant secretion in alveolar type II cells in culture
    Stephen P Arold
    Dept of Biomedical Engineering, Boston Univ, Boston, MA 02215, USA
    Am J Physiol Lung Cell Mol Physiol 296:L574-81. 2009
    ..Variable stretch-induced mechanotransduction may also have implications for other areas of mechanobiology...
  48. ncbi request reprint On the role of surface tension in the pathophysiology of emphysema
    Edward P Ingenito
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Am J Respir Crit Care Med 171:300-4. 2005
  49. ncbi request reprint Differential effects of static and cyclic stretching during elastase digestion on the mechanical properties of extracellular matrices
    Rajiv Jesudason
    Department of Biomedical Engineering, Boston University, 44 Cummington St, Boston, MA 02215, USA
    J Appl Physiol 103:803-11. 2007
    ..05). We conclude that not only the presence but the dynamic nature of mechanical forces have a significant impact on enzyme activity, hence the deterioration of the functional properties of the ECM during exposure to enzymes...
  50. pmc Estimating the diameter of airways susceptible for collapse using crackle sound
    Arnab Majumdar
    Dept of Biomedical Engineering, Boston Univ, 44 Cummington St, Boston, MA 02215, USA
    J Appl Physiol (1985) 107:1504-12. 2009
    ..Thus our results indicate that there are airways of a given range of diameters that can become unstable during deflation and vulnerable to collapse and subsequent injury...
  51. pmc Lung tissue mechanics as an emergent phenomenon
    Bela Suki
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts, USA
    J Appl Physiol (1985) 110:1111-8. 2011
    ..Finally, we discuss the inevitability of why lung tissue mechanics need to be complex...
  52. pmc Proteoglycans maintain lung stability in an elastase-treated mouse model of emphysema
    Ayuko Takahashi
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts
    Am J Respir Cell Mol Biol 51:26-33. 2014
    ....
  53. ncbi request reprint Design of a new stretching apparatus and the effects of cyclic strain and substratum on mouse lung epithelial-12 cells
    Stephen P Arold
    Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA 02215, USA
    Ann Biomed Eng 35:1156-64. 2007
    ..This suggests that, while this cell line does not demonstrate stretch-induced surfactant secretion, the underlying extracellular matrix plays a crucial factor in both cell death and signal transduction in response to strain...
  54. pmc Tidal stretches differently regulate the contractile and cytoskeletal elements in intact airways
    Erzsebet Bartolak-Suki
    Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America
    PLoS ONE 9:e94828. 2014
    ..We conclude that physiological Ptm variations affect cellular processes in intact airways with constriction determined by the balance among contractile and CSK molecules and structure. ..
  55. ncbi request reprint Effects of elastase on the mechanical and failure properties of engineered elastin-rich matrices
    Lauren D Black
    Dept of Biochemistry, 715 Albany St, Boston, MA 02118, USA
    J Appl Physiol 98:1434-41. 2005
    ....
  56. pmc Amelioration of emphysema in mice through lentiviral transduction of long-lived pulmonary alveolar macrophages
    Andrew A Wilson
    Pulmonary Center and Department of Medicine, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts 02118, USA
    J Clin Invest 120:379-89. 2010
    ..Our results challenge the dogma that AMs are short lived and suggest that these differentiated cells may be a possible target cell population for in vivo gene therapy applications, including the sustained correction of hAAT deficiency...
  57. ncbi request reprint Rheology of airway smooth muscle cells is associated with cytoskeletal contractile stress
    Dimitrije Stamenovic
    Department of Biomedical Engineering, Boston University, 44 Cummington St, Boston, MA 02215, USA
    J Appl Physiol (1985) 96:1600-5. 2004
    ....
  58. pmc Tidal stretches do not modulate responsiveness of intact airways in vitro
    Adam S LaPrad
    Dept of Biomedical Engineering, Boston Univ, 44 Cummington St, Boston, MA 02215, USA
    J Appl Physiol (1985) 109:295-304. 2010
    ..3% (P = 0.009). The lack of modulation of airway responsiveness by Ptm oscillations in intact, healthy airways suggests that ASM level mechanisms alone may not be the sole determinant of airway responsiveness...
  59. pmc A computational model of the response of adherent cells to stretch and changes in substrate stiffness
    Harikrishnan Parameswaran
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts
    J Appl Physiol (1985) 116:825-34. 2014
    ....
  60. pmc Modeling the dynamics of airway constriction: effects of agonist transport and binding
    Samir D Amin
    Dept of Biomedical Engineering, Boston Univ, Boston, MA 02215, USA
    J Appl Physiol (1985) 109:553-63. 2010
    ..Additionally, the model offers new insights into several phenomena including the intra- and interbreath dynamics of airway constriction throughout the tree structure...
  61. ncbi request reprint Epithelial and endothelial damage induced by mechanical ventilation modes
    Bela Suki
    aDepartment of Biomedical Engineering, Boston University, Boston, Massachusetts bThoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Curr Opin Crit Care 20:17-24. 2014
    ..The following review details the mechanics of the lung parenchyma at different spatial scales and the response of its resident cells to deforming stress in order to provide the biologic underpinnings of lung protective care...

Research Grants17

  1. CONNECTIVE TISSUE MECHANICS IN EMPHYSEMA AND FIBROSIS
    Bela Suki; Fiscal Year: 1999
    ....
  2. Effects of mechanical forces on lung injury and repair
    Bela Suki; Fiscal Year: 2010
    ..The research proposed here involves investigating how cells and connective tissue stretch in the lung during breathing and may open a new direction in understanding the disease with high potential to develop new treatments. ..
  3. Regulatory roles of variable mechanical stimuli in cell function
    Bela Suki; Fiscal Year: 2009
    ....
  4. Mechanisms of Progression in Late Stage Emphysema
    Bela Suki; Fiscal Year: 2009
    ..These results will motivate a more rational approach to detection, treatment design, and treatment assessment of emphysema. ..
  5. Effects of mechanical forces on lung injury and repair
    Bela Suki; Fiscal Year: 2009
    ..The research proposed here involves investigating how cells and connective tissue stretch in the lung during breathing and may open a new direction in understanding the disease with high potential to develop new treatments. ..
  6. Mechanisms of Progression in Late Stage Emphysema
    Bela Suki; Fiscal Year: 2007
    ..These results will motivate a more rational approach to detection, treatment design, and treatment assessment of emphysema. ..
  7. Mechanisms of Progression in Late Stage Emphysema
    Bela Suki; Fiscal Year: 2006
    ..These results will motivate a more rational approach to detection, treatment design, and treatment assessment of emphysema. ..
  8. Ventilation Improves Lung Physiology and Biology
    Bela Suki; Fiscal Year: 2006
    ..abstract_text> ..
  9. Ventilation Improves Lung Physiology and Biology
    Bela Suki; Fiscal Year: 2005
    ..abstract_text> ..
  10. Role of Mechanical Forces in the Progession of Emphysema
    Bela Suki; Fiscal Year: 2005
    ....
  11. Ventilation Improves Lung Physiology and Biology
    Bela Suki; Fiscal Year: 2004
    ..abstract_text> ..
  12. Role of Mechanical Forces in the Progession of Emphysema
    Bela Suki; Fiscal Year: 2004
    ....
  13. Role of Mechanical Forces in the Progession of Emphysema
    Bela Suki; Fiscal Year: 2003
    ....
  14. Role of Mechanical Forces in the Progession of Emphysema
    Bela Suki; Fiscal Year: 2002
    ....
  15. CONNECTIVE TISSUE MECHANICS IN EMPHYSEMA AND FIBROSIS
    Bela Suki; Fiscal Year: 2000
    ....
  16. Regulatory roles of variable mechanical stimuli in cell function
    Bela Suki; Fiscal Year: 2010
    ....