Affiliation: Boston University
- Heat-shock transcription factor HSF1 has a critical role in human epidermal growth factor receptor-2-induced cellular transformation and tumorigenesisL Meng
Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA
Oncogene 29:5204-13. 2010..Therefore, HSF1 is critical for proliferation of HER2-expressing cells, most likely because it maintains the levels of HSPs, which in turn control regulators of senescence p21 and survivin...
- Heat shock protein Hsp72 plays an essential role in Her2-induced mammary tumorigenesisL Meng
Department of Biochemistry, Boston University School of Medicine, MA, USA
Oncogene 30:2836-45. 2011..Therefore, Hsp72 has an essential role in Her2-induced tumorigenesis by regulating oncogene-induced senescence pathways...
- Less is more: improving proteostasis by translation slow downMichael Y Sherman
Department of Biochemistry, Boston University Medical School, Boston, MA 02118, USA Electronic address
Trends Biochem Sci 38:585-91. 2013..Accordingly, by slowing down translation one can significantly improve protein folding. In this review, we discuss how to target translational processes to improve proteostasis and implications in treating protein misfolding diseases. ..
- Molecular chaperones regulate p53 and suppress senescence programsMichael Y Sherman
Department of Biochemistry, Boston University Medical School, 715 Albany Street, K323, Boston, MA 02118, United States
FEBS Lett 581:3711-5. 2007..Here, we discuss a possibility that in cancer cells high levels of chaperones serve to keep the p53 signaling under control, thus allowing cancer cells to evade the default senescence and form tumors...
- Universal genome in the origin of metazoa: thoughts about evolutionMichael Sherman
Department of Biochemistry Boston University Medical School, 715 Albany St, Boston, Massachusetts 02118, USA
Cell Cycle 6:1873-7. 2007..g., a program of eye development or antibody synthesis in sea urchin. An example of natural turning on of a complex latent program in a lower taxon is discussed...
- Major heat shock protein Hsp72 controls oncogene-induced senescenceMichael Sherman
Department of Biochemistry, Boston University Medical School, Boston, Massachusetts, USA
Ann N Y Acad Sci 1197:152-7. 2010..Importantly, Hsp72 is able to suppress both p53-dependent and p53-independent senescence pathways. We propose that targeting Hsp72 may be a promising approach toward development of novel cancer therapies...
- Heat shock proteins in cancerMichael Sherman
Department of Biochemistry, Boston University School of Medicine, Massachusetts, USA
Ann N Y Acad Sci 1113:192-201. 2007..In this review we address the dual function of intracellular and extracellular located small Hsps and members of the Hsp70 family and its immunological consequences for cancer immunity...
- Cell Mechanisms of Abnormal Protein AggregationMichael Sherman; Fiscal Year: 2007..Exploration of fundamental mechanisms of protein aggregation that we undertake in this project will help to understand the nature of several neurological disorders. ..