Michael Sherman

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Heat-shock transcription factor HSF1 has a critical role in human epidermal growth factor receptor-2-induced cellular transformation and tumorigenesis
    L Meng
    Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA
    Oncogene 29:5204-13. 2010
  2. pmc Heat shock protein Hsp72 plays an essential role in Her2-induced mammary tumorigenesis
    L Meng
    Department of Biochemistry, Boston University School of Medicine, MA, USA
    Oncogene 30:2836-45. 2011
  3. ncbi request reprint Less is more: improving proteostasis by translation slow down
    Michael Y Sherman
    Department of Biochemistry, Boston University Medical School, Boston, MA 02118, USA Electronic address
    Trends Biochem Sci 38:585-91. 2013
  4. pmc Molecular chaperones regulate p53 and suppress senescence programs
    Michael Y Sherman
    Department of Biochemistry, Boston University Medical School, 715 Albany Street, K323, Boston, MA 02118, United States
    FEBS Lett 581:3711-5. 2007
  5. ncbi request reprint Universal genome in the origin of metazoa: thoughts about evolution
    Michael Sherman
    Department of Biochemistry Boston University Medical School, 715 Albany St, Boston, Massachusetts 02118, USA
    Cell Cycle 6:1873-7. 2007
  6. doi request reprint Major heat shock protein Hsp72 controls oncogene-induced senescence
    Michael Sherman
    Department of Biochemistry, Boston University Medical School, Boston, Massachusetts, USA
    Ann N Y Acad Sci 1197:152-7. 2010
  7. ncbi request reprint Heat shock proteins in cancer
    Michael Sherman
    Department of Biochemistry, Boston University School of Medicine, Massachusetts, USA
    Ann N Y Acad Sci 1113:192-201. 2007

Research Grants

  1. HSP72 AND REGULATION OF STRESS KINASES IN TUMOR CELLS
    Michael Sherman; Fiscal Year: 2000
  2. Cellular Mechanisms of Aggregation of Abnormal Proteins
    Michael Y Sherman; Fiscal Year: 2010
  3. Heat shock proteins in signaling and cancer
    Michael Sherman; Fiscal Year: 2009
  4. Cellular Mechanisms of Aggregation of Abnormal Proteins
    Michael Sherman; Fiscal Year: 2009
  5. Cell Mechanisms of Abnormal Protein Aggregation
    Michael Sherman; Fiscal Year: 2007
  6. Heat shock proteins in cancer and signaling
    Michael Sherman; Fiscal Year: 2007
  7. Cell Mechanisms of Abnormal Protein Aggregation
    Michael Sherman; Fiscal Year: 2006
  8. Heat shock proteins in signaling and cancer
    Michael Y Sherman; Fiscal Year: 2010
  9. Heat shock proteins in cancer and signaling
    Michael Sherman; Fiscal Year: 2005
  10. Cell Mechanisms of Abnormal Protein Aggregation
    Michael Sherman; Fiscal Year: 2005

Collaborators

Detail Information

Publications7

  1. pmc Heat-shock transcription factor HSF1 has a critical role in human epidermal growth factor receptor-2-induced cellular transformation and tumorigenesis
    L Meng
    Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA
    Oncogene 29:5204-13. 2010
    ..Therefore, HSF1 is critical for proliferation of HER2-expressing cells, most likely because it maintains the levels of HSPs, which in turn control regulators of senescence p21 and survivin...
  2. pmc Heat shock protein Hsp72 plays an essential role in Her2-induced mammary tumorigenesis
    L Meng
    Department of Biochemistry, Boston University School of Medicine, MA, USA
    Oncogene 30:2836-45. 2011
    ..Therefore, Hsp72 has an essential role in Her2-induced tumorigenesis by regulating oncogene-induced senescence pathways...
  3. ncbi request reprint Less is more: improving proteostasis by translation slow down
    Michael Y Sherman
    Department of Biochemistry, Boston University Medical School, Boston, MA 02118, USA Electronic address
    Trends Biochem Sci 38:585-91. 2013
    ..Accordingly, by slowing down translation one can significantly improve protein folding. In this review, we discuss how to target translational processes to improve proteostasis and implications in treating protein misfolding diseases. ..
  4. pmc Molecular chaperones regulate p53 and suppress senescence programs
    Michael Y Sherman
    Department of Biochemistry, Boston University Medical School, 715 Albany Street, K323, Boston, MA 02118, United States
    FEBS Lett 581:3711-5. 2007
    ..Here, we discuss a possibility that in cancer cells high levels of chaperones serve to keep the p53 signaling under control, thus allowing cancer cells to evade the default senescence and form tumors...
  5. ncbi request reprint Universal genome in the origin of metazoa: thoughts about evolution
    Michael Sherman
    Department of Biochemistry Boston University Medical School, 715 Albany St, Boston, Massachusetts 02118, USA
    Cell Cycle 6:1873-7. 2007
    ..g., a program of eye development or antibody synthesis in sea urchin. An example of natural turning on of a complex latent program in a lower taxon is discussed...
  6. doi request reprint Major heat shock protein Hsp72 controls oncogene-induced senescence
    Michael Sherman
    Department of Biochemistry, Boston University Medical School, Boston, Massachusetts, USA
    Ann N Y Acad Sci 1197:152-7. 2010
    ..Importantly, Hsp72 is able to suppress both p53-dependent and p53-independent senescence pathways. We propose that targeting Hsp72 may be a promising approach toward development of novel cancer therapies...
  7. ncbi request reprint Heat shock proteins in cancer
    Michael Sherman
    Department of Biochemistry, Boston University School of Medicine, Massachusetts, USA
    Ann N Y Acad Sci 1113:192-201. 2007
    ..In this review we address the dual function of intracellular and extracellular located small Hsps and members of the Hsp70 family and its immunological consequences for cancer immunity...

Research Grants18

  1. HSP72 AND REGULATION OF STRESS KINASES IN TUMOR CELLS
    Michael Sherman; Fiscal Year: 2000
    ..Results of this research may suggest whether JNK phosphatase and Hsp72 could be attractive new targets for anticancer drug design. ..
  2. Cellular Mechanisms of Aggregation of Abnormal Proteins
    Michael Y Sherman; Fiscal Year: 2010
    ..This work will uncover how organisms try to protect themselves from development of Hungtington's and certain other diseases. ..
  3. Heat shock proteins in signaling and cancer
    Michael Sherman; Fiscal Year: 2009
    ..Here we will investigate mechanisms of bypassing cell senescence and develop small molecules that restore the block and prevent cancer. ..
  4. Cellular Mechanisms of Aggregation of Abnormal Proteins
    Michael Sherman; Fiscal Year: 2009
    ..This work will uncover how organisms try to protect themselves from development of Hungtington's and certain other diseases. ..
  5. Cell Mechanisms of Abnormal Protein Aggregation
    Michael Sherman; Fiscal Year: 2007
    ..Exploration of fundamental mechanisms of protein aggregation that we undertake in this project will help to understand the nature of several neurological disorders. ..
  6. Heat shock proteins in cancer and signaling
    Michael Sherman; Fiscal Year: 2007
    ..These experiments will test a hypothesis that inhibitors of the heat shock response can enhance the anti-cancer activities of proteasome and Hsp90 inhibitors. ..
  7. Cell Mechanisms of Abnormal Protein Aggregation
    Michael Sherman; Fiscal Year: 2006
    ..Exploration of fundamental mechanisms of protein aggregation that we undertake in this project will help to understand the nature of several neurological disorders. ..
  8. Heat shock proteins in signaling and cancer
    Michael Y Sherman; Fiscal Year: 2010
    ..Here we will investigate mechanisms of bypassing cell senescence and develop small molecules that restore the block and prevent cancer. ..
  9. Heat shock proteins in cancer and signaling
    Michael Sherman; Fiscal Year: 2005
    ..These experiments will test a hypothesis that inhibitors of the heat shock response can enhance the anti-cancer activities of proteasome and Hsp90 inhibitors. ..
  10. Cell Mechanisms of Abnormal Protein Aggregation
    Michael Sherman; Fiscal Year: 2005
    ..Exploration of fundamental mechanisms of protein aggregation that we undertake in this project will help to understand the nature of several neurological disorders. ..
  11. Cell Mechanisms of Abnormal Protein Aggregation
    Michael Sherman; Fiscal Year: 2004
    ..Exploration of fundamental mechanisms of protein aggregation that we undertake in this project will help to understand the nature of several neurological disorders. ..
  12. HSP72 AND REGULATION OF STRESS KINASES IN TUMOR CELLS
    Michael Sherman; Fiscal Year: 2004
    ..Results of this research may suggest whether JNK phosphatase and Hsp72 could be attractive new targets for anticancer drug design. ..
  13. HSP72 AND REGULATION OF STRESS KINASES IN TUMOR CELLS
    Michael Sherman; Fiscal Year: 2003
    ..Results of this research may suggest whether JNK phosphatase and Hsp72 could be attractive new targets for anticancer drug design. ..
  14. HSP72 AND REGULATION OF STRESS KINASES IN TUMOR CELLS
    Michael Sherman; Fiscal Year: 2001
    ..Results of this research may suggest whether JNK phosphatase and Hsp72 could be attractive new targets for anticancer drug design. ..
  15. HSP72 AND REGULATION OF STRESS KINASES IN TUMOR CELLS
    Michael Sherman; Fiscal Year: 2002
    ..Results of this research may suggest whether JNK phosphatase and Hsp72 could be attractive new targets for anticancer drug design. ..
  16. HSP72 AND REGULATION OF STRESS KINASES IN TUMOR CELLS
    Michael Sherman; Fiscal Year: 2001
    ..Results of this research may suggest whether JNK phosphatase and Hsp72 could be attractive new targets for anticancer drug design. ..
  17. Heat shock proteins in cancer and signaling
    Michael Sherman; Fiscal Year: 2006
    ..These experiments will test a hypothesis that inhibitors of the heat shock response can enhance the anti-cancer activities of proteasome and Hsp90 inhibitors. ..