AVRUM E contact SPIRA

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Bridging the clinical gaps: genetic, epigenetic and transcriptomic biomarkers for the early detection of lung cancer in the post-National Lung Screening Trial era
    John F Brothers
    Bioinformatics Program, Boston University, Boston, MA, USA
    BMC Med 11:168. 2013
  2. pmc Reversible and permanent effects of tobacco smoke exposure on airway epithelial gene expression
    Jennifer Beane
    Bioinformatics Program, Boston University, Cummington Street, Boston, MA 02215, USA
    Genome Biol 8:R201. 2007
  3. pmc Smoking-induced gene expression changes in the bronchial airway are reflected in nasal and buccal epithelium
    Sriram Sridhar
    Pulmonary Center, Boston University School of Medicine, Albany Street, Boston Massachusetts, USA
    BMC Genomics 9:259. 2008
  4. pmc Discovering biological connections between experimental conditions based on common patterns of differential gene expression
    Adam C Gower
    Bioinformatics Program, Boston University, Boston, Massachusetts 02215, USA
    BMC Bioinformatics 12:381. 2011
  5. ncbi request reprint Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer
    Avrum Spira
    The Pulmonary Center, Boston University Medical Center, 715 Albany Street, Boston, Massachusetts 02118, USA
    Nat Med 13:361-6. 2007
  6. doi request reprint Upper airway gene expression in smokers: the mouth as a "window to the soul" of lung carcinogenesis?
    Avrum Spira
    Section of Computational Biomedicine, Department of Medicine, and The Pulmonary Center, Boston University Medical Center, 72 East Concord Street, Boston, MA 02118
    Cancer Prev Res (Phila) 3:255-8. 2010
  7. pmc Similarities and differences between smoking-related gene expression in nasal and bronchial epithelium
    Xiaoling Zhang
    Bioinformatics Program, Boston University, Boston, Massachusetts 02118, USA
    Physiol Genomics 41:1-8. 2010
  8. pmc Airway PI3K pathway activation is an early and reversible event in lung cancer development
    Adam M Gustafson
    Section of Computational Biomedicine, Department of Medicine and Pulmonary Center, Boston University Medical Center, Boston, MA 02118, USA
    Sci Transl Med 2:26ra25. 2010
  9. pmc MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium
    Frank Schembri
    Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 106:2319-24. 2009
  10. ncbi request reprint Gene expression in lung adenocarcinomas of smokers and nonsmokers
    Charles A Powell
    Department of Medicine, Columbia College of Physicians and Surgeons, New York, New York, USA
    Am J Respir Cell Mol Biol 29:157-62. 2003

Detail Information

Publications29

  1. pmc Bridging the clinical gaps: genetic, epigenetic and transcriptomic biomarkers for the early detection of lung cancer in the post-National Lung Screening Trial era
    John F Brothers
    Bioinformatics Program, Boston University, Boston, MA, USA
    BMC Med 11:168. 2013
    ..This review highlights recent genetic, transcriptomic and epigenomic biomarkers that are emerging as tools for the early detection of lung cancer both in the diagnostic and screening setting. ..
  2. pmc Reversible and permanent effects of tobacco smoke exposure on airway epithelial gene expression
    Jennifer Beane
    Bioinformatics Program, Boston University, Cummington Street, Boston, MA 02215, USA
    Genome Biol 8:R201. 2007
    ..The identification of irreversible effects of tobacco smoke on airway gene expression may provide insights into the causes of this elevated risk...
  3. pmc Smoking-induced gene expression changes in the bronchial airway are reflected in nasal and buccal epithelium
    Sriram Sridhar
    Pulmonary Center, Boston University School of Medicine, Albany Street, Boston Massachusetts, USA
    BMC Genomics 9:259. 2008
    ..In this study, we explored relationships in whole-genome gene expression between extrathorcic (buccal and nasal) and intrathoracic (bronchial) epithelium in healthy current and never smokers...
  4. pmc Discovering biological connections between experimental conditions based on common patterns of differential gene expression
    Adam C Gower
    Bioinformatics Program, Boston University, Boston, Massachusetts 02215, USA
    BMC Bioinformatics 12:381. 2011
    ..The second query, which used a signature of silencing of the transcription factor p63 (a key regulator of epidermal differentiation), identified datasets related to stratified squamous epithelia or epidermal diseases such as melanoma...
  5. ncbi request reprint Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer
    Avrum Spira
    The Pulmonary Center, Boston University Medical Center, 715 Albany Street, Boston, Massachusetts 02118, USA
    Nat Med 13:361-6. 2007
    ..These findings indicate that gene expression in cytologically normal large-airway epithelial cells can serve as a lung cancer biomarker, potentially owing to a cancer-specific airway-wide response to cigarette smoke...
  6. doi request reprint Upper airway gene expression in smokers: the mouth as a "window to the soul" of lung carcinogenesis?
    Avrum Spira
    Section of Computational Biomedicine, Department of Medicine, and The Pulmonary Center, Boston University Medical Center, 72 East Concord Street, Boston, MA 02118
    Cancer Prev Res (Phila) 3:255-8. 2010
    ....
  7. pmc Similarities and differences between smoking-related gene expression in nasal and bronchial epithelium
    Xiaoling Zhang
    Bioinformatics Program, Boston University, Boston, Massachusetts 02118, USA
    Physiol Genomics 41:1-8. 2010
    ..Our findings suggest that nasal epithelial gene expression may serve as a relatively noninvasive surrogate to measure physiological responses to cigarette smoke and/or other inhaled exposures in large-scale epidemiological studies...
  8. pmc Airway PI3K pathway activation is an early and reversible event in lung cancer development
    Adam M Gustafson
    Section of Computational Biomedicine, Department of Medicine and Pulmonary Center, Boston University Medical Center, Boston, MA 02118, USA
    Sci Transl Med 2:26ra25. 2010
    ..Our work further suggests that additional lung cancer chemoprevention trials either targeting the PI3K pathway or measuring airway PI3K activation as an intermediate endpoint are warranted...
  9. pmc MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium
    Frank Schembri
    Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 106:2319-24. 2009
    ..These data indicate that mir-218 levels modulate the airway epithelial gene expression response to cigarette smoke and support a role for miRNAs in regulating host response to environmental toxins...
  10. ncbi request reprint Gene expression in lung adenocarcinomas of smokers and nonsmokers
    Charles A Powell
    Department of Medicine, Columbia College of Physicians and Surgeons, New York, New York, USA
    Am J Respir Cell Mol Biol 29:157-62. 2003
    ..Our findings, although limited by small sample size, suggest that additional studies comparing noninvolved to tumor tissue may identify pathogenetic mechanisms and therapeutic targets that differ in AC of smokers and nonsmokers...
  11. ncbi request reprint State of the art. Chronic obstructive pulmonary disease, inflammation, and lung cancer
    Jerome S Brody
    Pulmonary Center and Department of Medicine, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Proc Am Thorac Soc 3:535-7. 2006
    ....
  12. ncbi request reprint miR-129 regulates cell proliferation by downregulating Cdk6 expression
    Junjie Wu
    Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    Cell Cycle 9:1809-18. 2010
    ..Together, our data indicate that miR-129 plays an important role in regulating cell proliferation by downregulation of Cdk6...
  13. ncbi request reprint Noninvasive method for obtaining RNA from buccal mucosa epithelial cells for gene expression profiling
    Avrum Spira
    Pulmonary Center, Boston University Medical Center, 715 Albany Street, Room 304, Boston, MA 02118, USA
    Biotechniques 36:484-7. 2004
  14. ncbi request reprint Impact of cigarette smoke on the normal airway transcriptome
    Avrum Spira
    Pulmonary Center, Boston University School of Medicine, Boston, University, Boston, MA 02118 2526, USA
    Chest 125:115S. 2004
  15. pmc Airway gene expression in chronic obstructive pulmonary disease
    Katrina Steiling
    The Pulmonary Center, Boston University Medical Center, 72 East Concord Street R 304, Boston, MA 02118
    Proc Am Thorac Soc 6:697-700. 2009
    ....
  16. pmc Effects of cigarette smoke on the human airway epithelial cell transcriptome
    Avrum Spira
    Pulmonary Center and Department of Medicine, Boston University School of Medicine, 715 Albany Street, MA 02118, USA
    Proc Natl Acad Sci U S A 101:10143-8. 2004
    ....
  17. pmc Comparison of proteomic and transcriptomic profiles in the bronchial airway epithelium of current and never smokers
    Katrina Steiling
    The Pulmonary Center, Boston University Medical Center, Boston, Massachusetts, United States of America
    PLoS ONE 4:e5043. 2009
    ....
  18. ncbi request reprint Gene expression profiling of human lung tissue from smokers with severe emphysema
    Avrum Spira
    The Pulmonary Center and Department of Medicine, Boston University School of Medicine, 715 Albany Street, R304, Boston, MA 02118, USA
    Am J Respir Cell Mol Biol 31:601-10. 2004
    ....
  19. pmc The field of tissue injury in the lung and airway
    Katrina Steiling
    The Pulmonary Center, Boston University Medical Center, Boston, Massachusetts 02118, USA
    Cancer Prev Res (Phila) 1:396-403. 2008
    ....
  20. doi request reprint A prediction model for lung cancer diagnosis that integrates genomic and clinical features
    Jennifer Beane
    The Pulmonary Center, Boston University Medical Center, Boston, MA 02118, USA
    Cancer Prev Res (Phila) 1:56-64. 2008
    ..These findings suggest that use of the clinicogenomic model may expedite more invasive testing and definitive therapy for smokers with lung cancer and reduce invasive diagnostic procedures for individuals without lung cancer...
  21. ncbi request reprint Comparison of smoking-induced gene expression on Affymetrix Exon and 3'-based expression arrays
    Xiaoling Zhang
    Boston University, Boston, Massachusetts 02215, USA
    Genome Inform 18:247-57. 2007
    ..These findings suggest that the all-Exon array is a more robust platform for measuring airway epithelial gene expression and can serve as an effective tool for exploring host response to and damage from cigarette smoke...
  22. pmc Alterations in gene expression in T1 alpha null lung: a model of deficient alveolar sac development
    Guetchyn Millien
    Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    BMC Dev Biol 6:35. 2006
    ..Since little is known about the molecular pathways driving alveolar sacculation, we used expression microarrays to identify genes altered in the abnormal lungs and, by inference, may play roles in normal lung morphogenesis...
  23. pmc SIEGE: Smoking Induced Epithelial Gene Expression Database
    Vishal Shah
    Bioinformatics Program, College of Engineering, Boston University, 44 Cummington Street, Boston, MA 02215, USA
    Nucleic Acids Res 33:D573-9. 2005
    ..Query results are embedded with graphical capabilities as well as with links to other databases containing valuable gene resources, including Entrez Gene, GO, Biocarta, GeneCards, dbSNP and the NCBI Map Viewer...
  24. pmc Clinical impact of high-throughput gene expression studies in lung cancer
    Jennifer Beane
    Bioinformatics Program, Boston University School of Engineering, Boston, Massachusetts, USA
    J Thorac Oncol 4:109-18. 2009
    ....
  25. pmc Translating the COPD transcriptome: insights into pathogenesis and tools for clinical management
    Julie E Zeskind
    Bioinformatics Program, Boston University, Boston, MA 02118, USA
    Proc Am Thorac Soc 5:834-41. 2008
    ..Given these similarities, we argue that additional lung tissue and airway gene-expression studies are warranted, and present a roadmap for how such studies could lead to clinically relevant tools that would impact COPD management...
  26. ncbi request reprint The SERPINE2 gene is associated with chronic obstructive pulmonary disease
    Dawn DeMeo
    Channing Laboratory, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Proc Am Thorac Soc 3:502. 2006
  27. pmc Characterization of the mid-foregut transcriptome identifies genes regulated during lung bud induction
    Guetchyn Millien
    Department of Medicine, Boston University School of Medicine, Evans Biomedical Research Center, Boston, MA 02118, USA
    Gene Expr Patterns 8:124-39. 2008
    ..This characterization of the mid-foregut transcriptome provides new insights into molecular events leading to lung organogenesis...
  28. pmc Transcriptomic studies of the airway field of injury associated with smoking-related lung disease
    Adam C Gower
    Boston University School of Medicine, Boston, MA 02118, USA
    Proc Am Thorac Soc 8:173-9. 2011
    ....
  29. ncbi request reprint Apoptosis genes in human alveolar macrophages infected with virulent or attenuated Mycobacterium tuberculosis: a pivotal role for tumor necrosis factor
    Avrum Spira
    St James s Hospital, James s St, Dublin 3, Ireland
    Am J Respir Cell Mol Biol 29:545-51. 2003
    ..Given the importance of TNF in host defense against tuberculosis, the ability to repress the expression of genes activated by TNF may constitute a bacillary virulence mechanism...

Research Grants8

  1. Airway gene expression in smokers: an early diagnostic biomarker for lung cancer
    Avrum Spira; Fiscal Year: 2009
    ..These gene expression-based biomarkers may eliminate the need for additional and often more invasive diagnostic tests that are costly, incur risk, and prolong the diagnostic evaluation of smokers with suspicion of lung cancer. ..
  2. Airway gene expression in smokers: an early diagnostic biomarker for lung cancer
    AVRUM E SPIRA; Fiscal Year: 2010
    ..These gene expression-based biomarkers may eliminate the need for additional and often more invasive diagnostic tests that are costly, incur risk, and prolong the diagnostic evaluation of smokers with suspicion of lung cancer. ..
  3. Linking airway genomics to the pathogenesis and clinical heterogeneity of COPD
    AVRUM E contact SPIRA; Fiscal Year: 2010
    ..End of Abstract) ..