BARBARA SLACK

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Collagen type I selectively activates ectodomain shedding of the discoidin domain receptor 1: involvement of Src tyrosine kinase
    Barbara E Slack
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Cell Biochem 98:672-84. 2006
  2. pmc Surface expression and limited proteolysis of ADAM10 are increased by a dominant negative inhibitor of dynamin
    Robyn M Carey
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    BMC Cell Biol 12:20. 2011
  3. pmc Inhibition of dynamin-dependent endocytosis increases shedding of the amyloid precursor protein ectodomain and reduces generation of amyloid beta protein
    Robyn M Carey
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    BMC Cell Biol 6:30. 2005
  4. pmc Constitutive shedding of the amyloid precursor protein ectodomain is up-regulated by tumour necrosis factor-alpha converting enzyme
    B E Slack
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, 85 East Newton Street, Rm M1007, Boston, MA 02118, USA
    Biochem J 357:787-94. 2001
  5. pmc Adhesion-dependent redistribution of MAP kinase and MEK promotes muscarinic receptor-mediated signaling to the nucleus
    Barbara E Slack
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Cell Biochem 95:366-78. 2005
  6. pmc The m3 muscarinic acetylcholine receptor is coupled to mitogen-activated protein kinase via protein kinase C and epidermal growth factor receptor kinase
    B E Slack
    Boston University School of Medicine, Department of Pathology and Laboratory Medicine, 85 East Newton Street, Room M1007, Boston, MA 02118, USA
    Biochem J 348:381-7. 2000
  7. doi Differential regulation of mTOR-dependent S6 phosphorylation by muscarinic acetylcholine receptor subtypes
    Barbara E Slack
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Cell Biochem 104:1818-31. 2008
  8. pmc Tyrosine phosphorylation of paxillin and focal adhesion kinase by activation of muscarinic m3 receptors is dependent on integrin engagement by the extracellular matrix
    B E Slack
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston MA 02118, USA
    Proc Natl Acad Sci U S A 95:7281-6. 1998
  9. pmc Bone morphogenetic protein 9 induces the transcriptome of basal forebrain cholinergic neurons
    Ignacio Lopez-Coviella
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 102:6984-9. 2005
  10. ncbi Developmental pattern of expression of BMP receptors and Smads and activation of Smad1 and Smad5 by BMP9 in mouse basal forebrain
    Ignacio Lopez-Coviella
    Department of Psychiatry, Boston University School of Medicine, 715 Albany Street, Room L 810, Boston, MA 02118, USA
    Brain Res 1088:49-56. 2006

Collaborators

  • Robyn M Carey
  • Frederic Checler
  • Abraham Fisher
  • B Berse
  • Ignacio Lopez-Coviella
  • Moustapha Alfa Cissé
  • Vesela P Kovacheva
  • Claire Sunyach
  • Bruno Vincent
  • Tiffany M Mellott
  • Aletta Schnitzler
  • Victoria Zemelko
  • Jan K Blusztajn
  • R Scott Thies
  • Veronica Diesl
  • Tiffany J Mellott
  • Maximillian T Follettie
  • Jan Krzysztof Blusztajn

Detail Information

Publications11

  1. pmc Collagen type I selectively activates ectodomain shedding of the discoidin domain receptor 1: involvement of Src tyrosine kinase
    Barbara E Slack
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Cell Biochem 98:672-84. 2006
    ..Delayed shedding of the DDR1 ectodomain may represent a mechanism that limits DDR1-dependent cell adhesion and migration on collagen matrices...
  2. pmc Surface expression and limited proteolysis of ADAM10 are increased by a dominant negative inhibitor of dynamin
    Robyn M Carey
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    BMC Cell Biol 12:20. 2011
    ..This was accompanied by a reduction in Aβ generation. In the present study, we investigated whether surface expression of the α-secretase ADAM (a disintegrin and metalloprotease)10 is also regulated by dynamin-dependent endocytosis...
  3. pmc Inhibition of dynamin-dependent endocytosis increases shedding of the amyloid precursor protein ectodomain and reduces generation of amyloid beta protein
    Robyn M Carey
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    BMC Cell Biol 6:30. 2005
    ..In this study, we investigated the effects of modulators of endocytosis on APP processing...
  4. pmc Constitutive shedding of the amyloid precursor protein ectodomain is up-regulated by tumour necrosis factor-alpha converting enzyme
    B E Slack
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, 85 East Newton Street, Rm M1007, Boston, MA 02118, USA
    Biochem J 357:787-94. 2001
    ....
  5. pmc Adhesion-dependent redistribution of MAP kinase and MEK promotes muscarinic receptor-mediated signaling to the nucleus
    Barbara E Slack
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Cell Biochem 95:366-78. 2005
    ..This may represent a mechanism for priming the nucleus with MEK and MAPK, leading to more rapid and pronounced increases in intranuclear phospho-MAPK upon GPCR stimulation...
  6. pmc The m3 muscarinic acetylcholine receptor is coupled to mitogen-activated protein kinase via protein kinase C and epidermal growth factor receptor kinase
    B E Slack
    Boston University School of Medicine, Department of Pathology and Laboratory Medicine, 85 East Newton Street, Room M1007, Boston, MA 02118, USA
    Biochem J 348:381-7. 2000
    ..Moreover, the EGF-receptor-dependent pathway may be subject to negative-feedback regulation via m3 receptor-coupled activation of PKC...
  7. doi Differential regulation of mTOR-dependent S6 phosphorylation by muscarinic acetylcholine receptor subtypes
    Barbara E Slack
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Cell Biochem 104:1818-31. 2008
    ..The results demonstrate that multiple muscarinic receptor subtypes regulate mTOR, and that both MAPK-dependent and -independent mechanisms may mediate the response in a cell context-specific manner...
  8. pmc Tyrosine phosphorylation of paxillin and focal adhesion kinase by activation of muscarinic m3 receptors is dependent on integrin engagement by the extracellular matrix
    B E Slack
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston MA 02118, USA
    Proc Natl Acad Sci U S A 95:7281-6. 1998
    ..The activated integrins transmit a signal into the cell's interior leading to tyrosine phosphorylation of paxillin and FAK. This represents a novel mechanism for regulation of tyrosine phosphorylation by muscarinic receptors...
  9. pmc Bone morphogenetic protein 9 induces the transcriptome of basal forebrain cholinergic neurons
    Ignacio Lopez-Coviella
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 102:6984-9. 2005
    ..Approximately 30% of genes induced by BMP9 in vitro were overexpressed in purified BFCN, indicating that they belong to the BFCN transcriptome in situ and suggesting that BMP signaling contributes to maturation of BFCN in vivo...
  10. ncbi Developmental pattern of expression of BMP receptors and Smads and activation of Smad1 and Smad5 by BMP9 in mouse basal forebrain
    Ignacio Lopez-Coviella
    Department of Psychiatry, Boston University School of Medicine, 715 Albany Street, Room L 810, Boston, MA 02118, USA
    Brain Res 1088:49-56. 2006
    ..These data show that BMP9 activates the canonical BMP signaling pathway and suggest that this could be one of the mechanisms responsible for the induction of the cholinergic phenotype by BMP9 in the basal forebrain...
  11. ncbi M1 and M3 muscarinic receptors control physiological processing of cellular prion by modulating ADAM17 phosphorylation and activity
    Moustapha Alfa Cissé
    Institut de Pharmacologie Moleculaire et Cellulaire, 06560 Valbonne, France
    J Neurosci 27:4083-92. 2007
    ..Thus, our data provide strong evidence that muscarinic receptor activation increases the physiological processing of PrP(c) by upregulating the phosphorylation state and activity of ADAM17 protease...

Research Grants10

  1. INTEGRIN DEPENDENCE OF MUSCARINIC RECEPTOR SIGNALING
    BARBARA SLACK; Fiscal Year: 2002
    ..abstract_text> ..
  2. INTEGRIN DEPENDENCE OF MUSCARINIC RECEPTOR SIGNALING
    BARBARA SLACK; Fiscal Year: 2000
    ..abstract_text> ..
  3. MEMBRANE TURNOVER AND AMYLOID PRECURSOR PROTEIN RELEASE
    BARBARA SLACK; Fiscal Year: 2001
    ..The proposed experiments will establish the fundamental role of tyrosine kinases in the control of APP processing. ..
  4. INTEGRIN DEPENDENCE OF MUSCARINIC RECEPTOR SIGNALING
    BARBARA SLACK; Fiscal Year: 2001
    ..abstract_text> ..
  5. MEMBRANE TURNOVER AND AMYLOID PRECURSOR PROTEIN RELEASE
    BARBARA SLACK; Fiscal Year: 2000
    ..The proposed experiments will establish the fundamental role of tyrosine kinases in the control of APP processing. ..
  6. MEMBRANE TURNOVER AND AMYLOID PRECURSOR PROTEIN RELEASE
    BARBARA SLACK; Fiscal Year: 1999
    ..The proposed experiments will establish the fundamental role of tyrosine kinases in the control of APP processing. ..
  7. INTEGRIN DEPENDENCE OF MUSCARINIC RECEPTOR SIGNALING
    BARBARA SLACK; Fiscal Year: 2003
    ..abstract_text> ..